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Journal Articles

Abstract LB060: NMNAT-mediated NAD⁺ metabolism promotes glioma growth by modulating p53 post-translational modifications and nuclear atypia

Jiaqi Liu, Xianzun Tao, Yi Zhu, Xiang Gao, Tijana Canic, Kai Ruan, Zoraida Diaz-Perez, Sakir Humayun Gultekin, Priyamvada Rai, Qunfeng Dong, Grace Zhai

Cancer Res (2025) 85 (8_Supplement_2): LB060.

https://doi.org/10.1158/1538-7445.AM2025-LB060

Published: 25 April 2025

View articletitled, Abstract LB060: NMNAT-mediated NAD+ metabolism promotes glioma growth by modulating p53 post-translational modifications and nuclear atypia

Journal Articles

Abstract PO2-04-03: BL-M07D1, an antibody-drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study

Erwei Song, Herui Yao, Meili Sun, Hong Zong, Rongbo Lin, Wen Zou, Muran Ding, Jing Yu, Sa Xiao, Hongwei Wang, Hai Zhu, Martin Olivo, Yi Zhu

Cancer Res (2024) 84 (9_Supplement): PO2-04-03.

https://doi.org/10.1158/1538-7445.SABCS23-PO2-04-03

Published: 02 May 2024

View articletitled, Abstract PO2-04-03: BL-M07D1, an antibody-drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study

Journal Articles

Abstract PS08-07: BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody-drug conjugate, in patients with Locally Advanced or Metastatic Breast Cancer and other Solid Tumor: Results from a phase 1 study

Jiong Wu, Jian Zhang, Yiqun Du, Wen Zou, Muran Ding, Hui Yang, Sa Xiao, Hongwei Wang, Hai Zhu, Martin Olivo, Yi Zhu

Cancer Res (2024) 84 (9_Supplement): PS08-07.

https://doi.org/10.1158/1538-7445.SABCS23-PS08-07

Published: 02 May 2024

View articletitled, Abstract PS08-07: BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody-drug conjugate, in patients with Locally Advanced or Metastatic Breast Cancer and other Solid Tumor: Results from a phase 1 study

Journal Articles

Abstract 6190: Patterns of EGFR and HER3 co-expression in solid tumors

Matthew Wood, Cody Morrison, Jahan Salar Khalili, Yi Zhu

Cancer Res (2024) 84 (6_Supplement): 6190.

https://doi.org/10.1158/1538-7445.AM2024-6190

Published: 22 March 2024

View articletitled, Abstract 6190: Patterns of EGFR and HER3 co-expression in solid tumors

Journal Articles

Abstract 3140: BL-M05D1, a novel claudin 18.2-targeting ADC, demonstrates specific potent anti-tumor efficacy in preclinical evaluation

Weili Wan, Kelcey Dinkel, Austin Sanford, Shuwen Zhao, Shi Zhuo, Yong Zhang, Lan Chen, Ruigang Li, Jahan Salar Khalili, Xiao Sa, Yongqi Yan, Xuejiao Shen, Yi Zhu

Cancer Res (2024) 84 (6_Supplement): 3140.

https://doi.org/10.1158/1538-7445.AM2024-3140

Published: 22 March 2024

View articletitled, Abstract 3140: BL-M05D1, a novel claudin 18.2-targeting ADC, demonstrates specific potent anti-tumor efficacy in preclinical evaluation

Journal Articles

Abstract 3139: BL-M11D1, a novel CD33-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Weili Wan, Shuwen Zhao, Shi Zhuo, Yong Zhang, Lan Chen, Ruigang Li, Jahan Salar Khalili, Xiao Sa, Yongqi Yan, Xuejiao Shen, Yi Zhu

Cancer Res (2024) 84 (6_Supplement): 3139.

https://doi.org/10.1158/1538-7445.AM2024-3139

Published: 22 March 2024

View articletitled, Abstract 3139: BL-M11D1, a novel CD33-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Journal Articles

Abstract 5679: Tetra-specific antibody GNC-035: guidance and navigation control (GNC) molecule development for treatment of ROR1+ malignancies

Jahan Salar Khalili, Sa Xiao, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 5679.

https://doi.org/10.1158/1538-7445.AM2023-5679

Published: 04 April 2023

View articletitled, Abstract 5679: Tetra-specific antibody GNC-035: guidance and navigation control (GNC) molecule development for treatment of ROR1+ malignancies

Journal Articles

Abstract 5680: Tetra-specific antibody GNC-039: guidance and navigation control (GNC) molecule development for treatment of EGFRvIII+ malignancies

Jahan Salar Khalili, Sa Xiao, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 5680.

https://doi.org/10.1158/1538-7445.AM2023-5680

Published: 04 April 2023

View articletitled, Abstract 5680: Tetra-specific antibody GNC-039: guidance and navigation control (GNC) molecule development for treatment of EGFRvIII+ malignancies

Journal Articles

Abstract 2642: BL-B01D1, a novel EGFR×HER3-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Weili Wan, Shuwen Zhao, Shi Zhuo, Yong Zhang, Lan Chen, Gangrui Li, Blair Renshaw, Jahan Salar Khalili, Sa Xiao, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 2642.

https://doi.org/10.1158/1538-7445.AM2023-2642

Published: 04 April 2023

View articletitled, Abstract 2642: BL-B01D1, a novel EGFR×HER3-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Journal Articles

Abstract 6309: Anti-tumor efficacy of SI-B001, a novel EGFR × HER3 bispecific antibody, against EGFR-driven epithelial tumors alone or in combination with paclitaxel and carboplatin

Blair Renshaw, Jahan Salar Khalili, Sa Xiao, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 6309.

https://doi.org/10.1158/1538-7445.AM2023-6309

Published: 04 April 2023

View articletitled, Abstract 6309: Anti-tumor efficacy of SI-B001, a novel EGFR × HER3 bispecific antibody, against EGFR-driven epithelial tumors alone or in combination with paclitaxel and carboplatin

Journal Articles

Abstract 5681: Tetra-specific antibody GNC-038: guidance and navigation gontrol (GNC) molecule development for treatment of CD19+ malignancies

Jahan Salar Khalili, Sa Xiao, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 5681.

https://doi.org/10.1158/1538-7445.AM2023-5681

Published: 04 April 2023

View articletitled, Abstract 5681: Tetra-specific antibody GNC-038: guidance and navigation gontrol (GNC) molecule development for treatment of CD19+ malignancies

Journal Articles

Abstract 2644: BL-M02D1, a novel Trop2-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Yong Zhang, Weili Wan, Shi Zhuo, Lan Chen, Gangrui Li, Shuwen Zhao, Jahan Salar Khalili, Sa Xiao, Yongqi Yan, Xuejiao Shen, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 2644.

https://doi.org/10.1158/1538-7445.AM2023-2644

Published: 04 April 2023

View articletitled, Abstract 2644: BL-M02D1, a novel Trop2-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Journal Articles

Abstract 2643: BL-M07D1, a novel HER2-targeting ADC, demonstrates potent anti-tumor efficacy in preclinical pharmacodynamic models

Weili Wan, Shuwen Zhao, Shi Zhuo, Yong Zhang, Lan Chen, Gangrui Li, Jahan Salar Khalili, Sa Xiao, Yongqi Yan, Xuejiao Shen, Yi Zhu

Cancer Res (2023) 83 (7_Supplement): 2643.

https://doi.org/10.1158/1538-7445.AM2023-2643

Published: 04 April 2023

View articletitled, Abstract 2643: BL-M07D1, a novel HER2-targeting ADC, demonstrates potent anti-tumor efficacy in preclinical pharmacodynamic models

Journal Articles

Abstract 4538: A safe and potent agonist ADG106 targeting a unique epitope of CD137 with novel mechanism of actions

Guizhong Liu, Felix Du, Xiaohong She, Yi Zhu, Anthony W. Tolcher, Peter Luo

Cancer Res (2020) 80 (16_Supplement): 4538.

https://doi.org/10.1158/1538-7445.AM2020-4538

Published: 15 August 2020

View articletitled, Abstract 4538: A safe and potent agonist ADG106 targeting a unique epitope of CD137 with novel mechanism of actions

Journal Articles

Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy

Steven Gunawan, Ayaz Muhammad, Stuart W. J. Ember, Jin-Yi Zhu, Rebecca A. Jacobsen, Norbert Berndt, Que T. Lambert, Gary W. Reuther, Harshani R. Lawrence, Ernst Schonbrunn, Nicholas J. Lawrence

Cancer Res (2015) 75 (15_Supplement): 3643.

https://doi.org/10.1158/1538-7445.AM2015-3643

Published: 01 August 2015

View articletitled, Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy

Journal Articles

Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Jiangzhi Chen, Hong Xu, Xiuqun Zou, Jiamin Wang, Yi Zhu, Hao Chen, Baiyong Shen, Xiaxing Deng, Aiwu Zhou, Y. Eugene Chin, Frank J. Rauscher, III, Chenghong Peng, Zhaoyuan Hou

Cancer Res (2014) 74 (16): 4353–4363.

https://doi.org/10.1158/0008-5472.CAN-14-0181

Published: 13 August 2014

View articletitled, Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract 3902: Development of Aurora A inhibitors with ortho-halophenyl substituted pyrimidines: Unusual potency, SAR and X-ray crystallography studies.

Harshani R. Lawrence, Mathew P. Martin, Yunting Luo, Roberta Pireddu, Harsukh Gevariya, Sevil Ozcan, Jin-Yi Zhu, Mercedes Rodriguez, Roy Elias, Hua Yang, Said M. Sebti, Ernst Schonbrunn, Nicholas J. Lawrence

Cancer Res (2012) 72 (8_Supplement): 3902.

https://doi.org/10.1158/1538-7445.AM2012-3902

Published: 15 April 2012

View articletitled, Abstract 3902: Development of Aurora A inhibitors with ortho-halophenyl substituted pyrimidines: Unusual potency, SAR and X-ray crystallography studies.

Journal Articles

Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases

Roberta Pireddu, Kara Forinash, Nan N. Sun, Mathew P. Martin, Shen-Shu Sung, Brian Alexander, Jin-Yi Zhu, Wayne C. Guida, Ernst Schönbrunn, Saïd M. Sebti, Nicholas J. Lawrence

Cancer Res (2012) 72 (8_Supplement): 3904.

https://doi.org/10.1158/1538-7445.AM2012-3904

Published: 15 April 2012

View articletitled, Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases

Journal Articles

Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer

Ronil A. Patel, Kara D. Forinash, Roberta Pireddu, Ying Sun, Mathew P. Martin, Jin-Yi Zhu, Brian G. Alexander, Ernst Schonbrunn, Nicholas J. Lawrence, Said M. Sebti

Cancer Res (2012) 72 (8_Supplement): 2942.

https://doi.org/10.1158/1538-7445.AM2012-2942

Published: 15 April 2012

View articletitled, Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer

Journal Articles

Abstract 5120: Large-scale proteome analysis reveals complex molecular abnormalities in gastric cancer

Tiannan Guo, Yi Zhu, Wai Har Ng, Oi Lian Kon, Siu Kwan Sze

Cancer Res (2011) 71 (8_Supplement): 5120.

https://doi.org/10.1158/1538-7445.AM2011-5120

Published: 15 April 2011

View articletitled, Abstract 5120: Large-scale proteome analysis reveals complex molecular abnormalities in gastric cancer

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Abstract LB060: NMNAT-mediated NAD⁺ metabolism promotes glioma growth by modulating p53 post-translational modifications and nuclear atypia

Abstract PO2-04-03: BL-M07D1, an antibody-drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study

Abstract PS08-07: BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody-drug conjugate, in patients with Locally Advanced or Metastatic Breast Cancer and other Solid Tumor: Results from a phase 1 study

Abstract 6190: Patterns of EGFR and HER3 co-expression in solid tumors

Abstract 3140: BL-M05D1, a novel claudin 18.2-targeting ADC, demonstrates specific potent anti-tumor efficacy in preclinical evaluation

Abstract 3139: BL-M11D1, a novel CD33-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Abstract 5679: Tetra-specific antibody GNC-035: guidance and navigation control (GNC) molecule development for treatment of ROR1+ malignancies

Abstract 5680: Tetra-specific antibody GNC-039: guidance and navigation control (GNC) molecule development for treatment of EGFRvIII+ malignancies

Abstract 2642: BL-B01D1, a novel EGFR×HER3-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Abstract 6309: Anti-tumor efficacy of SI-B001, a novel EGFR × HER3 bispecific antibody, against EGFR-driven epithelial tumors alone or in combination with paclitaxel and carboplatin

Abstract 5681: Tetra-specific antibody GNC-038: guidance and navigation gontrol (GNC) molecule development for treatment of CD19+ malignancies

Abstract 2644: BL-M02D1, a novel Trop2-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation

Abstract 2643: BL-M07D1, a novel HER2-targeting ADC, demonstrates potent anti-tumor efficacy in preclinical pharmacodynamic models

Abstract 4538: A safe and potent agonist ADG106 targeting a unique epitope of CD137 with novel mechanism of actions

Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy

Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Abstract 3902: Development of Aurora A inhibitors with ortho-halophenyl substituted pyrimidines: Unusual potency, SAR and X-ray crystallography studies.

Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases

Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer

Abstract 5120: Large-scale proteome analysis reveals complex molecular abnormalities in gastric cancer

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