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Yi Yu
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Journal Articles

Abstract PO1-15-07: Subtyping-directed precision treatment refines traditional one-size-fits-all therapy in HR+/HER2- breast cancer: a sub-study of the MULAN umbrella trial

Xiu-Zhi Zhu, Xi Jin, Hu-Yun-Long Zhang, Xiyu Liu, Yi-Fan Zhou, Yi-Yu Chen, Tong Fu, Ming-Liang Jin, Ya-Xin Zhao, Yi-Fan Xie, Ruo-Xi Wang, Zhong-Hua Wang, Lei Fan, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-15-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-15-07
Published: 02 May 2024
View article titled, Abstract PO1-15-07: Subtyping-directed precision treatment refines traditional one-size-fits-all therapy in HR+/HER2- breast cancer: a sub-study of the MULAN umbrella trial
Journal Articles

Abstract PO2-13-04: Single cell characterization of senescent CD8+ T cell promotes immunotherapy resistance in early-stage triple-negative breast cancer

Tong Fu, Yi-Yu Chen, Xi Jin, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-13-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-13-04
Published: 02 May 2024
View article titled, Abstract PO2-13-04: Single cell characterization of senescent CD8+ T cell promotes immunotherapy resistance in early-stage triple-negative breast cancer
Journal Articles

Abstract 5806: Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus

Ya-Hui Chi, Chun-Ping Chang, Teng-Kuang Yeh, Chiung-Tong Chen, Wan-Ping Wang, Yen-Ting Chen, Chia-Hua Tsai, Yan-Fu Chen, Yi-Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chen-Lung Huang, Ya-Ping Chen, Hong Zhuang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5806.
https://doi.org/10.1158/1538-7445.AM2024-5806
Published: 22 March 2024
View article titled, Abstract 5806: Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
Journal Articles

Abstract 3242: TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors

Alvin Lu, Brian Haines, Ji Lei, Wenhai Zhang, Minjie Zhang, Douglas A. Whittington, Maria Lucia Ferdinez, Yi Yu, Samuel R. Meier, Ashley Choi, Alborz Bejnood, Madhavi Bandi, Katherine Lazarides, Xuewen Pan, Lina Gu, Alice W. Tsai, Sirimas Sudsakorn, Colin Liang, Jon Come, Brett Williams, Scott Throner, Joseph Vacca, John P. Maxwell, Jannik N. Anderson, Alan Huang, Chengyin Min, Yingnan P. Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3242.
https://doi.org/10.1158/1538-7445.AM2024-3242
Published: 22 March 2024
View article titled, Abstract 3242: TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors
Journal Articles

Abstract 4636: Genome-wide drug anchor screens identify CAAP1 and AKAP17A as regulators of PRMT5 inhibitor sensitivity

Satoshi Yoda, Matthew R. Tonini, Hilary E. Nicolson, Samuel Poleretzky, Silvia Fenoglio, Steven Lombardo, Lauren Grove, Samuel R. Meier, Ashley Choi, Yi Yu, Kevin M. Cottrell, John P. Maxwell, Teng, Jannik N. Andersen, Kimberly J. Briggs
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4636.
https://doi.org/10.1158/1538-7445.AM2024-4636
Published: 22 March 2024
View article titled, Abstract 4636: Genome-wide drug anchor screens identify CAAP1 and AKAP17A as regulators of PRMT5 inhibitor sensitivity
Journal Articles

Abstract 4631: Evaluation of the impact of homozygous MTAP truncations on the activity and selectivity of MTA-cooperative PRMT5 inhibitors

Matthew R. Tonini, Andre A. Mignault, Douglas A. Whittington, Steven A. Lombardo, Binzhang Shen, Hannah Stowe, Satoshi Yoda, Shangtao Liu, Minjie Zhang, Kevin M. Cottrell, Samuel R. Meier, Heidi Rego, Jennifer Morawiak, Ellen Hooper, Yi Yu, Heather DiBenedetto, Adam S. Crystal, Teng, Kimberly Briggs
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4631.
https://doi.org/10.1158/1538-7445.AM2024-4631
Published: 22 March 2024
View article titled, Abstract 4631: Evaluation of the impact of homozygous MTAP truncations on the activity and selectivity of MTA-cooperative PRMT5 inhibitors
Journal Articles

Abstract 5584: Experimental ‘loss-of function’ annotation of STK11 mutations with prognostic and therapeutic implications (TNG260mutationfinder.com)

Leanne G. Ahronian, Preksha Shahagadkar, Lauren Flynn, Lauren Grove, Shangtao Liu, Samuel R. Meier, Binzheng Shen, Hannah Stowe, Hsin-Jung Wu, Yi Yu, Andre Mignault, Iga Sienczylo, Heather DiBenedetto, Silvia Fenoglio, Teng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5584.
https://doi.org/10.1158/1538-7445.AM2024-5584
Published: 22 March 2024
View article titled, Abstract 5584: Experimental ‘loss-of function’ annotation of STK11 mutations with prognostic and therapeutic implications (TNG260mutationfinder.com)
Journal Articles

Abstract 558: Stearoyl-CoA desaturase is a synthetic lethal target in SMAD4-deficient cancers

Alvin Lu, Silvia Fenoglio, Hsin-Jung Wu, Minjie Zhang, Alice Tsai, Maria L. Ferdinez, Lauren Grove, Shangtao Liu, Edward Wu, Ashley Choi, Scott Throner, Samuel Meier, Yi Yu, Wenhai Zhang, John Maxwell, Jannik N. Andersen, Teng Teng, Brian B. Haines, Yingnan P. Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 558.
https://doi.org/10.1158/1538-7445.AM2024-558
Published: 22 March 2024
View article titled, Abstract 558: Stearoyl-CoA desaturase is a synthetic lethal target in SMAD4-deficient cancers
Journal Articles

Abstract 4527: TNG348 is synergistic with PARP inhibitors in tumor models with elevated replication stress

Antoine Simoneau, Hsin-Jung Wu, Charlotte Pratt, Grace Comer, Shangtao Liu, Samuel Meier, Tenzing Khendu, Ashley Choi, Hongxiang Zhang, Binzhang Shen, Douglas Whittington, Sirimas Sudsakorn, Wenhai Zhang, Yi Yu, Yingnan Chen, Brian Haines, Adam Crystal, Jannik N. Andersen, John Maxwell, Scott Throner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4527.
https://doi.org/10.1158/1538-7445.AM2024-4527
Published: 22 March 2024
View article titled, Abstract 4527: TNG348 is synergistic with PARP inhibitors in tumor models with elevated replication stress
Journal Articles

Abstract ND12: TNG260: A novel, orally active, CoREST-selective deacetylase inhibitor for the treatment of STK11-mutant cancers

Leanne G. Ahronian, Minjie Zhang, Chengyin Min, Alice W. Tsai, Jacques Ermolieff, Patrick McCarren, Margaret Wyman, David Guerin, Ye Wang, Alborz Bejnood, Kenjie Amemiya, Brian McMillan, Nikitha Das, Preksha Shahagadkar, Brian Doyon, Andre Mignault, Colin Liang, Vassil Elitzin, Samuel R. Meier, Ashley Choi, Yi Yu, John P. Maxwell, Brian B. Haines, Jannik N. Andersen, Heather DiBenedetto, Aaron Weitzman, Alan Huang, Xinyuan Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): ND12.
https://doi.org/10.1158/1538-7445.AM2023-ND12
Published: 29 May 2023
View article titled, Abstract ND12: TNG260: A novel, orally active, CoREST-selective deacetylase inhibitor for the treatment of STK11-mutant cancers
Journal Articles

Abstract LB059: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil Alexandrov
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB059.
https://doi.org/10.1158/1538-7445.AM2023-LB059
Published: 14 April 2023
View article titled, Abstract LB059: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer
Journal Articles

Abstract 4968: Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers

Antoine Simoneau, Hsin-Jung Wu, Madhavi Bandi, Katherine Lazarides, Sining Sun, Shangtao Liu, Samuel Meier, Ashley Choi, Hongxiang Zhang, Binzhang Shen, Douglas Whittington, Sirimas Sudsakorn, Wenhai Zhang, Yi Yu, Yong Liu, Colin Liang, Michael Palmieri, Yingnan Chen, Brian Haines, Alice Tsai, Minjie Zhang, Alan Huang, Jannik Andersen, Tianshu Feng, Scott Throner, John Maxwell
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4968.
https://doi.org/10.1158/1538-7445.AM2023-4968
Published: 04 April 2023
View article titled, Abstract 4968: Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers
Journal Articles

Abstract 523: Targeting myc-amplified cancers with a novel prodrug inhibiting aurora A kinase

Ya-Hui Chi, Chun-Ping Chang, Teng-Kuang Yeh, Wan-Ping Wang, Yen-Ting Chen, Chia-Hua Tsai, Yan-Fu Chen, Yi-Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 523.
https://doi.org/10.1158/1538-7445.AM2023-523
Published: 04 April 2023
View article titled, Abstract 523: Targeting myc-amplified cancers with a novel prodrug inhibiting aurora A kinase
Journal Articles

Abstract 1224: UMIBB: A novel nonparametric Bayesian method improves robustness and sensitivity of analysis in pooled CRISPR-Cas9 screens leveraging unique molecular identifiers

Ashley Choi, Samuel Meier, Silvia Fenoglio, Tianshu Feng, Justin Engel, Binzhang Shen, Shangtao Liu, Teng Teng, Tenzing Khendu, Alan Huang, Jannik Andersen, Xuewen Pan, Yi Yu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1224.
https://doi.org/10.1158/1538-7445.AM2022-1224
Published: 15 June 2022
View article titled, Abstract 1224: UMIBB: A novel nonparametric Bayesian method improves robustness and sensitivity of analysis in pooled CRISPR-Cas9 screens leveraging unique molecular identifiers
Journal Articles

Abstract 2603: USP1 inhibitor synthetic lethality in BRCA1-mutant cancer is driven by PCNA ubiquitination

Justin Engel, Madhavi Bandi, Antione Simoneau, Katherine Lazarides, Deepali Gotur, Truc Pham, Shangtao Liu, Samuel Meier, Ashley Choi, Hongxiang Zhang, Binzhang Shen, Fang Li, Douglas Whittington, Shanzhong Gong, Xuewen Pan, Yi Yu, Lina Gu, Scott Throner, John Maxwell, Yingnan Chen, Alan Huang, Jannik Andersen, Tianshu Feng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2603.
https://doi.org/10.1158/1538-7445.AM2022-2603
Published: 15 June 2022
View article titled, Abstract 2603: USP1 inhibitor synthetic lethality in BRCA1-mutant cancer is driven by PCNA ubiquitination
Journal Articles

Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Ya-Hui Chi, Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Mine-Hsine Wu, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiung-Tong Chen, Chuan Shih
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1937.
https://doi.org/10.1158/1538-7445.AM2020-1937
Published: 15 August 2020
View article titled, Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
Journal Articles

Abstract 3851: An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer

Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Dai-Hui Jhuo, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Po-Chu Kuo, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiun-Tong Chen, Chuan Shih, Ya-Hui Chi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3851.
https://doi.org/10.1158/1538-7445.AM2019-3851
Published: 01 July 2019
View article titled, Abstract 3851: An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer
Journal Articles

Abstract 1963: ARQ 531, a potent reversible BTK inhibitor, exhibits potent antitumor activity in ibrutinib-resistant diffuse large B-cell lymphoma

Sudharshan Eathiraj, Yi Yu, Ron Savage, Jennifer A. Woyach, Sean D. Reiff, Amy J. Johnson, Brian Schwartz
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1963.
https://doi.org/10.1158/1538-7445.AM2018-1963
Published: 01 July 2018
View article titled, Abstract 1963: ARQ 531, a potent reversible BTK inhibitor, exhibits potent antitumor activity in ibrutinib-resistant diffuse large B-cell lymphoma
Journal Articles

Abstract 2943: In vivo combination of miransertib (ARQ 092) with anti-PD-1 antibody, trametinib, lapatinib, trastuzumab and paclitaxel

Yi Yu, Terence Hall, Sudharshan Eathiraj, Ron E. Savage, Brian Schwartz
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2943.
https://doi.org/10.1158/1538-7445.AM2018-2943
Published: 01 July 2018
View article titled, Abstract 2943: In vivo combination of miransertib (ARQ 092) with anti-PD-1 antibody, trametinib, lapatinib, trastuzumab and paclitaxel
Journal Articles

Abstract 4797: In vitro and in vivo effect of ARQ 531 on Trk family kinases

Yi Yu, Gabi Schwartz, Pascal Schamber, Ron E. Savage, Sudharshan Eathiraj, Terence Hall, Brian Schwartz
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4797.
https://doi.org/10.1158/1538-7445.AM2018-4797
Published: 01 July 2018
View article titled, Abstract 4797: In vitro and in vivo effect of ARQ 531 on Trk family kinases