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The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma

Cancer Res (2025) 85 (9): 1628–1643.

https://doi.org/10.1158/0008-5472.CAN-24-1893

Published: 02 May 2025

View articletitled, The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma

Includes: Supplementary data

Journal Articles

Abstract LB135: BCG014: A CDH3-targeting ADC with a novel TOP1 inhibitor demonstrates robust anti-tumor efficacy in PDX models

Yi Yang, Kaiqing Zhang, Kunying Hao, Chengzhang Shang

Cancer Res (2025) 85 (8_Supplement_2): LB135.

https://doi.org/10.1158/1538-7445.AM2025-LB135

Published: 25 April 2025

View articletitled, Abstract LB135: BCG014: A CDH3-targeting ADC with a novel TOP1 inhibitor demonstrates robust anti-tumor efficacy in PDX models

Journal Articles

Abstract 3836: Discovery of a highly potent fully human VEGF nanobody from RenNano transgenic mice that exhibits a superior blocking activity on VEGF function

Yi Yang, Weiqiu Lan, Baihong Liu, Yang Chen

Cancer Res (2025) 85 (8_Supplement_1): 3836.

https://doi.org/10.1158/1538-7445.AM2025-3836

Published: 21 April 2025

View articletitled, Abstract 3836: Discovery of a highly potent fully human VEGF nanobody from RenNano transgenic mice that exhibits a superior blocking activity on VEGF function

Journal Articles

Abstract 3449: The role of N-terminal cleavage of Trop2 in tumor progression and therapeutic resistance in triple negative breast cancer

Andrea E. Wilson, Junping Wei, Gangjun Lei, Tao Wang, Xiao-Yi Yang, Melissa Gajda, Cong-Xiao Liu, Zachary C. Hartman

Cancer Res (2025) 85 (8_Supplement_1): 3449.

https://doi.org/10.1158/1538-7445.AM2025-3449

Published: 21 April 2025

View articletitled, Abstract 3449: The role of N-terminal cleavage of Trop2 in tumor progression and therapeutic resistance in triple negative breast cancer

Journal Articles

Abstract 6081: Bispecific antibody drug conjugates (bsADCs) targeting DLL3 and B7-H3 demonstrated potent anti-tumor activity in preclinical models of small cell lung cancer (SCLC)

Kaiqing Zhang, Liu Yang, Peiran Li, Yu Qi, Jushi Gai, Luheng Du, Gao An, Chengzhang Shang, Yanan Guo, Yi Yang, Frank An

Cancer Res (2025) 85 (8_Supplement_1): 6081.

https://doi.org/10.1158/1538-7445.AM2025-6081

Published: 21 April 2025

View articletitled, Abstract 6081: Bispecific antibody drug conjugates (bsADCs) targeting DLL3 and B7-H3 demonstrated potent anti-tumor activity in preclinical models of small cell lung cancer (SCLC)

Journal Articles

Abstract 6022: YH006: a next-generation CTLA-4×OX40 Treg antagonist, demonstrates superior tumor-infiltrating Treg-depletion efficacy and favorable manufacturability

Sarah Chan, Baihong Liu, Bahetiyaer Huwatibieke, Jing Zhang, Yang Chen, Minjuan Meng, Wenchao Zheng, Lei Zhang, Yi Yang

Cancer Res (2025) 85 (8_Supplement_1): 6022.

https://doi.org/10.1158/1538-7445.AM2025-6022

Published: 21 April 2025

View articletitled, Abstract 6022: YH006: a next-generation CTLA-4×OX40 Treg antagonist, demonstrates superior tumor-infiltrating Treg-depletion efficacy and favorable manufacturability

Journal Articles

Abstract 4776: Preclinical study of bispecific antibody drug conjugates (bsADCs) targeting DLL3 and SEZ6 demonstrated potent anti-tumor activity in small cell lung cancer (SCLC) xenograft models

Ting Yi, Liu Yang, Kunying Hao, Wenpeng Cao, Yu Qi, Jushi Gai, Luheng Du, Gao An, Chengzhang Shang, Yi Yang, Frank An

Cancer Res (2025) 85 (8_Supplement_1): 4776.

https://doi.org/10.1158/1538-7445.AM2025-4776

Published: 21 April 2025

View articletitled, Abstract 4776: Preclinical study of bispecific antibody drug conjugates (bsADCs) targeting DLL3 and SEZ6 demonstrated potent anti-tumor activity in small cell lung cancer (SCLC) xenograft models

Journal Articles

Abstract 2125: The trispecific T cell engager platform enhances T cell function and therapeutic efficacy via integrated 4-1BB nanobody co-stimulation

Kaiqing Zhang, Baihong Liu, Liu Yang, Saina Ma, Jiawei Wu, Jinhua Zhao, Yang Chen, Xueyuan Jiang, Peiyan Pan, Jing Zhang, Yi Yang

Cancer Res (2025) 85 (8_Supplement_1): 2125.

https://doi.org/10.1158/1538-7445.AM2025-2125

Published: 21 April 2025

View articletitled, Abstract 2125: The trispecific T cell engager platform enhances T cell function and therapeutic efficacy via integrated 4-1BB nanobody co-stimulation

Journal Articles

Abstract 1576: RenBiologics- a fully human antibody library generated by RenMice facilitates the development of antibody drugs

Ting Yi, Jun Du, Yue Zhang, Yuting Hu, Shujin Zhang, Xin Ji, Yi Yang

Cancer Res (2025) 85 (8_Supplement_1): 1576.

https://doi.org/10.1158/1538-7445.AM2025-1576

Published: 21 April 2025

View articletitled, Abstract 1576: RenBiologics- a fully human antibody library generated by RenMice facilitates the development of antibody drugs

Journal Articles

Abstract 2115: SIM0680, a potent antibody-drug conjugate for the treatment of solid tumors expressing ENPP3

Abdullah Emran, Yutian Zhang, Yi Yang, Liting Xue, Lu Gong, Amin Al-Shami, Yayuan Fu, Renhong Tang

Cancer Res (2025) 85 (8_Supplement_1): 2115.

https://doi.org/10.1158/1538-7445.AM2025-2115

Published: 21 April 2025

View articletitled, Abstract 2115: SIM0680, a potent antibody-drug conjugate for the treatment of solid tumors expressing ENPP3

Journal Articles

Abstract 4768: Development of fully human TCR-mimic antibodies targeting intracellular tumor antigens using humanized RenTCR-mimic transgenic mice

Han Zhang, Wanbo Tang, Jun Du, Yue Zhang, Limin Zhao, Xin Jiao, Baihong Liu, Yi Yang

Cancer Res (2025) 85 (8_Supplement_1): 4768.

https://doi.org/10.1158/1538-7445.AM2025-4768

Published: 21 April 2025

View articletitled, Abstract 4768: Development of fully human TCR-mimic antibodies targeting intracellular tumor antigens using humanized RenTCR-mimic transgenic mice

Journal Articles

Abstract 1763: Arsenoplatin-7, a family member of arsenoplatins, as a novel therapeutic strategy to overcome platinum-resistance in ovarian cancer

Wenan Qiang, Denana Miodragovic, Yi Yang, Bong Jin Hong, Chi-Hao Luan, David Fang, Daniela E. Matei, Thomas V. O’Halloran

Cancer Res (2025) 85 (8_Supplement_1): 1763.

https://doi.org/10.1158/1538-7445.AM2025-1763

Published: 21 April 2025

View articletitled, Abstract 1763: Arsenoplatin-7, a family member of arsenoplatins, as a novel therapeutic strategy to overcome platinum-resistance in ovarian cancer

Journal Articles

Abstract 2822: AdipoRon suppresses breast cancer growth through autophagy-mediated ferroptosis

Yong-Han Su, Yi-Zhen Wu, Hsin-Yi Yang, Tzu-Yi Chia, Jou-Fang Hsu, Ching-Ying Kuo

Cancer Res (2025) 85 (8_Supplement_1): 2822.

https://doi.org/10.1158/1538-7445.AM2025-2822

Published: 21 April 2025

View articletitled, Abstract 2822: AdipoRon suppresses breast cancer growth through autophagy-mediated ferroptosis

Journal Articles

Abstract 2128: Uncovering the multiple therapeutic mechanisms of trastuzumab deruxtecan (T-DXd): effective extracellular payload release and immunomodulatory stimulation

Li-Chung Tsao, John S. Wang, Xingru Ma, Sirajbir Sodhi, Joey V. Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao-Yi Yang, Gang-jun Lei, Ivan Spasojevic, Ping Fan, Timothy N. Trotter, Michael A. Morse, Herbert K. Lyerly, Zachary C. Hartman

Cancer Res (2025) 85 (8_Supplement_1): 2128.

https://doi.org/10.1158/1538-7445.AM2025-2128

Published: 21 April 2025

View articletitled, Abstract 2128: Uncovering the multiple therapeutic mechanisms of trastuzumab deruxtecan (T-DXd): effective extracellular payload release and immunomodulatory stimulation

Journal Articles

Abstract 6507: Using induced pluripotent stem cells to model tyrosine kinase inhibitor response heterogeneity in chronic myeloid leukemia

John Joson Ng, Lin Ming Lee, Yi Yang Lim, Kian Leong Lee, Fengcong John Ouyang, Vaidehi Krishnan, Sin Tiong Ong

Cancer Res (2025) 85 (8_Supplement_1): 6507.

https://doi.org/10.1158/1538-7445.AM2025-6507

Published: 21 April 2025

View articletitled, Abstract 6507: Using induced pluripotent stem cells to model tyrosine kinase inhibitor response heterogeneity in chronic myeloid leukemia

Journal Articles

Abstract 4793: BCG033: a first-in-class PTK7×TROP2 bispecific ADC demonstrating potent and broad efficacy in various preclinical models

Lillian Ma, Na Zhang, Chengzhang Shang, Yi Yang

Cancer Res (2025) 85 (8_Supplement_1): 4793.

https://doi.org/10.1158/1538-7445.AM2025-4793

Published: 21 April 2025

View articletitled, Abstract 4793: BCG033: a first-in-class PTK7×TROP2 bispecific ADC demonstrating potent and broad efficacy in various preclinical models

Journal Articles

Abstract LB130: Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses

Huichao Liang, Yanan Guo, Meimei Yin, Aki Kawagishi, Takaho Terada, Yoshihiko Kihara, Toru Kanke, Chaoshe Guo, W. Frank An, Yi Yang

Cancer Res (2024) 84 (7_Supplement): LB130.

https://doi.org/10.1158/1538-7445.AM2024-LB130

Published: 05 April 2024

View articletitled, Abstract LB130: Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses

Journal Articles

Abstract LB127: A first-in-class bispecific ADC targeting FORL1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model

Yifu Zhang, Chengzhang Shang, Chaoshe Guo, Yi Yang

Cancer Res (2024) 84 (7_Supplement): LB127.

https://doi.org/10.1158/1538-7445.AM2024-LB127

Published: 05 April 2024

View articletitled, Abstract LB127: A first-in-class bispecific ADC targeting FORL1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model

Journal Articles

Abstract 2893: Inhibition of ADAMTS4 and 5 to regulate the tumor microenvironment

Cham han Lee, Seong Keun Kim, Sung Moo Kim, Young Sang Kim, Sang Hyeob Lee, Seong Yun Ha, Yun Sun Lee, Jin Yi Yang

Cancer Res (2024) 84 (6_Supplement): 2893.

https://doi.org/10.1158/1538-7445.AM2024-2893

Published: 22 March 2024

View articletitled, Abstract 2893: Inhibition of ADAMTS4 and 5 to regulate the tumor microenvironment

Journal Articles

Abstract 2618: BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models

Sufei Yao, Chengzhang Shang, Zhuolin Li, Gao An, Chaoshe Guo, W. Frank An, Yi Yang

Cancer Res (2024) 84 (6_Supplement): 2618.

https://doi.org/10.1158/1538-7445.AM2024-2618

Published: 22 March 2024

View articletitled, Abstract 2618: BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models

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The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma

Abstract LB135: BCG014: A CDH3-targeting ADC with a novel TOP1 inhibitor demonstrates robust anti-tumor efficacy in PDX models

Abstract 3836: Discovery of a highly potent fully human VEGF nanobody from RenNano transgenic mice that exhibits a superior blocking activity on VEGF function

Abstract 3449: The role of N-terminal cleavage of Trop2 in tumor progression and therapeutic resistance in triple negative breast cancer

Abstract 6081: Bispecific antibody drug conjugates (bsADCs) targeting DLL3 and B7-H3 demonstrated potent anti-tumor activity in preclinical models of small cell lung cancer (SCLC)

Abstract 6022: YH006: a next-generation CTLA-4×OX40 Treg antagonist, demonstrates superior tumor-infiltrating Treg-depletion efficacy and favorable manufacturability

Abstract 4776: Preclinical study of bispecific antibody drug conjugates (bsADCs) targeting DLL3 and SEZ6 demonstrated potent anti-tumor activity in small cell lung cancer (SCLC) xenograft models

Abstract 2125: The trispecific T cell engager platform enhances T cell function and therapeutic efficacy via integrated 4-1BB nanobody co-stimulation

Abstract 1576: RenBiologics- a fully human antibody library generated by RenMice facilitates the development of antibody drugs

Abstract 2115: SIM0680, a potent antibody-drug conjugate for the treatment of solid tumors expressing ENPP3

Abstract 4768: Development of fully human TCR-mimic antibodies targeting intracellular tumor antigens using humanized RenTCR-mimic transgenic mice

Abstract 1763: Arsenoplatin-7, a family member of arsenoplatins, as a novel therapeutic strategy to overcome platinum-resistance in ovarian cancer

Abstract 2822: AdipoRon suppresses breast cancer growth through autophagy-mediated ferroptosis

Abstract 2128: Uncovering the multiple therapeutic mechanisms of trastuzumab deruxtecan (T-DXd): effective extracellular payload release and immunomodulatory stimulation

Abstract 6507: Using induced pluripotent stem cells to model tyrosine kinase inhibitor response heterogeneity in chronic myeloid leukemia

Abstract 4793: BCG033: a first-in-class PTK7×TROP2 bispecific ADC demonstrating potent and broad efficacy in various preclinical models

Abstract LB130: Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses

Abstract LB127: A first-in-class bispecific ADC targeting FORL1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model

Abstract 2893: Inhibition of ADAMTS4 and 5 to regulate the tumor microenvironment

Abstract 2618: BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models

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