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Journal Articles

Abstract 7320: KGX105, a conditionally active prodrug of EGFRxCD3 T cell engager induces anti-tumor potency

Free
Yutao Gao, Jing Wang, Shumin Yang, Jie Huang, Hui Chen, Huiping Jiang, Haixiang Wu, Yi Wu, Weidong Jiang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7320.
https://doi.org/10.1158/1538-7445.AM2025-7320
Published: 21 April 2025
View articletitled, Abstract 7320: KGX105, a conditionally active prodrug of EGFRxCD3 T cell engager induces anti-tumor potency
Journal Articles

Abstract 3858: Therapeutic targeting of cofilin-1 phosphorylation by peptidomimetics inhibits lung cancer metastasis

Free
Min-Ying Lin, Jyh-Der Leu, Chun-Yi Wu, Yi-Jang Lee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3858.
https://doi.org/10.1158/1538-7445.AM2025-3858
Published: 21 April 2025
View articletitled, Abstract 3858: Therapeutic targeting of cofilin-1 phosphorylation by peptidomimetics inhibits lung cancer metastasis
Journal Articles

Abstract 3479: iPSC-derived γδT with novel combinatorial KO demonstrated significant anti-tumor activity and extended longevity without cytokine support

Free
Jhang-Sian Yu, Ming-Chin Ko, Chia-Hung Lin, Yi-Han Dai, Ke-Hsun Hsu, I-Ting Chen, Ting-Yi Wu, Jin-Yi Lu, Ying-Tsen Tung, Edward Po-Fan Chu, Yuan-Yu Hsia, Yo-Chuen Lin, Chieh-Teng Cheng, Tzu-Chien Kuo, Yi-Ting Lai, Wei-Ting Chen, Darien Zhing Herr Chan, Lee-Yieng Lim, Chih-Lung Chen, Chun-Yu Lin, Lin-Yu Liao, Wan-Chen Tsai, Lien-Szu Wu, Ching-Ying Huang, De-Kuan Chang, Alex Shih-Min Huang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3479.
https://doi.org/10.1158/1538-7445.AM2025-3479
Published: 21 April 2025
View articletitled, Abstract 3479: iPSC-derived γδT with novel combinatorial KO demonstrated significant anti-tumor activity and extended longevity without cytokine support
Journal Articles

Abstract 3475: KGX103, a conditionally active prodrug of PD-1-targeting IL-15 induces antitumor activity by preferentially activating PD-1+ intratumoral T cells in cis

Free
Jiangfeng Fan, Zhiqiang Bai, Jing Wang, Shumin Yang, Yucheng Luo, Jie Huang, Hui Chen, Haixiang Wu, Yi Wu, Weidong Jiang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3475.
https://doi.org/10.1158/1538-7445.AM2025-3475
Published: 21 April 2025
View articletitled, Abstract 3475: KGX103, a conditionally active prodrug of PD-1-targeting IL-15 induces antitumor activity by preferentially activating PD-1+ intratumoral T cells in cis
Journal Articles

C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis

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Jun-Rui Feng, Xue Li, Cong Han, Yue Chang, Yu Fu, Gong-Chang Feng, Yutiantian Lei, Hai-Yun Li, Patrick Ming-Kuen Tang, Shang-Rong Ji, Yuzhu Hou, Yi Wu
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4184–4198.
https://doi.org/10.1158/0008-5472.CAN-24-0253
Published: 16 December 2024
View articletitled, C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis
Open the PDF for C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis in another window
Includes: Supplementary data
Journal Articles

LX1 Dual Targets AR Variants and AKR1C3 in Advanced Prostate Cancer Therapy

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Shu Ning, Cameron M. Armstrong, Enming Xing, Amy R. Leslie, Richard Y. Gao, Masuda Sharifi, Zachary A. Schaaf, Wei Lou, Xiangrui Han, Desiree H. Xu, Rui Yang, Jeffrey Cheng, Shabber Mohammed, Nicholas Mitsiades, Chengfei Liu, Alan P. Lombard, Chun-Yi Wu, Xiaolin Cheng, Pui-Kai Li, Allen C. Gao
Journal: Cancer Research
Cancer Res (2024) 84 (21): 3617–3628.
https://doi.org/10.1158/0008-5472.CAN-24-0440
Published: 04 November 2024
View articletitled, LX1 Dual Targets AR Variants and AKR1C3 in Advanced Prostate Cancer Therapy
Open the PDF for LX1 Dual Targets AR Variants and AKR1C3 in Advanced Prostate Cancer Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 5638: Total-sync ultra-content microscopic opto-biotinylation enables high-sensitivity hypothesis-free subcellular protein discovery

Free
Jung-Chi Liao, Chih-Wei Chang, Yi-De Chen, Chantal Hoi Yin Cheung, Chia-Wen Chung, Hsiao-Jen Chang, Yong-Da Sie, You-Pi Liu, Yu-Chih Lin, Hsiang-Ju Kai, Weng Man Chong, Hsin-Yi Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5638.
https://doi.org/10.1158/1538-7445.AM2023-5638
Published: 04 April 2023
View articletitled, Abstract 5638: Total-sync ultra-content microscopic opto-biotinylation enables high-sensitivity hypothesis-free subcellular protein discovery
Journal Articles

Abstract 4400: Translational drug interaction database (TDID): A knowledgebase for drug interactions

Free
Shijun Zhang, Heng-Yi Wu, Rohith Vanam, chien-WeiChiang, Lei Wang, Lang Li
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4400.
https://doi.org/10.1158/1538-7445.AM2020-4400
Published: 15 August 2020
View articletitled, Abstract 4400: Translational drug interaction database (TDID): A knowledgebase for drug interactions
Journal Articles

Abstract 4852: CBLC functions as a novel therapeutic target to enhance the efficacy of paclitaxel on EGFR wild-type lung adenocarcinoma by downregulating AURKA

Free
Shiao-Ya Hong, Yu-Rung Kao, Yi-Ping Lin, Meng-Hsuan Lee, Jyun-Yi Wu, Cheng-Wen Wu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4852.
https://doi.org/10.1158/1538-7445.AM2020-4852
Published: 15 August 2020
View articletitled, Abstract 4852: CBLC functions as a novel therapeutic target to enhance the efficacy of paclitaxel on EGFR wild-type lung adenocarcinoma by downregulating AURKA
Journal Articles

A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis

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Kun Liao, Shuye Deng, Liyan Xu, Wenfeng Pan, Shiyu Yang, Fufu Zheng, Xingui Wu, Hongrong Hu, Zhijun Liu, Junhang Luo, Rui Zhang, Dong-Ming Kuang, Jiajun Dong, Yi Wu, Hui Zhang, Penghui Zhou, Jin-Xin Bei, Yang Xu, Yin Ji, Peng Wang, Huai-Qiang Ju, Rui-Hua Xu, Bo Li
Journal: Cancer Research
Cancer Res (2020) 80 (4): 675–688.
https://doi.org/10.1158/0008-5472.CAN-19-2060
Published: 14 February 2020
View articletitled, A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis
Open the PDF for A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma

Free
Pei-Yi Wu, I-Shing Yu, Yueh-Chien Lin, Yu-Tzu Chang, Chien-Chin Chen, Kuan-Hung Lin, Tzu-Hsuan Tseng, Mati Kargren, Yu-Ling Tai, Tang-Long Shen, Yen-Lin Liu, Bo-Jeng Wang, Chi-Hao Chang, Wei-Min Chen, Hsueh-Fen Juan, Shiu-Feng Huang, Ya-Yun Chan, Yung-Feng Liao, Wen-Ming Hsu, Hsinyu Lee
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5550–5562.
https://doi.org/10.1158/0008-5472.CAN-18-3272
Published: 01 November 2019
View articletitled, Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma
Open the PDF for Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Free
Xiu-Hui Zhan, Ji-Wei Jiao, Hai-Feng Zhang, Xiu-E Xu, Jian-Zhong He, Run-Liu Li, Hai-Ying Zou, Zhi-Yong Wu, Shao-Hong Wang, Jian-Yi Wu, Lian-Di Liao, Juan-Juan Wang, Yin-Wei Cheng, Kai Zhang, Gera Neufeld, Li-Yan Xu, En-Min Li
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4951–4964.
https://doi.org/10.1158/0008-5472.CAN-19-0860
Published: 01 October 2019
View articletitled, LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion
Open the PDF for LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion in another window
Includes: Supplementary data
Journal Articles

Abstract CT055: Microdose induced oxaliplatin-DNA adducts as a predictive biomarker of response in colorectal cancer

Free
Justin Chen, May Cho, Maike Zimmermann, Thomas Semrad, Chun-Yi Wu, Aiming Yu, Chong-Xian Pan, Paul T. Henderson, Edward J. Kim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT055.
https://doi.org/10.1158/1538-7445.AM2019-CT055
Published: 01 July 2019
View articletitled, Abstract CT055: Microdose induced oxaliplatin-DNA adducts as a predictive biomarker of response in colorectal cancer
Journal Articles

Abstract 609: Neutrophils play a critical role in mediating antitumor activity of a combination therapy of radiation and immunotherapy

Free
Mi-Hua Tao, Chia-Jen Wu, Yi-Ting Tsai, Ping-Yi Wu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 609.
https://doi.org/10.1158/1538-7445.AM2018-609
Published: 01 July 2018
View articletitled, Abstract 609: Neutrophils play a critical role in mediating antitumor activity of a combination therapy of radiation and immunotherapy
Journal Articles

Abstract 721: Suppression of orthotopic liver cancers by a combinatorial therapy of radiation and adenoviral vectors expressing interleukin 12

Free
Mi-Hua Tao, Wen-Shan Tsao, Ping-Yi Wu
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 721.
https://doi.org/10.1158/1538-7445.AM2014-721
Published: 01 October 2014
View articletitled, Abstract 721: Suppression of orthotopic liver cancers by a combinatorial therapy of radiation and adenoviral vectors expressing interleukin 12
Journal Articles

Abstract 5197: Quantitative phosphorproteomics identified GPER-initiated PKA signal transduction event in breast cancer stem cell

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Alan Chuan-Ying Lai, Yi-Ting Wang, Ruey-Jen Lin, Hsin-Yi Wu, Wen-Wei Chang, Wen-Ying Chang, Yu-Ju Chen, Alice L. Yu
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5197.
https://doi.org/10.1158/1538-7445.AM2012-5197
Published: 15 April 2012
View articletitled, Abstract 5197: Quantitative phosphorproteomics identified GPER-initiated PKA signal transduction event in breast cancer stem cell
Journal Articles

Abstract 3245: Novel anticancer agents – lead discovery and optimization

Free
Liping Meng, Don-Hong Wang, Chun-Yi Wu, Kit S. Lam
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3245.
https://doi.org/10.1158/1538-7445.AM2011-3245
Published: 15 April 2011
View articletitled, Abstract 3245: Novel anticancer agents – lead discovery and optimization
Journal Articles

Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer

Free
Ruo-Kai Lin, Chiu-Yi Wu, Jer-Wei Chang, Li-Jung Juan, Han-Shui Hsu, Chih-Yi Chen, Yun-Yueh Lu, Yen-An Tang, Yi-Chieh Yang, Pan-Chyr Yang, Yi-Ching Wang
Journal: Cancer Research
Cancer Res (2010) 70 (14): 5807–5817.
https://doi.org/10.1158/0008-5472.CAN-09-4161
Published: 14 July 2010
View articletitled, Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer
Open the PDF for Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma

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Jenn-Ren Hsiao, Kung-Chao Chang, Chaio-Wei Chen, Shih-Yi Wu, Ih-Jen Su, Mei-Chi Hsu, Ying-Tai Jin, Sen-Tien Tsai, Kenzo Takada, Yao Chang
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4461–4467.
https://doi.org/10.1158/0008-5472.CAN-09-0277
Published: 15 May 2009
View articletitled, Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma
Open the PDF for Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract #2494: A noncanonical regulation of pericellular fibronectin matrix assembly on suspended cancer cell surfaces by RhoA

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Hung-Chi Cheng, Jun-Yi Wu, Bendicht Pauli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2494.
Published: 01 May 2009
View articletitled, Abstract #2494: A noncanonical regulation of pericellular fibronectin matrix assembly on suspended cancer cell surfaces by RhoA