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Journal Articles

Abstract P5-13-18: Upregulation of immune response biomarkers by ribociclib plus endocrine therapy (ET) in paired tumor samples from phase I studies

Dejan Juric, Chong Ma, Ralph Tiedt, Yoon-Sim Yap, Joanne Chiu, Pamela Munster, Roohi Ismail-Khan, Laura Garcia-Estevez, Ingrid A. Mayer, Carlos Becerra, Nadia Solovieff, Agnes Lteif, Faye Su, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-18.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-13-18
Published: 15 February 2022
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Journal Articles

Abstract P2-10-09: Oxysterol profiling in breast adipose tissue identifies brassicasterol and 24-hydroxycholesterol as breast cancer risk predictors

I-Chun Chen, Wen-Hung Kuo, Fu-Chang Hu, Ming-Yang Wang, Yen-Shen Lu, Dieter Lütjohann, Ching-Hung Lin
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-10-09.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-10-09
Published: 15 February 2022
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Journal Articles

Abstract P2-01-09: Clinical impact of ESR1 mutation ctDNA on survival outcome is dependent on PI3KCA/TP53 ctDNA mutation status

Tom Wei-Wu Chen, Wen Hsiao, Ming-Shen Dai, Ching-Hung Lin, Dwang-Ying Chang, I-Chun Chen, Ming-Yang Wang, Ling-Yi Huang, Shu-Han Chang, Shu-Min Huang, Ann-Lii Cheng, Kien Thiam Tan, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-01-09.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-01-09
Published: 15 February 2022
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Journal Articles

Abstract PD2-05: Genomic profiling of PAM50-based intrinsic subtypes in HR+/HER2- advanced breast cancer (ABC) across the MONALEESA (ML) studies

Aleix Prat, Nadia Solovieff, Faye Su, Aditya Bardia, Patrick Neven, Gabriel N. Hortobagyi, Debu Tripathy, Stephen Chia, Dennis Slamon, Yen-Shen Lu, Tetiana Taran, Agnes Lteif, Carlos L. Arteaga, Fabrice André
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD2-05
Published: 15 February 2022
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Journal Articles

Abstract CT028: A pilot study of pembrolizumab and exemestane/leuprolide in premenopausal hormone receptor positive/HER2 negative locally advanced or metastatic breast cancer (PEER)

I-Chun Chen, Ching-Hung Lin, Dwan-Ying Chang, Tom Wei-Wu Chen, Ming-Yang Wang, Wei-Li Ma, Yi-Ting Lin, Shu-Min Huang, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT028.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT028
Published: 01 July 2021
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Journal Articles

Abstract OT-13-10: Global Phase 3 Study of Adagloxad Simolenin (OBI-822) and OBI-821 Versus Placebo Treatment for High Risk Early Stage Triple Negative Breast Cancer Patients (TNBC) Following Neoadjuvant or Adjuvant Chemotherapy

Hope Rugo, Louis W.C. Chow, Javier Cortes, Peter A. Fasching, Xu-Bing He, Pei Hsu, Chiun-Sheng Huang, Sung-Bae Kim, Yen-Shen Lu, Michelle Melisko, Rita Nanda, Tillman E Pearce, Priyanka Sharma, Richard Schwab
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-13-10.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-13-10
Published: 15 February 2021
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Journal Articles

Abstract PD2-04: Updated overall survival (OS) results from the phase III MONALEESA-7 trial of pre- or perimenopausal patients with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2−) advanced breast cancer (ABC) treated with endocrine therapy (ET) ± ribociclib

Debu Tripathy, Seock-Ah Im, Marco Colleoni, Fabio Franke, Aditya Bardia, Nadia Harbeck, Sara Hurvitz, Louis Chow, Joohyuk Sohn, Keun Seok Lee, Saul Campos-Gomez, Rafael Villanueva Vazquez, Kyung Hae Jung, K Govind Babu, Paul Wheatley-Price, Michelino De Laurentiis, Young-Hyuck Im, Sherko Kümmel, Nagi El-Saghir, Mei-Ching Liu, Sharonjeet Kaur, Claudia Gasch, Craig Wang, Yongyu Wang, Arunava Chakravartty, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD2-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD2-04
Published: 15 February 2021
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Journal Articles

Abstract OT1-08-03: Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of adagloxad simolenin (OBI-822) and OBI-821 treatment in patients with early-stage triple-negative breast cancer (TNBC) at high risk for recurrence

Hope S Rugo, Louis WC Chow, Javier Cortes, Peter A Fasching, Binghe Xu, Chiun-Sheng Huang, Sung-Bae Kim, Yen-Shen Lu, Rita Nanda, Priyanka Sharma, Richard B Schwab, Chen-En Tsai
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT1-08-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-OT1-08-03
Published: 15 February 2020
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Journal Articles

Abstract P5-01-21: PIK3CA and ESR1 mutations detected in circulating tumor DNA (ctDNA) are predictive factors for late-line hormone-based therapies in ER+/HER2- metastatic breast cancer (MBC)

Tom Wei-Wu Chen, Ming-Shen Dai, Dwang-Ying Chang, Ching-Hung Lin, I-Chun Chen, Ming-Yang Wang, Ling-Yi Huang, An Hsu, De-Wei Zhuo, Kien Thiam Tan, Yen-Jung Lu, Shu-Han Chang, Ann-Lii Cheng, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-01-21.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P5-01-21
Published: 15 February 2020
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Journal Articles

Abstract P2-20-05: Systemic bevacizumab, etoposide and cisplatin (the BEEP regimen) improves the survival of leptomeningeal metastasis of breast cancer

Tom Wei-Wu Chen, I-Shiow Jan, Dwang-Ying Chang, Ching-Hung Lin, I-Chun Chen, Ho-Min Chen, Ann-Lii Cheng, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-20-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-20-05
Published: 15 February 2020
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Journal Articles

Abstract 4007: Decipher the myth between progression-free survival and overall survival in HER-2 positive metastatic nreast cancer: Anti-HER2 antibody as the constant winner—A hypothesis-driven meta-regression analysis

I-Chun Chen, Fu-Chiang Hu, Ching-Hung Lin, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4007.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4007
Published: 01 July 2019
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Journal Articles

Abstract CT141: Genetic landscape of premenopausal HR+/HER2- advanced breast cancer (ABC) based on comprehensive circulating tumor DNA analysis and association with clinical outcomes in the Phase III MONALEESA-7 trial

Aditya Bardia, Faye Su, Nadia Solovieff, Seock-Ah Im, Joohyuk Sohn, Keun Seok Lee, Saul Campos-Gomez, Kyung Hae Jung, Rafael Villanueva Vazquez, Yen-Shen Lu, Fabio Franke, Sara Hurvitz, Nadia Harbeck, Louis Chow, Karen Rodriguez Lorenc, Tetiana Taran, Naveen Babbar, Debu Tripathy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT141.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT141
Published: 01 July 2019
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Journal Articles

Abstract 3274: The impact of pregnancy on breast cancer survival: A retrospective analysis based on national data

Shu-Chun Chuang, Ching-Hung Lin, Yen-Shen Lu, Chao A. Hsiung
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3274.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3274
Published: 01 July 2017
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Journal Articles

Abstract 4490: Comparisons of genetic alterations of breast cancer between East and West: Special emphases on young patients with ER+/HER2- tumors

Ching-Hung Lin, Tzu-Pin Lu, Ruby Yun-Ju Huang, Yen-Shen Lu, Ko-Yun Lo, Kuan-Ting Kuo, Eric Y. Chuang, Pei-Fang Wu, I-Chun Chen, Jean Paul Thiery, Chiun-Sheng Huang, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4490.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4490
Published: 15 July 2016
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Journal Articles

Abstract 2670: BKM120 and BYL719 (PI3K inhibitors) sensitize estrogen receptor positive breast cancer cells to tamoxifen

I-Chun Chen, Ming Gao, Lii-Ping Hsiao, Yi-Wen Huang, Huei-Chieh Yu, Ling-Chiun Yeh, Ann-Lii Cheng, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2670.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2670
Published: 01 August 2015
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Journal Articles

Abstract OT1-1-11: The B-YOND study: A phase II three-arm randomized trial of the combination of tamoxifen plus goserelin acetate with BYL719 or buparlisib (BKM120) in premenopausal patients with hormone receptor-positive/HER2-negative locally advanced or metastatic breast

Yen-Shen Lu, Yeon Hee Park, Zhimin Shao, Roberta Valenti
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): OT1-1-11.
DOI: https://doi.org/10.1158/1538-7445.SABCS14-OT1-1-11
Published: 01 May 2015
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Journal Articles

Abstract 270: The association between medical history and breast cancer risk: A nationwide population-based case-control study using claim data

Shu-Chun Chuang, Guo-Jie Wu, Yen-Shen Lu, Ching-Hung Lin, Chao Agnes Hsiung
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 270.
DOI: https://doi.org/10.1158/1538-7445.AM2014-270
Published: 01 October 2014
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Journal Articles

Abstract 2984: Normalization of tumor vasculature by anti-angiogenesis therapy in metastatic tumor: A clinical study to determine the timing and effect

Yen-Shen Lu, Bang-Bin Chen, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Ann-Lii Cheng, Tiffany Ting-Fang Shih
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2984.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2984
Published: 01 October 2014
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Abstract 3886: Activated insulin-like growth factor (IGF) signaling pathway is a potential therapeutic target for brain metastasis from lung cancer.

Pei-Fang Wu, Ching-Hung Lin, Wen-Chang Huang, Wen-Chi Feng, Yen-Shen Lu, Chih-Hsin Yang, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3886.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3886
Published: 15 April 2013
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Abstract 2450: Either pan class I PI3K inhibitor or PI3K alpha selective inhibitor sensitizes head and neck squamous cell carcinoma cells to Erlotinib, an EGFR TKI.

Ming Gao, Yen-Shen Lu, Li-Ping Hsiao, Suz Wen Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2450.
DOI: https://doi.org/10.1158/1538-7445.AM2013-2450
Published: 15 April 2013
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