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Journal Articles

Abstract 2718: A novel TROP2-targeted immune stimulating antibody conjugate (ISAC) with potent anti-tumoral activtiy and accpetable safety

Ye Chen, Fei You, Chenchen Zhu, Yao Xiong, Li Li, Nana Luo, Shuaixiang Zhou, Fushuai Wang, Chenyang Xu, Fan Fei, Chang Li, Jianglu Wang, Jinling Xu, Huizhong Xiong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2718.
https://doi.org/10.1158/1538-7445.AM2024-2718
Published: 22 March 2024
View articletitled, Abstract 2718: A novel TROP2-targeted immune stimulating antibody conjugate (ISAC) with potent anti-tumoral activtiy and accpetable safety
Journal Articles

Abstract CT153: Pemigatinib in Chinese patients with advanced/metastatic or surgically unresectable cholangiocarcinoma Including FGFR2 fusion or rearrangement: Updated overall survival from an open-label, single-arm, multicenter Phase II study

Guoming Shi, Xiaoyong Huang, Tianfu Wen, Tianqiang Song, Ming Kuang, Haibo Mou, Lequn Bao, Haitao Zhao, Hong Zhao, Xielin Feng, Bixiang Zhang, Tao Peng, Yubao Zhang, Xiangcheng Li, Hongsheng Yu, Yu Cao, Yang Luo, Ye Chen, Mingxia Chen, Jia Fan, Jian Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT153.
https://doi.org/10.1158/1538-7445.AM2023-CT153
Published: 14 April 2023
View articletitled, Abstract CT153: Pemigatinib in Chinese patients with advanced/metastatic or surgically unresectable cholangiocarcinoma Including FGFR2 fusion or rearrangement: Updated overall survival from an open-label, single-arm, multicenter Phase II study
Journal Articles

Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities

Liang Xu, Ye Chen, Yulun Huang, Edwin Sandanaraj, John S. Yu, Ruby Yu-Tong Lin, Pushkar Dakle, Xin-Yu Ke, Yuk Kien Chong, Lynnette Koh, Anand Mayakonda, Kassoum Nacro, Jeffrey Hill, Mo-Li Huang, Sigal Gery, See Wee Lim, Zhengyun Huang, Ying Xu, Jianxiang Chen, Longchuan Bai, Shaomeng Wang, Hiroaki Wakimoto, Tseng Tsai Yeo, Beng Ti Ang, Markus Müschen, Carol Tang, Tuan Zea Tan, Phillip H. Koeffler
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2123.
https://doi.org/10.1158/1538-7445.AM2021-2123
Published: 01 July 2021
View articletitled, Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities
Journal Articles

Abstract 1265: Discovery of GT19077, a c-Myc/Max protein-protein Interaction (PPI) small molecule inhibitor, and GT19506 a c-Myc PROTAC molecule, for targeting c-Myc-driven blood cancers and small cell lung cancers

Liandong Ma, Youzhi Tong, Qianxiang Zhou, Zhaohui Yang, Honghau Yan, Ye Chen, Ruo Xu, Jie Pan, Xiaoqi Gou, Weidong Qian, Jie Chen, Qi Sun, Luhua Lai
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1265.
https://doi.org/10.1158/1538-7445.AM2021-1265
Published: 01 July 2021
View articletitled, Abstract 1265: Discovery of GT19077, a c-Myc/Max protein-protein Interaction (PPI) small molecule inhibitor, and GT19506 a c-Myc PROTAC molecule, for targeting c-Myc-driven blood cancers and small cell lung cancers
Journal Articles

Abstract 2438: Genetic activation of JUN fuels the core regulatory circuitry of de-differentiated liposarcoma

Ye Chen, Pushkar Dakle, Tuan Zea Tan, Ruby Yu-Tong Lin, Mark E. Puhaindran, Sigal Gery, Liang Xu, Phillip H. Koeffler
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2438.
https://doi.org/10.1158/1538-7445.AM2021-2438
Published: 01 July 2021
View articletitled, Abstract 2438: Genetic activation of JUN fuels the core regulatory circuitry of de-differentiated liposarcoma
Journal Articles

Abstract LB-111: GT19077, a c-Myc/Max protein-protein interaction (PPI) small molecule inhibitor, selectively targets c-Myc-additive B-cell and myeloid malignancies

Liandong Ma, Youzhi Tong, Zhaohui Yang, Qian Xiang Zhou, Jie Chen, Ye Chen, Honglei Bi, Jie Pan, Qi Sun, Ru Xu, Luhua Lai
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-111.
https://doi.org/10.1158/1538-7445.AM2020-LB-111
Published: 15 August 2020
View articletitled, Abstract LB-111: GT19077, a c-Myc/Max protein-protein interaction (PPI) small molecule inhibitor, selectively targets c-Myc-additive B-cell and myeloid malignancies
Journal Articles

Abstract 4741: Monocytic myeloid derived suppressor cells (M-MDSC) from spleen are multipotent while tumor M-MDSC have limited plasticity

Ryan D. Calvert, James C. Fleet, Ye Chen, Alex Pothen, Bartek Rajwa, Pierrick G. Fournier, Patricia Juarez, Theresa A. Guise, Timothy L. Ratliff, Ben D. Elzey
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4741.
https://doi.org/10.1158/1538-7445.AM2018-4741
Published: 01 July 2018
View articletitled, Abstract 4741: Monocytic myeloid derived suppressor cells (M-MDSC) from spleen are multipotent while tumor M-MDSC have limited plasticity
Journal Articles

Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma

Ye Chen, Liang Xu, Marina Dutra-Clarke, Anand Mayakonda, De-Chen Lin, Lynnette Koh, Yuk Kien Chong, Edwin Sandanaraj, Vikas Madan, Henry Yang, Ngan Doan, Jonathan W. Said, William H. Yong, Markus Müschen, Beng Ti Ang, Carol Tang, Joshua J. Breunig, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1524.
https://doi.org/10.1158/1538-7445.AM2017-1524
Published: 01 July 2017
View articletitled, Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma
Journal Articles

Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
View articletitled, Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target
Journal Articles

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

Weiguo Zhang, Gautam Borthakur, Chen Gao, Ye Chen, Hong Mu, Vivian R. Ruvolo, Kenichi Nomoto, Nanding Zhao, Marina Konopleva, Michael Andreeff
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1528–1537.
https://doi.org/10.1158/0008-5472.CAN-15-1580
Published: 14 March 2016
View articletitled, The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
Open the PDF for The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract 4944: Identification of B-cell lymphoma 6 as a novel therapeutic target in glioblastoma

Ye Chen, Liang Xu, Masaharu Hazawa, Anand M. Thippeswamy, Henry Yang, Markus Müschen, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4944.
https://doi.org/10.1158/1538-7445.AM2015-4944
Published: 01 August 2015
View articletitled, Abstract 4944: Identification of B-cell lymphoma 6 as a novel therapeutic target in glioblastoma
Journal Articles

Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma

Liang Xu, De-Chen Lin, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shi-zhu Yu, Michael Kahn, Dong Yin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 122.
https://doi.org/10.1158/1538-7445.AM2015-122
Published: 01 August 2015
View articletitled, Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma
Journal Articles

Abstract 4344: Olfactomedin 4 plays a tumor-suppressor role and is a novel candidate biomarker in the prostate cancer progression and independent of PSA

Hongzhen Li, Ye Chen, Wenli Liu, Jianqiong Zhu, Chin Kay, Xujing Wang, Griffin P. Rodgers
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4344.
https://doi.org/10.1158/1538-7445.AM2015-4344
Published: 01 August 2015
View articletitled, Abstract 4344: Olfactomedin 4 plays a tumor-suppressor role and is a novel candidate biomarker in the prostate cancer progression and independent of PSA
Journal Articles

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

De-Chen Lin, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1815–1827.
https://doi.org/10.1158/0008-5472.CAN-14-1433
Published: 30 April 2015
View articletitled, Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma
Open the PDF for Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma in another window
Includes: Supplementary data
Journal Articles

Abstract 2606: Bone marrow microenvironment contributes to stem cell phenotype in acute myeloid leukemia.

Venkata Lokesh Battula, Ye Chen, Frank Yang, Marina Konopleva, Michael Andreeff
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2606.
https://doi.org/10.1158/1538-7445.AM2013-2606
Published: 15 April 2013
View articletitled, Abstract 2606: Bone marrow microenvironment contributes to stem cell phenotype in acute myeloid leukemia.
Journal Articles

Abstract 2971: Human extramedullary bone and bone marrow in mice: First in vivo model of a genetically controlled hematopoietic environment - Role of CTGF and HIF1-α

Michael Andreeff, Ye Chen, Venkata Lokesh Battula, Nicole A. Hofmann, Andreas Reinisch, Yue Xi Shi, Rui Yu Wang, Sergej Konoplev, Dirk Strunk, Marina Konopleva
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2971.
https://doi.org/10.1158/1538-7445.AM2012-2971
Published: 15 April 2012
View articletitled, Abstract 2971: Human extramedullary bone and bone marrow in mice: First in vivo model of a genetically controlled hematopoietic environment - Role of CTGF and HIF1-α
Journal Articles

Abstract 4264: NFκB activation in mesenchymal stromal cells induced by leukemia-stroma interaction plays a central role in stroma-mediated chemo-resistance of leukemic cells

Rodrigo O. Jacamo, Ye Chen, Zhiqiang Wang, Wencai Ma, Min Zhang, Batulla L. Venkata, Wendy D. Schober, Richard E. Davis, Marina Konopleva, Michael Andreeff
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4264.
https://doi.org/10.1158/1538-7445.AM2012-4264
Published: 15 April 2012
View articletitled, Abstract 4264: NFκB activation in mesenchymal stromal cells induced by leukemia-stroma interaction plays a central role in stroma-mediated chemo-resistance of leukemic cells