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Yasuhiro Mitsuuchi
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Journal Articles

Abstract 1806: Birinapant, a bivalent SMAC-mimetic, promotes efficient cellular IAP E3 ligase activity and formation of a pro-apoptotic RIPK1:caspase-8 complex while monovalent IAP inhibitors are less efficient - implications for therapeutic utility

Yasuhiro Mitsuuchi, Christopher A. Benetatos, Thomas Haimowitz, Yijun Deng, Angeline C. Mufalli, Martin E. Seipel, Jennifer M. Burns, Gurpreet S. Kapoor, C. Glenn Begley, Stephen M. Condon
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1806.
https://doi.org/10.1158/1538-7445.AM2014-1806
Published: 01 October 2014
View article titled, Abstract 1806: Birinapant, a bivalent SMAC-mimetic, promotes efficient cellular IAP E3 ligase activity and formation of a pro-apoptotic RIPK1:caspase-8 complex while monovalent IAP inhibitors are less efficient - implications for therapeutic utility
Journal Articles

Abstract 2278: The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8:RIPK1 complex via p38MAPK pathway

Gurpreet Singh Kapoor, Christopher A. Benetatos, Yasuhiro Mitsuuchi, Eric M. Neiman, Guangyao Yu, Mark A. Mckinlay, Jennifer Burns, John Silke, Stephen M. Condon, Srinivas K. Chunduru
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2278.
https://doi.org/10.1158/1538-7445.AM2014-2278
Published: 01 October 2014
View article titled, Abstract 2278: The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8:RIPK1 complex via p38MAPK pathway
Journal Articles

Abstract 3333: Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound cIAP1 and cIAP2.

Yasuhiro Mitsuuchi, Stephen M. Condon, Eric M. Neiman, Christopher A. Benetatos, Martin E. Seipel, Gurpreet Singh Kapoor, Angeline C. Mufalli, Guangyao Yu, Orla Maguire, Hans Minderman, Mark A. Mckinlay, Martin Graham, David Weng, Srinivas Chunduru
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3333.
https://doi.org/10.1158/1538-7445.AM2013-3333
Published: 15 April 2013
View article titled, Abstract 3333: Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound cIAP1 and cIAP2.
Journal Articles

Abstract 599: Potential biomarkers of Smac mimetic tumor sensitivity: inhibitor of apoptosis protein DNA copy number.

Gurpreet S. Kapoor, Brian Geier, Eric M. Neiman, Yasuhiro Mitsuuchi, Christopher A. Benetatos, Stephen M. Condon, Srinivas Chunduru, C. Glenn Begley
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 599.
https://doi.org/10.1158/1538-7445.AM2013-599
Published: 15 April 2013
View article titled, Abstract 599: Potential biomarkers of Smac mimetic tumor sensitivity: inhibitor of apoptosis protein DNA copy number.
Journal Articles

Abstract 3336: The Smac Mimetic Birinapant Synergistically Induces Apoptosis in Combination with Type I Interferons and GM-CSF.

Christopher A. Benetatos, Jennifer M. Burns, Ernest C. Borden, Daniel Lindner, Yasuhiro Mitsuuchi, Mark A. Mckinlay, Gurpreet Singh Kapoor, Eric M. Neiman, Martin E. Seipel, Guangyao Yu, Martin Graham, David Weng, Stephen M. Condon, C. Glenn Begley, Srinivas Chunduru
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3336.
https://doi.org/10.1158/1538-7445.AM2013-3336
Published: 15 April 2013
View article titled, Abstract 3336: The Smac Mimetic Birinapant Synergistically Induces Apoptosis in Combination with Type I Interferons and GM-CSF.
Journal Articles

Abstract 5302: Characterization of tumor cell lines resistant to birinapant, a novel bivalent smac mimetic.

Eric M. Neiman, Christopher A. Benetatos, Gurpreet S. Kapoor, Yasuhiro Mitsuuchi, Mark A. McKinlay, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Srinivas K. Chunduru
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5302.
https://doi.org/10.1158/1538-7445.AM2013-5302
Published: 15 April 2013
View article titled, Abstract 5302: Characterization of tumor cell lines resistant to birinapant, a novel bivalent smac mimetic.
Journal Articles

New endothelial cell system designed to deliver drugs by apoptosis.

Yasuhiro Mitsuuchi, Dennis R. Powell, Ping Guo, Feng Zhou, James M. Gallo
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 868.
Published: 01 April 2004
View article titled, New endothelial cell system designed to deliver drugs by apoptosis.
Journal Articles

AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells

Satoshi Tanno, Sachie Tanno, Yasuhiro Mitsuuchi, Deborah A. Altomare, Guang-Hui Xiao, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2001) 61 (2): 589–593.
Published: 01 January 2001
View article titled, AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells
Open the PDF for AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells in another window
Journal Articles

The Phosphatidylinositol 3-Kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21WAF1/CIP1/SDI1 Induced by Cisplatin and Paclitaxel

Yasuhiro Mitsuuchi, Steven W. Johnson, Muthu Selvakumaran, Stephen J. Williams, Thomas C. Hamilton, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2000) 60 (19): 5390–5394.
Published: 01 October 2000
View article titled, The Phosphatidylinositol 3-Kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21<sup>WAF1/CIP1/SDI1</sup> Induced by Cisplatin and Paclitaxel
Open the PDF for The Phosphatidylinositol 3-Kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21<sup>WAF1/CIP1/SDI1</sup> Induced by Cisplatin and Paclitaxel in another window