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Journal Articles

Abstract 6832: SYS6041, a next-generation Folate Receptor α-targeted antibody-drug conjugates for the treatment of FRα-expressing malignancies

Free
Jieru Liu, Huan Li, Mo Dan, Xiwu Hui, Bin Yao, Yang Zhang, Linlin Xiao, Bin Kang, Can Yuan, Bin Bao, Miaomiao Wei, Chunqing Qu, Yanling Li, Wei Yang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6832.
https://doi.org/10.1158/1538-7445.AM2025-6832
Published: 21 April 2025
View articletitled, Abstract 6832: SYS6041, a next-generation Folate Receptor α-targeted antibody-drug conjugates for the treatment of FRα-expressing malignancies
Journal Articles

Abstract 4338: SYS6042, a novel anti-TROP2 pH-sensitive antibody-drug conjugate (ADC) with improved therapeutic window

Free
Yancui Wang, Xiao Gao, Mo Dan, Xiwu Hui, Bing Yao, Yang Zhang, Congcong Niu, Can Yuan, Xiaoque Zhu, Zhaopeng Sun, Bin Kang, Miaomiao Wei
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4338.
https://doi.org/10.1158/1538-7445.AM2025-4338
Published: 21 April 2025
View articletitled, Abstract 4338: SYS6042, a novel anti-TROP2 pH-sensitive antibody-drug conjugate (ADC) with improved therapeutic window
Journal Articles

Abstract 2835: Lamin AC deficiency promotes genomic instability through increased R-loop accumulation

Free
Christopher William Schultz, Sourav Saha, Anjali Dhall, Yang Zhang, Parth Desai, Lorinc Pongor, David A. Scheiblin, Valentin Magidson, Yilun Sun, Christophe Redon, Suresh Kumar, Manan Krishnamurthy, Henrique B. Dias, Vasilisa Askenova, Elizabeth Giordanio, Nobuyuki Takahashi, Michael Nirula, Yasuhiro Arakawa, Ukhyun Jo, Beverly A. Teacher, Mirit I. Aladjem, Stephen Lockett, Marry Dasso, Yves Pommier, Ajit K. Sharma, Anish Thomas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2835.
https://doi.org/10.1158/1538-7445.AM2025-2835
Published: 21 April 2025
View articletitled, Abstract 2835: Lamin AC deficiency promotes genomic instability through increased R-loop accumulation
Journal Articles

Abstract 2612: Elucidation of PAX3::FOXO1 initiation mechanisms in human induced pluripotent stem cell models

Free
Bradley T. Stevens, Yang Zhang, Jamaica F. Siwak, Shondra M. Pruett-Miller, Brian J. Abraham, Mark E. Hatley
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2612.
https://doi.org/10.1158/1538-7445.AM2025-2612
Published: 21 April 2025
View articletitled, Abstract 2612: Elucidation of PAX3::FOXO1 initiation mechanisms in human induced pluripotent stem cell models
Journal Articles

Abstract 4337: SYS6051, a next-generation tissue factor-targeted antibody-drug conjugates for the treatment of TF-expressing malignancies

Free
Xiaojuan Wu, Mingyue Shen, Mo Dan, Xiwu Hui, Bing Yao, Yanling Li, Wei Yang, Hanqian Xu, Can Yuan, Yufei Sun, Bin Kang, Yang Zhang, Linlin Xiao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4337.
https://doi.org/10.1158/1538-7445.AM2025-4337
Published: 21 April 2025
View articletitled, Abstract 4337: SYS6051, a next-generation tissue factor-targeted antibody-drug conjugates for the treatment of TF-expressing malignancies
Journal Articles

Abstract 5127: Metastatic organotropism in small cell lung cancer

Free
Manan Krishnamurthy, Anjali Dhall, Christopher W. Schultz, Michelle Baird, Parth A. Desai, Jacob Odell, Sarthak Sahoo, Nobu Takahashi, Michael Nirula, Sophie Zhuang, Yue Huang, Brett Schroeder, Yang Zhang, Christophe Redon, Christina Robinson, Lai Thang, Lilia Ileva, Nimit L. Patel, Joseph D. Kalen, Alice-Anaïs Varlet, Noam Zuela-Sopilniak, Ankita Jha, Darawalee W. Zong, Donna Butcher, Tamara Morgan, Alyah Afzal, Raj Chari, Karim Baktiar, Suresh Kumar, Lorinc Pongor, Simone Difilippantonio, Mirit I. Aladjem, Yves Pommier, Mohit K. Jolly, Jan Lammerding, Ajit K. Sharma, Anish Thomas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5127.
https://doi.org/10.1158/1538-7445.AM2025-5127
Published: 21 April 2025
View articletitled, Abstract 5127: Metastatic organotropism in small cell lung cancer
Journal Articles

Abstract 4256: HY0001a: A novel antibody-drug conjugate (ADC) targeting CUB domain containing protein 1 (CDCP1)

Free
Wenjun Yan, Yang Zhang, Mengyun Zhang, Bo An, Yujing Zhang, Qing Xiong, Guifeng Chen, Ao Fu, Dan Sun, Xiaoqiang Cai, Huaqin Chen, Mingxia Geng, Haibo Wang, Chengwei Yan, Yike Yuan, Tao Wei
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4256.
https://doi.org/10.1158/1538-7445.AM2025-4256
Published: 21 April 2025
View articletitled, Abstract 4256: HY0001a: A novel antibody-drug conjugate (ADC) targeting CUB domain containing protein 1 (CDCP1)
Journal Articles

Abstract 957: A novel therapeutic modality integrating antibody therapy and oncolytic virotherapy for enhanced tumor targeting and treatment

Free
Wenxin Xu, Can Chen, Huan Zheng, Jieying Xu, Mengshi Jiang, Li Zhang, Deyu Xu, Hongjie Cheng, Yang Zhang, Mengmeng Liu, Jinlu Cai, Fang Hu, Lieming Ding
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 957.
https://doi.org/10.1158/1538-7445.AM2025-957
Published: 21 April 2025
View articletitled, Abstract 957: A novel therapeutic modality integrating antibody therapy and oncolytic virotherapy for enhanced tumor targeting and treatment
Journal Articles

Abstract A001: PAX3-FOXO1-induced transcriptional dysregulation in rhabdomyosarcoma

Free
Bradley T. Stevens, Yang Zhang, Randolph K. Larsen, Grace E. Adkins, Jack D. Hopkins, Darden W. Kimbrough, Matthew R. Garcia, Mark E. Hatley, Brian J. Abraham
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A001.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A001
Published: 05 September 2024
View articletitled, Abstract A001: PAX3-FOXO1-induced transcriptional dysregulation in rhabdomyosarcoma
Journal Articles

Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance

Free
Noha AM Shendy, Yang Zhang, Ha-Won Lee, Stephanie Nance, Yousef Khashana, Mohammad AM Nezhady, Elaine Ritter, Shivendra Singh, Qi Liu, Yiping Fan, Jun Yang, Anand G. Patel, Jun Qi, Taosheng Chen, Brian J. Abraham, Adam D. Durbin
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A054.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A054
Published: 05 September 2024
View articletitled, Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance
Journal Articles

Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer

Free
Brett Schroeder, Nobuyuki Takahashi, Howard Yang, Renee Donahue, Zachary Skidmore, Alissa Konicki, Michael Nirula, Max Greenberg, George Chrisafis, Yang Zhang, Yo-Ting Tsai, Linda Sciuto, Samantha Nichols, Melissa Abel, Parth Desai, Rajesh Kumar, Christopher Schultz, Danielle Pinkiert, Chante Graham, Ajit Sharma, Justin Malin, Manan Krishnamurthy, Sophie Zhuang, Maxwell Lee, Lorenzo Rinaldi, Jeffrey Schlom, Lalage Wakefield, Anish Thomas
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT257.
https://doi.org/10.1158/1538-7445.AM2024-CT257
Published: 05 April 2024
View articletitled, Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer
Journal Articles

Abstract 6931: Characterization of cancer evolution landscape based on accurate detection of somatic mutations in single tumor cells

Free
Muchun Niu, Yang Zhang, Jiayi Luo, Jefferson C. Sinson, Alastair M. Thompson, Chenghang Zong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6931.
https://doi.org/10.1158/1538-7445.AM2024-6931
Published: 22 March 2024
View articletitled, Abstract 6931: Characterization of cancer evolution landscape based on accurate detection of somatic mutations in single tumor cells
Journal Articles

Abstract 136: Determining the genomic basis of PAX3-FOXO1 mediated transformation in rhabdomyosarcoma

Free
Bradley T. Stevens, Yang Zhang, Randolph K. Larsen, Grace E. Adkins, Jack D. Hopkins, Darden W. Kimbrough, Matthew R. Garcia, Brian J. Abraham, Mark E. Hatley
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 136.
https://doi.org/10.1158/1538-7445.AM2024-136
Published: 22 March 2024
View articletitled, Abstract 136: Determining the genomic basis of PAX3-FOXO1 mediated transformation in rhabdomyosarcoma
Journal Articles

Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma

Open Access
Fanfan Fan, Jian Gao, Yue Zhao, Jun Wang, Lu Meng, Jiaqiang Ma, Teng Li, Han Han, Jinglei Lai, Zhendong Gao, Xiongfei Li, Ran Guo, Zhiwei Cao, Yang Zhang, Xiaoming Zhang, Haiquan Chen
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2690–2703.
https://doi.org/10.1158/0008-5472.CAN-22-3140
Published: 15 August 2023
View articletitled, Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Open the PDF for Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT086: H3.3-K27M neoantigen vaccine elicits CD4+ and CD8+ T cells immunity and improved prognosis against diffuse intrinsic pontine glioma

Free
Yang Zhang, Nan Ji, Gang Chen, Haiyang Wu, Yi Wang, Xiao’ou Li, Wei Xu, Ling Peng, Tian Li, Yi Wang, Li-Feng Zhang, Shengjun Sun, Xiaobing Zhao, Si Li, Peter Alexander, Liwei Zhang, Qi-Jing Li
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT086.
https://doi.org/10.1158/1538-7445.AM2023-CT086
Published: 14 April 2023
View articletitled, Abstract CT086: H3.3-K27M neoantigen vaccine elicits CD4+ and CD8+ T cells immunity and improved prognosis against diffuse intrinsic pontine glioma
Journal Articles

Abstract 6300: Therapeutic potential of EO-3021/SYSA1801, a Claudin18.2 antibody-drug conjugate, for the treatment of CLDN18.2-expressing cancers

Free
Mo Dan, Xiwu Hui, Yancui Wang, Can Yuan, Thomas O'Hare, Valerie Malyvanh Jansen, Shawn M. Leland, Yang Zhang, David Dornan, Xiaoyan Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6300.
https://doi.org/10.1158/1538-7445.AM2023-6300
Published: 04 April 2023
View articletitled, Abstract 6300: Therapeutic potential of EO-3021/SYSA1801, a Claudin18.2 antibody-drug conjugate, for the treatment of CLDN18.2-expressing cancers
Journal Articles

Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies

Free
Chunyan Zhao, Jianfei Wang, Aiguo Liu, Xin Gao, Yanfen Teng, Lei Liu, Yang Zhang, Xiaohong Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3451.
https://doi.org/10.1158/1538-7445.AM2023-3451
Published: 04 April 2023
View articletitled, Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies
Journal Articles

Abstract 2315: Temporal changes in circulating tumor cells and circulating tumor DNA in patients with resectable pancreatic ductal adenocarcinoma

Free
Yang Zhang, Pablo J. Dopico, Minh-Chau N. Le, Zhijie Yang, Youxiang Wang, Sherise C. Rogers, Thomas J. George, Hugh Z. Fan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2315.
https://doi.org/10.1158/1538-7445.AM2023-2315
Published: 04 April 2023
View articletitled, Abstract 2315: Temporal changes in circulating tumor cells and circulating tumor DNA in patients with resectable pancreatic ductal adenocarcinoma
Journal Articles

Abstract 481: Investigating molecular glues as a new therapeutic approach to high-risk neuroblastoma

Free
Ian Delahunty, Gisele Nishiguchi, Yang Zhang, Abigail Fish, Anand Mayasundari, Jun Qi, Brian Abraham, Anang Shelat, Zoran Rankovic, Adam Durbin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 481.
https://doi.org/10.1158/1538-7445.AM2023-481
Published: 04 April 2023
View articletitled, Abstract 481: Investigating molecular glues as a new therapeutic approach to high-risk neuroblastoma
Journal Articles

Abstract 5828: Distinct immunosuppressive tumor microenvironment modulates small cell lung carcinoma neuroendocrine phenotypic plasticity and heterogeneity

Free
Parth Anil Desai, Nobuyuki Takahashi, Yingying Cao, Christopher Schultz, Darryl Nousome, Desiree Tillo, Lakshya Chauhan, Mayank tandon, Rajesh kumar Bhardwaj, Delphine Lissa, Vinodh Rajapakse, Suresh kumar, Yang Zhang, Elmeskini Rajaa, Donna Butcher, Linda Scuito, Jingjing Gong, Brett Schroder, Andrew Warner, Samantha Nichols, Jordan Kimberly, Alejandro Schaffer, Mohit kumar Jolly, Stephen Hewitt, Anish Thomas
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5828.
https://doi.org/10.1158/1538-7445.AM2023-5828
Published: 04 April 2023
View articletitled, Abstract 5828: Distinct immunosuppressive tumor microenvironment modulates small cell lung carcinoma neuroendocrine phenotypic plasticity and heterogeneity