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Journal Articles

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Nadia Boufaied, Paolo Chetta, Tarek Hallal, Stefano Cacciatore, Daniela Lalli, Carole Luthold, Kevin Homsy, Eddie L. Imada, Sudeepa Syamala, Cornelia Photopoulos, Anna Di Matteo, Anna de Polo, Alessandra Maria Storaci, Ying Huang, Francesca Giunchi, Patricia A. Sheridan, Gregory Michelotti, Quang-De Nguyen, Xin Zhao, Yang Liu, Elai Davicioni, Daniel E. Spratt, Simone Sabbioneda, Giovanni Maga, Lorelei A. Mucci, Claudia Ghigna, Luigi Marchionni, Lisa M. Butler, Leigh Ellis, François Bordeleau, Massimo Loda, Valentina Vaira, David P. Labbé, Giorgia Zadra
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1834–1855.
https://doi.org/10.1158/0008-5472.CAN-23-0519
Published: 04 June 2024
View article titled, Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Open the PDF for Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract CT023: Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Making a cold tumor hot

Sujit S. Nair, Dimple Chakravarty, Sreekumar Balan, Alexander Hakansson, Manuel Duval, Elai Davicioni, Yang Liu, Swati Bhardwaj, Tin Htwe Thin, Monica Garcia-barros, Kenneth Haines, Majd Al Shaarani, Rachel Weil, Marcia Meseck, Parita Ratnani, Monali Fatterpekar, Ivan Jambor, Elena Gonzalez-Gugel, Adam Farkas, Vinayak Wagaskar, Kacie Schlussel, Cristina Pasat-karasik, Kamala Bhatt, Zachary Dovey, Adriana Pedraza, Akriti Gupta, Dara Lundon, Ante Peros, Sneha Parekh, Lily Davenport, Xiangfu Zhang, Raghav Gupta, Macy Robison, Cynthia Knauer, Ethan Ellis, Dmitry Rykunov, Boris Reva, Babu Padanilam, Matthew D. Galsky, Rachel Brody, Mani Menon, Andres Salazar, Nina Bhardwaj, Ashutosh K. Tewari
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT023.
https://doi.org/10.1158/1538-7445.AM2024-CT023
Published: 05 April 2024
View article titled, Abstract CT023: Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Making a cold tumor hot
Journal Articles

Abstract LB057: Pre-clinical characterization of IBI343, a site-specifically conjugated anti-Claundin18.2 ADC, for treating solid tumors

Shuaixiang Zhou, Xiong Yao, Jian Guan, Keke Fei, Jia Lu, Weiwei Wu, Yang Liu, Tianyu Zhu, Zhuangguang Liao, Shi Chen, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB057.
https://doi.org/10.1158/1538-7445.AM2024-LB057
Published: 05 April 2024
View article titled, Abstract LB057: Pre-clinical characterization of IBI343, a site-specifically conjugated anti-Claundin18.2 ADC, for treating solid tumors
Journal Articles

Abstract 4537: VB15010 is a potent PARP1 selective inhibitor and durable trapper with improved pharmacological activities

Douglas D. Fang, Yueqin Liu, Yang Liu, Haolong Zhang, Jinping Wu, Jie Wei, Wei Sha, Charles Z. Ding
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4537.
https://doi.org/10.1158/1538-7445.AM2024-4537
Published: 22 March 2024
View article titled, Abstract 4537: VB15010 is a potent PARP1 selective inhibitor and durable trapper with improved pharmacological activities
Journal Articles

Abstract 7417: SpatialCS: A tool to effectively integrate histological annotations and spatial transcriptomics analysis

Yanshuo Chu, Kyung Serk Cho, Isha Khanduri, Tieling Zhou, Jiahui Jiang, Yunhe Liu, Xinmiao Yan, Guangsheng Pei, Yibo Dai, Yang Liu, Ruiping Wang, Akshaya S Jadhav, Sharia Hernandez, Humam Kadara, Luisa Maren Solis Soto, Scott Kopetz, Dipen Maheshbhai Maru, Linghua Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7417.
https://doi.org/10.1158/1538-7445.AM2024-7417
Published: 22 March 2024
View article titled, Abstract 7417: SpatialCS: A tool to effectively integrate histological annotations and spatial transcriptomics analysis
Journal Articles

Abstract 4398: TET2 accelerates clonal hematopoiesis in an age-dependent manner

Shilpita Karmakar, Yang Liu, Efthymios Motakis, Kaustav Sengupta, Travis Roeder, Kristina Mujica, Jennifer Trowbridge, Hideyuki Oguro, Sheng Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4398.
https://doi.org/10.1158/1538-7445.AM2024-4398
Published: 22 March 2024
View article titled, Abstract 4398: <em>TET2</em> accelerates clonal hematopoiesis in an age-dependent manner
Journal Articles

Abstract 1697: Phase separation of BHLHE40 up-regulates SREBF1 and inhibits ferroptosis in pancreatic cancer cells

Yizhi Cao, Xuelong Wang, Yang Liu, Pengyi Liu, Jiejie Qin, Youwei Zhu, Shuyu Zhai, Minmin Shi, Weishen Wang, Xiaxing Deng, Chenghong Peng, Hao Chen, Ruibao Ren, Lingxi Jiang, Baiyong Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1697.
https://doi.org/10.1158/1538-7445.AM2024-1697
Published: 22 March 2024
View article titled, Abstract 1697: Phase separation of BHLHE40 up-regulates SREBF1 and inhibits ferroptosis in pancreatic cancer cells
Journal Articles

Abstract 649: SOX11 regulates BCR signaling via the PAX5/CD19 axis in MCL

Rudra Prasad Dutta, Heng-Huan Lee, Violetta V Leshchenko, Ravi Prakash Shukla, Yang Liu, Jian Jin, Michael Wang, Samir Parekh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 649.
https://doi.org/10.1158/1538-7445.AM2024-649
Published: 22 March 2024
View article titled, Abstract 649: SOX11 regulates BCR signaling via the PAX5/CD19 axis in MCL
Journal Articles

Abstract 6895: Application of MiniPDX® in clinical indication identification and anti-tumor drug development

Bin Xie, Hongkui Chen, Shizhu Zhao, Le Li, Song Xi, Yu Di, Yang Liu, Xinlei Chen, Xiaorong Gu, Zhenle Bi, Kaimeng Hu, Loc Van, Josh Caggiula, Candice Tang, Danyi Wen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6895.
https://doi.org/10.1158/1538-7445.AM2024-6895
Published: 22 March 2024
View article titled, Abstract 6895: Application of MiniPDX® in clinical indication identification and anti-tumor drug development
Journal Articles

Abstract 602: Targeting CDK9 with a novel potent and selective inhibitor, YX0798, in CAR-T-relapsed mantle cell lymphoma models

Vivian Jiang, Yu Xue, Hong Kim, Joseph McIntosh, Haiying Chen, Tianci Zhang, Yang Liu, Jia Zhou, Michael Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 602.
https://doi.org/10.1158/1538-7445.AM2024-602
Published: 22 March 2024
View article titled, Abstract 602: Targeting CDK9 with a novel potent and selective inhibitor, YX0798, in CAR-T-relapsed mantle cell lymphoma models
Journal Articles

Abstract 5300: BH3120, PD-L1 X 4-1BB bispecific antibody, plus PD-1 antagonist results in synergistic anti-tumor efficacy with excellent safety profile

Jun Wang, Jing Wang, Yang Liu, Jiangcheng Xu, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5300.
https://doi.org/10.1158/1538-7445.AM2024-5300
Published: 22 March 2024
View article titled, Abstract 5300: BH3120, PD-L1 X 4-1BB bispecific antibody, plus PD-1 antagonist results in synergistic anti-tumor efficacy with excellent safety profile
Journal Articles

Abstract 676: The integrated stress activator BTM-3566 overcomes therapeutic resistance in mantle cell lymphoma

Yang Liu, Heng-Huan Lee, Joseph McIntosh, Yijing Li, Tianci Zhang, Wei Wang, Matthew J. Kostura, Michael Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 676.
https://doi.org/10.1158/1538-7445.AM2024-676
Published: 22 March 2024
View article titled, Abstract 676: The integrated stress activator BTM-3566 overcomes therapeutic resistance in mantle cell lymphoma
Journal Articles

Abstract 544: Reverse engineering strategy for new targets identification

Bin Xie, Taimei Zhang, Le Li, Hongkui Chen, Yang Liu, Lintao Bi, Danyi Wen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 544.
https://doi.org/10.1158/1538-7445.AM2024-544
Published: 22 March 2024
View article titled, Abstract 544: Reverse engineering strategy for new targets identification
Journal Articles

Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells

Li Xia, Jie-Yang Liu, Meng-Ying Yang, Xue-Hong Zhang, Yue Jiang, Qian-Qian Yin, Chen-Hui Luo, Hong-Chen Liu, Zhi-Jie Kang, Cheng-Tao Zhang, Bei-Bei Gao, Ai-Wu Zhou, Hai-Yan Cai, Edmund K. Waller, Jin-Song Yan, Ying Lu
Journal: Cancer Research
Cancer Res (2024) 84 (3): 479–492.
https://doi.org/10.1158/0008-5472.CAN-23-1632
Published: 01 February 2024
View article titled, Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells
Open the PDF for Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells in another window
Includes: Supplementary data
Journal Articles

A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, Weiyan Xu, Youhui Zhang, Jinfeng Chen, Mengshu Cao, Liang Zhang, Xiaoyan Qiu
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1866–1882.
https://doi.org/10.1158/0008-5472.CAN-22-2733
Published: 02 June 2023
View article titled, A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
Open the PDF for A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract B049: Radiogenomic profiling of prostate tumors prior to external beam radiotherapy (EBRT) converges on a transcriptomic signature of TGF-beta activity driving tumor recurrence

Adam G. Sowalsky, Anson T. Ku, Uma Shankavaram, Shana Y. Trostel, Houssein A. Sater, Stephanie A. Harmon, Nicole V. Carrabba, Yang Liu, Radka Stoyanova, Elai Davicioni, Alan Pollack, Baris Turkbey, Deborah E. Citrin
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B049.
https://doi.org/10.1158/1538-7445.PRCA2023-B049
Published: 02 June 2023
View article titled, Abstract B049: Radiogenomic profiling of prostate tumors prior to external beam radiotherapy (EBRT) converges on a transcriptomic signature of TGF-beta activity driving tumor recurrence
Journal Articles

Abstract 5721: Automated annotation for large-scale clinicogenomic models of lung cancer treatment response and overall survival

Justin Jee, Chris Fong, Karl Pichotta, Thinh Tran, Anisha Luthra, Mirella Altoe, Steven Maron, Ronglai Shen, Si-Yang Liu, Michele Waters, Joseph Kholodenko, Brooke Mastrogiacomo, Susie Kim, A Rose Brannon, Michael F. Berger, Axel Martin, Jason Chang, Anton Safonov, Jorge S. Reis-Filho, Deborah Schrag, Sohrab P. Shah, Pedram Razavi, Bob T. Li, Gregory J. Riely, Nikolaus Schultz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5721.
https://doi.org/10.1158/1538-7445.AM2023-5721
Published: 04 April 2023
View article titled, Abstract 5721: Automated annotation for large-scale clinicogenomic models of lung cancer treatment response and overall survival
Journal Articles

Abstract 5394: Detecting pulmonary malignancy against benign nodules using non-invasive cfDNA fragmentomics assay

Shun Xu, Ji Luo, Wanxiangfu Tang, Hua Bao, Jiajun Wang, Shuang Chang, Haimeng Tang, Zifang Zou, Xiaoxi Fan, Yang Liu, Changrui Jiang, Xue Wu, Yang Shao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5394.
https://doi.org/10.1158/1538-7445.AM2023-5394
Published: 04 April 2023
View article titled, Abstract 5394: Detecting pulmonary malignancy against benign nodules using non-invasive cfDNA fragmentomics assay
Journal Articles

Abstract 4259: Identification of anti-neoplastic therapy given before initial visit at a referral center using natural language processing applied to medical oncology initial consultation notes

Thinh N. Tran, Karl B. Pichotta, Si-Yang Liu, Christopher Fong, Anisha Luthra, Brooke Mastrogiacomo, Steven Maron, Deborah Schrag, Sohrab P. Shah, Pedram Razavi, Bob T. Li, Gregory J. Riely, Nikolaus Schultz, Justin Jee
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4259.
https://doi.org/10.1158/1538-7445.AM2023-4259
Published: 04 April 2023
View article titled, Abstract 4259: Identification of anti-neoplastic therapy given before initial visit at a referral center using natural language processing applied to medical oncology initial consultation notes
Journal Articles

Abstract 3165: ImmuneSig: A deep learning framework to develop gene expression signature of immune checkpoint inhibitor therapy

Yang Liu, Aashna Jhaveri, Sudhenshna Bodapati, Cheryl Wong, Franziska Michor
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3165.
https://doi.org/10.1158/1538-7445.AM2023-3165
Published: 04 April 2023
View article titled, Abstract 3165: ImmuneSig: A deep learning framework to develop gene expression signature of immune checkpoint inhibitor therapy