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Journal Articles

Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors

Cuiqing Yang, Xiaohui Shao, Feng Zhou, Lei Zhou, Qi Deng, Yun Zhang, Guangcun Cheng, Yingying Hu, Huaiyuan Ma, Yadan Wu, Shuai Wang, Jie Zang, Lei Liu, Wenqing Yang, Yang Liu, Chunlei Xia, Jianzhong Hu, Ande Luo, Yayuan Fu, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6343.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6343
Published: 15 June 2022
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Journal Articles

Abstract 3955: Targeting transcription elongation via CDK9 in mantle cell lymphoma patients with dual resistance to BTK inhibition and CAR T therapy

Vivian Changying Jiang, Lingzhi Li, Alexa Jordan, Yu Xue, Fangfang Yan, Joseph McIntosh, Yang Liu, Yuxuan Che, Yijing Li, Qingsong Cai, Angela Leeming, Lukas Simon, Zhongming Zhao, Jia Zhou, Michael Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3955.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3955
Published: 15 June 2022
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Journal Articles

Abstract 5203: Discovery and development of SLD2435, a novel humanized IgG1 bispecific antibody simultaneously targeting human TIGIT and PVRIG for cancer immunotherapy

Xiaofeng Zhao, Yayuan Fu, Xiaoqing Liu, Fengli Shan, Zhenna Gao, Mengyu Wang, Huiming Xu, Hai Huang, Yang Liu, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5203.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5203
Published: 15 June 2022
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Journal Articles

Abstract 6164: Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment

Juan Yan, Yuedan Chen, Amish J. Patel, Cindy J. Lee, Sarah Warda, Briana G. Nixon, Elissa W. P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Ming Li, Liang Deng, Yu Chen, Ping Chi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6164.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6164
Published: 15 June 2022
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Journal Articles

Abstract 3596: RM-036, a first-in-class, orally-bioavailable, Tri-Complex covalent KRASG12D(ON) inhibitor, drives profound anti-tumor activity in KRASG12D mutant tumor models

John E. Knox, Jingjing Jiang, G. Leslie Burnett, Yang Liu, Caroline E. Weller, Zhican Wang, Laura McDowell, Shelby L. Steele, Shook Chin, Kang Jye Chou, Fang Wang, Mengqi Zhong, Elena S. Koltun, David Wildes, Mallika Singh, Adrian L. Gill, Jacqueline A. Smith
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3596.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3596
Published: 15 June 2022
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Journal Articles

Abstract 3597: Direct targeting of KRASG12X mutant cancers with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor

Elena S. Koltun, Meghan A. Rice, W. Clay Gustafson, David Wilds, Jingjing Jiang, Bianca J. Lee, Zhengping Wang, Stephanie Chang, Mike Flagella, Yunming Mu, Nuntana Dinglasan, Nicole Nasholm, James W. Evans, Yingyun Wang, Kyle Seamon, Yang Liu, Cristina Blaj, John Knox, Rebecca Freilich, Elsa Quintana, Jim Cregg, Alun Bermingham, Adrian L. Gill, Jacqueline Am Smith, Mallika Singh
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3597.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3597
Published: 15 June 2022
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Journal Articles

Abstract 3102: MiniPDX and omics analysis for clinical indication and biomarker identification

Shuai Wang, Yu Di, Rongyu Li, Yang Liu, Xiaorong Gu, Kaimeng Hu, Danyi Wen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3102.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3102
Published: 15 June 2022
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Journal Articles

Abstract 5605: BH3120: A novel bispecific antibody targeting 4-1BB and PD-L1 with well balanced efficacy and safety profiles

Jiangcheng Xu, Yang Liu, Jing Wang, Fei Fan, Haitao Gu, Lanxin Zhang, Jun Wang, Ding Song, Ailong Guo, Hongjuan Zhang, Kaixuan Su, Jiaojiao Su, Lijuan Li, Jingmei Cai, Aihong Zhang, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5605.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5605
Published: 15 June 2022
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Journal Articles

Abstract 771: Multi-omics profiling can predict for relapse and response to brexucabtagene autoleucel CAR T-cell therapy in patients with mantle cell lymphoma

Vivian Changying Jiang, Dapeng Hao, Preetesh Jain, Yijing Li, Qingsong Cai, Yang Liu, Yuxuan Che, Jovanny Vargas, Yixin Yao, Lei Nie, Enyu Dai, Guangchun Han, Ruiping Wang, Kunal Rai, Andrew Futreal, Christopher Flowers, Linghua Wang, Michael Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 771.
DOI: https://doi.org/10.1158/1538-7445.AM2022-771
Published: 15 June 2022
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Journal Articles

Functional Analysis of MET Exon 14 Skipping Alteration in Cancer Invasion and Metastatic Dissemination

Feng Wang, Yang Liu, Wanglong Qiu, Elaine Shum, Monica Feng, Dejian Zhao, Deyou Zheng, Alain Borczuk, Haiying Cheng, Balazs Halmos
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1365–1379.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1327
Published: 01 April 2022
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Includes: Supplementary data
Journal Articles

Abstract 3136: A novel algorism evaluating dominant clonality in Chinese NSCLC patients with concomitant EGFR and ALK variation

Yang Liu, Xianghong Yang, Yu Li, Yongchun Zhou, Yihua Chen, Peng Cheng, Renya Zhang, Xiaowei Qi, Lihua Yang, Guanjun Zhang, Lijuan Qu, Yanfeng Xi, Guanshan Zhu, Yuchen Han
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3136.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3136
Published: 01 July 2021
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Journal Articles

Abstract 3140: Tumor evolution selectively inactivates microRNA machinery for immune evasion

Haixin Zhao, Tian-yu Song, Min Long, Hong-Jie Fan, Yang Liu, Chen-Lu Geng, Xiaoxiao Xie, Dawei Huang, Zhengang Peng, Bo Peng, Yong Cang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3140.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3140
Published: 01 July 2021
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Journal Articles

Abstract 2981: Establishment and validation of humanized murine modeling platforms to facilitate immuno-oncology research

Yang Liu, Hai Huang, Danni Hao, Ran Pang, Mi Ye, Guojing Wu, Wenjing Li, Liting Xue, Zhenchuan Miao, Ming Yin, Wenqing Yang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2981.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2981
Published: 01 July 2021
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Journal Articles

Abstract 1112: Exploiting oncogene-conferred glutamine addiction as a therapeutic vulnerability in resistant mantle cell lymphoma

Lingzhi Li, Changying Jiang, Lucy J. Navsaria, Yang Liu, Joseph M. McIntosh, Michael Wang, Yinxin Yao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1112.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1112
Published: 01 July 2021
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Journal Articles

Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers

Elena Koltun, Jim Cregg, Meghan A. Rice, Dan M. Whalen, Rebecca Freilich, Jingjing Jiang, Richard Hansen, Alun Bermingham, John E. Knox, Jay Dinglasan, Kyle Seamon, Cristina Blaj, Stephanie S. Chang, Yang Liu, Jun Huang, Kang-Jye Chou, Laura McDowell, Bianca J. Lee, David Wildes, Zhengping Wang, Mallika Singh, Adrian L. Gill, Jacqueline A. Smith
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1260.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1260
Published: 01 July 2021
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Journal Articles

Oncometabolites in Cancer: Current Understanding and Challenges

Yang Liu, Chunzhang Yang
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2820–2823.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-3730
Published: 01 June 2021
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Journal Articles

Abstract 6630: Synergistic immuno photothermal nanotherapy (SYMPHONY) for combination cancer therapy

Yang Liu, Paolo Maccarini, Gregory M. Palmer, Brant A. Inman, Peter E. Fecci, Tuan Vo-Dinh
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6630.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6630
Published: 15 August 2020
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Journal Articles

Abstract 6237: Bone-targeted nanoparticle containing protein therapeutics as an effective delivery system for bone metastasis

Yimin Niu, Cuicui Gao, Hongbin Yang, Qiang Huo, Andrew Wang, Ming Xu, Yang Liu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6237.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6237
Published: 15 August 2020
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Journal Articles

Abstract 2154: Immune pressure selects ANKRD52 mutations for cancer cells to escape T cell-mediated killing

Tianyu Y. Song, Haixin Zhao, Hongjie Fan, Min Long, Chenlu Geng, Xiaoxiao Xie, Yang Liu, Wenrong Zhou, Ziyu Chen, Dawei Huang, Bo Peng, Zhengang Peng, Yong Cang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2154.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2154
Published: 15 August 2020
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Journal Articles

Abstract 3509: Racial variation in molecularly-defined prostate cancer subtypes

Kevin H. Kensler, Mohamed Alshalalfa, Brandon A. Mahal, Yang Liu, Elai Davicioni, Shivanshu Awasthi, Kosj Yamoah, Timothy R. Rebbeck
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3509.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3509
Published: 15 August 2020
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