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Journal Articles

Abstract 671: Cryo-electronmicroscopy of PI3K reveals additional regulatory features

Jonathan R. Hart, Su Yang, Xiao Liu, Yingna Xu, Xinyu Zou, Huibing Zhang, Qingtong Zhou, Tian Xia, Yan Zhang, Dehua Yang, Ming-Wei Wang, Peter K. Vogt
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 671.
DOI: https://doi.org/10.1158/1538-7445.AM2022-671
Published: 15 June 2022
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Journal Articles

Abstract 1862: Naphthoquinone analogues inhibit Wnt/β-catenin signaling and colorectal cancer tumorigenesis

Rosalie G. Hoyle, Andrew Morris, Piyusha Pagare, Shadid Uz Zaman, Zhikun Ma, Yan Zhang, Jiong Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1862.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1862
Published: 15 June 2022
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Abstract 5642: Discovery of SCR-8079, a novel and selective CDK2/4/6 inhibitor overcomes the resistance to CDK4/6 inhibition and demonstrates broad anti-tumor activities in breast cancers

Feng Zhou, Guimei Yang, Feng Tang, Yan Zhang, Wenqing Yang, Liting Xue, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5642.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5642
Published: 15 June 2022
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Journal Articles

Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)

Shun Lu, Yiping Zhang, Guojun Zhang, Jianying Zhou, Shundong Cang, Ying Cheng, Gang Wu, Peiguo Cao, Dongqing Lv, Xiangming Jin, Hong Jian, Chengshui Chen, Guanming Jiang, Panwen Tian, Kai Wang, Hui Zhao, Gongyan Chen, Qun Chen, Cuimin Ding, Junquan Yang, Renhua Guo, Guoping Sun, Bin Wang, Liyan Jiang, Wu Zhuang, Zhe Liu, Jian Fang, Yunpeng Liu, Jian Zhang, Jun Chen, Yueyin Pan, Qitao Yu, Min Zhao, Jiuwei Cui, Dianming Li, Tienan Yi, Zhuang Yu, Yan Yang, Yan Zhang, Xiuyi Zhi, Yunchao Huang, Rong Wu, Liangan Chen, Aimin Zang, Lejie Cao, Qingshan Li, Xiaoling Li, Yong Song, Donglin Wang, Shucai Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT170.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT170
Published: 01 July 2021
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Journal Articles

Abstract 1338: Discovery of novel, potent USP7 inhibitors that upregulate p53 leading to anti-proliferative effects in cancer cells

Alan Futran, Tao Lu, Katherine Amberg-Johnson, Xiaoxiao Yang, Saidi He, Jeffrey Bell, Sarah Boyce, Markus Dahlgren, Karen Dingley, Liping Fang, Heidi Koldsoe, Zef Konst, Fang-Yu Lin, Robert Pelleltier, Heng Qian, Mats Svensson, Michael Trzoss, Jie Xu, Shuping Xu, Zhaowu Xu, Engin Yapici, Yan Zhang, Li Xing, Takao Suzuki, Xianhai Huang, Jiayi Xu, Hamish Wright, Kristian Jensen, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1338.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1338
Published: 01 July 2021
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Journal Articles

Abstract 3004: Establishment of KRAS G12C mutant patient-derived xenograft (PDX) models for pre-clinical evaluation of KRAS G12C targeted anticancer therapy

Wenting Shi, Xuzhen Tang, Jingying Zhang, Xinhong Kuang, Yan Zhang, Jingjing Wang, Qingyang Gu, Qunsheng Ji
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3004.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3004
Published: 01 July 2021
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Journal Articles

Abstract 2014: Radiopathomics strategy combining multiparametric MRI with whole-slide image for pretreatment prediction of tumor regression grade to neoadjuvant chemoradiotherapy in rectal cancer

Lizhi Shao, Zhenyu Liu, Lili Feng, Xiaoying Lou, Zhenhui Li, Xiao-Yan Zhang, Xuezhi Zhou, Kai Sun, Da-Fu Zhang, Lin Wu, Guanyu Yang, Ying-Shi Sun, Ruihua Xu, Xiangbo Wan, Xinjuan Fan, Jie Tian
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2014.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2014
Published: 15 August 2020
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Journal Articles

Abstract CT406: Patients with cancer appear more vulnerable to SARS-COV-2: A multi-center study during the COVID-19 outbreak

Meng-Yuan Dai, Dian-bo Liu, Miao Liu, Fu-Xiang Zhou, Gui-Ling Li, Zhen Chen, Zhi-An Zhang, Hua-You Md, Meng Wu, Qi-Chao Zheng, Yong Xiong, Hui-Hua Xiong, Chun Wang, Chang-Chun Chen, Fei Xiong, Yan Zhang, Ya-Qin Peng, Si-Ping Ge, Bo Zhen, Ting-Ting Yu, Ling Wang, Hua Wang, Yu Liu, Ye-Shan Chen, Jun-Hua Mei, Xiao-Jia Gao, Zhu-Yan Li, Li-Juan Gan, Can He, Zhen Li, Yu-Ying Shi, Yu-Wen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei Ann Mucci, Mauricio Santillana, Hongbing Cai
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT406.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT406
Published: 15 August 2020
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Journal Articles

Abstract LB-021: Focal adhesive kinase inhibitor IN10018 sensitizes KRAS mutant cancer and overcomes drug resistance of KRAS G12C inhibition

Baoyuan Zhang, Yan Zhang, Jiangwei Zhang, Ping Liu, Bo Jiao, Zaiqi Wang, Ruibao Ren
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-021.
DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-021
Published: 15 August 2020
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Journal Articles

Abstract 4532: Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells

Fabien Dépis, Changyun Hu, Jessica Weaver, Lara McGrath, Boris Klebanov, Joshua Buggé, Ben Umiker, Christine Fregeau, Dhruvkumar Upadhyay, Anirudh Singh, Chang-Ai Xu, Vikki Spaulding, Michelle Priess, Masie Wong, Seema Naheed, Yan Zhang, Kristin Legendre, Edward C. Stack, Alessandro Mora, Margaret Willer, Kristan Meetze, Monica Gostissa, Michael A. Meehl, Donald R. Shaffer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4532.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4532
Published: 15 August 2020
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Journal Articles

Abstract 945: Advancing cancer immunotherapeutics: A focus on characterization of anti-CTLA-4 mAbs for better anti-tumor immunity and less toxicity

Xuexiang Du, Mingyue Liu, Yan Zhang, Fei Tang, Chunxia Ai, Peng Zhang, Pan Zheng, Yang Liu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 945.
DOI: https://doi.org/10.1158/1538-7445.AM2020-945
Published: 15 August 2020
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Journal Articles

Abstract B26: Comparative analysis of breast tumor microbiome in Black non-Hispanic (BNH) and White non-Hispanic (WNH) women

Srikantha Thyagarajan, Yan Zhang, Santosh Thapa, Michael S. Allen, Nicole Phillips, Jamboor K. Vishwanatha
Journal: Cancer Research
Cancer Res (2020) 80 (8_Supplement): B26.
DOI: https://doi.org/10.1158/1538-7445.MVC2020-B26
Published: 15 April 2020
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Journal Articles

Abstract 186: Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers

Yan Zhang, Dayong Zheng, Ting Zhou, Mohit Hulsurkar, Michael Ittmann, Long Shao, Martin Gleave, Wenliang Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 186.
DOI: https://doi.org/10.1158/1538-7445.AM2019-186
Published: 01 July 2019
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Journal Articles

Abstract 1917: High-throughput evaluation of treatment response in patient-derived glioma stem cell models

Ze-yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Jie Yang, Lihong Long, Lawrence Bronk, Qianghu Wang, Erik P. Sulman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1917.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1917
Published: 01 July 2019
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Journal Articles

Abstract 2807: Accessing the transcriptome of low-abundance tumor-infiltrating lymphocytes with SPRI beads

Aiqing He, Manling Ma-Edmonds, Chan Gao, Vishal Patel, David Galbraith, Yan Zhang, Qi Guo, Heshani DeSilva, Gennaro Dito, Amy Truong, Sunil Kuppasani, Kandasamy Ravi, Omar Jabado
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2807.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2807
Published: 01 July 2019
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Abstract 4678: Targeting MEK in EGFR amplified glioma stem like cells induces differentiation

Soon Young Park, Yuji Piao, Emmanuel Martinez-Ledesma, Jianwen Dong, Sabbir Khan, Sandeep Mittal, Ze-yan Zhang, Erik P. Sulman, Veerakumar Balasubramaniyan, John F. de Groot
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4678.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4678
Published: 01 July 2019
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Abstract 4698: Development of a CRISPR-Cas9D10A targetable, high-complexity, single-cell barcoding approach for capture of treatment resistant subclones from heterogeneous cancers

Ze-yan Zhang, Ravesanker Ezhilarasan, Yingwen Ding, Qianghu Wang, Jie Yang, Lihong Long, Roel G. Verhaak, Erik P. Sulman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4698.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4698
Published: 01 July 2019
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MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells

Masaaki Yamamoto, Caining Jin, Tsuyoshi Hata, Yota Yasumizu, Yan Zhang, Deli Hong, Takahiro Maeda, Masaaki Miyo, Masayuki Hiraki, Yozo Suzuki, Kunihiko Hinohara, Hasan Rajabi, Donald Kufe
Journal: Cancer Research
Cancer Res (2019) 79 (8): 2031–2041.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-3259
Published: 15 April 2019
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Journal Articles

Abstract 5498: Natural product-derived carbon nanodots overcome drug resistance through regulation of Hippo pathway effectors

Ayan A. Nurkesh, Mannix P. Balanay, Tleubek Yeleusizov, Darkhan Tursynkhan, Qing Yang, Xiaoling Wan, Limara Manarbek, Aisulu Maipas, Bakhyt Matkarimov, Yan Zhang, Haiyan Fan, Li-Xia Miao, Si-Pian Li, Zhenbang Chen, Yingqiu Xie
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5498.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5498
Published: 01 July 2018
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Abstract 1279: Passenger mutation landscape in cancer genomes

Sushant Kumar, Jonathan Warrel, Patrick Mcgillivray, William Meyerson, Shantao Li, Leonidas Salichos, Arif Harmanci, Alexander Fundichely, Calvin Chan, Carl Herrmann, Morten Nielsen, Lucas Lochovsky, Yan Zhang, Xiaotong Li, Ekta Khurana, Gad Getz, Mark Gerstein
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1279.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1279
Published: 01 July 2018
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