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Journal Articles

Abstract CT126: Aumolertinib as adjuvant therapy in patients with stage II-IIIB EGFR-mutated NSCLC after complete tumor resection: A randomized, double-blind, placebo-controlled, phase 3 trial (ARTS)

Free
Ying Cheng, Xiqin Zhang, Lin Wu, Wenxiang Wang, Wenqun Xing, Chunling Liu, Caigang Liu, Kai Chen, Jianhua Shi, Peng Zhang, Shidong Xu, Xiaodong Zhang, Xiaorong Dong, Haohui Fang, Xinmin Yu, Yang Gao, Gaofeng Li, Liang Chen, Huiyuan Gong, Renhua Guo, Zhenyuan Gao, Yinghua Ji, Lunxu Liu, Xianling Liu, Hui Tian, Fei Xiong, Xin Zhao, Lejie Cao, Qing Geng, Hongxu Liu, Jixian Liu, Li Yang, Zhenfa Zhang, Di Ge, Xingya Li, Minghui Wang, Yan Xu, Zhi Xu, Jun Chen, Zhaoxia Dai, Jian Hu, Juan Li, Shujun Li, Min Ye, Aimin Zang, Chanjuan Xie, Zhenzhong Su, Zhenmin Chen, Shaonan Fan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT126.
https://doi.org/10.1158/1538-7445.AM2025-CT126
Published: 25 April 2025
View articletitled, Abstract CT126: Aumolertinib as adjuvant therapy in patients with stage II-IIIB EGFR-mutated NSCLC after complete tumor resection: A randomized, double-blind, placebo-controlled, phase 3 trial (ARTS)
Journal Articles

Abstract CT142: Phase 1 study of BPI-23314, a novel BET inhibitor and degrader, in advanced myeloid leukemia (AML)

Free
Mingyuan Sun, Xiangyu Jin, Jing Guo, Xiaoyun Liu, Yan Xu, Hong Lan, Jiabing Wang, Jiangnan Zhen, Jing Yang, Lieming Ding, Junyuan Qi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT142.
https://doi.org/10.1158/1538-7445.AM2024-CT142
Published: 05 April 2024
View articletitled, Abstract CT142: Phase 1 study of BPI-23314, a novel BET inhibitor and degrader, in advanced myeloid leukemia (AML)
Journal Articles

Abstract 5087: ILB-3101, a novel B7H3-targeting ADC with Eribulin as payload, demonstrates strong tumor killing activities and favorable PK/TOX profile in preclinical evaluation

Free
Yushuan Shang, Junzhuan Qiu, Yanfei Xin, Min Zhao, Qiang Liu, Zhengsheng Wang, Xiaojing Gong, Yan Xu, Yan Li, Mingde Xia, Rulei Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5087.
https://doi.org/10.1158/1538-7445.AM2024-5087
Published: 22 March 2024
View articletitled, Abstract 5087: ILB-3101, a novel B7H3-targeting ADC with Eribulin as payload, demonstrates strong tumor killing activities and favorable PK/TOX profile in preclinical evaluation
Journal Articles

Abstract 1890: HMA800067, a novel CD38-targeting antibody-drug conjugate (ADC), demonstrated superior anti-tumor activity to daratumumab in preclinical B-cell malignancies models

Free
Yan Xu, Junqing Liang, Shuwen Jiang, Haibin Yang, Hui Zhang, Fangfang Mao, Jiahuan Zhu, Jianlin He, Na Yang, Jian Wang, WeiHan Zhang, Yongxin Ren, Weiguo Su
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1890.
https://doi.org/10.1158/1538-7445.AM2024-1890
Published: 22 March 2024
View articletitled, Abstract 1890: HMA800067, a novel CD38-targeting antibody-drug conjugate (ADC), demonstrated superior anti-tumor activity to daratumumab in preclinical B-cell malignancies models
Journal Articles

Abstract 3612: KAT8/SIRT7-medicated fascin-K41 acetylation/deacetylation regulates tumor metastasis

Free
Da-Jia Li, Yin-Wei Cheng, Li-Yan Xu, En-Min Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3612.
https://doi.org/10.1158/1538-7445.AM2023-3612
Published: 04 April 2023
View articletitled, Abstract 3612: KAT8/SIRT7-medicated fascin-K41 acetylation/deacetylation regulates tumor metastasis
Journal Articles

Abstract 3099: Hnd-01: a potent inhibitor of wild type mutant BTK

Free
Jing Zhang, Ahmed A. Samatar, Yue Tan, Shiqing Pi, Zhigang Zhou, Yan Xu, Daihong Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3099.
https://doi.org/10.1158/1538-7445.AM2023-3099
Published: 04 April 2023
View articletitled, Abstract 3099: Hnd-01: a potent inhibitor of wild type mutant BTK
Journal Articles

Abstract 501: Discovery of BPI-460372, a potent and selective inhibitor of TEAD for the treatment of solid tumors harboring Hippo pathway aberrations

Free
Hongling Shen, Xiaofeng Xu, Hongfei Rong, Xizhen Song, Jinheng Gao, Jie Chen, Di Zhu, Xiangdong Zhao, Jun Tong, Zhengyao Zou, Xiaoyun Liu, Jin Guo, Yan Xu, Yabin Li, Xiangyong Liu, Hong Chen, Jiayu Zhao, Yanju Liu, Xuepeng Ju, Haibo Chen, Hong Lan, Lieming Ding, Jiabing Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 501.
https://doi.org/10.1158/1538-7445.AM2023-501
Published: 04 April 2023
View articletitled, Abstract 501: Discovery of BPI-460372, a potent and selective inhibitor of TEAD for the treatment of solid tumors harboring Hippo pathway aberrations
Journal Articles

Abstract 310: CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stress

Free
Bing Wen, Li-Yan Xu, En-Min Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 310.
https://doi.org/10.1158/1538-7445.AM2023-310
Published: 04 April 2023
View articletitled, Abstract 310: CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stress
Journal Articles

Abstract 1612: Therapeutic co-targeting YAP1 and TAZ using antisense oligos (ASOs) suppress gastric cancer progression and peritoneal metastases

Free
Jingjing Wu, Ailing Scott, Yan Xu, Yuan Li, Yibo Fan, Ruiping Wang, Xiaodan Yao, Katsuhiro Yoshimura, Melissa Pool Pizzi, Kohei Yamashita, Shan Shao, Christopher Vellano, Linghua Wang, Alexey Revenko, Eric Dolinski, Jaffer A. Ajani, Shumei Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1612.
https://doi.org/10.1158/1538-7445.AM2023-1612
Published: 04 April 2023
View articletitled, Abstract 1612: Therapeutic co-targeting YAP1 and TAZ using antisense oligos (ASOs) suppress gastric cancer progression and peritoneal metastases
Journal Articles

Abstract 3096: A novel ZIP4-NOTCH3-HDAC4 axis in ovarian cancer stem cells

Free
Yan Xu, Qipeng Fan, Robert Emerson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3096.
https://doi.org/10.1158/1538-7445.AM2021-3096
Published: 01 July 2021
View articletitled, Abstract 3096: A novel ZIP4-NOTCH3-HDAC4 axis in ovarian cancer stem cells
Journal Articles

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers

Available to Purchase
Yiqing Zhao, Xiujing Feng, Yicheng Chen, J. Eva Selfridge, Shashank Gorityala, Zhanwen Du, Janet M. Wang, Yujun Hao, Gino Cioffi, Ronald A. Conlon, Jill S. Barnholtz-Sloan, Joel Saltzman, Smitha S. Krishnamurthi, Shaveta Vinayak, Martina Veigl, Yan Xu, David L. Bajor, Sanford D. Markowitz, Neal J. Meropol, Jennifer R. Eads, Zhenghe Wang
Journal: Cancer Research
Cancer Res (2020) 80 (21): 4815–4827.
https://doi.org/10.1158/0008-5472.CAN-20-0600
Published: 03 November 2020
View articletitled, 5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers
Open the PDF for 5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 1751: BPI-23314: A novel orally bioavailable small molecular BET inhibitor with target protein degradation activity

Free
Jing Guo, Yan Xu, Dan Yan, Bo Yu, Weiwei Yu, Haibo Chen, Xiaofeng Xu, Xiangyong Liu, Hong Lan, Lieming Ding, Jiabing Wang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1751.
https://doi.org/10.1158/1538-7445.AM2020-1751
Published: 15 August 2020
View articletitled, Abstract 1751: BPI-23314: A novel orally bioavailable small molecular BET inhibitor with target protein degradation activity
Journal Articles

Abstract 6458: Adverse recurrence prognostic implications of tumor CD47 expression in resected non-small cell lung cancer

Free
Yan Xu, Ji Li, Bing Tong, Shuang Wang, Wei Zhong, Minjiang Chen, Jing Zhao, Mengzhao Wang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6458.
https://doi.org/10.1158/1538-7445.AM2020-6458
Published: 15 August 2020
View articletitled, Abstract 6458: Adverse recurrence prognostic implications of tumor CD47 expression in resected non-small cell lung cancer
Journal Articles

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Free
Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shaoyan Hu, Li-Yan Xu, En-Min Li, Yanbing Ding, Samuel J. Klempner, Simon A. Gayther, Benjamin P. Berman, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (13): 2722–2736.
https://doi.org/10.1158/0008-5472.CAN-20-0390
Published: 02 July 2020
View articletitled, Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
Open the PDF for Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Free
Xiu-Hui Zhan, Ji-Wei Jiao, Hai-Feng Zhang, Xiu-E Xu, Jian-Zhong He, Run-Liu Li, Hai-Ying Zou, Zhi-Yong Wu, Shao-Hong Wang, Jian-Yi Wu, Lian-Di Liao, Juan-Juan Wang, Yin-Wei Cheng, Kai Zhang, Gera Neufeld, Li-Yan Xu, En-Min Li
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4951–4964.
https://doi.org/10.1158/0008-5472.CAN-19-0860
Published: 01 October 2019
View articletitled, LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion
Open the PDF for LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion in another window
Includes: Supplementary data
Journal Articles

Abstract 3081: DZD9008, an oral, wild type selective EGFR inhibitor for the treatment of non-small-cell lung cancer with Exon20 insertion and other activating mutations

Free
Yan Xu, Lin Zhang, Lifang Zhu, Yingchun Wang, Mei Wang, Zhenfan Yang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3081.
https://doi.org/10.1158/1538-7445.AM2019-3081
Published: 01 July 2019
View articletitled, Abstract 3081: DZD9008, an oral, wild type selective EGFR inhibitor for the treatment of non-small-cell lung cancer with Exon20 insertion and other activating mutations
Journal Articles

Abstract 3787: Reduced expression of INPP4B by promoter hypermethylation in Epstein-Barr virus-associated gastric carcinoma

Free
Yiwen Ma, Jichao Tan, Weihong Dai, Yu Zhang, Yu Zhang, Rongjin Lin, Yan Xu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3787.
https://doi.org/10.1158/1538-7445.AM2019-3787
Published: 01 July 2019
View articletitled, Abstract 3787: Reduced expression of INPP4B by promoter hypermethylation in Epstein-Barr virus-associated gastric carcinoma
Journal Articles

Abstract 4: Discovery of novel and highly potent small molecule inhibitors of chemokine receptor CXCR4

Free
Xiong Fang, Qian Meng, Xiao Fang, Siyu Zhu, Yazi Huang, Jing An, Yan Xu, Ziwei Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4.
https://doi.org/10.1158/1538-7445.AM2019-4
Published: 01 July 2019
View articletitled, Abstract 4: Discovery of novel and highly potent small molecule inhibitors of chemokine receptor CXCR4
Journal Articles

Abstract 2181: A novel CXCR4 antagonist strongly mobilizes hematopoietic stem cells in vivo

Free
Xiao Fang, Qian Meng, Xiong Fang, Yujia Mao, Yan Xu, Jing An, Ziwei Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2181.
https://doi.org/10.1158/1538-7445.AM2019-2181
Published: 01 July 2019
View articletitled, Abstract 2181: A novel CXCR4 antagonist strongly mobilizes hematopoietic stem cells in vivo
Journal Articles

Abstract 1071: Overexpression of SHH and GLI1 contributes to poor prognosis and peritoneal metastases in gastric adenocarcinoma

Free
Yan Xu, Yuan Li, Bovey Liu, Melissa Pool Pizzi, Yongxi Song, Kazuto Harada, Ailing Scott, Lang Ma, Jiankang Jin, Xiaochuan Dong, Ying Wang, Brian D. Badgwell, Jeannelyn S. Estrella, Roy-Chowdhuri Sinchita, Fatemeh G. Amlashi, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1071.
https://doi.org/10.1158/1538-7445.AM2018-1071
Published: 01 July 2018
View articletitled, Abstract 1071: Overexpression of SHH and GLI1 contributes to poor prognosis and peritoneal metastases in gastric adenocarcinoma