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Journal Articles

Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer

Mi Li, Amriti R. Lulla, Yan Wang, Spyros Tsavaschidis, Fuchenchu Wang, Cansu Karakas, Tuyen D.T. Nguyen, Tuyen N. Bui, Marc A. Pina, Mei-Kuang Chen, Sofia Mastoraki, Asha S. Multani, Natalie W. Fowlkes, Aysegul Sahin, C. Gary Marshall, Kelly K. Hunt, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (22): 3864–3880.
https://doi.org/10.1158/0008-5472.CAN-23-4130
Published: 15 November 2024
View article titled, Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer
Open the PDF for Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO1-16-04: Targeting PKMYT1 Kinase as a Therapeutic Strategy for Treatment of Triple Negative Breast Cancer with Low Molecular Weight Cyclin E (LMW-E) Expression

Mi Li, Amriti Lulla, Cansu Karakas, Spiridon Tsavaschidis, Yan Wang, Tuyen Nguyun, Tuyen Bui, Gary Marshall, Kelly Hunt, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-16-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-16-04
Published: 02 May 2024
View article titled, Abstract PO1-16-04: Targeting PKMYT1 Kinase as a Therapeutic Strategy for Treatment of Triple Negative Breast Cancer with Low Molecular Weight Cyclin E (LMW-E) Expression
Journal Articles

Abstract PO3-02-12: Dalpiciclib combination with letrozole as neoadjuvant therapy for HR-positive HER2-negative breast cancer: a single-arm, prospective exploratory clinical study

Jingruo Li, Yuanting Gu, Chuang Du, Jianhua Zhang, Yingying Zhang, Linfeng Zhang, Nan Wang, Lin Li, Fang Wang, Pengwei Lv, Hong Zong, Xinhong Pei, Bingjian Xue, Yan Wang, Dongcheng Gao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-02-12.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-02-12
Published: 02 May 2024
View article titled, Abstract PO3-02-12: Dalpiciclib combination with letrozole as neoadjuvant therapy for HR-positive HER2-negative breast cancer: a single-arm, prospective exploratory clinical study
Journal Articles

Abstract PO1-18-05: Combination treatment with CDK2 inhibitor (BLU-222) and either palbociclib or ribociclib is synergistic in pre-clinical models of CDK4/6 inhibitor-resistant breast cancer

Linjie Luo, Juliana Navarro-Yepes, Yan Wang, Tuyen Bui, Nicole Kettner, Debu Tripathy, Kelly Hunt, Kerrie Faia, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-18-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-18-05
Published: 02 May 2024
View article titled, Abstract PO1-18-05: Combination treatment with CDK2 inhibitor (BLU-222) and either palbociclib or ribociclib is synergistic in pre-clinical models of CDK4/6 inhibitor-resistant breast cancer
Journal Articles

Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers

Juliana Navarro-Yepes, Nicole Kettner, Xiayu Rao, Tuyen Bui, Cassandra Bishop, Hannah Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul Sahin, Funda Meric-Bernstam, Kelly Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-15-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-15-03
Published: 02 May 2024
View article titled, Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers
Journal Articles

Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer

Ziming Li, Xiaomin Dang, Dingzhi Huang, Shi Jin, Weiwei Li, Jianhua Shi, Xicheng Wang, Yiping Zhang, Zhengbo Song, Junping Zhang, Wu Zhuang, Xuewen Liu, Liyan Jiang, Xiangjiao Meng, Mingfang Zhao, Jianying Zhou, Liangming Zhang, Pingli Wang, Hui Luo, Junquan Yang, Shundong Cang, Xiang Wang, Jing Wang, Jiuwei Cui, Yan Yu, Zhihong Zhang, Junguo Lu, Weihua Yang, Gaofeng Li, Jifeng Feng, Dongqing Lv, Lin Wu, Yong Fang, Yan Wang, Yanqiu Zhao, Baoshan Cao, Wei Zhu, Zhixiang Zhuang, Qingshan Li, Mingxi Wang, Huan Zhou, Xiaorong Dong, Sheng Hu, Jian Fang, Yihong Zhang, Wenjia Wang, Ziyong Xiang, Zhe Shi, Ling Zhang, Shun Lu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT246.
https://doi.org/10.1158/1538-7445.AM2024-CT246
Published: 05 April 2024
View article titled, Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer
Journal Articles

Abstract CT119: Safety and efficacy of HS-10370 in KRAS G12C-mutated solid tumors including non-small cell lung cancer (NSCLC)

Xiaorong Dong, Xiangjiao Meng, Yan Zhang, Yan Wang, Jianhua Chen, Liang Han, Qiming Wang, Zhong Lin, Hongying Wei, Siheng Lin, Chuan Li, Qiong Wu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT119.
https://doi.org/10.1158/1538-7445.AM2024-CT119
Published: 05 April 2024
View article titled, Abstract CT119: Safety and efficacy of HS-10370 in KRAS G12C-mutated solid tumors including non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 6253: Single-cell RNA sequencing reveals metastatic site-specific biomarkers for predicting response to CDK4/6 inhibition in advanced HR+/HER2- breast cancer

Linjie Luo, Peng Yang, Sofia Mastoraki, Yan Wang, Nicole M. Kettner, Akshara Singareeka Raghavendra, Debasish Tripathy, Senthil Damodaran, Kelly K. Hunt, Ziyi Li, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6253.
https://doi.org/10.1158/1538-7445.AM2024-6253
Published: 22 March 2024
View article titled, Abstract 6253: Single-cell RNA sequencing reveals metastatic site-specific biomarkers for predicting response to CDK4/6 inhibition in advanced HR+/HER2- breast cancer
Journal Articles

Abstract 5948: FMC-376 a dual inhibitor of ON and OFF states of KRASG12C is broadly active in PDX models of resistance

Yan Wang, Richard M. Neve, Jocelyn Staunton, Kevin R. Webster
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5948.
https://doi.org/10.1158/1538-7445.AM2024-5948
Published: 22 March 2024
View article titled, Abstract 5948: FMC-376 a dual inhibitor of ON and OFF states of KRAS<sup>G12C</sup> is broadly active in PDX models of resistance
Journal Articles

Abstract 4622: Anti-tumor activity of CDK2 inhibitor BLU-222 in combination with CDK4/6 inhibitors for overcoming resistance in HR positive and triple negative metastatic breast cancers models

Linjie Luo, Yan Wang, Tuyen Bui, Mi Li, Serena Kim, Juliana Navarro-Yepes, Nicole M. Kettner, Debasish Tripathy, Kelly K. Hunt, Kerrie Faia, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4622.
https://doi.org/10.1158/1538-7445.AM2024-4622
Published: 22 March 2024
View article titled, Abstract 4622: Anti-tumor activity of CDK2 inhibitor BLU-222 in combination with CDK4/6 inhibitors for overcoming resistance in HR positive and triple negative metastatic breast cancers models
Journal Articles

Abstract 1057: A blood-based multi-omics test for multicancer early detection: Combined retrospective and prospective studies

Mao Mao, Shiyong Li, Qingqi Ren, Yi Luan, Weijie Liang, Shuaipeng Geng, Dao-Ling Huang, Dandan Zhu, Yinyin Chang, Wei Wu, Yingying Zhang, Linfeng Zhang, Yan Wang, Yumin Feng, Bing Wei, Jie Ma, Chaohui Duan, Guanghui Long
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1057.
https://doi.org/10.1158/1538-7445.AM2024-1057
Published: 22 March 2024
View article titled, Abstract 1057: A blood-based multi-omics test for multicancer early detection: Combined retrospective and prospective studies
Journal Articles

Abstract 4018: An innovative in vivo model for CAR-T cell therapy development: Tolerability and efficacy evaluation of CD19-targeting CAR-T cells on human lymphoma using the chicken CAM assay

Yan Wang, Xavier Rousset, Chloé Prunier, Emilien Dosda, Alejandra Gutierrez-Guerrero, Pauline Abrial, Inna Menkova, Jean Viallet
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4018.
https://doi.org/10.1158/1538-7445.AM2024-4018
Published: 22 March 2024
View article titled, Abstract 4018: An innovative <em>in vivo</em> model for CAR-T cell therapy development: Tolerability and efficacy evaluation of CD19-targeting CAR-T cells on human lymphoma using the chicken CAM assay
Journal Articles

Abstract 5949: The clinical dual KRASG12C inhibitor FMC-376 has demonstrated potential as both a monotherapy and in combination for the treatment of patients with KRASG12C mutation positive NSCLC

Yan Wang, Allison Roberts, Philamer Calses, Richard M. Neve, Jocelyn Staunton, Kevin R. Webster
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5949.
https://doi.org/10.1158/1538-7445.AM2024-5949
Published: 22 March 2024
View article titled, Abstract 5949: The clinical dual KRAS<sup>G12C</sup> inhibitor FMC-376 has demonstrated potential as both a monotherapy and in combination for the treatment of patients with KRAS<sup>G12C</sup> mutation positive NSCLC
Journal Articles

Abstract 5003: Efficacy of the STC-1010 a new allogenic cancer vaccine in different colorectal cancer models

George Alzeeb, Céline Gongora, Corentin Richard, Romain Boidot, Tanguy Fortin, Yan Wang, Alban Bessede, Benoit Pinteur, Lionel Chalus, Corinne Tortorelli, Paul Bravetti, François Ghiringhelli
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5003.
https://doi.org/10.1158/1538-7445.AM2024-5003
Published: 22 March 2024
View article titled, Abstract 5003: Efficacy of the STC-1010 a new allogenic cancer vaccine in different colorectal cancer models
Journal Articles

Abstract 3263: VEGFA mediates traditional EGFR-TKI resistance in non-small cell lung cancer with EGFR exon 20 insertions

Yaning Yang, Chengming Liu, Guangjian Yang, Haiyan Xu, Siyu Lei, Yan Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3263.
https://doi.org/10.1158/1538-7445.AM2024-3263
Published: 22 March 2024
View article titled, Abstract 3263: VEGFA mediates traditional EGFR-TKI resistance in non-small cell lung cancer with EGFR exon 20 insertions
Journal Articles

Abstract 5189: The potential of minimal residual disease (MRD) in guiding adjuvant therapy (AT) decisions in non-small cell lung cancer (NSCLC)

Siyu Lei, Haiyan Xu, Yaning Yang, Linyan Tian, Ting Ma, Yan Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5189.
https://doi.org/10.1158/1538-7445.AM2024-5189
Published: 22 March 2024
View article titled, Abstract 5189: The potential of minimal residual disease (MRD) in guiding adjuvant therapy (AT) decisions in non-small cell lung cancer (NSCLC)
Journal Articles

DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance

Hui Wang, Yanyang Zhang, Yu Tian, Wanlin Yang, Yan Wang, Hui Hou, Hanbo Pan, Siyu Pei, Hongda Zhu, Zenan Gu, Yanyun Zhang, Dongfang Dai, Wei Chen, Mingyue Zheng, Qingquan Luo, Yichuan Xiao, Jia Huang
Journal: Cancer Research
Cancer Res (2024) 84 (5): 688–702.
https://doi.org/10.1158/0008-5472.CAN-23-0744
Published: 04 March 2024
View article titled, DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance
Open the PDF for DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance in another window
Includes: Supplementary data
Journal Articles

Abstract B059: A patient-derived xenograft (PDX) orthotopic mouse model of rare gynecologic mesonephric-like adenocarcinoma as a platform of personalized medicine

Yasuto Kinose, Kanako Kasuya, Yan Wang, Mai Koizumi, Aska Toda, Koji Nakamura, Mahiru Kawano, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B059.
https://doi.org/10.1158/1538-7445.OVARIAN23-B059
Published: 04 March 2024
View article titled, Abstract B059: A patient-derived xenograft (PDX) orthotopic mouse model of rare gynecologic mesonephric-like adenocarcinoma as a platform of personalized medicine
Journal Articles

Abstract A023: Cytokine loss leads to decreased tumor differentiation and a more aggressive phenotype

Whitney J. Bell, Nancy Kren, Yan Wang, Jennifer Modliszewski, Yi Xu, Meijiang Guan, Kathleen DelGiorno, Jen Jen Yeh, Yuliya Pylayeva-Gupta
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A023.
https://doi.org/10.1158/1538-7445.PANCA2023-A023
Published: 16 January 2024
View article titled, Abstract A023: Cytokine loss leads to decreased tumor differentiation and a more aggressive phenotype
Journal Articles

Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers

Juliana Navarro-Yepes, Nicole M. Kettner, Xiayu Rao, Cassandra Santaella Bishop, Tuyen N. Bui, Hannah F. Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul A. Sahin, Funda Meric-Bernstam, Kelly K. Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2023) 83 (19): 3264–3283.
https://doi.org/10.1158/0008-5472.CAN-23-0705
Published: 02 October 2023
View article titled, Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers
Open the PDF for Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers in another window
Includes: Supplementary data