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Journal Articles

Abstract LB255: MCTarg: A plasma-based metabolic biomarker model for multi-cancer early detection

Free
Yan Li, Xinping Xu, Chunyan Zeng, Bei Qing, Yun He, Yanlong Liu, Guodong Song, Jianhua Hu, Tianqi Shao, Li Liu, Qingyan Wei, Shuqi Yu, He Wen, Junyuan Hu, Wei Zhang, Youxiang Chen, Zhenkun Xia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB255.
https://doi.org/10.1158/1538-7445.AM2025-LB255
Published: 25 April 2025
View articletitled, Abstract LB255: MCTarg: A plasma-based metabolic biomarker model for multi-cancer early detection
Journal Articles

Abstract 343: GenSci143, a novel B7-H3×PSMA bispecific and potential best-in-class ADC, for the treatment of metastatic castration-resistant prostate cancer

Free
Yao Xu, Fu Li, Zhiyu Cui, Hongmei Xie, Wei Yan, Yan Li, Weiming He, Wenqiang Zhai, Fanglong Yang, John L. Xu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 343.
https://doi.org/10.1158/1538-7445.AM2025-343
Published: 21 April 2025
View articletitled, Abstract 343: GenSci143, a novel B7-H3×PSMA bispecific and potential best-in-class ADC, for the treatment of metastatic castration-resistant prostate cancer
Journal Articles

Abstract 1277: Ex ovo system for rapid and quantitative modelling of immunotherapy responses in pre-clinical and patient-derived xenografts: PDXovo

Free
Olivia R. Grafinger, Kabir A. Khan, Esther I. Matus, Sara Mar, Yan Li, David Goertz, Jean Gariépy, Katarzyna J. Jerzak, Robert Kerbel, Hon S. Leong
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1277.
https://doi.org/10.1158/1538-7445.AM2025-1277
Published: 21 April 2025
View articletitled, Abstract 1277: Ex ovo system for rapid and quantitative modelling of immunotherapy responses in pre-clinical and patient-derived xenografts: PDXovo
Journal Articles

Abstract 3416: Advancing cancer immunotherapy: PD-L1-targeted IFNa2a fusion protein RO7694744

Free
Moritz Rapp, Harald Duerr, Gabriel Schnetzler, Davide Bertoldo, Jack Bates, Laura Kruempelmann, Alexandra Baumgartner, Marion Lichtenauer, Sandra Bunte, Kerstin Paetzold, Martina Antoniolli, Malika Ait-Goughoulte, Yvonnne Kienast, Johannes Sam, Steffen Dettling, Martin Lechmann, Robert Mader, Daniela Willend, Barbara Leutgeb, Anja Irmisch, Claudia Mueller, Metodi Donev, Andreas Roller, Nino Gochitashvili, Kerstin Meier, Yan Li, Meher Majety, Marina Bacac, Christian Klein, Pablo Umana
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3416.
https://doi.org/10.1158/1538-7445.AM2025-3416
Published: 21 April 2025
View articletitled, Abstract 3416: Advancing cancer immunotherapy: PD-L1-targeted IFNa2a fusion protein RO7694744
Journal Articles

Abstract 2430: Artificial intelligence enables prediction of MET amplification & associated morphologic features from H&E-stained NSCLC specimens

Free
Nhat Le, Ylaine Gerardin, Syed Ashar Javed, Jennifer Hipp, Jacqueline Brosnan-Cashman, Miles Markey, Lara Murray, Bahar Rahsepar, Aditee Shrotre, Adam Luo, William Wijaya, Dawn Spelke, Pok Fai Wong, Joshua Hernandez, Sheila Bheddah, Ramya Seshadri, Steven Chirieleison, Patrick Caplazi, Yan Sun, Athan Vasilopoulos, Amita Mistry, Yan Li, Francine Chen, Peter Ansell, Kenneth Emancipator, Kevin Kolahi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2430.
https://doi.org/10.1158/1538-7445.AM2025-2430
Published: 21 April 2025
View articletitled, Abstract 2430: Artificial intelligence enables prediction of MET amplification & associated morphologic features from H&E-stained NSCLC specimens
Journal Articles

Abstract 2425: AI-powered approaches accurately predict t(11;14) positive multiple myeloma from H&E-stained histologic sections by identifying regions demonstrating lymphoplasmacytic cytology

Free
Neel Patel, Raymond Biju, Syed Ashar Javed, Sandrine Degryse, Lara Murray, Xiao Zhou, Jeremy A. Ross, William Wijaya, Pedro Munoz, Aditee Shrotre, Joann Palma, Patrick Calpazi, Yan Li, Pok Fai Wong, Francine Chen, Kenneth Emancipator, Kevin Kolahi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2425.
https://doi.org/10.1158/1538-7445.AM2025-2425
Published: 21 April 2025
View articletitled, Abstract 2425: AI-powered approaches accurately predict t(11;14) positive multiple myeloma from H&E-stained histologic sections by identifying regions demonstrating lymphoplasmacytic cytology
Journal Articles

Abstract 762: Spatial transcriptomic characterization of uterine carcinosarcomas identifies MECOM as a tumor regulator

Free
Sanaa N. Borrego, Elizabeth Kertowidjojo, Yan Li, Agnes Bilecz, Bridget Rodig, Lucy Kelliher, Hilary Kenny, Ernst Lengyel, Katherine C. Kurnit
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 762.
https://doi.org/10.1158/1538-7445.AM2025-762
Published: 21 April 2025
View articletitled, Abstract 762: Spatial transcriptomic characterization of uterine carcinosarcomas identifies MECOM as a tumor regulator
Journal Articles

Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma

Free
Qing-Jie Li, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, Jun-Yan Li, Sha Gong, Kai-Lin Chen, Na Liu, Jun Ma, Yin Zhao, Ling-Long Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1999.
https://doi.org/10.1158/1538-7445.AM2024-1999
Published: 22 March 2024
View articletitled, Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma
Journal Articles

Abstract 7578: BRD4 protein degradation for p53 mutant diffuse intrinsic pontine glioma (DIPG) via various delivery approaches for ARV-825 by using camel milk exosomes

Free
Aakash Nathani, Mounika Aare, Li Sun, Yan Li, Mandip Singh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7578.
https://doi.org/10.1158/1538-7445.AM2024-7578
Published: 22 March 2024
View articletitled, Abstract 7578: BRD4 protein degradation for p53 mutant diffuse intrinsic pontine glioma (DIPG) via various delivery approaches for ARV-825 by using camel milk exosomes
Journal Articles

Abstract 1346: Combined role of interleukin-15 stimulated natural killer cell-derived extracellular vesicles and carboplatin in Osimertinib resistant H1975 lung cancer with EGFR mutations

Free
Aakash Nathani, Li Sun, Islauddin Khan, Mounika Aare, Arvind Bagde, Yan Li, Mandip Sachdeva
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1346.
https://doi.org/10.1158/1538-7445.AM2024-1346
Published: 22 March 2024
View articletitled, Abstract 1346: Combined role of interleukin-15 stimulated natural killer cell-derived extracellular vesicles and carboplatin in Osimertinib resistant H1975 lung cancer with EGFR mutations
Journal Articles

Abstract 386: BACH1 is a key regulator of the tumor hypoxia response

Free
Long Chi Nguyen, Christopher Dann, Dongbo Yang, Madeline Henn, Emily Shi, Thomas Li, Letícia Stock, Wenchao Liu, Margarite Matossian, Andrea Valdespino, Yoo Jane Han, Jing Zhang, Geetha Priyanka Yerradoddi, Yan Li, Mitsuyo Matsumoto, Olufunmilayo I. Olopade, Kazuhiko Igarashi, Marsha R. Rosner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 386.
https://doi.org/10.1158/1538-7445.AM2024-386
Published: 22 March 2024
View articletitled, Abstract 386: BACH1 is a key regulator of the tumor hypoxia response
Journal Articles

Abstract 1635: Inhibition of FANCA Suppresses Breast Cancer Development by Regulating Cell Cycle Progression

Free
Liang Luo, Wenjun Liu, Fenghua Yuan, Fang Li, Anna Palovcak, Daniel Calkins, Karoline Briegel Briegel, Yan Li, Christian Mason, Zhao-Jun Liu, Sylvia Daunert, Yanbin Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1635.
https://doi.org/10.1158/1538-7445.AM2024-1635
Published: 22 March 2024
View articletitled, Abstract 1635: Inhibition of FANCA Suppresses Breast Cancer Development by Regulating Cell Cycle Progression
Journal Articles

Abstract 5087: ILB-3101, a novel B7H3-targeting ADC with Eribulin as payload, demonstrates strong tumor killing activities and favorable PK/TOX profile in preclinical evaluation

Free
Yushuan Shang, Junzhuan Qiu, Yanfei Xin, Min Zhao, Qiang Liu, Zhengsheng Wang, Xiaojing Gong, Yan Xu, Yan Li, Mingde Xia, Rulei Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5087.
https://doi.org/10.1158/1538-7445.AM2024-5087
Published: 22 March 2024
View articletitled, Abstract 5087: ILB-3101, a novel B7H3-targeting ADC with Eribulin as payload, demonstrates strong tumor killing activities and favorable PK/TOX profile in preclinical evaluation
Journal Articles

Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29

Free
Jia-Yi Lin, Wei-Wei Zhang, Qing-Jie Li, Xue-Liang Fang, Jun-Yan Li, Shi-Wei He, Ying-Qin Li, Jun Ma, Na Liu, Yin Zhao, Rui Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1113.
https://doi.org/10.1158/1538-7445.AM2024-1113
Published: 22 March 2024
View articletitled, Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29
Journal Articles

Abstract 6661: Profiling response to oncolytic adenovirus and immune checkpoint inhibitors by mass cytometry in a triple negative breast cancer mouse model

Free
Weidong Xu, Qiaoshan Lin, Yan Li, Beniamin Filimon, Soon Cheon Shin, Michael Olson, Mengjie Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6661.
https://doi.org/10.1158/1538-7445.AM2024-6661
Published: 22 March 2024
View articletitled, Abstract 6661: Profiling response to oncolytic adenovirus and immune checkpoint inhibitors by mass cytometry in a triple negative breast cancer mouse model
Journal Articles

Abstract C029: Multiple non-redundant immune checkpoints direct therapeutic resistance to chemotherapy and anti-CSF1R in pancreatic ductal adenocarcinoma

Free
Meredith L. Stone, Veronica M. Herrera, Yan Li, Heather Coho, Yuqing Yue, Kathleen Graham, Devora Delman, Shaun O'Brien, Gregory L. Beatty
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C029.
https://doi.org/10.1158/1538-7445.PANCA2023-C029
Published: 16 January 2024
View articletitled, Abstract C029: Multiple non-redundant immune checkpoints direct therapeutic resistance to chemotherapy and anti-CSF1R in pancreatic ductal adenocarcinoma
Journal Articles

Abstract B030: Spatial coupling of microbes and immune cells shapes the tumor microenvironment in human cancers

Free
Yan Li, Renee B. Chang, Meredith L. Stone, Yuqing Xue, Heather Coho, Kelly Markowitz, Dhruv Patel, Veronica M. Herrera, Joey H. Li, Devora Delman, Liti Zhang, Shaanti Choi-Bose, Michael Giannone, Jae W. Lee, Gregory Beatty
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B030.
https://doi.org/10.1158/1538-7445.PANCA2023-B030
Published: 16 January 2024
View articletitled, Abstract B030: Spatial coupling of microbes and immune cells shapes the tumor microenvironment in human cancers
Journal Articles

Abstract 638: EPB-53 prevents NASH-HCC transition via regulation of SPHK1-S1P-HIPPO signaling and immune modulation in a murine model

Free
Min Tan, Eugenia Pujol, Santiago Vazquez, Jingwen Zhang, Jun Yan, Robert C. Martin, Manuel Vazquez-Carrera, Yan Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 638.
https://doi.org/10.1158/1538-7445.AM2023-638
Published: 04 April 2023
View articletitled, Abstract 638: EPB-53 prevents NASH-HCC transition via regulation of SPHK1-S1P-HIPPO signaling and immune modulation in a murine model
Journal Articles

Abstract 3983: Defining the role of FANCA in breast cancer development and cell cycle progression

Free
Liang Luo, Wenjun Liu, Anna Palovcak, Fenghua Yuan, Fang Li, Daniel Calkins, Yan Li, Karoline Briegel, Daniel Bilbao, Evan Roberts, Christian Mason, Zhao-Jun Liu, Sylvia Daunert, Yanbin Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3983.
https://doi.org/10.1158/1538-7445.AM2023-3983
Published: 04 April 2023
View articletitled, Abstract 3983: Defining the role of FANCA in breast cancer development and cell cycle progression
Journal Articles

Abstract 2878: Identification of immunosuppressive and tumor-promoting neutrophils in human bone marrow and a novel mouse model that supports human neutrophil engraftment

Free
Wei Liu, Keying Che, Chun Lu, Jia Wei, Yan Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2878.
https://doi.org/10.1158/1538-7445.AM2023-2878
Published: 04 April 2023
View articletitled, Abstract 2878: Identification of immunosuppressive and tumor-promoting neutrophils in human bone marrow and a novel mouse model that supports human neutrophil engraftment