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Journal Articles

PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression

Qi Zhou, Leijia Li, Feifei Sha, Yiming Lei, Xuan Tian, Lingjun Chen, Yan Chen, Huiling Liu, Yunwei Guo
Journal: Cancer Research
Cancer Res (2023) 83 (14): 2372–2386.
https://doi.org/10.1158/0008-5472.CAN-22-3561
Published: 14 July 2023
View article titled, PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression
Open the PDF for PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract LB188: Discovery and development of fully human TACI/BCMA bispecific armored CAR for the treatment of relapsed/refractory multiple myeloma

Garima Agrahari, Wenle Liang, Katie O'Callaghan, Keming Zhang, Ning Jiang, Xiaoyi Jin, Ryan Feng, Jenna Nguyen, Sam Hassan, Annie Luu, Tony Ruan, Kehao Zhao, Yan Chen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB188.
https://doi.org/10.1158/1538-7445.AM2023-LB188
Published: 14 April 2023
View article titled, Abstract LB188: Discovery and development of fully human TACI/BCMA bispecific armored CAR for the treatment of relapsed/refractory multiple myeloma
Journal Articles

Abstract 4283: scMSI: Accurately detect the sub-clonal micro-satellite instability by an integrative Bayesian model

Yuqian Liu, Yan Chen, Huanwen Wu, Xuanping Zhang, Xin Lai, Xin Yi, Zhiyong Liang, Jiayin Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4283.
https://doi.org/10.1158/1538-7445.AM2023-4283
Published: 04 April 2023
View article titled, Abstract 4283: scMSI: Accurately detect the sub-clonal micro-satellite instability by an integrative Bayesian model
Journal Articles

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression

Yun-Guang Hong, Zhigang Yang, Yan Chen, Tian Liu, Yuyuan Zheng, Chun Zhou, Guo-Cai Wu, Yinhui Chen, Juan Xia, Ruiting Wen, Wenxin Liu, Yi Zhao, Jin Chen, Xiangwei Gao, Zhanghui Chen
Journal: Cancer Research
Cancer Res (2023) 83 (6): 845–860.
https://doi.org/10.1158/0008-5472.CAN-21-4249
Published: 15 March 2023
View article titled, The RNA m<sup>6</sup>A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression
Open the PDF for The RNA m<sup>6</sup>A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression in another window
Includes: Supplementary data
Journal Articles

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo J. Hatanpaa, John A. Copland, Ralph J. DeBerardinis, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2388–2402.
https://doi.org/10.1158/0008-5472.CAN-21-3868
Published: 05 July 2022
View article titled, Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
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Includes: Supplementary data
Journal Articles

Abstract LB214: Discovery of EPIM-001, a tumor targeted engineered IL2 with biased IL2Rβ agonist activities

Kehao Zhao, Sam Hassan, Yan Chen, Jenna Nguyen, Ning Jiang, Gening Zhang, Irene Li, Ryan Feng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB214.
https://doi.org/10.1158/1538-7445.AM2022-LB214
Published: 15 June 2022
View article titled, Abstract LB214: Discovery of EPIM-001, a tumor targeted engineered IL2 with biased IL2Rβ agonist activities
Journal Articles

Abstract CT226: Final progression-free survival analysis of JUPITER-02, a randomized, double-blind, phase 3 study of toripalimab or placebo plus gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma

Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Yingrui Shi, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Rui-Hua Xu, Coherus Biosciences and Shanghai Junshi Biosciences
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT226.
https://doi.org/10.1158/1538-7445.AM2022-CT226
Published: 15 June 2022
View article titled, Abstract CT226: Final progression-free survival analysis of JUPITER-02, a randomized, double-blind, phase 3 study of toripalimab or placebo plus gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma
Journal Articles

Abstract 5263: Whole-genome sequencing as an alternative to analyze copy number abnormalities in acute myeloid leukemia and myelodysplastic syndrome

Xiaodong Lyu, Tao Li, Dandan Zhu, Mengna Zhang, Yuexin Cheng, Yan Chen, Zhenling Li, Shiyong Li, Wei Wu, Shuaipeng Geng, Jingshuai Li, Xiangxiang He, Yangwei Li, Yinyin Chang, Zunmin Zhu, Mao Mao, Yongping Song
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5263.
https://doi.org/10.1158/1538-7445.AM2022-5263
Published: 15 June 2022
View article titled, Abstract 5263: Whole-genome sequencing as an alternative to analyze copy number abnormalities in acute myeloid leukemia and myelodysplastic syndrome
Journal Articles

Abstract 5111: Prompt assessment of molecular tumor load and treatment response in patients with lymphoma by a blood-based multi-omics approach

Xinhua Wang, Yu Chang, Zhiming Li, Yinyin Chang, Dandan Zhu, Shuaipeng Geng, Fangyuan Chang, Shiyong Li, Yan Chen, Mingzhi Zhang, Mao Mao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5111.
https://doi.org/10.1158/1538-7445.AM2022-5111
Published: 15 June 2022
View article titled, Abstract 5111: Prompt assessment of molecular tumor load and treatment response in patients with lymphoma by a blood-based multi-omics approach
Journal Articles

Abstract LB002: Development of fully human anti-CD19 &CD22 bispecific tandem CAR-T for the treatment of resistant or relapsed B cell malignancies

Jenna Nguyen, Gening Zhang, Keming Zhang, Ning Jiang, Ryan Feng, Jeffrey Wong, Annie Luu, Yan Chen, Kehao Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB002.
https://doi.org/10.1158/1538-7445.AM2022-LB002
Published: 15 June 2022
View article titled, Abstract LB002: Development of fully human anti-CD19 &amp;CD22 bispecific tandem CAR-T for the treatment of resistant or relapsed B cell malignancies
Journal Articles

Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

Hui Qin Wang, Iain J. Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Gina Trabucco, David S. Quinn, Tyler A. Longmire, Nidhi Patel, Roshani Patil, Matthew D. Shirley, Yan Chen, Hao Wang, David A. Ruddy, Claire Fabre, Juliet A. Williams, Peter S. Hammerman, Jennifer Mataraza, Barbara Platzer, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3079–3091.
https://doi.org/10.1158/0008-5472.CAN-20-0189
Published: 01 June 2021
View article titled, Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
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Includes: Supplementary data
Journal Articles

Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry

Yadav Sapkota, Na Qin, Matthew J. Ehrhardt, Zhaoming Wang, Yan Chen, Carmen L. Wilson, Jeremie Estepp, Parul Rai, Jane S. Hankins, Paul W. Burridge, John L. Jefferies, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, Gregory T. Armstrong, Daniel A. Mulrooney, Yutaka Yasui
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2556–2565.
https://doi.org/10.1158/0008-5472.CAN-20-2675
Published: 01 May 2021
View article titled, Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry
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Includes: Supplementary data
Journal Articles

Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma

Lizhen Liu, Sailan Liu, Peng Deng, Yujing Liang, Rong Xiao, Lin-Quan Tang, Jinghong Chen, Qiu-Yan Chen, Peiyong Guan, Shu-Mei Yan, Xiangliang Huang, Jing Han Hong, Jianfeng Chen, Yichen Sun, Bin Tean Teh, Qiang Yu, Hai-Qiang Mai, Jing Tan
Journal: Cancer Research
Cancer Res (2021) 81 (5): 1413–1425.
https://doi.org/10.1158/0008-5472.CAN-20-2125
Published: 01 March 2021
View article titled, Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth

Yong Wang, Maowu Luo, Yan Chen, Yijie Wang, Bo Zhang, Zhenhua Ren, Lei Bao, Yanan Wang, Jennifer E. Wang, Yang-Xin Fu, Weibo Luo, Yingfei Wang
Journal: Cancer Research
Cancer Res (2021) 81 (1): 174–186.
https://doi.org/10.1158/0008-5472.CAN-20-1710
Published: 04 January 2021
View article titled, ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth
Open the PDF for ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth in another window
Includes: Supplementary data
Journal Articles

CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors

Yijie Wang, Yan Chen, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3880–3891.
https://doi.org/10.1158/0008-5472.CAN-20-1049
Published: 15 September 2020
View article titled, CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Open the PDF for CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors in another window
Includes: Supplementary data
Journal Articles

HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis

Yanling Niu, Lei Bao, Yan Chen, Chenliang Wang, Maowu Luo, Bo Zhang, Mi Zhou, Jennifer E. Wang, Yisheng V. Fang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2020) 80 (5): 964–975.
https://doi.org/10.1158/0008-5472.CAN-19-1532
Published: 02 March 2020
View article titled, HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis
Open the PDF for HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 3110: Shorter naïve T cell telomere length is associated with thyroid subsequent malignant neoplasm: A report from the Childhood Cancer Survivor Study (CCSS)

Maria M. Gramatges, Geraldine Aubert, Elmira Hariri, Yan Chen, John A. Whitton, Wendy M. Leisenring, Michael A. Arnold, Joseph P. Neglia, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Smita Bhatia
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3110.
https://doi.org/10.1158/1538-7445.AM2019-3110
Published: 01 July 2019
View article titled, Abstract 3110: Shorter naïve T cell telomere length is associated with thyroid subsequent malignant neoplasm: A report from the Childhood Cancer Survivor Study (CCSS)
Journal Articles

Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies

Ensar Halilovic, Maïa Chanrion, Prakash Mistry, Markus Wartmann, Shumei Qiu, Sneha Sanghavi, Yan Chen, Gaëlle Lysiak, Ana Leticia Maragno, Ulrike Pfaar, Felix Huth, Marie Schoumacher, Audrey Claperon, Laurence Kraus-Berthier, Sébastien Banquet, Alix Derreal, Heiko Maacke, Frédéric Colland, Olivier Geneste, Erick Morris, Youzhen Wang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4477.
https://doi.org/10.1158/1538-7445.AM2019-4477
Published: 01 July 2019
View article titled, Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies
Journal Articles

Abstract B070: Epithelial-marker absent and disease-marker specific circulating and disseminated tumor cells are rarely detected in men with localized prostate cancer

Stephanie Glavaris, Heather Chalfin, Changxue Lu, Yan Chen, Emily Caruso, Kenneth Valkenburg, Jun Luo, Kenneth Pienta
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B070.
https://doi.org/10.1158/1538-7445.PRCA2017-B070
Published: 14 August 2018
View article titled, Abstract B070: Epithelial-marker absent and disease-marker specific circulating and disseminated tumor cells are rarely detected in men with localized prostate cancer
Journal Articles

Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Juniper A. Scribner, Jennifer G. Brown, Sharad Sharma, Hua Li, Michael Chiechi, Pam Li, Thomas Son, Anushka De Costa, Yan Chen, Francine Chen, Bhaswati Barat, Ling Huang, Christina Wolff, Jeff Hooley, Tim E. Hotaling, Timur Gaynutdinov, Valentina Ciccarone, James Tamura, Scott Koenig, Syd Johnson, Paul A. Moore, Ezio Bonvini, Deryk Loo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 820.
https://doi.org/10.1158/1538-7445.AM2018-820
Published: 01 July 2018
View article titled, Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer