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Journal Articles

Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma

Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo Hatanpaa, John A. Copland, Ralph J. DeBerardinis, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res canres.3868.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3868
Published: 02 May 2022
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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

Hui Qin Wang, Iain J. Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Gina Trabucco, David S. Quinn, Tyler A. Longmire, Nidhi Patel, Roshani Patil, Matthew D. Shirley, Yan Chen, Hao Wang, David A. Ruddy, Claire Fabre, Juliet A. Williams, Peter S. Hammerman, Jennifer Mataraza, Barbara Platzer, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3079–3091.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-0189
Published: 01 June 2021
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Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry

Yadav Sapkota, Na Qin, Matthew J. Ehrhardt, Zhaoming Wang, Yan Chen, Carmen L. Wilson, Jeremie Estepp, Parul Rai, Jane S. Hankins, Paul W. Burridge, John L. Jefferies, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, Gregory T. Armstrong, Daniel A. Mulrooney, Yutaka Yasui
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2556–2565.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-2675
Published: 01 May 2021
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Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma

Lizhen Liu, Sailan Liu, Peng Deng, Yujing Liang, Rong Xiao, Lin-Quan Tang, Jinghong Chen, Qiu-Yan Chen, Peiyong Guan, Shu-Mei Yan, Xiangliang Huang, Jing Han Hong, Jianfeng Chen, Yichen Sun, Bin Tean Teh, Qiang Yu, Hai-Qiang Mai, Jing Tan
Journal: Cancer Research
Cancer Res (2021) 81 (5): 1413–1425.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-2125
Published: 01 March 2021
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ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth

Yong Wang, Maowu Luo, Yan Chen, Yijie Wang, Bo Zhang, Zhenhua Ren, Lei Bao, Yanan Wang, Jennifer E. Wang, Yang-Xin Fu, Weibo Luo, Yingfei Wang
Journal: Cancer Research
Cancer Res (2021) 81 (1): 174–186.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1710
Published: 04 January 2021
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CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors

Yijie Wang, Yan Chen, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3880–3891.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1049
Published: 15 September 2020
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HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis

Yanling Niu, Lei Bao, Yan Chen, Chenliang Wang, Maowu Luo, Bo Zhang, Mi Zhou, Jennifer E. Wang, Yisheng V. Fang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2020) 80 (5): 964–975.
DOI: https://doi.org/10.1158/0008-5472.CAN-19-1532
Published: 02 March 2020
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Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies

Ensar Halilovic, Maïa Chanrion, Prakash Mistry, Markus Wartmann, Shumei Qiu, Sneha Sanghavi, Yan Chen, Gaëlle Lysiak, Ana Leticia Maragno, Ulrike Pfaar, Felix Huth, Marie Schoumacher, Audrey Claperon, Laurence Kraus-Berthier, Sébastien Banquet, Alix Derreal, Heiko Maacke, Frédéric Colland, Olivier Geneste, Erick Morris, Youzhen Wang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4477.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4477
Published: 01 July 2019
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Abstract 3110: Shorter naïve T cell telomere length is associated with thyroid subsequent malignant neoplasm: A report from the Childhood Cancer Survivor Study (CCSS)

Maria M. Gramatges, Geraldine Aubert, Elmira Hariri, Yan Chen, John A. Whitton, Wendy M. Leisenring, Michael A. Arnold, Joseph P. Neglia, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Smita Bhatia
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3110.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3110
Published: 01 July 2019
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Journal Articles

Abstract B070: Epithelial-marker absent and disease-marker specific circulating and disseminated tumor cells are rarely detected in men with localized prostate cancer

Stephanie Glavaris, Heather Chalfin, Changxue Lu, Yan Chen, Emily Caruso, Kenneth Valkenburg, Jun Luo, Kenneth Pienta
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B070.
DOI: https://doi.org/10.1158/1538-7445.PRCA2017-B070
Published: 14 August 2018
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Abstract 5427: Inhibition of hypoxia-inducible factor 1 (HIF-1) transcriptional activity and cell mobility via G9a/GLP-mediated methylation of HIF-1α

Lei Bao, Yan Chen, Hsien-Tsung Lai, Cheng-Ming Chiang, Gregg L. Semenza, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5427.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5427
Published: 01 July 2018
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Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Juniper A. Scribner, Jennifer G. Brown, Sharad Sharma, Hua Li, Michael Chiechi, Pam Li, Thomas Son, Anushka De Costa, Yan Chen, Francine Chen, Bhaswati Barat, Ling Huang, Christina Wolff, Jeff Hooley, Tim E. Hotaling, Timur Gaynutdinov, Valentina Ciccarone, James Tamura, Scott Koenig, Syd Johnson, Paul A. Moore, Ezio Bonvini, Deryk Loo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 820.
DOI: https://doi.org/10.1158/1538-7445.AM2018-820
Published: 01 July 2018
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Abstract 82: Epigenetic reader ZMYND8 bridges BRD4 and hypoxia-inducible factors to mediate breast cancer progression and metastasis

Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Jennifer Wang, Chenliang Wang, Xuan Zou, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 82.
DOI: https://doi.org/10.1158/1538-7445.AM2018-82
Published: 01 July 2018
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Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers

Hui Qin Wang, Jinsheng Liang, Iain Mulford, Fiona Sharp, Swann Gaulis, Yan Chen, Gina Trabucco, David Quinn, Joseph D. Growney, Matthew J. Meyer, Juliet Williams, Peter Hammerman, Francesco Hofmann, Glenn Dranoff, Jeffrey Engelman, Jennifer Mataraza, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5560.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5560
Published: 01 July 2018
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miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer

Ting-Ting Yan, Lin-Lin Ren, Chao-Qin Shen, Zhen-Hua Wang, Ya-Nan Yu, Qian Liang, Jia-Yin Tang, Ying-Xuan Chen, Dan-Feng Sun, Witold Zgodzinski, Marek Majewski, Piotr Radwan, Ilona Kryczek, Ming Zhong, Jinxian Chen, Qiang Liu, Weiping Zou, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
Journal: Cancer Research
Cancer Res (2018) 78 (7): 1751–1765.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-2101
Published: 01 April 2018
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Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)

Leila Dardaei, Hui Qin Wang, Paul Fordjour, Manrose Singh, Grainne Kerr, Satoshi Yoda, Jinsheng Liang, Yichen Cao, Yan Chen, Justin F. Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T. Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H. DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Cyril H. Benes, Alice T. Shaw, Aaron N. Hata, Fang Li, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1007.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1007
Published: 01 July 2017
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Abstract 42: Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Thomas Son, Juniper A. Scribner, Jeff Hooley, Michael Chiechi, Pam Li, Timothy E. Hotaling, Anushka De Costa, Yan Chen, Francine Chen, Bhaswati Barat, Valentina Ciccarone, Timur Gaynutdinov, James Tamura, Scott Koenig, Syd Johnson, Paul A. Moore, Ezio Bonvini, Deryk Loo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 42.
DOI: https://doi.org/10.1158/1538-7445.AM2017-42
Published: 01 July 2017
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Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Qianhui Dou, Hai-Ning Chen, Kui Wang, Kefei Yuan, Yunlong Lei, Kai Li, Jiang Lan, Yan Chen, Zhao Huang, Na Xie, Lu Zhang, Rong Xiang, Edouard C. Nice, Yuquan Wei, Canhua Huang
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4457–4469.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2887
Published: 31 July 2016
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Abstract 1201: Anti-B7-H3 antibody-drug conjugates as potential therapeutics for solid cancer

Deryk Loo, Juniper A. Scribner, Thomas Son, Jeff Hooley, Timothy Hotaling, Michael Chiechi, Pam Li, Anushka De Costa, Yan Chen, Ann Easton, Francine Z. Chen, Bhaswati Barat, Valentina Ciccarone, James Tamura, Mark Kubik, Scott Koenig, Syd Johnson, Paul A. Moore, Ezio Bonvini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1201.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1201
Published: 15 July 2016
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PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells

Hai-Ning Chen, Kefei Yuan, Na Xie, Kui Wang, Zhao Huang, Yan Chen, Qianhui Dou, Min Wu, Edouard C. Nice, Zong-Guang Zhou, Canhua Huang
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1122–1134.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-1962
Published: 29 February 2016
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