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Ya'an Kang
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Journal Articles

Abstract PO-066: High uptake, retention, and in vivo activity of L-Annamycin in pancreatic cancer models

Ya'an Kang, Rafal Zielinski, Roberto Cardenas Zuniga, Radjendirane Venugopal, Maria Poimenidou, Magdalena Remiszewski, Shaohua Peng, Edd Felix, Krzysztof Grela, Stanislaw Skora, Van N. Nguyen, Izabela Fokt, Waldemar Priebe
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-066.
https://doi.org/10.1158/1538-7445.PANCA21-PO-066
Published: 15 November 2021
View articletitled, Abstract PO-066: High uptake, retention, and in vivo activity of L-Annamycin in pancreatic cancer models
Journal Articles

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya'an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4054–4065.
https://doi.org/10.1158/0008-5472.CAN-20-3792
Published: 01 August 2021
View articletitled, Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Open the PDF for Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma

Carla Mottini, Hideo Tomihara, Diego Carrella, Alessia Lamolinara, Manuela Iezzi, Justin K. Huang, Carla A. Amoreo, Simonetta Buglioni, Isabella Manni, Frederick S. Robinson, Rosalba Minelli, Ya'an Kang, Jason B. Fleming, Michael P. Kim, Christopher A. Bristow, Daniela Trisciuoglio, Antonella Iuliano, Donatella Del Bufalo, Diego Di Bernardo, Davide Melisi, Giulio F. Draetta, Gennaro Ciliberto, Alessandro Carugo, Luca Cardone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5612–5625.
https://doi.org/10.1158/0008-5472.CAN-19-0187
Published: 01 November 2019
View articletitled, Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma
Open the PDF for Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4732: CDK4/6 inhibition with lerociclib (G1T38) enhances response to PI3K or ERK inhibitors in high-throughput, ex vivo pancreatic PDX screens

Bingbing Dai, Daniel M. Freed, Jessica A. Sorrentino, Jithesh Jose Augustine, Tara G. Hughes, Ya'an Kang, Patrick J. Roberts, Jason B. Fleming, Michael P. Kim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4732.
https://doi.org/10.1158/1538-7445.AM2019-4732
Published: 01 July 2019
View articletitled, Abstract 4732: CDK4/6 inhibition with lerociclib (G1T38) enhances response to PI3K or ERK inhibitors in high-throughput, ex vivo pancreatic PDX screens
Journal Articles

Abstract 116: IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma

Longhao Sun, Liang Liu, Weijun Tian, Zhixiang Zhang, Ya'an Kang, Huamin Wang, Jason B. Fleming, Boris C. Pasche, Wei Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 116.
https://doi.org/10.1158/1538-7445.AM2018-116
Published: 01 July 2018
View articletitled, Abstract 116: IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma
Journal Articles

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

Yan Wang, Jung-Mao Hsu, Ya'an Kang, Yongkun Wei, Pei-Chih Lee, Shing-Jyh Chang, Yi-Hsin Hsu, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Chia-Wei Li, Hsin-Wei Liao, Shih-Shin Chang, Weiya Xia, How-Wen Ko, Chao-Kai Chou, Jason B. Fleming, Huamin Wang, Rosa F. Hwang, Yue Chen, Jun Qin, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (23): 7049–7058.
https://doi.org/10.1158/0008-5472.CAN-16-0715
Published: 30 November 2016
View articletitled, Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
Open the PDF for Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation in another window
Includes: Supplementary data
Journal Articles

Abstract 2741: NF-κB activation by IL-1α and p62 feedforward loops is required for Kras-induced pancreatic ductal adenocarcinoma.

Jianhua Ling, Ya'an Kang, Paul Chiao
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2741.
https://doi.org/10.1158/1538-7445.AM2013-2741
Published: 15 April 2013
View articletitled, Abstract 2741: NF-κB activation by IL-1α and p62 feedforward loops is required for Kras-induced pancreatic ductal adenocarcinoma.
Journal Articles

TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation

Zhongkui Li, Zhe Chang, Lucia J. Chiao, Ya'an Kang, Qianghua Xia, Cihui Zhu, Jason B. Fleming, Douglas B. Evans, Paul J. Chiao
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7851–7859.
https://doi.org/10.1158/0008-5472.CAN-08-4002
Published: 01 October 2009
View articletitled, TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation
Open the PDF for TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation in another window
Includes: Supplementary data
Journal Articles

Lympho-epithelial kazal-type-inhibitor (LEKTI) controls in vitro invasiveness and expression of matrix metalloproteinases in head and neck squamaous cell carcinomas (HNSCCs) cells.

Arumugam Jayakumar, Hua-Kang Wu, Katrina Briggs, Ya’an Kang, Ying Henderson, Mitchell J. Frederick, Adel K. El-Naggar, Thomas D. Shellenberger, Xiaoning Sun, Gary L. Clayman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 56–57.
Published: 01 May 2005
View articletitled, Lympho-epithelial kazal-type-inhibitor (LEKTI) controls in vitro invasiveness and expression of matrix metalloproteinases in head and neck squamaous cell carcinomas (HNSCCs) cells.
Journal Articles

Regulation of the proteolytic activity of human kallikrein 5 (hK5) by tissue and plasma inhibitors

Iacovos P. Michael, Nahoko Komatsu, Arumugam Jayakumar, Ya’an Kang, Gary L. Clayman, Eleftherios P. Diamandis
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 698.
Published: 01 May 2005
View articletitled, Regulation of the proteolytic activity of human kallikrein 5 (hK5) by tissue and plasma inhibitors