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Y. Alan Wang
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Journal Articles

Abstract 6403: In vivo CRISPR/Cas9 screening identifies fatty acid synthase (FASN) as a target to enhance anti-PD-1 therapy in pancreatic cancer

Free
Feng Guo, Chia-Chin Wu, David Eisenbarth, Tadahito Yasuda, Fei Gao, Hyejin Oh, Y Alan Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6403.
https://doi.org/10.1158/1538-7445.AM2025-6403
Published: 21 April 2025
View articletitled, Abstract 6403: In vivo CRISPR/Cas9 screening identifies fatty acid synthase (FASN) as a target to enhance anti-PD-1 therapy in pancreatic cancer
Journal Articles

Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Free
Jiexi Li, Zhengdao Lan, Wenting Liao, Jielin Liu, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. LaBella, Wen-Hao Hsu, Xiaoying Shang, Denise Spring, Y Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3515.
https://doi.org/10.1158/1538-7445.AM2023-3515
Published: 04 April 2023
View articletitled, Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
Journal Articles

Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC

Free
Rumi Lee, Jiexi Li, Jun Li, Chang-Jiun Wu, Shan Jiang, Wen-Hao Hsu, Deepavali Chakravarti, Peiwen Chen, Kyle A. LaBella, Jing Li, Denise J. Spring, Di Zhao, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): IA014.
https://doi.org/10.1158/1538-7445.CRC22-IA014
Published: 01 December 2022
View articletitled, Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC
Journal Articles

Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Free
Jiexi Li, Zhengdao Lan, Wenting Liao, James W. Horner, Jielin Liu, Shan Jiang, Hong S. Shim, Max Slotnik, Kyle A. LaBella, Wen-Hao Hsu, Denise J. Spring, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): PR011.
https://doi.org/10.1158/1538-7445.CRC22-PR011
Published: 01 December 2022
View articletitled, Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
Journal Articles

An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer

Free
Xin Lu, Xiaolu Pan, Chang-Jiun Wu, Di Zhao, Shan Feng, Yong Zang, Rumi Lee, Sunada Khadka, Samirkumar B. Amin, Eun-Jung Jin, Xiaoying Shang, Pingna Deng, Yanting Luo, William R. Morgenlander, Jacqueline Weinrich, Xuemin Lu, Shan Jiang, Qing Chang, Nora M. Navone, Patricia Troncoso, Ronald A. DePinho, Y. Alan Wang
Journal: Cancer Research
Cancer Res (2018) 78 (14): 3823–3833.
https://doi.org/10.1158/0008-5472.CAN-17-3564
Published: 15 July 2018
View articletitled, An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer
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Journal Articles

Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

Free
Yinhui Yang, Alexandra M. Blee, Dejie Wang, Jian An, Yunqian Pan, Yuqian Yan, Tao Ma, Yundong He, Joseph Dugdale, Xiaonan Hou, Jun Zhang, S. John Weroha, Wei-Guo Zhu, Y. Alan Wang, Ronald A. DePinho, Wanhai Xu, Haojie Huang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (23): 6524–6537.
https://doi.org/10.1158/0008-5472.CAN-17-0686
Published: 30 November 2017
View articletitled, Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion
Open the PDF for Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion in another window
Includes: Supplementary data
Journal Articles

Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Free
Avnish Kapoor, Wantong Yao, Haoqiang Ying, Sujun Hua, Alison Liewen, Anguraj Sadanandam, Ramsey Al-Khalil, Andrea Viale, Piergiorgio Pettazzoni, Nora Sanchez, Alexei Protopopov, Jianhua Zhang, Timothy Heffernan, Randy L. Johnson, Lynda Chin, Y. Alan Wang, Giulio Draetta, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A94.
https://doi.org/10.1158/1538-7445.PANCA2014-A94
Published: 30 June 2015
View articletitled, Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
Journal Articles

Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms

Free
Stefan Klingler, Baofeng Guo, Jun Yao, Haiyan Yan, Ling Zhang, Angelina V. Vaseva, Sida Chen, Peter Canoll, James W. Horner, Y. Alan Wang, Ji-Hye Paik, Haoqiang Ying, Hongwu Zheng
Journal: Cancer Research
Cancer Res (2015) 75 (10): 2109–2119.
https://doi.org/10.1158/0008-5472.CAN-14-3122
Published: 13 May 2015
View articletitled, Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Open the PDF for Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms in another window
Includes: Supplementary data
Journal Articles

Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Free
Haoqiang Ying, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Alec C. Kimmelman, Eric S. Martin, Jeffery Chang, Aram Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Costas A. Lyssiotis, Lynda Chin, Lewis C. Cantley, Ronald A. DePinho, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A101.
https://doi.org/10.1158/1538-7445.PANCA2012-A101
Published: 03 April 2014
View articletitled, Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Journal Articles

ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development

Free
Kate C. Shen, Henry Heng, Yaolin Wang, Shu Lu, Guo Liu, Chu-Xia Deng, S.C. Brooks, Y. Alan Wang
Journal: Cancer Research
Cancer Res (2005) 65 (19): 8747–8753.
https://doi.org/10.1158/0008-5472.CAN-05-1471
Published: 03 October 2005
View articletitled, ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
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