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Journal Articles

Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Vanessa Tonin Garrido, Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Purushottam Lamichhane, Siddharth Mehra, Samara P. Singh, Austin R. Dosch, Oliver Umland, Michael n N. VanSaun, Peter J. Hosein, Nagaraj Nagathihalli, Nipun Merchant
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4187.
https://doi.org/10.1158/1538-7445.AM2022-4187
Published: 15 June 2022
View article titled, Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer
Journal Articles

Abstract PO-056: Targeting of cancer associated fibroblast-specific MEK1 and STAT3 to overcome immunosuppressive microenvironment in Pancreatic Ductal Adenocarcinoma (PDAC)

Siddharth Mehra, Xizi Dai, Anna Bianchi, Austin Dosch, Iago de Castro Silva, Prateek Sharma, Samara Singh, Supriya Srinivasan, Nagaraj Nagathihalli, Jashodeep Datta, Nipun Merchant
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-056.
https://doi.org/10.1158/1538-7445.PANCA20-PO-056
Published: 13 November 2020
View article titled, Abstract PO-056: Targeting of cancer associated fibroblast-specific MEK1 and STAT3 to overcome immunosuppressive microenvironment in Pancreatic Ductal Adenocarcinoma (PDAC)
Journal Articles

Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer

Austin R. Dosch, Samara Singh, Xizi Dai, Siddharth Mehra, Anna Bianchi, Iago De Castro Silva, Supriya Srinivasan, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-049.
https://doi.org/10.1158/1538-7445.PANCA20-PO-049
Published: 13 November 2020
View article titled, Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer
Journal Articles

Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Austin R. Dosch, Xizi Dai, Michelle L. Reyzer, Deukwoo Kwon, Richard Caprioli, Nipun B. Merchant, Nagaraj S. Nagathihalli
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A11.
https://doi.org/10.1158/1538-7445.PANCA19-A11
Published: 13 December 2019
View article titled, Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer
Journal Articles

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, Nipun B. Merchant
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6235–6246.
https://doi.org/10.1158/0008-5472.CAN-18-0634
Published: 01 November 2018
View article titled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
Open the PDF for Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer in another window
Journal Articles

Abstract 5042: CREB transgenic mice to study alcohol-associated pancreatic carcinogenesis

Tulasigeri Totiger, Supriya Srinivasan, Michael VanSaun, Chandrashekhar Joshi, Chanjuan Shi, Xizi Dai, Rajinder Dawra, Alexander Gaidarski, Eric Nestler, Nipun Merchant, Nagaraj Nagathihalli
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5042.
https://doi.org/10.1158/1538-7445.AM2018-5042
Published: 01 July 2018
View article titled, Abstract 5042: CREB transgenic mice to study alcohol-associated pancreatic carcinogenesis
Journal Articles

Abstract B78: RAD51 sensitizes pancreatic cancer cells to AKT inhibition

Surpiya Srinivasan, Chanjuan Shi, Casey Roberts, Xizi Dai, Fanuel Messaggio, Krisztina Kovacs, Michael VanSaun, Nipun Merchant, Nagaraj Nagathihalli
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B78.
https://doi.org/10.1158/1538-7445.PANCA16-B78
Published: 14 December 2016
View article titled, Abstract B78: RAD51 sensitizes pancreatic cancer cells to AKT inhibition
Journal Articles

Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer

Casey Roberts, Michael N. VanSaun, Purushottam Lamichhane, Fanuel Messaggio, Krisztina Kovacs, Supriya Srinivasan, Xizi Dai, Jennifer Barretta, Nagaraj Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B75.
https://doi.org/10.1158/1538-7445.PANCA16-B75
Published: 14 December 2016
View article titled, Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer