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Journal Articles

Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Yong Yean Kim, Girma Woldemichael, Berkley Gryder, Silvia Pomella, Ranuka Sinniah, Josh Kowalczyk, Young Song, Mehal Churiwal, Joseph Barchi, John Schneekloth, Xinyu Wen, Hsein-Chao Chou, Barry Okeefe, John Shern, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 703.
DOI: https://doi.org/10.1158/1538-7445.AM2022-703
Published: 15 June 2022
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Journal Articles

Abstract 3581: Multi-omic analysis identifies mechanisms of resistance to CD19 CAR T-cell therapy in children with acute lymphoblastic leukemia

Katherine E. Masih, Rebecca Gardner, Hsien-Chao Chou, Abdalla Abdelmaksoud, Young K. Song, Luca Mariani, Vineela Gangalapudi, Berkley E. Gryder, Ashley Wilson, Serifat O. Adebola, Benjamin Z. Stanton, Chaoyu Wang, Xinyu Wen, Gregoire Altan-Bonnet, Michael C. Kelly, Jun S. Wei, Martha L. Bulyk, Michael C. Jensen, Rimas J. Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3581.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3581
Published: 15 June 2022
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Journal Articles

Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion

Sara A. Byron, William P.D. Hendricks, Abhinav B. Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie I. Brown, Don E. Eslin, Deanna Mitchell, Albert Cornelius, William Roberts, Michael S. Isakoff, Javier E. Oesterheld, Randal K. Wada, Jawhar Rawwas, Kathleen Neville, Peter E. Zage, Virginia L. Harrod, Genevieve Bergendahl, Elizabeth VanSickle, Karl Dykema, Jeffrey Bond, Hsien-Chao Chou, Jun S. Wei, Xinyu Wen, Hue V. Reardon, Alison Roos, Sara Nasser, Tyler Izatt, Daniel Enriquez, Apurva M. Hegde, Faith Cisneros, Austin Christofferson, Bryce Turner, Szabolcs Szelinger, Jonathan J. Keats, Rebecca F. Halperin, Javed Khan, Giselle L. Saulnier Sholler, Jeffrey M. Trent
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5818–5832.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1033
Published: 01 December 2021
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Includes: Supplementary data
Journal Articles

Abstract 1885: Potent tumoricidal activity of a FGFR4 CART in rhabdomyosarcoma

Adam Cheuk, Meijie Tian, Jeetendra Kumar, Peter Azorsa, Nityashree Shivaprasad, Dina Schneider, Berkley Gryder, Jun Wei, Young Song, Xinyu Wen, Sivasish Sindiri, Joon-Yong Chung, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1885.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1885
Published: 01 July 2021
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Journal Articles

Abstract LB-141: Increased epigenetic plasticity and tumor heterogeneity predict resistance to CD19 CAR T cell therapy in pre-treatment pediatric acute lymphoblastic leukemia

Katherine E. Masih, Abdalla Abdelmaksoud, David Milewski, Berkley E. Gryder, Rebecca Gardner, Ashley L. Wilson, Benjamin Z. Stanton, Young K. Song, Chaoyu Wang, Xinyu Wen, Serifat Adebola, Zachary Rae, Adam Cheuk, Justin Lack, Gregoire Altan-Bonnet, Michael Kelly, Jun Wei, Michael Jensen, Rimas J. Orentas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-141.
DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-141
Published: 15 August 2020
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Journal Articles

Abstract 3445: Immuno-transcriptomic profiling identifies actionable genomic alterations in pediatric solid malignancies

Jun S. Wei, Andrew S. Brohl, Sivasish Sindiri, David Milewski, Young K. Song, Sushma Nagaraj, Vineela Gangalapudi, Xinyu Wen, Marc Ladanyi, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3445.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3445
Published: 15 August 2020
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Journal Articles

Abstract 6613: Identification of targetable HLA*A2:01 restricted peptides in osteosarcoma

David Milewski, Sivasish Sindiri, Jun S. Wei, Andrew Brohl, Young Song, Xinyu Wen, Andrew Qi, Udayan Guha, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6613.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6613
Published: 15 August 2020
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Journal Articles

Abstract PR17: Immunogenomic landscape of pediatric solid malignancies

Jun S. Wei, Andrew S. Brohl, Sivasish Sindiri, Young K. Song, Sushma Najaraj, Vineela Gangalapudi, Xinyu Wen, Marc Ladanyi, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): PR17.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-PR17
Published: 15 July 2020
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Journal Articles

Abstract A11: A comprehensive and integrative omic analysis of multiply relapsed refractory pediatric pre-B cell acute lymphoblastic leukemia predicts response to CD19 CAR T-cell therapy

Katherine E. Masih, Rebecca Gardner, Berkley E. Gryder, Abdalla Abdelmaksoud, Ashley Wilson, Serifat Adebola, Benjamin Z. Stanton, Young K. Song, Justin Lack, Chaoyu Wang, Xinyu Wen, Zachary Rae, Adam Cheuk, Gregoire Altan-Bonnet, Michael Kelly, Jun S. Wei, Michael C. Jensen, Rimas J. Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A11.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A11
Published: 15 July 2020
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Journal Articles

Abstract B15: Genomic classification and prognosis in rhabdomyosarcoma: A report from the Children’s Oncology Group, the Institute of Cancer Research, and the National Cancer Institute

Jack Shern, Joanna Selfe, Rajesh Patidar, Young Song, Marielle Yohe, Jun Wei, Xinyu Wen, Erin Rudinski, Donald Barkauskas, David Hall, Corinne Linardic, Meriel Jenney, Julia Chisholm, Rebecca Brown, Anna Kelsey, Susanne Gatz, Stephen Skapek, Douglas Hawkins, Janet Shipley, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B15.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B15
Published: 15 July 2020
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Journal Articles

Abstract A08: Development of FGFR4-specific chimeric antibody receptor (CAR) T cell and bispecific T cell engager (BiTE) for rhabdomyosarcoma (RMS) immunotherapy

Adam Cheuk, Nityashree Shivaprasad, Dina Schneider, Marielle Yohe, Meijie Tan, Peter Azorsa, Ronald Sams, Silvia Pomella, Berkley Gryder, Rossella Rota, Ben Stanton, Jun Wei, Young Song, Xinyu Wen, Sivasish Sindiri, Jeetendra Kumar, Robert Hawley, Joon-Yong Chung, Doncho Zhelev, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A08.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A08
Published: 15 July 2020
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Journal Articles

Abstract 3653: Immunogenomic landscape of pediatric solid malignancies

Jun S. Wei, Andrew S. Brohl, Young K. Song, Sushma Najaraj, Vineela Gangalapudi, Ashley Walton, Xinyu Wen, Marc Ladanyi, Javed Khan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3653.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3653
Published: 01 July 2019
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Journal Articles

Abstract LB-056: An integrated genomic, epigenetic, proteomic, and single cell analysis of pediatric B cell acute lymphoblastic leukemia to elucidate resistance mechanisms to CD19 CAR T cell therapy

Katherine E. Masih, Rebecca Gardner, Berkley E. Gryder, Justin Lack, Benjamin Z. Stanton, Ashley Wilson, Olivia Finney, Sivasish Sindiri, Young Song, Zachary Rae, Michael Kelly, Chaoyu Wang, Xinyu Wen, Adam Cheuk, Jun S. Wei, Michael Jensen, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-056.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-056
Published: 01 July 2019
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Journal Articles

Abstract 1744: RNAseq identified immune signatures associated with adverse outcome in high-risk neuroblastoma

Jun S. Wei, Shile Zhang, Igor Kuznetsov, Young K. Song, Shahab Asgharzadeh, Sivasish Sindiri, Xinyu Wen, Rajesh Patidar, Jaime M. Guidry Auvil, Daniela S. Gerhard, Robert Seeger, John M. Maris, Javed Khan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1744.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1744
Published: 01 July 2017
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Journal Articles

Abstract 126: The transcriptome landscape of high-risk neuroblastoma

Jun S. Wei, Shile Zhang, Young K. Song, Shahab Asgharzadeh, Sivasish Sindiri, Xinyu Wen, Rajesh Patidar, Jaime M. Guidry Auvil, Daniela S. Gerhard, Robert Seeger, John M. Maris, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 126.
DOI: https://doi.org/10.1158/1538-7445.AM2016-126
Published: 15 July 2016
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Journal Articles

Abstract PR16: Targeting the chromatin architecture established by PAX3-FOXO1 in rhabdomyosarcoma

Berkley E. Gryder, Marielle E. Yohe, Jack Shern, Hsien-Chao Chou, Young Song, Rajesh Patidar, Sam Li, Sivasish Sindiri, Abigail Cleveland, Hongling Liao, Xinyu Wen, Xiaohu Zhang, Lesley Mathews-Griner, Rajarshi Guha, Paul Shinn, Marc Ferrer, Scott Martin, Madhu Lal, Craig Thomas, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): PR16.
DOI: https://doi.org/10.1158/1538-7445.PEDCA15-PR16
Published: 04 April 2016
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Journal Articles

Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma

Dominik Bogen, Jun S. Wei, David O. Azorsa, Pinar Ormanoglu, Eugen Buehler, Rajarshi Guha, Jonathan M. Keller, Lesley A. Mathews Griner, Marc Ferrer, Young K. Song, Hongling Liao, Arnulfo Mendoza, Berkley E. Gryder, Sivasish Sindri, Jianbin He, Xinyu Wen, Xinyu Wen, Shile Zhang, John F. Shern, Marielle E. Yohe, Sabine Taschner-Mandl, Jason Shohet, Craig J. Thomas, Scott E. Martin, Peter F. Ambros, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B31.
DOI: https://doi.org/10.1158/1538-7445.PEDCA15-B31
Published: 04 April 2016
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Journal Articles

Abstract 1077: Use of the SVClassify algorithm to classify pediatric solid tumor translocation variant calls as likely true or false positives

Jo Lynne Harenza, Hemang M. Parikh, Jun S. Wei, Xinyu Wen, Sivasish Sindiri, Rajesh Patidar, Marc Salit, Paul S. Meltzer, Javed Khan, Justin Zook
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1077.
DOI: https://doi.org/10.1158/1538-7445.AM2015-1077
Published: 01 August 2015
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Journal Articles

Abstract 3218: Transcriptome characterization by RNA sequencing identifies molecular and clinical subgroups in high risk neuroblastoma

Shile Zhang, Jun S. Wei, Rajesh Patidar, Young K. Song, Sivasish Sindiri, Xinyu Wen, Shahab Asgharzadeh, Robert C. Seeger, John M. Maris, Jamie M. Guidry Auvil, Daniela S. Gerhard, Javed Khan
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3218.
DOI: https://doi.org/10.1158/1538-7445.AM2015-3218
Published: 01 August 2015
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Journal Articles

Abstract A12: Systematic identification of germline mutations in rhabdomyosarcoma and neuroblastoma using massively paralleled sequencing

Jun S. Wei, Rajesh Patidar, John Shern, Shile Zhang, Trevor Pugh, Sharon J. Diskin, Sivasish Sindiri, Young K. Song, Hongling Liao, Xinyu Wen, Jianjun Wang, Stephen X. Skapek, James R. Anderson, Frederic G. Barr, Robert C. Seeger, John M. Maris, Douglas Hawkins, Javed Khan
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): A12.
DOI: https://doi.org/10.1158/1538-7445.PEDCAN-A12
Published: 09 October 2014
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