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Journal Articles

Abstract 2656: Reversible chemical modification of antibodies: A complementary approach to tuning FcγR binding that maintains anti-tumor activity while mitigating peripheral immune activation

Philip N. Moquist, Chris I. Leiske, Noah A. Bindman, Xinqun Zhang, Nicole Duncan, Weiping Zeng, Serena W. Wo, Abbie Wong, Clark M. Henderson, Karalyne Crowder, Haley D. Neff-LaFord, Django Sussman, Shyra J. Gardai, Matthew R. Levengood

Cancer Res (2023) 83 (7_Supplement): 2656.

https://doi.org/10.1158/1538-7445.AM2023-2656

Published: 04 April 2023

View article titled, Abstract 2656: Reversible chemical modification of antibodies: A complementary approach to tuning FcγR binding that maintains anti-tumor activity while mitigating peripheral immune activation

Journal Articles

Abstract 750: Modular coiled-coil masking domains for tumor-specific antibody activation

Vivian H. Trang, Xinqun Zhang, Melissa M. Dominguez, Weiping Zeng, Julia H. Cochran, Ivan J. Stone, Peter D. Senter, Matthew R. Levengood

Cancer Res (2018) 78 (13_Supplement): 750.

https://doi.org/10.1158/1538-7445.AM2018-750

Published: 01 July 2018

View article titled, Abstract 750: Modular coiled-coil masking domains for tumor-specific antibody activation

Journal Articles

Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities

Matthew R. Levengood, Xinqun Zhang, Kim K. Emmerton, Joshua H. Hunter, Peter D. Senter

Cancer Res (2017) 77 (13_Supplement): 982.

https://doi.org/10.1158/1538-7445.AM2017-982

Published: 01 July 2017

View article titled, Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities

Journal Articles

Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

Fu Li, Michelle Ulrich, Mechthild Jonas, Germein Linares, Xinqun Zhang, Lori Westendorf, Dennis Benjamin, Che-Leung Law

Cancer Res (2016) 76 (14_Supplement): 1285.

https://doi.org/10.1158/1538-7445.AM2016-1285

Published: 15 July 2016

View article titled, Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

Journal Articles

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Fu Li, Kim K. Emmerton, Mechthild Jonas, Xinqun Zhang, Jamie B. Miyamoto, Jocelyn R. Setter, Nicole D. Nicholas, Nicole M. Okeley, Robert P. Lyon, Dennis R. Benjamin, Che-Leung Law

Cancer Res (2016) 76 (9): 2710–2719.

https://doi.org/10.1158/0008-5472.CAN-15-1795

Published: 01 May 2016

View article titled, Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Includes: Supplementary data

Journal Articles

Abstract 5507: Characterization of ADC bystander killing in admixed tumor model

Fu Li, Kim Kissler Emmerton, Mechthild Jonas, Xinqun Zhang, Che-Leung Law

Cancer Res (2015) 75 (15_Supplement): 5507.

https://doi.org/10.1158/1538-7445.AM2015-5507

Published: 01 August 2015

View article titled, Abstract 5507: Characterization of ADC bystander killing in admixed tumor model

Journal Articles

Abstract 3694: Relationship between in vivo antitumor activity of ADC and payload release in preclinical models

Fu Li, Xinqun Zhang, Kim Emmerton, Mechthild Jonas, Jocelyn Setter, Bill Arthur, Nicole Okeley, Robert Lyon, Dennis Benjamin, Che-Leung Law

Cancer Res (2014) 74 (19_Supplement): 3694.

https://doi.org/10.1158/1538-7445.AM2014-3694

Published: 01 October 2014

View article titled, Abstract 3694: Relationship between <em>in vivo</em> antitumor activity of ADC and payload release in preclinical models

Journal Articles

Abstract 4465: Differential MMAE delivery from ADCs utilizing the valine-citrulline-PAB and β-glucuronide cleavable linker systems

Nicole M. Okeley, Heather A. VanEpps, Xinqun Zhang, Jocelyn R. Setter, Patrick J. Burke, Joseph Z. Hamilton, Robert P. Lyon

Cancer Res (2014) 74 (19_Supplement): 4465.

https://doi.org/10.1158/1538-7445.AM2014-4465

Published: 01 October 2014

View article titled, Abstract 4465: Differential MMAE delivery from ADCs utilizing the valine-citrulline-PAB and β-glucuronide cleavable linker systems

Journal Articles

Abstract 5334: Mechanism of cysteine-mcMMAF release from the stably linked antibody-drug conjugate SGN-75

Xinqun Zhang, Nicole M. Okeley, Jocelyn Setter, Che-Leung Law, Dennis R. Benjamin, Peter D. Senter, Stephen C. Alley

Cancer Res (2010) 70 (8_Supplement): 5334.

https://doi.org/10.1158/1538-7445.AM10-5334

Published: 15 April 2010

View article titled, Abstract 5334: Mechanism of cysteine-mcMMAF release from the stably linked antibody-drug conjugate SGN-75

Journal Articles

Abstract #3234: Antibody-targeted delivery of auristatin using SGN-35 leads to one to two logs greater intratumoral auristatin concentrations than non-targeted therapy

Stephen Alley, Ezogelin Oflazoglu, Mechthild Jonas, Xinqun Zhang, Nicole Okeley, Kim Kissler, Martha Anderson, Dana Kennedy, Eric Sievers

Cancer Res (2009) 69 (9_Supplement): 3234.

Published: 01 May 2009

View article titled, Abstract #3234: Antibody-targeted delivery of auristatin using SGN-35 leads to one to two logs greater intratumoral auristatin concentrations than non-targeted therapy

Journal Articles

Biodistribution of a dual labeled anti-CD70 auristatin antibody-drug conjugate in tumor-bearing mice: experimental and modeled data

Stephen Alley, Xinqun Zhang, Nicole Okeley, Martha Anderson, Che-Leung Law, Peter Senter, Dennis Benjamin

Cancer Res (2008) 68 (9_Supplement): 4063.

Published: 01 May 2008

View article titled, Biodistribution of a dual labeled anti-CD70 auristatin antibody-drug conjugate in tumor-bearing mice: experimental and modeled data

Journal Articles

Effects of linker chemistry on tumor targeting by anti-CD70 antibody-drug conjugates

Stephen Alley, Xinqun Zhang, Nicole Okeley, Martha Anderson, Ezogelin Oflazoglu, Ivan Stone, Che-Leung Law, Peter Senter, Dennis Benjamin

Cancer Res (2007) 67 (9_Supplement): 916.

Published: 01 May 2007

View article titled, Effects of linker chemistry on tumor targeting by anti-CD70 antibody-drug conjugates

Journal Articles

Alpha-methylacyl-CoA racemase real time RT-PCR for detection of circulating tumor cells in peripheral blood of prostate cancer patients.

Xinqun Zhang, Barbara K. Zehentner, Heather Secrist, Dawn C. Hayes, Gary Goodman, David H. Persing, Nancy Kiviat, Jiangchun Xu, Raymond L. Houghton

Cancer Res (2004) 64 (7_Supplement): 853.

Published: 01 April 2004

View article titled, Alpha-methylacyl-CoA racemase real time RT-PCR for detection of circulating tumor cells in peripheral blood of prostate cancer patients.

Journal Articles

Identification and Characterization of Prostein, a Novel Prostate-specific Protein

Jiangchun Xu, Michael Kalos, John A. Stolk, Eden J. Zasloff, Xinqun Zhang, Raymond L. Houghton, Aristides Maltez Filho, Marcos Nolasco, Roberto Badaró, Steven G. Reed

Cancer Res (2001) 61 (4): 1563–1568.

Published: 02 February 2001

View article titled, Identification and Characterization of Prostein, a Novel Prostate-specific Protein

Journal Articles

Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray

Jiangchun Xu, John A. Stolk, Xinqun Zhang, Sandra J. Silva, Raymond L. Houghton, Masazumi Matsumura, Thomas S. Vedvick, Kevin B. Leslie, Roberto Badaro, Steven G. Reed

Cancer Res (2000) 60 (6): 1677–1682.

Published: 01 March 2000

View article titled, Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray

Journal Articles

Microfilament Depletion and Circumvention of Multiple Drug Resistance by Sphinxolides

Xinqun Zhang, Luigi Minale, Angela Zampella, Charles D. Smith

Cancer Res (1997) 57 (17): 3751–3758.

Published: 01 September 1997

View article titled, Microfilament Depletion and Circumvention of Multiple Drug Resistance by Sphinxolides

Journal Articles

Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells

Charles D. Smith, Xinqun Zhang, Susan L. Mooberry, Gregory M. L. Patterson, Richard E. Moore

Cancer Res (1994) 54 (14): 3779–3784.

Published: 01 July 1994

View article titled, Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells

NARROW

Abstract 2656: Reversible chemical modification of antibodies: A complementary approach to tuning FcγR binding that maintains anti-tumor activity while mitigating peripheral immune activation

Abstract 750: Modular coiled-coil masking domains for tumor-specific antibody activation

Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities

Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Abstract 5507: Characterization of ADC bystander killing in admixed tumor model

Abstract 3694: Relationship between in vivo antitumor activity of ADC and payload release in preclinical models

Abstract 4465: Differential MMAE delivery from ADCs utilizing the valine-citrulline-PAB and β-glucuronide cleavable linker systems

Abstract 5334: Mechanism of cysteine-mcMMAF release from the stably linked antibody-drug conjugate SGN-75

Abstract #3234: Antibody-targeted delivery of auristatin using SGN-35 leads to one to two logs greater intratumoral auristatin concentrations than non-targeted therapy

Biodistribution of a dual labeled anti-CD70 auristatin antibody-drug conjugate in tumor-bearing mice: experimental and modeled data

Effects of linker chemistry on tumor targeting by anti-CD70 antibody-drug conjugates

Alpha-methylacyl-CoA racemase real time RT-PCR for detection of circulating tumor cells in peripheral blood of prostate cancer patients.

Identification and Characterization of Prostein, a Novel Prostate-specific Protein

Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray

Microfilament Depletion and Circumvention of Multiple Drug Resistance by Sphinxolides

Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells

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