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Journal Articles

Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma

Ki-Fong Man, Lei Zhou, Ying-Tung Lam, Jun Yu, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5799.
https://doi.org/10.1158/1538-7445.AM2023-5799
Published: 04 April 2023
View article titled, Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma
Journal Articles

Abstract 4145: Frizzled-4 expression enhances hepatocellular carcinoma progression, sorafenib resistance and suppresses anti-tumor CD8 T cell immunity

Jie Luo, Lanqi Gong, Yuma Yang, Qin Liu, Jiao Huang, Xiaona Fang, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4145.
https://doi.org/10.1158/1538-7445.AM2023-4145
Published: 04 April 2023
View article titled, Abstract 4145: Frizzled-4 expression enhances hepatocellular carcinoma progression, sorafenib resistance and suppresses anti-tumor CD8 T cell immunity
Journal Articles

Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma

Xiaona Fang, Shan Liu, Liuxian Ban, Jiao Huang, Jie Luo, Lanqi Gong, Baifeng Zhang, Beilei Liu, Jinlin Huang, Yuma Yang, Ching Ngar Wong, Qian Yan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2441.
https://doi.org/10.1158/1538-7445.AM2023-2441
Published: 04 April 2023
View article titled, Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma
Journal Articles

Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma

Kai Yu Ng, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2429.
https://doi.org/10.1158/1538-7445.AM2023-2429
Published: 04 April 2023
View article titled, Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma
Journal Articles

Abstract 4699: Pan-cancer single-cell analysis reveals the interactions of SPP1+MMP12+ macrophages with metastasis-initiating cells that drives metastasis

Baifeng Zhang, Dora Lai-wan Kwong, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4699.
https://doi.org/10.1158/1538-7445.AM2023-4699
Published: 04 April 2023
View article titled, Abstract 4699: Pan-cancer single-cell analysis reveals the interactions of <em>SPP1+MMP12+</em> macrophages with metastasis-initiating cells that drives metastasis
Journal Articles

Retraction: ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling

Qian Yan, Lingxi Jiang, Ming Liu, Dandan Yu, Yu Zhang, Yan Li, Shuo Fang, Yan Li, Ying-Hui Zhu, Yunfei Yuan, Xin Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4299.
https://doi.org/10.1158/0008-5472.CAN-22-2783
Published: 15 November 2022
View article titled, Retraction: ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling
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Journal Articles

Abstract 6127: Single-cell spatial transcriptome sequencing characterizes CD70+ immune-resilient nasopharyngeal carcinoma cells as a vital mediator of Treg-induced suppression

Lanqi Gong, Jie Luo, Yuma Yang, Yu Zhang, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6127.
https://doi.org/10.1158/1538-7445.AM2022-6127
Published: 15 June 2022
View article titled, Abstract 6127: Single-cell spatial transcriptome sequencing characterizes CD70+ immune-resilient nasopharyngeal carcinoma cells as a vital mediator of Treg-induced suppression
Journal Articles

Abstract 6064: ADAR1-dependent RNA editing of GLI1 drives hepatocellular carcinoma stem cell self-renewal by initiating mitophagy

Jie Luo, Lanqi Gong, Yuma Yang, Jiao Huang, Xiaona Fang, Baifeng Zhang, Ying Tang, Beilei Liu, Ming Liu, Lu Bai, Victor Ho-Fun Lee, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6064.
https://doi.org/10.1158/1538-7445.AM2022-6064
Published: 15 June 2022
View article titled, Abstract 6064: ADAR1-dependent RNA editing of GLI1 drives hepatocellular carcinoma stem cell self-renewal by initiating mitophagy
Journal Articles

Abstract 5982: Single-cell RNA sequencing (scRNA-Seq) from mice model reveals metastatic and stemness signatures in esophageal squamous cell carcinoma (ESCC)

Ching Ngar Wong, Yu Zhang, Beibei Ru, Hong Yu Zhou, Kwong Yiu Lam, Xin Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5982.
https://doi.org/10.1158/1538-7445.AM2022-5982
Published: 15 June 2022
View article titled, Abstract 5982: Single-cell RNA sequencing (scRNA-Seq) from mice model reveals metastatic and stemness signatures in esophageal squamous cell carcinoma (ESCC)
Journal Articles

Abstract 5981: Single cell RNA sequencing uncovers high-plasticity cell state during tumor metastasis

Yu Zhang, Ching Ngar Wong, Lanqi Gong, Xin-yuan Guan, Beibei Ru, Beilei Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5981.
https://doi.org/10.1158/1538-7445.AM2022-5981
Published: 15 June 2022
View article titled, Abstract 5981: Single cell RNA sequencing uncovers high-plasticity cell state during tumor metastasis
Journal Articles

Editor's Note: Characterization of a Novel Mechanism of Genomic Instability Involving the SEI1/SET/NM23H1 Pathway in Esophageal Cancers

Yan Li, Chang-Jun Nie, Liang Hu, Yanru Qin, Hai-Bo Liu, Ting-Ting Zeng, Leilei Chen, Li Fu, Wen Deng, Shu-Peng Chen, Wei-Hua Jia, Chunyu Zhang, Dan Xie, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2197.
https://doi.org/10.1158/0008-5472.CAN-22-1137
Published: 06 June 2022
View article titled, Editor's Note: Characterization of a Novel Mechanism of Genomic Instability Involving the SEI1/SET/NM23H1 Pathway in Esophageal Cancers
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Journal Articles

ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Shayi Wu, Miao Chen, Jiao Huang, Feifei Zhang, Zhaojie Lv, Yongxu Jia, Yu-Zhu Cui, Liang-Zhan Sun, Ying Wang, Ying Tang, Krista R. Verhoeft, Yan Li, Yanru Qin, Xiang Lin, Xin-Yuan Guan, Ka-On Lam
Journal: Cancer Research
Cancer Res (2021) 81 (4): 986–1000.
https://doi.org/10.1158/0008-5472.CAN-20-0049
Published: 15 February 2021
View article titled, ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly
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Includes: Multimedia, Supplementary data
Journal Articles

Tumor Fibroblast–Derived FGF2 Regulates Expression of SPRY1 in Esophageal Tumor–Infiltrating T Cells and Plays a Role in T-cell Exhaustion

Qing-yun Chen, Yi-ni Li, Xin-yue Wang, Xu Zhang, Yi Hu, Lei Li, Da-qin Suo, Ke Ni, Zhuo Li, Jia-rong Zhan, Ting-ting Zeng, Ying-hui Zhu, Yan Li, Li-jia Ma, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2020) 80 (24): 5583–5596.
https://doi.org/10.1158/0008-5472.CAN-20-1542
Published: 15 December 2020
View article titled, Tumor Fibroblast–Derived FGF2 Regulates Expression of SPRY1 in Esophageal Tumor–Infiltrating T Cells and Plays a Role in T-cell Exhaustion
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Includes: Supplementary data
Journal Articles

Abstract 295: Protein phosphatase, Mg2+/Mn2+ dependent 1G promotes proliferation via modulating phosphorylation of retinoblastoma protein and associates with poor outcome in hepatocellular carcinoma

Wen Hu, Xin Yuan Guan, Lei Li, Yinghui Zhu, Yan Li, Ting Ting Zeng, Yun Fei Wen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 295.
https://doi.org/10.1158/1538-7445.AM2020-295
Published: 15 August 2020
View article titled, Abstract 295: Protein phosphatase, Mg2+/Mn2+ dependent 1G promotes proliferation via modulating phosphorylation of retinoblastoma protein and associates with poor outcome in hepatocellular carcinoma
Journal Articles

Epstein–Barr Virus miRNA BART2-5p Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing RND3

Chen Jiang, Lei Li, Yan-Qun Xiang, Maria Li Lung, Tingting Zeng, Jiabin Lu, Sai Wah Tsao, Mu-Sheng Zeng, Jing-Ping Yun, Dora L.W. Kwong, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1957–1969.
https://doi.org/10.1158/0008-5472.CAN-19-0334
Published: 15 May 2020
View article titled, Epstein–Barr Virus miRNA BART2-5p Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing RND3
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Includes: Supplementary data
Journal Articles

Abstract 2957: Nasopharyngeal cancer

Ngar Woon Kam, See Wing Chan, George Sai-Wah Tsao, Xin-Yuan Guan, Dora Lai Wan Kwong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2957.
https://doi.org/10.1158/1538-7445.AM2019-2957
Published: 01 July 2019
View article titled, Abstract 2957: Nasopharyngeal cancer
Journal Articles

CSTF2-Induced Shortening of the RAC1 3′UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder

Xin Chen, Jia-Xing Zhang, Jun-Hang Luo, Song Wu, Gang-Jun Yuan, Ning-Fang Ma, Yong Feng, Mu-Yan Cai, Ri-Xin Chen, Jun Lu, Li-Juan Jiang, Jie-Wei Chen, Xiao-Han Jin, Hai-Liang Liu, Wei Chen, Xin-Yuan Guan, Tie-Bang Kang, Fang-Jian Zhou, Dan Xie
Journal: Cancer Research
Cancer Res (2018) 78 (20): 5848–5862.
https://doi.org/10.1158/0008-5472.CAN-18-0822
Published: 15 October 2018
View article titled, CSTF2-Induced Shortening of the <em>RAC1</em> 3′UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder
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Includes: Supplementary data
Journal Articles

PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism

Yan Li, Shuhai Lin, Lei Li, Zhi Tang, Yumin Hu, Xiaojiao Ban, Tingting Zeng, Ying Zhou, Yinghui Zhu, Song Gao, Wen Deng, Xiaoshi Zhang, Dan Xie, Yunfei Yuan, Peng Huang, Jinjun Li, Zongwei Cai, Xin-Yuan Guan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (16): 4471–4481.
https://doi.org/10.1158/0008-5472.CAN-17-2172
Published: 14 August 2018
View article titled, <em>PDSS2</em> Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism
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Includes: Supplementary data
Journal Articles

Abstract 1432: Deranged tyrosine metabolism drives tumorigenesis in liver cancer

Man Tong, Tin Lok Wong, Steve Tin-Chi Luk, Noelia Che, Xin Yuan Guan, Yun Fei Yuan, Terence Kin-Wah Lee, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1432.
https://doi.org/10.1158/1538-7445.AM2018-1432
Published: 01 July 2018
View article titled, Abstract 1432: Deranged tyrosine metabolism drives tumorigenesis in liver cancer
Journal Articles

Abstract 1349: Functional and mechanistic characterization of PRMT6 regulated autophagy in hepatocellular carcinoma

Noélia Che, Man Tong, Kai Yu Ng, Phillis WF Kau, Xin Yuan Guan, Michael SY Huen, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1349.
https://doi.org/10.1158/1538-7445.AM2018-1349
Published: 01 July 2018
View article titled, Abstract 1349: Functional and mechanistic characterization of PRMT6 regulated autophagy in hepatocellular carcinoma