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Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells

Yun Dai, Shuang Chen, Liang Zhou, Yu Zhang, Yun Leng, Xin-Yan Pei, Hui Lin, Robert Z. Orlowski, Steven Grant

Cancer Res (2014) 74 (19_Supplement): 4600.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4600

Published: 01 October 2014

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Journal Articles

Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.

Xin-Yan Pei, Yun Dai, Jessica Felthousen, Shuang Chen, Yukie Takabatake, Leena E. Youssefian, Wesley W. Bodie, Lora B. Kramer, Robert Z. Orlowski, Steven Grant

Cancer Res (2013) 73 (8_Supplement): 3390.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3390

Published: 15 April 2013

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Journal Articles

Abstract 3346: A20/TNFAIP3, a novel target of histone deacetylase inhibitor-induced NF-κB activation, functionally disables the extrinsic apoptotic pathway in human leukemia cells.

Liang Zhou, Shuang Chen, Hui Lin, Xin-Yan Pei, Mandy M. Aust, Mohamed Rahmani, Roberto Rosato, Yun Dai, Steven Grant

Cancer Res (2013) 73 (8_Supplement): 3346.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3346

Published: 15 April 2013

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Journal Articles

Abstract 3420: The novel Chk1 inhibitor MK8776 sensitizes AML cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.

Shuang Chen, Maciej Kmieciak, Liang Zhou, Hui Lin, Xin-Yan Pei, Yun Dai, Steven Grant

Cancer Res (2013) 73 (8_Supplement): 3420.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3420

Published: 15 April 2013

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Journal Articles

CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Shuang Chen, Yun Dai, Xin-Yan Pei, Jennifer Myers, Li Wang, Lora B. Kramer, Mandy Garnett, Daniella M. Schwartz, Florence Su, Gary L. Simmons, Justin D. Richey, Dustin G. Larsen, Paul Dent, Robert Z. Orlowski, Steven Grant

Cancer Res (2012) 72 (16): 4225–4237.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-1118

Published: 14 August 2012

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Includes: Multimedia, Supplementary data

Journal Articles

Abstract 4667: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1 anti-apoptotic function and bortezomib resistance in human multiple myeloma cells

Xin-Yan Pei, Yun Dai, Jessica Felthousen, Shuang Chen, Li Wang, Yukie Takabatake, Leena E. Youssefian, Wesley W. Bodie, Lora Kramer, Steven Grant

Cancer Res (2012) 72 (8_Supplement): 4667.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4667

Published: 15 April 2012

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Journal Articles

Abstract 4649: Nbk/Bik induced by flavopiridol switches GX15-070-induced autophagy to apoptosis in human multiple myeloma cells

Yun Dai, Shuang Chen, Li Wang, Xin-Yan Pei, Jennifer Myers, Daniella Schwartz, Nadine Thompson, Dustin Larsen, Justin Richey, Florence Su, Robert Z. Orlowski, Steven Grant

Cancer Res (2012) 72 (8_Supplement): 4649.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4649

Published: 15 April 2012

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Journal Articles

Abstract 5367: Simultaneous inhibition of Chk1 and MEK1/2 targets non-proliferating multiple myeloma cells

Xin-Yan Pei, Yun Dai, Leena E. Youssefian, Shuang Chen, Wesley Bodie, Yukie Takabatake, George Almenara, Lora Kramer, Paul Dent, Steven Grant

Cancer Res (2011) 71 (8_Supplement): 5367.

DOI: https://doi.org/10.1158/1538-7445.AM2011-5367

Published: 15 April 2011

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Journal Articles

Abstract 667: Mechanisms underlying synergistic interactions between the CDK inhibitor flavopiridol (Alvocidib) and the BH3 mimetic GX15-070 (Obatoclax) in human multiple myeloma cells

Yun Dai, Shuang Chen, Li Wang, Jennifer Myers, Nadine Thompson, Xin-Yan Pei, Robert Orlowski, Paul Dent, Steven Grant

Cancer Res (2010) 70 (8_Supplement): 667.

DOI: https://doi.org/10.1158/1538-7445.AM10-667

Published: 15 April 2010

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Journal Articles

Abstract #4624: MKK7-dependent activation of SAPK/JNK is critical for parthenolide-mediated NF-\#954; B inhibition to potentiate histone deacetylase inhibitor lethality in human leukemia cells

Yun Dai, Monica Guzman, Shuang Chen, Sin-Kei Yeung, Xin-Yan Pei, Craig Jordan, Steven Grant

Cancer Res (2009) 69 (9_Supplement): 4624.

Published: 01 May 2009

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Journal Articles

Src inhibitors potentiate UCN-01-induced apoptosis in human multiple myeloma cells through mechanisms involving disruption of the MEK1/2/ERK1/2 pathway and anti-angiogenesis in vitro and in vivo

Yun Dai, Rena Shah, Shuang Chen, Xin-Yan Pei, Paul Dent, Steven Grant

Cancer Res (2008) 68 (9_Supplement): 1476.

Published: 01 May 2008

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Journal Articles

Upregulation of the BH3-only protein Bim by histone deacetylase inhibitors is involved in interactions with ABT-737 that promote apoptosis in human leukemia and myeloma cells

Shuang Chen, Yun Dai, Xin-Yan Pei, Steven Grant

Cancer Res (2008) 68 (9_Supplement): 5839.

Published: 01 May 2008

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Journal Articles

The MEK1/2 inhibitor AZD6244 (ARRY-142886) interacts synergistically with the novel Chk1 inhibitor AZD7762 to induce apoptosis in human multiple myeloma cells

Xin-Yan Pei, Yun Dai, Shuang Chen, Wesley Bodie, Lora Kramer, Paul Dent, Steven Grant

Cancer Res (2008) 68 (9_Supplement): LB-103.

Published: 01 May 2008

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Journal Articles

Potentiation of UCN-01 lethality by MEK1/2 inhibitors in human multiple myeloma cells involves modulation of Bim phosphorylation and degradation

Xin-Yan Pei, Yun Dai, Sarah Tenorio, Hisashi Harada, Jianghua Lu, Paul Dent, Steven Grant

Cancer Res (2007) 67 (9_Supplement): 3210.

Published: 01 May 2007

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Journal Articles

The farnesyltransferase inhibitor L744832 potentiates UCN-01- induced apoptosis in human multiple myeloma cells exhibiting conventional and stromal cell-related forms of resistance

Xin-Yan Pei, Yun Dai, Mohamed Rahmani, Weiqun Li, Paul Dent, Steven Grant

Cancer Res (2005) 65 (9_Supplement): 1404.

Published: 01 May 2005

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Journal Articles

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to STI571 through either Bcr/abl-dependent or -independent mechanisms

Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Paul Dent, Steven Grant

Cancer Res (2004) 64 (7_Supplement): 125.

Published: 01 April 2004

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Journal Articles

The small molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical- and JNK-dependent mechanism

Xin-Yan Pei, Yun Dai, Steven Grant

Cancer Res (2004) 64 (7_Supplement): 124.

Published: 01 April 2004

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NARROW

Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells

Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.

Abstract 3346: A20/TNFAIP3, a novel target of histone deacetylase inhibitor-induced NF-κB activation, functionally disables the extrinsic apoptotic pathway in human leukemia cells.

Abstract 3420: The novel Chk1 inhibitor MK8776 sensitizes AML cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.

CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Abstract 4667: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1 anti-apoptotic function and bortezomib resistance in human multiple myeloma cells

Abstract 4649: Nbk/Bik induced by flavopiridol switches GX15-070-induced autophagy to apoptosis in human multiple myeloma cells

Abstract 5367: Simultaneous inhibition of Chk1 and MEK1/2 targets non-proliferating multiple myeloma cells

Abstract 667: Mechanisms underlying synergistic interactions between the CDK inhibitor flavopiridol (Alvocidib) and the BH3 mimetic GX15-070 (Obatoclax) in human multiple myeloma cells

Abstract #4624: MKK7-dependent activation of SAPK/JNK is critical for parthenolide-mediated NF-\#954; B inhibition to potentiate histone deacetylase inhibitor lethality in human leukemia cells

Src inhibitors potentiate UCN-01-induced apoptosis in human multiple myeloma cells through mechanisms involving disruption of the MEK1/2/ERK1/2 pathway and anti-angiogenesis in vitro and in vivo

Upregulation of the BH3-only protein Bim by histone deacetylase inhibitors is involved in interactions with ABT-737 that promote apoptosis in human leukemia and myeloma cells

The MEK1/2 inhibitor AZD6244 (ARRY-142886) interacts synergistically with the novel Chk1 inhibitor AZD7762 to induce apoptosis in human multiple myeloma cells

Potentiation of UCN-01 lethality by MEK1/2 inhibitors in human multiple myeloma cells involves modulation of Bim phosphorylation and degradation

The farnesyltransferase inhibitor L744832 potentiates UCN-01- induced apoptosis in human multiple myeloma cells exhibiting conventional and stromal cell-related forms of resistance

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to STI571 through either Bcr/abl-dependent or -independent mechanisms

The small molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical- and JNK-dependent mechanism

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