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Journal Articles

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4

Jinquan Liu, Bo Yuan, Jin Cao, Hongjie Luo, Shuchen Gu, Mengdi Zhang, Ran Ding, Long Zhang, Fangfang Zhou, Mien-Chie Hung, Pinglong Xu, Xia Lin, Jianping Jin, Xin-Hua Feng
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5007–5020.
https://doi.org/10.1158/0008-5472.CAN-21-0431
Published: 01 October 2021
View article titled, AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4
Open the PDF for AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4 in another window
Includes: Supplementary data
Journal Articles

A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis

Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I.J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4441–4454.
https://doi.org/10.1158/0008-5472.CAN-21-1112
Published: 01 September 2021
View article titled, A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer

Fei Yue, Weiyu Jiang, Amy T Ku, Adelaide IJ Young, Weijie Zhang, Eric P Souto, Yankun Gao, Zhihan Yu, Yi Wang, Chad J Creighton, Chandandeep Nagi, Tao Wang, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD15-03.
https://doi.org/10.1158/1538-7445.SABCS20-PD15-03
Published: 15 February 2021
View article titled, Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer
Journal Articles

miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features

Yuanzhuo Gu, Xiyang Wei, Yulin Sun, Hongjun Gao, Xin Zheng, Linda L. Wong, Ling Jin, Niya Liu, Brenda Hernandez, Karolina Peplowska, Xiaohang Zhao, Qi-Min Zhan, Xin-Hua Feng, Zhao-You Tang, Junfang Ji
Journal: Cancer Research
Cancer Res (2019) 79 (5): 941–953.
https://doi.org/10.1158/0008-5472.CAN-18-1675
Published: 01 March 2019
View article titled, miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features
Open the PDF for miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features in another window
Includes: Supplementary data
Journal Articles

HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer

Fei Huang, Qiaoni Shi, Yuzhen Li, Linlin Xu, Chi Xu, Fenfang Chen, Hai Wang, Hongwei Liao, Zai Chang, Fang Liu, Xiang H.-F. Zhang, Xin-Hua Feng, Jing-Dong J. Han, Shiwen Luo, Ye-Guang Chen
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6073–6085.
https://doi.org/10.1158/0008-5472.CAN-18-0136
Published: 01 November 2018
View article titled, HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Open the PDF for HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

Yuan Si, Xinyan Ji, Xiaolei Cao, Xiaoming Dai, Lingyi Xu, Hongxia Zhao, Xiaocan Guo, Huan Yan, Haitao Zhang, Chu Zhu, Qi Zhou, Mei Tang, Zongping Xia, Li Li, Yu-Sheng Cong, Sheng Ye, Tingbo Liang, Xin-Hua Feng, Bin Zhao
Journal: Cancer Research
Cancer Res (2017) 77 (18): 4868–4880.
https://doi.org/10.1158/0008-5472.CAN-17-0391
Published: 14 September 2017
View article titled, Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1
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Includes: Supplementary data
Journal Articles

SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling

Yu-Ching Lin, Li-Ting Lu, Hsin-Yi Chen, Xueyan Duan, Xia Lin, Xin-Hua Feng, Ming-Jer Tang, Ruey-Hwa Chen
Journal: Cancer Research
Cancer Res (2014) 74 (23): 6935–6946.
https://doi.org/10.1158/0008-5472.CAN-14-1330
Published: 30 November 2014
View article titled, SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling
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Includes: Supplementary data
Journal Articles

Abstract 1971: Small C-terminal domain phosphatase 1 stabilizes PML to regulate the progression of renal clear cell carcinoma.

Yu-Ching Lin, Li-Ting Lu, Xin-Hua Feng, Ruey-Hwa Chen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1971.
https://doi.org/10.1158/1538-7445.AM2013-1971
Published: 15 April 2013
View article titled, Abstract 1971: Small C-terminal domain phosphatase 1 stabilizes PML to regulate the progression of renal clear cell carcinoma.
Journal Articles

BCL6 Represses Smad Signaling in Transforming Growth Factor-β Resistance

Degang Wang, Jianyin Long, Fangyan Dai, Min Liang, Xin-Hua Feng, Xia Lin
Journal: Cancer Research
Cancer Res (2008) 68 (3): 783–789.
https://doi.org/10.1158/0008-5472.CAN-07-0008
Published: 01 February 2008
View article titled, BCL6 Represses Smad Signaling in Transforming Growth Factor-β Resistance
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Journal Articles

Accelerated ubiquitination and degradation of tumor suppressor SMAD4/DPC4 by ubiquitin E3 ligase Skp2

Xia Lin, Min Liang, Yao-Yun Liang, Katharine Wrighton, Dana Ungermannova, Xiao-Ping Wang, F. Charles Brunicardi, Xuedong Liu, Xin-Hua Feng
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 620.
Published: 15 April 2006
View article titled, Accelerated ubiquitination and degradation of tumor suppressor SMAD4/DPC4 by ubiquitin E3 ligase Skp2
Journal Articles

Ubiquitination and proteolysis of cancer-derived mutants of Smad4 by Skp2

Xia Lin, Min Liang, Yao-Yun Liang, Katharine Wrighton, Dana Ungermannova, Xiao-Ping Wang, F. Charles Brunicardi, Xuedong Liu, Xin-Hua Feng
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 676.
Published: 01 May 2005
View article titled, Ubiquitination and proteolysis of cancer-derived mutants of Smad4 by Skp2