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Journal Articles

Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers

Meagan B. Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E. Cohen, Chun Li, Brooke M. Swalm, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C. Dar, Yongxin Han, Michael Hale, Margit Hagel, Klaus P. Hoeflich
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND10.
https://doi.org/10.1158/1538-7445.AM2024-ND10
Published: 05 April 2024
View article titled, Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers
Journal Articles

Abstract LB037: E3 pairing and structural mechanisms underlying anti-tumor activity of clinical STAT3 degrader KT-333

Kirti Sharma, Xue Fei, Yatao Shi, Christopher Browne, Dirk Walther, Caroline Daigle, Anand Ramanathan, Richard Miller, Karen Yuan, Kiran Mahasenan, Sean Zhu, Xin Huang, Bin Yang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB037.
https://doi.org/10.1158/1538-7445.AM2024-LB037
Published: 05 April 2024
View article titled, Abstract LB037: E3 pairing and structural mechanisms underlying anti-tumor activity of clinical STAT3 degrader KT-333
Journal Articles

Abstract LB272: Sequential inhibition of PARP and BET as a rational therapeutic strategy for glioblastoma multiforme

Xin Peng, Xin Huang, Shaolu Zhang, Naixin Zhang, Shengfan Huang, Yingying Wang, Zhenxing Zhong, Shan Zhu, Haiwang Gao, Zixiang Yu, Xiaotong Yan, Zhennan Tao, Yuxiang Dai, Zhe Zhang, Xi Chen, Feng Wang, Francois X. Claret, Ning Ji, Yuxu Zhong, Dexin Kong
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB272.
https://doi.org/10.1158/1538-7445.AM2024-LB272
Published: 05 April 2024
View article titled, Abstract LB272: Sequential inhibition of PARP and BET as a rational therapeutic strategy for glioblastoma multiforme
Journal Articles

Abstract 161: Aged mice decelerate bone metastasis of prostate cancer by decreasing infiltration of M2 macrophages

Xiao Zhang, Wei Yu, Xin Huang, Yi Lu, Jian Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 161.
https://doi.org/10.1158/1538-7445.AM2024-161
Published: 22 March 2024
View article titled, Abstract 161: Aged mice decelerate bone metastasis of prostate cancer by decreasing infiltration of M2 macrophages
Journal Articles

Abstract 7613: Association of KAT6A expression with clinical outcomes in previously treated HR-positive and HER2-negative metastatic breast cancer

Massimo Cristofanilli, Li Liu, Shibing Deng, Xin Huang, Fabrice André, Sibylle Loibl, Angela DeMichele, Eric Gauthier, Yuan Liu, Nicholas C. Turner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7613.
https://doi.org/10.1158/1538-7445.AM2024-7613
Published: 22 March 2024
View article titled, Abstract 7613: Association of KAT6A expression with clinical outcomes in previously treated HR-positive and HER2-negative metastatic breast cancer
Journal Articles

Abstract 2752: ICA1 promotes prostate cancer progression and metastasis via AR down-regulation

Fuhao Wang, Yu He, Xin Huang, Ming Chang, Xiao Zhang, Xiaoyi Li, Xinyu Ye, Yi Lu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2752.
https://doi.org/10.1158/1538-7445.AM2024-2752
Published: 22 March 2024
View article titled, Abstract 2752: ICA1 promotes prostate cancer progression and metastasis via AR down-regulation
Journal Articles

Abstract 5387: Host-derived CCL2 drives prostate cancer bone metastasis via CCND2/STAT3 pathway

Jie Meng, Ming Chang, Siyuan Qin, Xin Huang, Weiping Liang, Haibo Tong, Jian Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5387.
https://doi.org/10.1158/1538-7445.AM2024-5387
Published: 22 March 2024
View article titled, Abstract 5387: Host-derived CCL2 drives prostate cancer bone metastasis <em>via</em> CCND2/STAT3 pathway
Journal Articles

Abstract 5776: Target identification, selectivity profiling and binding site mapping of small molecule and peptide drugs by LiP-MS

Fabio Sabino, Martin Soste, Dominique Kamber, Maria Stella Ritorto, Klaus Hoeflich, Michael Hale, Bradley Quade, Xin Huang, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5776.
https://doi.org/10.1158/1538-7445.AM2024-5776
Published: 22 March 2024
View article titled, Abstract 5776: Target identification, selectivity profiling and binding site mapping of small molecule and peptide drugs by LiP-MS
Journal Articles

Abstract 5426: Multi-omic characterization and predictive features of advanced ovarian cancer patients in a large phase III cohort

Cyril Ramathal, David Masica, Peter Ansell, Bridget Riley-Gillis, Jacob Degner, Thanh Bui, Priya Narayanan, Josue Samayoa, Xin Huang, Robert F. Coleman, Jeffrey F. Waring
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5426.
https://doi.org/10.1158/1538-7445.AM2023-5426
Published: 04 April 2023
View article titled, Abstract 5426: Multi-omic characterization and predictive features of advanced ovarian cancer patients in a large phase III cohort
Journal Articles

Abstract P4-01-07: FS-1502, an anti-HER2 ADC, in Patients with HER2-Expressing Advanced Solid Tumors: A Phase 1a Dose-Escalation Study

Qiao Li, Xian Wang, Ying Cheng, Yunjiang Liu, Jianhua Chang, Zhuo Wang, Chunjiao Wu, Mingxia Wang, Ai-Min Hui, Zhuli Wu, Yongli Jin, Xin Huang, Liping Zhong, Lei Diao, Han Zhao, Binghe Xu
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-01-07.
https://doi.org/10.1158/1538-7445.SABCS22-P4-01-07
Published: 01 March 2023
View article titled, Abstract P4-01-07: FS-1502, an anti-HER2 ADC, in Patients with HER2-Expressing Advanced Solid Tumors: A Phase 1a Dose-Escalation Study
Journal Articles

Abstract P1-12-03: Antidiarrheal prophylaxis with loperamide for patients with lymph node-negative (N0) or micrometastatic (N1mi), HER2-positive breast cancer who received adjuvant pyrotinib plus nab-paclitaxel: a randomized sub-study of PHAEDRA

Changjun Wang, Yan Lin, Yidong Zhou, Feng Mao, Jinghong Guan, Songjie Shen, Xuejing Wang, Xiaohui Zhang, Yanna Zhang, Bo Pan, Ying Zhong, Li Peng, Yan Li, Xin Huang, Ying Xu, Qiang Sun
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-12-03.
https://doi.org/10.1158/1538-7445.SABCS22-P1-12-03
Published: 01 March 2023
View article titled, Abstract P1-12-03: Antidiarrheal prophylaxis with loperamide for patients with lymph node-negative (N0) or micrometastatic (N1mi), HER2-positive breast cancer who received adjuvant pyrotinib plus nab-paclitaxel: a randomized sub-study of PHAEDRA
Journal Articles

PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells

Yun Li, Hengxing Chen, Xuan Xie, Bing Yang, Xiaojuan Wang, Jingyuan Zhang, Tian Qiao, Jiao Guan, Yuntan Qiu, Yong-Xin Huang, Duanqing Tian, Xinyi Yao, Daning Lu, H. Phillip Koeffler, Yin Zhang, Dong Yin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 398–413.
https://doi.org/10.1158/0008-5472.CAN-22-2370
Published: 03 February 2023
View article titled, PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Open the PDF for PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 5836: SMC4 promotes prostate cancer organ-specific metastasis by modifying cancer cell metabolism

Wei Zhang, Xin Huang, yueming Li, yingxuan Gong, xiuzhi Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5836.
https://doi.org/10.1158/1538-7445.AM2022-5836
Published: 15 June 2022
View article titled, Abstract 5836: SMC4 promotes prostate cancer organ-specific metastasis by modifying cancer cell metabolism
Journal Articles

Abstract 5461: H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

Wei Huang, Lin Zhu, Xiaoe Yan, Xin Huang, Jia Hao, Shan Li, Xiangyu Li, Zhiming Chen, Yunchuan Jia, Haibo Li, Jianming Zhang, Xianming Deng, Caihong Yun
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5461.
https://doi.org/10.1158/1538-7445.AM2022-5461
Published: 15 June 2022
View article titled, Abstract 5461: H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC
Journal Articles

Abstract P1-18-13: Efficacy and safety of palbociclib plus endocrine therapy in Black and Hispanic patients with hormone receptor positive/human epidermal growth factor receptor 2-negative advanced breast cancer (HR+/HER2- ABC) participating in the PALOMA trials

Claudine Isaacs, Reshma Mahtani, Filipa Lynce, Bethany Sleckman, Aurelio Castrellon, Sujith Kalmadi, Kathy Puyana Theall, Xin Huang, Eustratios Bananis, Hope S. Rugo
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-18-13.
https://doi.org/10.1158/1538-7445.SABCS21-P1-18-13
Published: 15 February 2022
View article titled, Abstract P1-18-13: Efficacy and safety of palbociclib plus endocrine therapy in Black and Hispanic patients with hormone receptor positive/human epidermal growth factor receptor 2-negative advanced breast cancer (HR+/HER2- ABC) participating in the PALOMA trials
Journal Articles

Abstract 3702: A lineage-specific lncRNA driven by Foxa1 associated super enhancer promotes tumor growth through interacting YBX1

Yin Zhang, Yong-xin Huang, Dan-lan Wang, Hai-yan Yan, Yin Dong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3702.
https://doi.org/10.1158/1538-7445.AM2020-3702
Published: 15 August 2020
View article titled, Abstract 3702: A lineage-specific lncRNA driven by Foxa1 associated super enhancer promotes tumor growth through interacting YBX1
Journal Articles

Abstract CT135: A phase 1b study of palbociclib + nab-paclitaxel in patients (pts) with metastatic adenocarcinoma of the pancreas (PDAC)

Manuel Hidalgo, Rocio Garcia Carbonero, Kian-Huat Lim, Wells Messersmith, Ignacio Garrido-Laguna, Erkut Borazanci, Andrew Lowy, Laura Medina Rodriguez, Daniel Laheru, Xin Huang, Meggan Tammaro, Jean-François Martini, Arthur Kudla, Kenneth Kern, Teresa Macarulla
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT135.
https://doi.org/10.1158/1538-7445.AM2020-CT135
Published: 15 August 2020
View article titled, Abstract CT135: A phase 1b study of palbociclib + nab-paclitaxel in patients (pts) with metastatic adenocarcinoma of the pancreas (PDAC)
Journal Articles

Abstract P5-06-31: Morphological apocrine and mucinous features of breast carcinoma: Does histology matter for survival?

Changjun Wang, Yu Song, Hanjiang Zhu, Yidong Zhou, Feng Mao, Yan Lin, Yanna Zhang, Xiaohui Zhang, Songjie Shen, Ying Zhong, Xin Huang, Qiang Sun
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-06-31.
https://doi.org/10.1158/1538-7445.SABCS19-P5-06-31
Published: 15 February 2020
View article titled, Abstract P5-06-31: Morphological apocrine and mucinous features of breast carcinoma: Does histology matter for survival?
Journal Articles

Abstract P5-12-14: The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: A meta-analysis

Yu Song, Changjun Wang, Wei Huang, Yidong Zhou, Ziyuan Chen, Hanjiang Zhu, Feng Mao, Yan Lin, Xiaohui Zhang, Songjie Shen, Ying Zhong, Xin Huang, Chang Chen, Qiang Sun
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-12-14.
https://doi.org/10.1158/1538-7445.SABCS19-P5-12-14
Published: 15 February 2020
View article titled, Abstract P5-12-14: The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: A meta-analysis
Journal Articles

Abstract 2784: Driver genes network promotes mesenchymal to epithelial transition and organ-specific metastasis

Ming Chang, Xin Huang, Songjian Lu, Wei Zhang, Weiping Liang, Evan Keller, Xinghua Lu, Jian Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2784.
https://doi.org/10.1158/1538-7445.AM2019-2784
Published: 01 July 2019
View article titled, Abstract 2784: Driver genes network promotes mesenchymal to epithelial transition and organ-specific metastasis