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Journal Articles

Abstract CT084: A phase 1 study of LY4101174 (ETx-22), an antibody-drug conjugate targeting nectin-4, in patients with advanced or metastatic urothelial cancer and other solid tumors (trial in progress)

Jonathan Rosenberg, Renaud Sabatier, Armelle Viceneux, Thibault de La Motte Rouge, Stephane Champiat, Loic Lebellec, Philippe Barthélémy, Guru Sonpavde, Xin Gao, Scot Niglio, Tian Zhang, Craig Gedye, Matthew Galsky, Matthew Milowsky, Melissa Reimers, Andrew Weickhardt, Enrique Grande, Daniel E. Castellano, Mehmet Bilen, Amita Patnaik, Robert Zerbib, Minna Balbas, Xiaojian Xu, Kaitlyn Aptaker, Arjun V. Balar, Ahmad H. Awada
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT084.
https://doi.org/10.1158/1538-7445.AM2024-CT084
Published: 05 April 2024
View article titled, Abstract CT084: A phase 1 study of LY4101174 (ETx-22), an antibody-drug conjugate targeting nectin-4, in patients with advanced or metastatic urothelial cancer and other solid tumors (trial in progress)
Journal Articles

Abstract 4356: An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing

Zhongxiao Li, Bin Zhang, Jia Jia Chan, Hossein Tabatabaeian, Qing Yun Tong, Xiao Hong Chew, Xiaonan Fan, Charlene Chan, Patrick Driguez, Faith Cheong, Shi Wang, Bei En Siew, Ian Jse-Wei Tan, Kai-Yin Lee, Bettina Lieske, Wai-Kit Cheong, Dennis Kappei, Ker-Kan Tan, Xin Gao, Yvonne Tay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4356.
https://doi.org/10.1158/1538-7445.AM2024-4356
Published: 22 March 2024
View article titled, Abstract 4356: An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing
Journal Articles

Abstract CT119: A first-in-human phase 1 study of LOXO-435, a potent, highly isoform-selective FGFR3 inhibitor in advanced solid tumors with FGFR3 alterations (trial in progress)

Gopa Iyer, Arlene Siefker-Radtke, Matthew Milowsky, Neal Shore, Xin Gao, Melissa A. Reimers, Noah Hahn, Rasha Cosman, Nobuaki Matsubara, Andrea Necchi, Debbie Robbrecht, Armelle Vinceneux, Enrique Grande, Jae-Lyun Lee, Tian Zhang, Tormod Guren, Ulrich M. Lauer, Michal Sarfaty, Bernhard Eigl, Syed Hussain, Xiang Zhao, Arjun V. Balar, Kaitlyn Francese, Ryan Widau, Benjamin Garmezy
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT119.
https://doi.org/10.1158/1538-7445.AM2023-CT119
Published: 14 April 2023
View article titled, Abstract CT119: A first-in-human phase 1 study of LOXO-435, a potent, highly isoform-selective FGFR3 inhibitor in advanced solid tumors with <em>FGFR3</em> alterations (trial in progress)
Journal Articles

Abstract 482: Discovery of a novel and oral CHK1 inhibitor for the treatment of solid tumors

Xin Gao, Yonggang Liao, Qi Li, Ling Yang, Chunyan Zhao, Yanfen Teng, Lei Liu, Wenyuan Qian, Xiaohong Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 482.
https://doi.org/10.1158/1538-7445.AM2023-482
Published: 04 April 2023
View article titled, Abstract 482: Discovery of a novel and oral CHK1 inhibitor for the treatment of solid tumors
Journal Articles

Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies

Chunyan Zhao, Jianfei Wang, Aiguo Liu, Xin Gao, Yanfen Teng, Lei Liu, Yang Zhang, Xiaohong Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3451.
https://doi.org/10.1158/1538-7445.AM2023-3451
Published: 04 April 2023
View article titled, Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies
Journal Articles

Abstract P2-13-03: Feasibility of generating an external control comparator using RWD by matching with previously conducted RCTs: CDK4/6 Inhibitors for the treatment of Metastatic Breast Cancer

Christy Osgood, Jiaxin Fan, Xin Gao, Catherine Keane, Jonathan Bryan, James P. Roose, Erik Bloomquist, Aracelis Torres, Shrujal Baxi, Nathan Nussbaum, Fatima Rizvi, Shenghui Tang, Irene Nunes, Julia Beaver, Donna R. Rivera, Lynn Howie, Prashni Paliwal, Laleh Amiri-Kordestani
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-13-03.
https://doi.org/10.1158/1538-7445.SABCS22-P2-13-03
Published: 01 March 2023
View article titled, Abstract P2-13-03: Feasibility of generating an external control comparator using RWD by matching with previously conducted RCTs: CDK4/6 Inhibitors for the treatment of Metastatic Breast Cancer
Journal Articles

Notch Signaling Promotes Mature T-Cell Lymphomagenesis

Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3763–3773.
https://doi.org/10.1158/0008-5472.CAN-22-1215
Published: 17 October 2022
View article titled, Notch Signaling Promotes Mature T-Cell Lymphomagenesis
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Includes: Supplementary data
Journal Articles

Abstract P2-11-05: Generating real-world external comparators for randomized clinical trials (RCTs) in metastatic breast cancer (mBC) using electronic health records (EHRs)

Laleh Amiri-Kordestani, Xin Gao, Shrujal Baxi, Erik Bloomquist, Jonathan Bryan, Lynn Howie, Catherine Keane, Paul G. Kluetz, Christy Osgood, Prashni Paliwal, Donna R. Rivera, James Roose, Julie Schneider, Harpreet Singh, Shenghui Tang, Lijun Zhang, Julia A. Beaver
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-11-05.
https://doi.org/10.1158/1538-7445.SABCS21-P2-11-05
Published: 15 February 2022
View article titled, Abstract P2-11-05: Generating real-world external comparators for randomized clinical trials (RCTs) in metastatic breast cancer (mBC) using electronic health records (EHRs)
Journal Articles

Abstract 395: Aberrant HER2 signaling is a therapeutic target in a subset of castration-resistant prostate cancer

Joshua W. Russo, Xin Gao, David J. Einstein, Glenn J. Bubley, Steven P. Balk
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 395.
https://doi.org/10.1158/1538-7445.AM2019-395
Published: 01 July 2019
View article titled, Abstract 395: Aberrant HER2 signaling is a therapeutic target in a subset of castration-resistant prostate cancer
Journal Articles

Abstract 3885: 11q13 amplification selects for sensitivity to the ERK inhibitor KO-947 in squamous cell carcinomas

Francis J. Burrows, Linda Kessler, Tao Wu, Xin Gao, Jeffrey Chen, Rasmus Hansen, Shuangwei Li, Carol Thach, Shisheng Li, Ke Yu, Jeff Kucharski, Ulf Peters, Jun Feng, Yi Wang, Yvonne Yao, Ata Zarieh, Matt Janes, Jingchuan Zhang, Liansheng Li, Dana Hu-Lowe, Pingda Ren, Yi Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3885.
https://doi.org/10.1158/1538-7445.AM2018-3885
Published: 01 July 2018
View article titled, Abstract 3885: 11q13 amplification selects for sensitivity to the ERK inhibitor KO-947 in squamous cell carcinomas
Journal Articles

Abstract 5168: KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors

Francis Burrows, Linda Kessler, Jeffrey Chen, Xin Gao, Rasmus Hansen, Shuangwei Li, Carol Thach, Levan Darjania, Yvonne Yao, Yi Wang, Ata Zarieh, Ke Yu, Tao Wu, Jingchuan Zhang, Dana Hu-Lowe, Liansheng Li, Pingda Ren, Yi Liu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5168.
https://doi.org/10.1158/1538-7445.AM2017-5168
Published: 01 July 2017
View article titled, Abstract 5168: KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors
Journal Articles

Abstract 4250: 5′ deletion on ALK break-apart FISH and risk of false positive results

Xin Gao, Lynette M. Sholl, Mizuki Nishino, Jennifer Heng, Pasi A. Janne, Geoffrey R. Oxnard
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4250.
https://doi.org/10.1158/1538-7445.AM2015-4250
Published: 01 August 2015
View article titled, Abstract 4250: 5′ deletion on ALK break-apart FISH and risk of false positive results
Journal Articles

Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma

Ana Ortega-Molina, Isaac Boss, Heng Pan, Yanwen Jiang, Deqing Hu, Xin Gao, Rita Shaknovich, Ali Shilatifard, Ari M. Melnick, Hans-Guido Wendel
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-064.
https://doi.org/10.1158/1538-7445.AM2015-LB-064
Published: 01 August 2015
View article titled, Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma
Journal Articles

Abstract A66: IL-33 promotes CD8 T cell effector function and has a potent antitumor activity in vivo.

Xin Gao, Gang Li, Bo Teng, Qianting Yang, Yibei Zhu, Xueguang Zhang, Olivera J. Finn, Binfeng Lu
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): A66.
https://doi.org/10.1158/1538-7445.TUMIMM2012-A66
Published: 02 April 2014
View article titled, Abstract A66: IL-33 promotes CD8 T cell effector function and has a potent antitumor activity in vivo.
Journal Articles

Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma

Cigall Kadoch, Valerie S. Wong, Tara C. Rambaldo, William C. Hyun, Hua Xin Gao, Clifford A. Lowell, James L. Rubenstein
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5580.
https://doi.org/10.1158/1538-7445.AM10-5580
Published: 15 April 2010
View article titled, Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma
Journal Articles

Abstract #3117: Piwil2 variant PL2v60 promotes precancerous stem cell expansion

Rulong Shen, Yin Ye, De-Tao Yin, Qing-Tao Yan, Li Chen, Qien Wang, Altaf Wani, Gang He, Sanford Barsky, Jian-Xin Gao
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3117.
Published: 01 May 2009
View article titled, Abstract #3117: Piwil2 variant PL2v60 promotes precancerous stem cell expansion
Journal Articles

Mutant p53 collaborating with K-ras gene mutations and p16INK4a promoter methylation result in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice

Wenrui Duan, Li Gao, Xin Wu, Li Wang, Erinn Hade, Jian-Xin Gao, Sanford Barsky, Gregory Otterson, Miguel Villalona-Calero
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2960.
Published: 01 May 2008
View article titled, Mutant p53 collaborating with K-ras gene mutations and p16INK4a promoter methylation result in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice
Journal Articles

Cancer stem cells are also potent progenitors of tumor angiogenesis

Sanford Barsky, Rulong Shen, Li Chen, Yin Ye, Jian-Xin Gao
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1284.
Published: 01 May 2007
View article titled, Cancer stem cells are also potent progenitors of tumor angiogenesis
Journal Articles

Expression pattern of stem cell protein Piwil2 in human breast cancer

James Liu, Li Chen, Yin ye, Keding hua, David Jarjoura, Satomi Kuramochi-Miyagawa, Toru Nakano, Carl Morrison, Sanford Barsky, Rulong Shen, Jian-Xin Gao
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1277.
Published: 01 May 2007
View article titled, Expression pattern of stem cell protein Piwil2 in human breast cancer
Journal Articles

On the Site and Mode of Antigen Presentation for the Initiation of Clonal Expansion of CD8 T Cells Specific for a Natural Tumor Antigen

Xue-Feng Bai, Jian-Xin Gao, Jinqing Liu, Jing Wen, Pan Zheng, Yang Liu
Journal: Cancer Research
Cancer Res (2001) 61 (18): 6860–6867.
Published: 01 September 2001
View article titled, On the Site and Mode of Antigen Presentation for the Initiation of Clonal Expansion of CD8 T Cells Specific for a Natural Tumor Antigen
Open the PDF for On the Site and Mode of Antigen Presentation for the Initiation of Clonal Expansion of CD8 T Cells Specific for a Natural Tumor Antigen in another window