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Journal Articles

Abstract 6367: CHD1 loss hijacks SREBP2-mediated cholesterol biosynthesis to fuel SPOP-deficient prostate cancer and confers resistance to castration

Free
Feiyu Chen, Haoyan Li, Yin Wang, Ximing Tang, Kevin Lin, Qidong Li, Chenling Meng, Wei Shi, Javier Leo, Xin Liang, Jie Zhang, Vivien Van, Iqbal Mahmud, Bo Wei, Philip L. Lorenzi, Maria G. Raso, Ana Aparicio, Yue Lu, Daniel E. Frigo, Boyi Gan, Di Zhao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6367.
https://doi.org/10.1158/1538-7445.AM2025-6367
Published: 21 April 2025
View articletitled, Abstract 6367: CHD1 loss hijacks SREBP2-mediated cholesterol biosynthesis to fuel SPOP-deficient prostate cancer and confers resistance to castration
Journal Articles

Abstract 5061: Improved survival and unique mutational signatures in small cell lung cancer arising in patients with limited tobacco use

Free
Kyle Concannon, Moushumi Sahu, Whitney Lewis, Hai Tran, Lixia Diao, Yuanxin Xi, Benjamin Morris, Simon Heeke, Ximing Tang, John Stewart, Ivan Valiev, Gabriela Raso, Jing Wang, Koji Sasaki, Carl Gay, John Heymach, Lauren Byers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5061.
https://doi.org/10.1158/1538-7445.AM2024-5061
Published: 22 March 2024
View articletitled, Abstract 5061: Improved survival and unique mutational signatures in small cell lung cancer arising in patients with limited tobacco use
Journal Articles

Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response

Free
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Ximing Tang, Sen Pathak, Maria G. Raso, Jared Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2585.
https://doi.org/10.1158/1538-7445.AM2023-2585
Published: 04 April 2023
View articletitled, Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response
Journal Articles

Abstract 4460: Spatial profiling of immune biomarkers in resected treatment-naïve early stage lung adenocarcinoma

Free
Sharia D. Hernandez, Wei Lu, Alejandra G. Serrano, Claudio J. Arrechedera, Beatriz Sanchez-Espiridion, Nejla Ozirmak, Max Molina, Larisa Kostousov, Sean Barnes, Khaja Khan, Ximing Tang, Junya Fujimoto, Edwin R. Parra, Gabriela Raso, Stephanie T. Schmidt, Carmen Behrens, John Heymach, Jianjun Zhang, Ken Chen, Boris Sepesi, Tina Cascone, Don Gibbons, Ignacio I. Wistuba, Cara Haymaker, Luisa M. Solis
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4460.
https://doi.org/10.1158/1538-7445.AM2023-4460
Published: 04 April 2023
View articletitled, Abstract 4460: Spatial profiling of immune biomarkers in resected treatment-naïve early stage lung adenocarcinoma
Journal Articles

Abstract 1398: Clinical and transcriptomic analysis demonstrates improved survival and unique gene expression signatures among SCLC arising in patients with minimal tobacco use

Free
Kyle Concannon, Simon Heeke, Moushumi Sahu, Ximing Tang, Koji Sasaki, Sonia Patel, Maria Gabriela Raso, Hai Tran, Carl Gay, Lauren Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1398.
https://doi.org/10.1158/1538-7445.AM2023-1398
Published: 04 April 2023
View articletitled, Abstract 1398: Clinical and transcriptomic analysis demonstrates improved survival and unique gene expression signatures among SCLC arising in patients with minimal tobacco use
Journal Articles

Abstract 3473: Use of DNA methylation from tumor and plasma to identify four major small cell lung cancer subtypes with distinct biology and therapeutic vulnerabilities

Free
Simon Heeke, Carl M. Gay, Marcos R. Estecio, Allison Stewart, Hai Tran, Bingnan Zhang, Ximing Tang, Gabriela Raso, Kyle Concannon, Luana Guimaraes De Sousa, Whitney E. Lewis, Monique Nilsson, Yuanxin Xi, Lixia Diao, Qi Wang, Jianjun Zhang, Jing Wang, Ignacio I. Wistuba, Lauren A. Byers, John V. Heymach
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3473.
https://doi.org/10.1158/1538-7445.AM2022-3473
Published: 15 June 2022
View articletitled, Abstract 3473: Use of DNA methylation from tumor and plasma to identify four major small cell lung cancer subtypes with distinct biology and therapeutic vulnerabilities
Journal Articles

Abstract 5545: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Free
Yifan Zhou, Yusra B. Medik, Bhakti Patel, Daniel B. Zamler, Sijie Chen, Thomas Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, Elizabeth M. Park, Alexandria P. Cogdill, Daniel H. Johnson, Sarah B. Johnson, Khalida M. Wani, Debora A. Ledesma, Courtney W. Hudgens, Jingjing Wang, Md Abdul Wadud Khan, Aron Y. Joon, Weiyi Peng, Haiyan S. Li, Reetakshi Arora, Ximing Tang, Maria Gabriela Raso, Xuegong Zhang, Wai Chin Foo, Michael T. Tetzlaff, Gretchen E. Diehl, Karen Clise-Dwyer, Elizabeth M. Whitley, Matthew M. Gubin, James P. Allison, Patrick Hwu, Nadim J. Ajami, Adi Diab, Jennifer A. Wargo, Stephanie S. Watowich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5545.
https://doi.org/10.1158/1538-7445.AM2022-5545
Published: 15 June 2022
View articletitled, Abstract 5545: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration
Journal Articles

Abstract 1105: Tumor cells of the early metastatic process show up regulation of cytokine genes involved in migration of inflammatory cells

Free
Coya Tapia, Xiaoping Su, Ximing Tang, Lakshmi Kakaral, Aysegul Sahin, Wei Lu, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1105.
https://doi.org/10.1158/1538-7445.AM2018-1105
Published: 01 July 2018
View articletitled, Abstract 1105: Tumor cells of the early metastatic process show up regulation of cytokine genes involved in migration of inflammatory cells
Journal Articles

Abstract 634: SOX11 is a potential clinical marker for hormone receptor negative ductal carcinoma in situ

Free
Kazuharu Kai, Wei Lu, Fei Yang, Ximing Tang, Ignacio I. Wistuba, Subrata Sen, Alastair Thompson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 634.
https://doi.org/10.1158/1538-7445.AM2018-634
Published: 01 July 2018
View articletitled, Abstract 634: SOX11 is a potential clinical marker for hormone receptor negative ductal carcinoma in situ
Journal Articles

Abstract 4054: Gene expression difference (GED) revealed immune function gene down-regulation as tumor-associated inflammatory cell (TAIC) infiltration in microenvironment in non-small cell lung cancer (NSCLC)

Free
Ximing Tang, Wei Lu, Jiexin Zhang, Carmen Berhens, Edwin R. Parra, John Wineman, Jianjun Zhang, Don Lynn Gibbons, Mark Koeppel, BJ Kerns, Mark Stern, Boris Sepesi, Jack J. Lee, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4054.
https://doi.org/10.1158/1538-7445.AM2018-4054
Published: 01 July 2018
View articletitled, Abstract 4054: Gene expression difference (GED) revealed immune function gene down-regulation as tumor-associated inflammatory cell (TAIC) infiltration in microenvironment in non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 1144: Detection of a novel ALK fusion variant in lung adenocarcinoma using a comprehensive genomic analysis

Free
Kazuhiko Shien, Dennis Ruder, Ecaterina E. Ileana, Vassiliki A. Papadimitrakopoulou, Garrett M. Frampton, Carmen Behrens, Neda Kalhor, J. Jack Lee, Ximing Tang, Roy S. Herbst, Ignacio I. Wistuba, Julie G. Izzo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1144.
https://doi.org/10.1158/1538-7445.AM2016-1144
Published: 15 July 2016
View articletitled, Abstract 1144: Detection of a novel ALK fusion variant in lung adenocarcinoma using a comprehensive genomic analysis
Journal Articles

Abstract 2413: Cell type-specific deconvolution of heterogeneous tumor samples with immune infiltration using expression data

Free
Zeya Wang, Jeffrey S. Morris, Chris C. Holmes, Jaeil Ahn, Bo Li, Wei Lu, Ximing Tang, Ignacio I. Wistuba, Wenyi Wang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2413.
https://doi.org/10.1158/1538-7445.AM2016-2413
Published: 15 July 2016
View articletitled, Abstract 2413: Cell type-specific deconvolution of heterogeneous tumor samples with immune infiltration using expression data
Journal Articles

Abstract 756: Myo-inositol modulates the tumor microenvironment in a mouse model of lung cancer chemoprevention

Free
Nese Unver, Kirubel T. Zeleke, Ximing Tang, Samantha Holt, Seyed Javad M. Moghaddam, Hong Wang, Ignacio I. Wistuba, Samir M. Hanash, Edwin J. Ostrin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 756.
https://doi.org/10.1158/1538-7445.AM2016-756
Published: 15 July 2016
View articletitled, Abstract 756: Myo-inositol modulates the tumor microenvironment in a mouse model of lung cancer chemoprevention
Journal Articles

Abstract 3576: Rictor alterations elicit non-canonical signaling mechanisms contributing to tumorigenicity and therapeutic resistance in non-small cell lung cancer (NSCLC)

Free
Dennis Ruder, Vassiliki Papadimitrakopoulou, Kazuhiko Shien, Neda Kalhor, J. Jack Lee, Waun K. Hong, Ximing Tang, Luc Girard, John D. Minna, Lixia Diao, Jing Wang, Nana E. Hanson, James Sun, Vincent Miller, Garrett Frampton, Roy S. Herbst, Ignacio I. Wistuba, Julie G. Izzo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3576.
https://doi.org/10.1158/1538-7445.AM2015-3576
Published: 01 August 2015
View articletitled, Abstract 3576: Rictor alterations elicit non-canonical signaling mechanisms contributing to tumorigenicity and therapeutic resistance in non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 745: Oncostatin M receptor activation leads to molecular targeted therapy resistance in non-small cell lung cancer

Free
Kazuhiko Shien, Vassiliki A. Papadimitrakopoulou, Dennis Ruder, Nana E. Hanson, Neda Kalhor, J. Jack Lee, Waun Ki Hong, Ximing Tang, Roy S. Herbst, Luc Girard, John D. Minna, Jonathan M. Kurie, Ignacio I. Wistuba, Julie G. Izzo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 745.
https://doi.org/10.1158/1538-7445.AM2015-745
Published: 01 August 2015
View articletitled, Abstract 745: Oncostatin M receptor activation leads to molecular targeted therapy resistance in non-small cell lung cancer
Journal Articles

Abstract 2877: Focal adhesion kinsase (FAK) protein overexpression and gene copy number gain correlate with better outcome in patients with surgically resected NSCLC tumors

Free
Ximing Tang, Yiran Cai, Carmen Behrens, Heather Lin, J. Jack Lee, Ignacio. I. Wistuba
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2877.
https://doi.org/10.1158/1538-7445.AM2014-2877
Published: 01 October 2014
View articletitled, Abstract 2877: Focal adhesion kinsase (FAK) protein overexpression and gene copy number gain correlate with better outcome in patients with surgically resected NSCLC tumors
Journal Articles

Abstract 3098: ERCC1 gene copy number variations in resected non-small cell lung cancer

Free
Luc Friboulet, Ken A. Olaussen, Alexander Valent, Ximing Tang, Tao Tang, Yuanyuan Li, Carmen Behrens, Philippe Vielh, Angélique Robin, Aïcha Goubar, Pierre Validire, Ignacio Wistuba, Jean-Charles Soria
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3098.
https://doi.org/10.1158/1538-7445.AM2012-3098
Published: 15 April 2012
View articletitled, Abstract 3098: ERCC1 gene copy number variations in resected non-small cell lung cancer
Journal Articles

Abstract 3195: Formalin-fixed and paraffin-embedded (FFPE) DNA recovery for high-throughput genotyping of lung cancer tissues

Free
Hector Galindo, Luisa Solis, Junya Fujimoto, Nana E. Hanson, Christina McDowell, Erick Riquelme, XiMing Tang, Carmen Behrens, Jack J. Lee, Edward S. Kim, Ignacio I. Wistuba, Heidi S. Erickson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3195.
https://doi.org/10.1158/1538-7445.AM2012-3195
Published: 15 April 2012
View articletitled, Abstract 3195: Formalin-fixed and paraffin-embedded (FFPE) DNA recovery for high-throughput genotyping of lung cancer tissues
Journal Articles

Abstract 4819: Gene-expression profiles predict sorafenib efficacy in wild-type EGFR non-small cell lung cancer (NSCLC)

Free
Pierre Saintigny, George R. Blumenschein, Lixia Diao, Jing Wang, Kevin Coombes, Suyu Liu, Edward Kim, Anne Tsao, Roy Herbst, Christine Alden, Jack J. Lee, Ximing Tang, David Stewart, Merrill Kies, Frank Fossella, Hai Tran, Li Mao, Marshall Hicks, Jeremy Erasmus, Sanjay Gupta, Luc Girard, Michael Peyton, Suzanne Davis, Scott Lippman, Waun Ki Hong, John Minna, Ignacio Wistuba, John Heymach
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4819.
https://doi.org/10.1158/1538-7445.AM2012-4819
Published: 15 April 2012
View articletitled, Abstract 4819: Gene-expression profiles predict sorafenib efficacy in wild-type EGFR non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 3685: Analysis of EZH2 and TTF-1 protein expression identifies a subset of lung adenocarcinomas with better prognosis

Free
Carmen Behrens, Luisa Solis, Heather Lin, Ximing Tang, Ping Yuan, Humam Kadara, Erick Riquelme, Hector Galindp, Waun Ki Hong, J.Jack Lee, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3685.
https://doi.org/10.1158/1538-7445.AM2012-3685
Published: 15 April 2012
View articletitled, Abstract 3685: Analysis of EZH2 and TTF-1 protein expression identifies a subset of lung adenocarcinomas with better prognosis