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Abstract 359: Rb loss-related DNA damage repair deficiency mediates the synthetically lethal effect of ATR/PKMYT1 co-inhibition in TNBC and CDK4/6i-resistant ER+ breast cancer

Xiao-Ting Jiang, Mei-Kuang Chen, Jiwang Lee, Xiayu Rao, Jing Wang, Kelly Hunt, Khandan Keyomarsi

Cancer Res (2025) 85 (8_Supplement_1): 359.

https://doi.org/10.1158/1538-7445.AM2025-359

Published: 21 April 2025

View articletitled, Abstract 359: Rb loss-related DNA damage repair deficiency mediates the synthetically lethal effect of ATR/PKMYT1 co-inhibition in TNBC and CDK4/6i-resistant ER+ breast cancer

Journal Articles

Abstract 358: INK4A/B as predictive biomarkers for enhanced efficacy of dual WEE1 and PKMYT1 inhibition in CDK4/6 inhibitor-resistant breast cancer

Mei-Kuang Chen, Xiaoting Jiang, Xiayu Rao, Tuyen Bui, Yan Wang, Jing Wang, Grace DeAlessandro, Nicole L. Massoumi, Rachel Y. Kim, Roanna A. Debler, Serena Kim, Kelly K. Hunt, Felicia Gray, Shaoxian Sun, Khandan Keyomarsi

Cancer Res (2025) 85 (8_Supplement_1): 358.

https://doi.org/10.1158/1538-7445.AM2025-358

Published: 21 April 2025

View articletitled, Abstract 358: INK4A/B as predictive biomarkers for enhanced efficacy of dual WEE1 and PKMYT1 inhibition in CDK4/6 inhibitor-resistant breast cancer

Journal Articles

Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers

Juliana Navarro-Yepes, Nicole Kettner, Xiayu Rao, Tuyen Bui, Cassandra Bishop, Hannah Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul Sahin, Funda Meric-Bernstam, Kelly Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi

Cancer Res (2024) 84 (9_Supplement): PO3-15-03.

https://doi.org/10.1158/1538-7445.SABCS23-PO3-15-03

Published: 02 May 2024

View articletitled, Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers

Journal Articles

Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers

Juliana Navarro-Yepes, Nicole M. Kettner, Xiayu Rao, Cassandra Santaella Bishop, Tuyen N. Bui, Hannah F. Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul A. Sahin, Funda Meric-Bernstam, Kelly K. Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi

Cancer Res (2023) 83 (19): 3264–3283.

https://doi.org/10.1158/0008-5472.CAN-23-0705

Published: 02 October 2023

View articletitled, Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers

Includes: Supplementary data

Journal Articles

Abstract 1798: Mechanisms of acquired resistance to palbociclib reveals pathways of response to abemaciclib

Juliana Navarro-Yepes, Nicole M. Kettner, Tuyen Bui, Akshara S. Raghavendra, Xiayu Rao, Jing Wang, Aysegul Sahin, Senthil Damodaran, Debasish Tripathy, Kelly K. Hunt, Khandan Keyomarsi

Cancer Res (2022) 82 (12_Supplement): 1798.

https://doi.org/10.1158/1538-7445.AM2022-1798

Published: 15 June 2022

View articletitled, Abstract 1798: Mechanisms of acquired resistance to palbociclib reveals pathways of response to abemaciclib

Journal Articles

Abstract 515: Single-cell transcriptomic analysis of HR+/HER2- breast cancer identifies gene signatures that predict outcomes of luminal A and B subtypes

Sofia Mastoraki, Jerome Lin, Xiayu Rao, Sophie R. Liu, Harsh Batra, Maria G. Raso, Edwin R. Parra Cuentas, Akshara S. Raghavendra, Komal S. Rasaputra, Min Yi, Jing Wang, Aysegul Sahin, Debasish Tripathy, Kelly K. Hunt, Nicholas E. Navin, Khandan Keyomarsi

Cancer Res (2022) 82 (12_Supplement): 515.

https://doi.org/10.1158/1538-7445.AM2022-515

Published: 15 June 2022

View articletitled, Abstract 515: Single-cell transcriptomic analysis of HR+/HER2- breast cancer identifies gene signatures that predict outcomes of luminal A and B subtypes

Journal Articles

Abstract 3107: Identifying therapeutic vulnerabilities in HR-positive, HER2-negative advanced breast cancer patient-derived xenograft models refractory to CDK4/6 inhibition

Nicole M. Kettner, Juliana Navarro-Yepes, Tuyen N. Bui, Xiayu Rao, Jing Wang, Funda Meric-Bernstam, Kelly K. Hunt, Debu Tripathy, Khandan Keyomarsi

Cancer Res (2022) 82 (12_Supplement): 3107.

https://doi.org/10.1158/1538-7445.AM2022-3107

Published: 15 June 2022

View articletitled, Abstract 3107: Identifying therapeutic vulnerabilities in HR-positive, HER2-negative advanced breast cancer patient-derived xenograft models refractory to CDK4/6 inhibition

Journal Articles

Abstract 264: Neutrophil elastase (NE) inhibition enhances metastasis free survival by altering regulation of tumor intrinsic cytoskeletal and cellular adhesion pathways in murine breast cancer models

Amriti R. Lulla, Said Akli, Lucas D. Warma, Natalie W. Fowlkes, Kelly K. Hunt, Xiayu Rao, Jing Wang, Stephanie S. Watowich, Khandan Keyomarsi

Cancer Res (2022) 82 (12_Supplement): 264.

https://doi.org/10.1158/1538-7445.AM2022-264

Published: 15 June 2022

View articletitled, Abstract 264: Neutrophil elastase (NE) inhibition enhances metastasis free survival by altering regulation of tumor intrinsic cytoskeletal and cellular adhesion pathways in murine breast cancer models

Journal Articles

Abstract NG07: Cancer takes a nerve: Loss of p53 drives neuron reprogramming in head and neck cancer

Cancer Res (2021) 81 (13_Supplement): NG07.

https://doi.org/10.1158/1538-7445.AM2021-NG07

Published: 01 July 2021

View articletitled, Abstract NG07: Cancer takes a nerve: Loss of p53 drives neuron reprogramming in head and neck cancer

Journal Articles

Abstract 323: Combined inhibition of STAT-3 & DNA repair in palbociclib resistant breast cancer

Cancer Res (2019) 79 (13_Supplement): 323.

https://doi.org/10.1158/1538-7445.AM2019-323

Published: 01 July 2019

View articletitled, Abstract 323: Combined inhibition of STAT-3 & DNA repair in palbociclib resistant breast cancer

Journal Articles

Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Frederico O. Gleber-Netto, Meng Gao, Xiayu Rao, Christopher P. Vellano, Joseph R. Marszalek, Jing Wang, Faye M. Johnson, Curtis R. Pickering

Cancer Res (2019) 79 (13_Supplement): 4942.

https://doi.org/10.1158/1538-7445.AM2019-4942

Published: 01 July 2019

View articletitled, Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Journal Articles

Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Frederico O. Gleber-Netto, Xiayu Rao, Kelly Erikson, Keiko Akagi, Faye M. Johnson, Jing Wang, Joseph Califano, Maura L. Gillison, Jeffrey N. Myers, Curtis R. Pickering

Cancer Res (2018) 78 (13_Supplement): 4621.

https://doi.org/10.1158/1538-7445.AM2018-4621

Published: 01 July 2018

View articletitled, Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Journal Articles

Abstract 5506: NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties

Cancer Res (2018) 78 (13_Supplement): 5506.

https://doi.org/10.1158/1538-7445.AM2018-5506

Published: 01 July 2018

View articletitled, Abstract 5506: NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties

Journal Articles

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Cancer Res (2018) 78 (3): 781–797.

https://doi.org/10.1158/0008-5472.CAN-17-2802

Published: 31 January 2018

View articletitled, CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Includes: Supplementary data

Journal Articles

Abstract 5123: Multiplex in situ immunoprofiling and survival outcomes in non-small cell lung cancer

Steven H. Lin, James R. Mansfield, Xiayu Rao, Wen Jiang, Penny Fang, Kristin Roman, Chichung Wang, Ritsuko Komaki, Stephen Hahn, Stephen G. Swisher, Junya Fujimoto, Ignacio Wistuba, Jing Wang, Clifford C. Hoyt

Cancer Res (2016) 76 (14_Supplement): 5123.

https://doi.org/10.1158/1538-7445.AM2016-5123

Published: 15 July 2016

View articletitled, Abstract 5123: Multiplex in situ immunoprofiling and survival outcomes in non-small cell lung cancer

Journal Articles

Abstract 2592: Vitamin E forms and 13′-carboxychromanol, a long-chain metabolite of α-tocopherol, induce cell death by interrupting de novo sphingolipid synthesis in human cancer cells

Yumi Jang, Xiayu Rao, Qing Jiang

Cancer Res (2012) 72 (8_Supplement): 2592.

https://doi.org/10.1158/1538-7445.AM2012-2592

Published: 15 April 2012

View articletitled, Abstract 2592: Vitamin E forms and 13′-carboxychromanol, a long-chain metabolite of α-tocopherol, induce cell death by interrupting de novo sphingolipid synthesis in human cancer cells

Journal Articles

Abstract 217: Vitamin E forms induce apoptosis, necrosis, and autophagy and caused accumulation of sphingolipid intermediates in human colon cancer cells

Xiayu Rao, Qing Jiang

Cancer Res (2010) 70 (8_Supplement): 217.

https://doi.org/10.1158/1538-7445.AM10-217

Published: 15 April 2010

View articletitled, Abstract 217: Vitamin E forms induce apoptosis, necrosis, and autophagy and caused accumulation of sphingolipid intermediates in human colon cancer cells

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Abstract 359: Rb loss-related DNA damage repair deficiency mediates the synthetically lethal effect of ATR/PKMYT1 co-inhibition in TNBC and CDK4/6i-resistant ER+ breast cancer

Abstract 358: INK4A/B as predictive biomarkers for enhanced efficacy of dual WEE1 and PKMYT1 inhibition in CDK4/6 inhibitor-resistant breast cancer

Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers

Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers

Abstract 1798: Mechanisms of acquired resistance to palbociclib reveals pathways of response to abemaciclib

Abstract 515: Single-cell transcriptomic analysis of HR+/HER2- breast cancer identifies gene signatures that predict outcomes of luminal A and B subtypes

Abstract 3107: Identifying therapeutic vulnerabilities in HR-positive, HER2-negative advanced breast cancer patient-derived xenograft models refractory to CDK4/6 inhibition

Abstract 264: Neutrophil elastase (NE) inhibition enhances metastasis free survival by altering regulation of tumor intrinsic cytoskeletal and cellular adhesion pathways in murine breast cancer models

Abstract NG07: Cancer takes a nerve: Loss of p53 drives neuron reprogramming in head and neck cancer

Abstract 323: Combined inhibition of STAT-3 & DNA repair in palbociclib resistant breast cancer

Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Abstract 5506: NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Abstract 5123: Multiplex in situ immunoprofiling and survival outcomes in non-small cell lung cancer

Abstract 2592: Vitamin E forms and 13′-carboxychromanol, a long-chain metabolite of α-tocopherol, induce cell death by interrupting de novo sphingolipid synthesis in human cancer cells

Abstract 217: Vitamin E forms induce apoptosis, necrosis, and autophagy and caused accumulation of sphingolipid intermediates in human colon cancer cells

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