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Xiaoyun Wu
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Journal Articles

Abstract 2663: Preclinical profiling of BAY 2666605: The first PDE3A-SLFN12 complex inducer for cancer therapy

Silvia Goldoni, Martin Lange, Charlotte Kopitz, Stefan Kaulfuss, Sven Golfier, Adrian Tersteegen, Stefanie Bunse, Melanie Berthold, Thibaud Jordan, Philip Lienau, Franziska Siegel, Annette Walter, Henrik Seidel, Elisa Aquilanti, Andrew Baker, Xiaoyun Wu, Sooncheol Lee, Stefan Gradl, Emmanuelle di Tomaso, Matthew Meyerson, Knut Eis, Ashley Eheim, Heidi Greulich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2663.
https://doi.org/10.1158/1538-7445.AM2022-2663
Published: 15 June 2022
View articletitled, Abstract 2663: Preclinical profiling of BAY 2666605: The first PDE3A-SLFN12 complex inducer for cancer therapy
Journal Articles

Abstract ND04: BAY 2666605: The first PDE3A-SLFN12 complex inducer for cancer therapy

Stefan Gradl, Sooncheol Lee, Martin Lange, Xiaoyun Wu, Silvia Goldoni, Timothy Lewis, Charlotte Kopitz, Colin Garvie, Philip Lienau, Stephanie Hoyt, Henrik Seidel, Stephan Kaulfuss, Manuel Ellermann, Luc de Waal, Adrian Tersteegen, Sven Golfier, Detlev Suelzle, Christa Hegele-Hartung, James Carr, Frederick Brookfield, Michael Bruening, Melanie Berthold, Thibaud Jourdan, Monica Schenone, Galen Gao, Joseph McGaunn, Antje Wengner, Elisa Aquilanti, Franziska Siegel, Marine Garrido, Annette Walter, Isabelle Genvresse, Andrew Cherniack, Stuart Schreiber, Knut Eis, Ashley Eheim, Matthew Meyerson, Heidi Greulich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): ND04.
https://doi.org/10.1158/1538-7445.AM2022-ND04
Published: 15 June 2022
View articletitled, Abstract ND04: BAY 2666605: The first PDE3A-SLFN12 complex inducer for cancer therapy
Journal Articles

Abstract 867: Velcrin-induced cleavage of tRNA-Leu-TAA by SLFN12 RNase causes cancer cell death

Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Andrew D. Cherniack, Matthew Meyerson, Heidi Greulich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 867.
https://doi.org/10.1158/1538-7445.AM2022-867
Published: 15 June 2022
View articletitled, Abstract 867: Velcrin-induced cleavage of tRNA-Leu-TAA by SLFN12 RNase causes cancer cell death
Journal Articles

Abstract 54: Cryo-EM structure of the PDE3A-SLFN12 complex reveals requirements for the activation of SLFN12 RNase and DNMDP-induced cancer cell killing

Xiaoyun Wu, Colin Garvie, Sooncheol Lee, Steven Horner, Andrew Baker, Marcus Toetzl, Joseph McGaunn, Bethany Kaplan, Luc de Waal, Martin Lange, Timothy Lewis, Chris Lemke, Matthew Meyerson, Heidi Greulich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 54.
https://doi.org/10.1158/1538-7445.AM2021-54
Published: 01 July 2021
View articletitled, Abstract 54: Cryo-EM structure of the PDE3A-SLFN12 complex reveals requirements for the activation of SLFN12 RNase and DNMDP-induced cancer cell killing
Journal Articles

Abstract 1219: Deep mutational scanning of PDE3A identifies residues required for DNMDP response

Xiaoyun Wu, Malvina Papanastasiou, Gavin Schnitzler, Colin Garvie, Stephanie Hoyt, Terry Zhang, James Mullahoo, Andrew Baker, Joseph McGaunn, Bethany Kaplan, Sooncheol Lee, Martin Lange, Steven Carr, Xiaoping Yang, Federica Piccioni, Andrew Cherniack, Matthew Meyerson, Heidi Greulich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1219.
https://doi.org/10.1158/1538-7445.AM2021-1219
Published: 01 July 2021
View articletitled, Abstract 1219: Deep mutational scanning of PDE3A identifies residues required for DNMDP response
Journal Articles

Abstract 5880: Small-molecule modulators of PDE3/SLFN12 to kill cancer cells

Timothy A. Lewis, Luc de Waal, Xiaoyun Wu, Manuel Ellerman, Charlotte Kopitz, Antje Wengner, Knut Eis, Martin Lange, Adrian Tersteegen, Philip Lienau, Heidi Greulich, Matthew Meyerson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5880.
https://doi.org/10.1158/1538-7445.AM2018-5880
Published: 01 July 2018
View articletitled, Abstract 5880: Small-molecule modulators of PDE3/SLFN12 to kill cancer cells
Journal Articles

Abstract 2028: PDE3A modulation for cancer therapy

Xiaoyun Wu, Timothy Lewis, Luc de Waal, Galen Gao, Jian Zhang, Monica Schenone, Colin Garvie, Brett Diamond, Selena Lorrey, Andrew Cherniack, Steven Corsello, Alex Burgin, Todd Golub, Stuart Schreiber, Matthew Meyerson, Heidi Greulich
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2028.
https://doi.org/10.1158/1538-7445.AM2017-2028
Published: 01 July 2017
View articletitled, Abstract 2028: PDE3A modulation for cancer therapy
Journal Articles

Abstract 4368: High-throughput phenotyping of lung cancer somatic mutations

Alice H. Berger, Angela N. Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin Imielinski, Larson Hogstrom, Cong Zhu, Xiaoping Yang, Sasha Pantel, Ryo Sakai, Nathan Kaplan, David Root, Rajiv Narayan, Ted Natoli, David Lahr, Itay Tirosh, Pablo Tamayo, Gad Getz, Bang Wong, John Doench, Aravind Subramanian, Todd R. Golub, Matthew Meyerson, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4368.
https://doi.org/10.1158/1538-7445.AM2016-4368
Published: 15 July 2016
View articletitled, Abstract 4368: High-throughput phenotyping of lung cancer somatic mutations
Journal Articles

Abstract PR07: Towards precision functional genomics via next-generation functional mapping of cancer variants

Alice H. Berger, Eejung Kim, Angela Brooks, Nina Ilic, Yashaswi Shrestha, Yuen-Yi Tseng, Xiaoyun Wu, Lihua Zou, Atanas Kamburov, Xiaoping Yang, Cong Zhu, Paula Keskula, Sara Seepo, Andrew Hong, Philip Kantoff, Keith L. Ligon, Levi A. Garraway, John G. Doench, David E. Root, Matthew Meyerson, William C. Hahn, Gad Getz, Todd R. Golub, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): PR07.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-PR07
Published: 15 November 2015
View articletitled, Abstract PR07: Towards precision functional genomics via next-generation functional mapping of cancer variants
Journal Articles

Abstract PR12: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function

Alice Berger, Angela Brooks, Xiaoyun Wu, Larson Hogstrom, Itay Tirosh, Federica Piccioni, Mukta Bagul, Cong Zhu, Yashaswi Shretha, David Root, Pablo Tamayo, Ryo Sakai, Bang Wong, Aravind Subramanian, Todd Golub, Matthew Meyerson, Jesse Boehm
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): PR12.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-PR12
Published: 15 November 2015
View articletitled, Abstract PR12: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function
Journal Articles

Abstract PR04: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function

Alice Berger, Angela Brooks, Xiaoyun Wu, Larson Hogstrom, Itay Tirosh, Federica Piccioni, Mukta Bagul, Cong Zhu, Yashaswi Shretha, David Root, Pablo Tamayo, Ryo Sakai, Bang Wong, Aravind Subramanian, Todd Golub, Matthew Meyerson, Jesse Boehm
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): PR04.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-PR04
Published: 15 November 2015
View articletitled, Abstract PR04: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function
Journal Articles

Abstract 957: Towards precision functional genomics via next-generation functional mapping of cancer variants

Alice Berger, Eejung Kim, Angela Brooks, Yashaswi Shrestha, Yuen-Yi Tseng, Xiaoyun Wu, Nina Ilic, Lihua Zou, Atanas Kamburov, Xiaoping Yang, Cong Zhu, Paula Keskula, Sara Seepo, Andrew Hong, John Doench, Aravind Subramanian, Keith Ligon, Philip Kantoff, Katherine Janeway, Levi Garraway, David Root, Todd Golub, Matthew Meyerson, William Hahn, Gad Getz, Jesse Boehm
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 957.
https://doi.org/10.1158/1538-7445.AM2015-957
Published: 01 August 2015
View articletitled, Abstract 957: Towards precision functional genomics via next-generation functional mapping of cancer variants
Journal Articles

Abstract 5196: The discovery of small molecule inhibitors of Tankyrases 1 and 2, which modulate Axin homeostasis and inhibit Wnt signaling in vivo

Emma-Louise Cooke, Marat Alimzhanov, Lynsie Almeida, Larry Bao, Vahe Bedian, Jeffrey Brown, Chun Deng, Christopher Denz, Lakshmaiah Gingipalli, Jeffrey Johannes, Steven Kazmirski, Michelle Lamb, Zhong-Ying Liu, Vicki Racicot, Nancy Su, Haiyun Wang, Tao Wang, Xiaoyun Wu, Lihua Yu, Hai-Jun Zhang, Weijia Zheng, Paul Lyne
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5196.
https://doi.org/10.1158/1538-7445.AM2011-5196
Published: 15 April 2011
View articletitled, Abstract 5196: The discovery of small molecule inhibitors of Tankyrases 1 and 2, which modulate Axin homeostasis and inhibit Wnt signaling in vivo
Journal Articles

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

Lei Fu, Young-Ae Kim, Xuerong Wang, Xiaoyun Wu, Ping Yue, Sagar Lonial, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8967–8976.
https://doi.org/10.1158/0008-5472.CAN-09-2190
Published: 30 November 2009
View articletitled, Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy
Open the PDF for Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy in another window
Includes: Supplementary data