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Journal Articles

Abstract 3175: Comprehensive multi-omic characterization of hepatocellular carcinoma in Hispanic patients

Debodipta Das, Xiaojing Wang, Yu-Chiao Chiu, Hakim Bouamar, Yidong Chen, Siyuan Zheng, Francisco G. Cigarroa, Lu-Zhe Sun
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3175.
https://doi.org/10.1158/1538-7445.AM2023-3175
Published: 04 April 2023
View article titled, Abstract 3175: Comprehensive multi-omic characterization of hepatocellular carcinoma in Hispanic patients
Journal Articles

Abstract 3572: Genomic profiling of subcutaneous patient derived xenograft models of solid childhood cancer

Funan He, Abhik M. Bandyopadhyay, Laura Klesse, Anna Rogojina, Erin Butler, Taylor Hartshorne, Trevor Holland, Luz Perez Prado, Anne-Marie Langevan, Allison C. Grimes, Chatchawin Assanasen, Zhao Lai, Yi Zou, Dias Kurmashev, Lin Xu, Yang Xie, Yidong Chen, Xiaojing Wang, Gail E. Tomlinson, Stephen X. Skapek, Raushan T. Kurmasheva, Peter J. Houghton, Siyuan Zheng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3572.
https://doi.org/10.1158/1538-7445.AM2023-3572
Published: 04 April 2023
View article titled, Abstract 3572: Genomic profiling of subcutaneous patient derived xenograft models of solid childhood cancer
Journal Articles

Abstract 2272: Integration of multi-omics data reveals molecular features of Hispanic hepatocellular carcinoma

Debodipta Das, Xiaojing Wang, Yu-Chiao Chiu, Hakim Bouamar, Yidong Chen, Siyuan Zheng, Francisco G. Cigarroa, Lu-Zhe Sun
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2272.
https://doi.org/10.1158/1538-7445.AM2022-2272
Published: 15 June 2022
View article titled, Abstract 2272: Integration of multi-omics data reveals molecular features of Hispanic hepatocellular carcinoma
Journal Articles

Abstract 6288: Evaluation of therapeutic strategy for the treatment of kidney cancer using multimodal imaging

Li Liu, Hashini Wanniarachchi, Tianyuan Wang, Xiaojing Wang, Dean Sherry, Ralph P. Mason, Li Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6288.
https://doi.org/10.1158/1538-7445.AM2022-6288
Published: 15 June 2022
View article titled, Abstract 6288: Evaluation of therapeutic strategy for the treatment of kidney cancer using multimodal imaging
Journal Articles

Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability

Xiaoyu Liu, Zhi Li, Zhongmin Wang, Fei Liu, Linling Zhang, Jingjing Ke, Xu Xu, Yuefang Zhang, Yiting Yuan, Tao Wei, Qungang Shan, Yingjie Chen, Wei Huang, Jie Gao, Nan Wu, Fuliang Chen, Lunquan Sun, Zilong Qiu, Yuezhen Deng, Xiaojing Wang
Journal: Cancer Research
Cancer Res (2022) 82 (5): 791–804.
https://doi.org/10.1158/0008-5472.CAN-21-0763
Published: 03 March 2022
View article titled, Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability
Open the PDF for Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability in another window
Includes: Supplementary data
Journal Articles

Abstract 187: PCaT: An integrated platform for the analysis of pediatric cancer genomic data

Juechen Yang, Qilin Li, Xiaojing Wang, Peter Houghton, Siyuan Zheng
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 187.
https://doi.org/10.1158/1538-7445.AM2020-187
Published: 15 August 2020
View article titled, Abstract 187: PCaT: An integrated platform for the analysis of pediatric cancer genomic data
Journal Articles

Abstract 3406: GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility in vivo

Ciara Metcalfe, Wei Zhou, Jane Guan, Robert A. Blake, Tom De Bruyn, Jennifer M. Giltnane, Ellen Ingalla, Tracy Kleinheinz, Jun Liang, Vidhi Mody, Jason Oeh, Savita Ubhayakar, Ingrid Wertz, Amy Young, Jason Zbieg, Xiaojing Wang, Marc Hafner
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3406.
https://doi.org/10.1158/1538-7445.AM2020-3406
Published: 15 August 2020
View article titled, Abstract 3406: GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility <em>in vivo</em>
Journal Articles

Abstract DDT02-04: GDC-9545: Discovery of an oral estrogen receptor antagonist, degrader, and immobilizer for the treatment of ER+ breast cancer patients

Xiaojing Wang, Xiaojing Wang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): DDT02-04.
https://doi.org/10.1158/1538-7445.AM2020-DDT02-04
Published: 15 August 2020
View article titled, Abstract DDT02-04: GDC-9545: Discovery of an oral estrogen receptor antagonist, degrader, and immobilizer for the treatment of ER+ breast cancer patients
Journal Articles

Abstract PD7-05: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER+) HER2-negative (HER2-) metastatic breast cancer

Komal Jhaveri, Eric Paul Winer, Elgene Lim, Jose AlejandroPerez Fidalgo, Meritxell Bellet, Ingrid Alina Mayer, Valentina Boni, Jaymin M Patel, Aditya Bardia, Jose Manuel Garcia, Peter Kabos, Mary Gates, Ya-Chi Chen, Jill Fredrickson, Xiaojing Wang, Lori Sickels Friedman, Jill Spoerke, Steven Gendreau, Ciara Metcalfe, Lichuan Liu, Ching-Wei Chang, Sharareh Monemi, Monica Gonzalez, Ursula McCurry, Sandra Milan, Eric William Humke, Sherene Loi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD7-05.
https://doi.org/10.1158/1538-7445.SABCS19-PD7-05
Published: 15 February 2020
View article titled, Abstract PD7-05: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER<sup>+</sup>) HER2-negative (HER2<sup>-</sup>) metastatic breast cancer
Journal Articles

Abstract LB-006: Proteogenomic characterization of human colon cancer reveals new therapeutic opportunities

Bing Zhang, Suhas Vasaikar, Chen Huang, Xiaojing Wang, Vladislav A. Petyuk, Sara R. Savage, Bo Wen, Yongchao Dou, Yun Zhang, Zhiao Shi, Osama A. Arshad, Marina A. Gritsenko, Lisa J. Zimmerman, Jason E. McDermott, Therese R. Clauss, Ronald J. Moore, Rui Zhao, Matthew E. Monroe, Yi-Ting Wang, Matthew C. Chambers, Robbert J. Slebos, Ken S. Lau, Qianxing Mo, Li Ding, Matthew Ellis, Mathangi Thiagarajan, Christopher R. Kinsinger, Henry Rodriguez, Richard D. Smith, Karin D. Rodland, Daniel C. Liebler, Tao Liu, CPTAC Investigators
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-006.
https://doi.org/10.1158/1538-7445.AM2019-LB-006
Published: 01 July 2019
View article titled, Abstract LB-006: Proteogenomic characterization of human colon cancer reveals new therapeutic opportunities
Journal Articles

Cis-Acting circ-CTNNB1 Promotes β-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1

Feng Yang, Erhu Fang, Hong Mei, Yajun Chen, Huanhuan Li, Dan Li, Huajie Song, Jianqun Wang, Mei Hong, Wenjing Xiao, Xiaojing Wang, Kai Huang, Liduan Zheng, Qiangsong Tong
Journal: Cancer Research
Cancer Res (2019) 79 (3): 557–571.
https://doi.org/10.1158/0008-5472.CAN-18-1559
Published: 01 February 2019
View article titled, <em>Cis</em>-Acting <em>circ-CTNNB1</em> Promotes β-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1
Open the PDF for <em>Cis</em>-Acting <em>circ-CTNNB1</em> Promotes β-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1 in another window
Includes: Supplementary data
Journal Articles

Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors

Ingrid Wertz, Lorna Kategaya, Paola Di Lello, Lionel Rouge, Richard Pastor, Kevin R. Clark, Jason Drummond, Tracy Kleinheinz, Eva Lin, John-Paul Upton, Sumit Prakash, Johanna Heideker, Mark McCleland, Maria Stella Ritorto, Dario R. Alessi, Matthias Trost, Travis W. Bainbridge, Michael C. Kwok, Taylur P. Ma, Zachary Stiffler, Bradley Brasher, Yinyan Tang, Priya Jaishanker, Brian Hearn, Adam R. Renslo, Michelle R. Arkin, Frederick Cohen, Kebing Yu, Frank Peale, Florian Gnad, Matthew T. Chang, Christiaan Klijn, Elizabeth Blackwood, Scott E. Martin, William F. Forrest, James A. Ernst, Chudi Ndubaku, Xiaojing Wang, Maureen H. Beresini, Vickie Tsui, Carsten Schwerdtfeger, Robert A. Blake, Jeremy Murray, Till Maurer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): SY23-03.
https://doi.org/10.1158/1538-7445.AM2018-SY23-03
Published: 01 July 2018
View article titled, Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors
Journal Articles

Abstract NG05: Not all “SERDs” are equal: Context-independent ER degradation and full ER antagonism define the next generation of ER therapeutics

Jane Guan, Wei Zhou, Anneleen Daemen, Steven J. Hartman, Robert A. Blake, Amy Heidersbach, Mamie Yu, May Liang-Chu, Scott Martin, Cecile Chalouni, Irene Chen, Lori S. Friedman, Xiaojing Wang, Ciara Metcalfe
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): NG05.
https://doi.org/10.1158/1538-7445.AM2018-NG05
Published: 01 July 2018
View article titled, Abstract NG05: Not all “SERDs” are equal: Context-independent ER degradation and full ER antagonism define the next generation of ER therapeutics
Journal Articles

Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927

Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Andiliy Lai, Celine Bonnefous, Karensa Douglas, John Sensintaffar, Nhin Lu, KyoungJin Lee, Anna Aparicio, Josh Kaufman, Jing Qian, Gang Shao, Rene Prudente, James D. Joseph, Beatrice Darimont, Daniel Brigham, Richard Heyman, Peter J. Rix, Jeffrey H. Hager, Nicholas D. Smith, Robert A. Blake, Jae Chang, Edna Choo, Anneleen Daemen, Lori S. Friedman, Jane Guan, Steven Hartman, Ellen Ingalla, James R. Kiefer, Tracy Kleinheinz, Sharada Labadie, Ciara Metcalfe, Vidhi Mody, Michelle Nannini, Deepak Sampath, Amy Young, Maia Vinogradova, Wei Zhou, Jun Liang, Xiaojing Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1648.
https://doi.org/10.1158/1538-7445.AM2018-1648
Published: 01 July 2018
View article titled, Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
Journal Articles

Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization

Dan Li, Xiaojing Wang, Hong Mei, Erhu Fang, Lin Ye, Huajie Song, Feng Yang, Huanhuan Li, Kai Huang, Liduan Zheng, Qiangsong Tong
Journal: Cancer Research
Cancer Res (2018) 78 (5): 1169–1183.
https://doi.org/10.1158/0008-5472.CAN-17-2295
Published: 28 February 2018
View article titled, Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization
Open the PDF for Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization in another window
Includes: Supplementary data
Journal Articles

Abstract 3621: Characterization of the effects of estrogen receptor alpha Y537S and D538G mutations on receptor pharmacology

Steven J. Hartman, Tracy Kleinheinz, Jonathan White, Stephen Daly, Ria Goodwin, Wei Zhou, Jun Liang, Xiaojing Wang, Daniel F. Ortwine, Lori Friedman, Martin O’Rourke, Ciara Metcalfe, Robert A. Blake
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3621.
https://doi.org/10.1158/1538-7445.AM2017-3621
Published: 01 July 2017
View article titled, Abstract 3621: Characterization of the effects of estrogen receptor alpha Y537S and D538G mutations on receptor pharmacology
Journal Articles

Abstract 1864: Selective estrogen receptor degrader (SERD) activity in ESR1 mutant models

Wei Zhou, Robert A. Blake, Jim Nonomiya, Jing Qian, Lorna Kategaya, Ingrid Wertz, Anneleen Daemen, Thomas O'Brien, John Sensintaffar, Michael Moon, Michelle A. Nannini, Jason Oeh, Deepak Sampath, Xiaojing Wang, Nicholas Smith, Daniel Brigham, James Joseph, Jeffrey H. Hager, Lori S. Friedman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1864.
https://doi.org/10.1158/1538-7445.AM2015-1864
Published: 01 August 2015
View article titled, Abstract 1864: Selective estrogen receptor degrader (SERD) activity in ESR1 mutant models
Journal Articles

Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer

Manish K. Tripathi, Natasha G. Deane, Jing Zhu, Hanbing An, Shinji Mima, Xiaojing Wang, Sekhar Padmanabhan, Zhiao Shi, Naresh Prodduturi, Kristen K. Ciombor, Xi Chen, M. Kay Washington, Bing Zhang, R. Daniel Beauchamp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (23): 6947–6957.
https://doi.org/10.1158/0008-5472.CAN-14-1592
Published: 30 November 2014
View article titled, Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Open the PDF for Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4829: Evaluation prognostic significance of circulating tumor cells (CTCs) using multiplexed gold nanoparticles in patients with head and neck cancer

Xu Wang, Ximei Qian, Jonathan J. Beitler, Jun Zhang, Hyunseok Kang, Zhuo (Georgia) Chen, Kelly R. Magliocca, Xiaojing Wang, Zhengjia Chen, Shuming Nie, Dong M. Shin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4829.
https://doi.org/10.1158/1538-7445.AM2014-4829
Published: 01 October 2014
View article titled, Abstract 4829: Evaluation prognostic significance of circulating tumor cells (CTCs) using multiplexed gold nanoparticles in patients with head and neck cancer
Journal Articles

Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair

Patrick J. Halvey, Xiaojing Wang, Jing Wang, Ajaz A. Bhat, Punita Dhawan, Ming Li, Bing Zhang, Daniel C. Liebler, Robbert J.C. Slebos
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (1): 387–397.
https://doi.org/10.1158/0008-5472.CAN-13-2488
Published: 05 January 2014
View article titled, Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair
Open the PDF for Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair in another window
Includes: Supplementary data