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Journal Articles

Abstract LB564: (±) 14,15-epoxyeicosatrienoic acid induces hallmark ER and MYC gene expression and associated ER and c-Myc nuclear translocation in ER+/HER2- breast cancer cells

Jianxun Lei, Zhijun Guo, Julissa Molina-Vega, Paloma Cervantes, Swaathi Jayaraman, John R. Hawse, Carlos Perez, Juan Abrahante, Xiaojia Tang, Krishna Kalari, Jinhua Wang, John R. Falck, Carol Lange, Matthew P. Goetz, David Potter

Cancer Res (2022) 82 (12_Supplement): LB564.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB564

Published: 15 June 2022

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Journal Articles

Abstract P3-08-02: The frequency and somatic mutation landscape of Fibroblast growth factor receptor (FGFR) alterations in breast cancer

Karthik V Giridhar, Ethan S Sokol, Peter T Vedell, Jason P Sinnwell, Aakash Desai, Tufia C Haddad, Ciara C O’Sullivan, Roberto A Leon-Ferre, Siddhartha Yadav, Kostandinos Sideras, Brenda Ernst, Minetta C Liu, Abe Eyman Casey, Xiaojia Tang, Zoe Fleischmann, Karthikeyan Murugesan, Krishna R Kalari, Matthew P Goetz

Cancer Res (2022) 82 (4_Supplement): P3-08-02.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-08-02

Published: 15 February 2022

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Journal Articles

Abstract P5-13-22: Serum thymidine kinase 1 activity (TKa) levels and progression-free survival (PFS) in patients (pts) with hormone receptor positive (HR+) HER2-negative metastatic breast cancer (MBC) on palbociclib (Pb) and endocrine therapy (ET)

Cancer Res (2022) 82 (4_Supplement): P5-13-22.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-13-22

Published: 15 February 2022

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Journal Articles

Abstract P4-01-05: Multi-omics data shows downregulation of mismatch repair, purin and tublin pathways in AR-negative triple-negative chemotherapy-resistant tumors

Krishna R Kalari, Vera J Suman, Xiaojia Tang, Jason P Sinnwell, Kevin J Thompson, Peter T Vedell, Jodi M Carter, Sarah A McLaughlin, Alvaro Moreno Aspitia, Donald W Northfelt, Richard J Gray, Richard Weinshilboum, Liewei Wang, Judy C Boughey, Matthew Goetz

Cancer Res (2022) 82 (4_Supplement): P4-01-05.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P4-01-05

Published: 15 February 2022

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Journal Articles

Abstract P4-01-03: Multiomics data reveal novel biomarkers for CDK4/6 resistance

Cancer Res (2022) 82 (4_Supplement): P4-01-03.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P4-01-03

Published: 15 February 2022

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Journal Articles

Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death

Nagarajan Kannan, Syed Mohammed Musheer Aalam, Xiaojia Tang, Krishna Kalari, Purna Kashyap, Jun Chen, Stephen Johnson, Anguraj Sadanandam, Mark Sherman

Cancer Res (2021) 81 (13_Supplement): LB226.

DOI: https://doi.org/10.1158/1538-7445.AM2021-LB226

Published: 01 July 2021

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Journal Articles

Abstract PD7-04: Association between patient derived xenograft (PDX) take rate and breast cancer recurrence in the prospective breast cancer genome guided therapy study (BEAUTY)

Judy C. Boughey, Vera J. Suman, Jia Yu, Katelyn Santo, Jason P. Sinnwell, Jodi M. Carter, Krishna R. Kalari, Xiaojia Tang, Sarah A. McLaughlin, Alvaro Moreno Aspitia, John A. Copland, III, Donald W. Northfelt, Richard J. Gray, Katie N. Hunt, Amy Lynn Conners, Richard Weinshilboum, Liewei Wang, Matthew P. Goetz

Cancer Res (2021) 81 (4_Supplement): PD7-04.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD7-04

Published: 15 February 2021

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Journal Articles

Abstract PD8-04: Antitumor activity of Z-endoxifen (ENDX) is mediated via PKCβ1-dependent ERα loss and cell cycle arrest in ERα-positive breast cancer

Swaathi Jayaraman, Mary J Kuffel, Krishna R Kalari, Kevin J Thompson, Xiaojia Tang, Vera J Suman, Elizabeth S Bruinsma, Ciara C O'Sullivan, Liewei Wang, Richard Weinshilboum, James N Ingle, John R Hawse, Matthew P Goetz

Cancer Res (2021) 81 (4_Supplement): PD8-04.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD8-04

Published: 15 February 2021

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Journal Articles

Abstract PS5-24: Novel genomic variants and pathways associated with baseline serum thymidine kinase 1 levels in HR-positive HER2-negative MBC patients commencing palbociclib and letrozole

Cancer Res (2021) 81 (4_Supplement): PS5-24.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS5-24

Published: 15 February 2021

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Journal Articles

Abstract P2-11-07: Comprehensive tumor sequencing to identify biomarkers of palbociclib response: First report of the PROMISE study

Cancer Res (2020) 80 (4_Supplement): P2-11-07.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-11-07

Published: 15 February 2020

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Journal Articles

Abstract P4-09-03: Phenotypes of breast tumor cells and normal lymphocytes are determined by the integration of minor changes in expression of multiple genes: A new dimension in quantitative inheritance

Larry R Pease, Sara J Felts, Adam D Scheid, Xiaojia Tang, Krishna R Kalari

Cancer Res (2020) 80 (4_Supplement): P4-09-03.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-P4-09-03

Published: 15 February 2020

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Journal Articles

Abstract P6-04-06: Protein kinase C beta 1 (PKCβ1), a novel drug target of Z-endoxifen, inhibits growth of estrogen receptor positive (ER+) breast cancer via activation of the NF-kB transcription factor RelA

Swaathi Jayaraman, Mary J Kuffel, Krishna R Kalari, Kevin J Thompson, Xiaojia Tang, Elizabeth S Bruinsma, John R Hawse, Matthew P Goetz

Cancer Res (2020) 80 (4_Supplement): P6-04-06.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-P6-04-06

Published: 15 February 2020

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Journal Articles

Abstract 2898: Stochastic variation in gene expression is selected during clonal evolution of spontaneous mouse mammary tumors

Sara J. Felts, Xiaojia Tang, Virginia P. Van Keulen, Krishna R. Kalari, Larry R. Pease

Cancer Res (2019) 79 (13_Supplement): 2898.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2898

Published: 01 July 2019

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Journal Articles

Abstract 3298: Distinct microbiome populations within breast cancer microenvironments

Kevin J. Thompson, Jason Sinnwell, Xiaojia Tang, James N. Ingle, Matthew P. Goetz, Krishna R. Kalari

Cancer Res (2016) 76 (14_Supplement): 3298.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3298

Published: 15 July 2016

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Journal Articles

Abstract PD3-3: Impact of neoadjuvant chemotherapy on the clonal composition of breast cancer

Cancer Res (2015) 75 (9_Supplement): PD3-3.

DOI: https://doi.org/10.1158/1538-7445.SABCS14-PD3-3

Published: 01 May 2015

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Journal Articles

Abstract 1195: Feasibility of using percutaneous tumor biopsies from a prospective neoadjuvant breast cancer study to develop patient derived xenografts and assess in vivo chemotherapy sensitivity

Cancer Res (2014) 74 (19_Supplement): 1195.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1195

Published: 01 October 2014

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Journal Articles

Abstract 4185: Analysis of sequencing data to identify potential drug targets for an individual newly diagnosed with basal breast cancer who failed to respond to current standard neoadjuvant chemotherapy

Cancer Res (2014) 74 (19_Supplement): 4185.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4185

Published: 01 October 2014

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Journal Articles

Abstract 5592: Molecular classification of triple negative breast cancer via RNA-sequencing data

Kevin J. Thompson, Xiaojia Tang, Zhifu Sun, Jason P. Sinnwell, Hugues Sicotte, Douglas W. Mahoney, Steven Hart, Peter T. Vedell, Poulami Barman, Jeanette E. Eckel Passow, Eric D. Wieben, James N. Ingle, Judy C. Boughey, Liewei Wang, Richard Weinshilboum, Krishna R. Kalari, Matthew P. Goetz

Cancer Res (2014) 74 (19_Supplement): 5592.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5592

Published: 01 October 2014

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Journal Articles

Abstract 3185: The eSNV-Detect: a computational system to identify expressed single nucleotide variants from tumor transcriptomes.

Xiaojia Tang, Saurabh Baheti, Khader Shameer, Kevin J. Thompson, Jean-Pierre Kocher, Edith A. Perez, Aubrey E. Thompson, Krishna R. Kalari

Cancer Res (2013) 73 (8_Supplement): 3185.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3185

Published: 15 April 2013

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Journal Articles

Abstract 4926: Modeling the transcriptome landscape of HER2+ breast cancer

Krishna R. Kalari, High-Seng Chai, Yan W. Asmann, Xiaojia Tang, David Rossell, Saurabh Baheti, Asha Nair, Tiffany R. Baker, Brian M. Necela, Jennifer M. Carr, Steve N. Hart, Zhifu Sun, Jennifer M. Kachergus, Curtis S. Younkin, Jean-Pierre A. Kocher, Aubrey E. Thompson, Edith A. Perez

Cancer Res (2012) 72 (8_Supplement): 4926.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4926

Published: 15 April 2012

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NARROW

Abstract LB564: (±) 14,15-epoxyeicosatrienoic acid induces hallmark ER and MYC gene expression and associated ER and c-Myc nuclear translocation in ER+/HER2- breast cancer cells

Abstract P3-08-02: The frequency and somatic mutation landscape of Fibroblast growth factor receptor (FGFR) alterations in breast cancer

Abstract P5-13-22: Serum thymidine kinase 1 activity (TKa) levels and progression-free survival (PFS) in patients (pts) with hormone receptor positive (HR+) HER2-negative metastatic breast cancer (MBC) on palbociclib (Pb) and endocrine therapy (ET)

Abstract P4-01-05: Multi-omics data shows downregulation of mismatch repair, purin and tublin pathways in AR-negative triple-negative chemotherapy-resistant tumors

Abstract P4-01-03: Multiomics data reveal novel biomarkers for CDK4/6 resistance

Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death

Abstract PD7-04: Association between patient derived xenograft (PDX) take rate and breast cancer recurrence in the prospective breast cancer genome guided therapy study (BEAUTY)

Abstract PD8-04: Antitumor activity of Z-endoxifen (ENDX) is mediated via PKCβ1-dependent ERα loss and cell cycle arrest in ERα-positive breast cancer

Abstract PS5-24: Novel genomic variants and pathways associated with baseline serum thymidine kinase 1 levels in HR-positive HER2-negative MBC patients commencing palbociclib and letrozole

Abstract P2-11-07: Comprehensive tumor sequencing to identify biomarkers of palbociclib response: First report of the PROMISE study

Abstract P4-09-03: Phenotypes of breast tumor cells and normal lymphocytes are determined by the integration of minor changes in expression of multiple genes: A new dimension in quantitative inheritance

Abstract P6-04-06: Protein kinase C beta 1 (PKCβ1), a novel drug target of Z-endoxifen, inhibits growth of estrogen receptor positive (ER+) breast cancer via activation of the NF-kB transcription factor RelA

Abstract 2898: Stochastic variation in gene expression is selected during clonal evolution of spontaneous mouse mammary tumors

Abstract 3298: Distinct microbiome populations within breast cancer microenvironments

Abstract PD3-3: Impact of neoadjuvant chemotherapy on the clonal composition of breast cancer

Abstract 1195: Feasibility of using percutaneous tumor biopsies from a prospective neoadjuvant breast cancer study to develop patient derived xenografts and assess in vivo chemotherapy sensitivity

Abstract 4185: Analysis of sequencing data to identify potential drug targets for an individual newly diagnosed with basal breast cancer who failed to respond to current standard neoadjuvant chemotherapy

Abstract 5592: Molecular classification of triple negative breast cancer via RNA-sequencing data

Abstract 3185: The eSNV-Detect: a computational system to identify expressed single nucleotide variants from tumor transcriptomes.

Abstract 4926: Modeling the transcriptome landscape of HER2+ breast cancer

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