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Journal Articles

Abstract LB061: Evaluation of the in vivo efficacy of the B7-H3 targeting antibody-drug conjugate (ADC) DS7300a: A report fro the Pediatric Preclinical In Vivo Resting (PIVOT) program

Richard Gorlick, E. Anders Kolb, Yifei Wang, Peter Houghton, Raushan Kurmasheva, Yael Mosse, John Maris, Matthew Tsang, David Groff, Kateryna Krytska, Xiao-Nan Li, Yuchen Du, Jun Hasegawa, Nanae Izumi, Steven Neuhauser, Anuj Srivastava, Tim Stearns, Vivek Philip, Emily L. Jocoy, Jeff Chuang, Carol J. Bult, Beverly Teicher, Malcolm Smith
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB061.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB061
Published: 15 June 2022
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Journal Articles

Abstract 912: A novel genetically engineered H3.3G34R model reveals cooperation with ATRX loss in upregulation of PRC2 target genes

Aalaa Abdallah, Herminio J. Cardona, David J. Picketts, Daniel J. Brat, Xiao-Nan Li, Oren J. Becher
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 912.
DOI: https://doi.org/10.1158/1538-7445.AM2022-912
Published: 15 June 2022
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Journal Articles

Abstract 3898: Discovering novel therapies in the treatment of osteosarcoma

Casey Mehrhoff, Yuchen Du, Sophie Xiao, Robert Byrd, Chris Tsz-Kwong Man, Daniele Procissi, David Walterhouse, Xiao Nan Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3898.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3898
Published: 15 June 2022
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Journal Articles

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma

Jessica M. Rusert, Edwin F. Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Sameerah Wahab, Yoko T. Udaka, Darren Finlay, Huriye Seker-Cin, Brendan Reardon, Susanne Gröbner, Jonathan Serrano, Jonas Ecker, Lin Qi, Mari Kogiso, Yuchen Du, Patricia A. Baxter, Jacob J. Henderson, Michael E. Berens, Kristiina Vuori, Till Milde, Yoon-Jae Cho, Xiao-Nan Li, James M. Olson, Iris Reyes, Matija Snuderl, Terence C. Wong, David P. Dimmock, Shareef A. Nahas, Denise Malicki, John R. Crawford, Michael L. Levy, Eliezer M. Van Allen, Stefan M. Pfister, Pablo Tamayo, Marcel Kool, Jill P. Mesirov, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5393–5407.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1655
Published: 02 December 2020
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Includes: Supplementary data
Journal Articles

Abstract IA11: Overcoming immune evasion in pediatric brain tumors

Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan, Meher B. Masihi, Jessica M. Rusert, Paula S. Norris, Florent Carrette, Megan M. Romero, Sorana A. Morrissy, Patryk Skowron, Florence M.G. Cavalli, Hamza Farooq, Vijay Ramaswamy, Alaide Morcavallo, Jacob J. Henderson, James M. Olson, Yoon-Jae Cho, Xiao-Nan Li, Louis Chesler, Marco A. Marra, Oren J. Becher, Linda M. Bradley, Carl F. Ware, Michael D. Taylor, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA11.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-IA11
Published: 15 July 2020
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Journal Articles

Abstract B17: A C19MC-LIN28A-MYCN oncogenic circuit driven by hijacked super-enhancers is a distinct therapeutic vulnerability in ETMRs—a lethal brain tumor

Iqra Mumal, Patrick Sin-Chan, Tannu Suwal, Irtisha Singh, Xiao-Nan Li, Charles Lin, Stephen Mack, Jeremy Rich, Annie Huang
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B17.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B17
Published: 15 July 2020
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Journal Articles

Abstract LB-320: PPTC testing of an OLIG2 inhibitor CT-179 in patient-derived orthotopic xenograft mouse models of pediatric GBM

Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank Braun, Mari Kogiso, Sarah Injac, Mary Sobieski, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Stephen Erickson, Beverly Teicher, Malcolm A. Smith, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-320.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-320
Published: 01 July 2019
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Journal Articles

Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts

Eric Earley, Richard Gorlick, Peter J. Houghton, John M. Maris, Xiao-Nan Li, Richard B. Lock, Beverly Teicher, Malcolm A. Smith, Stephen W. Erickson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-321.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-321
Published: 01 July 2019
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Journal Articles

Abstract A47: Inhibition of histone methyltransferase with novel epipolythiodioxopiperazines (ETP) alkaloids in pediatric high-grade glioma

Stephen Dombrowski, Thamara Abou-Antoun, Anthony Mansour, Rewa Arar, Mohammad Movassaghi, Erin Murphy, Shuvojit Banerjee, Xiao-Nan Li, Peter Houghton, Darell Bigner, Angel Montero Carcaboso, Jeremy Rich, Violette Recinos
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): A47.
DOI: https://doi.org/10.1158/1538-7445.PEDCA17-A47
Published: 01 October 2018
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Journal Articles

Abstract LB-167: Novel LSD-1 inhibitor validation in new established clinically PFA patient-derived orthotopic xenograft (PDOX) models of ependymoma

Huiyuan Zhang, Sibo Zhao, Yuchen Du, Lin Qi, Frank K. Braun, Mari Kogiso, Holly B. Lindsay, Sarah G. Injac, Laszlo Perlaky, Patricia Baxter, Jack M. Su, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-167.
DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-167
Published: 01 July 2018
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Journal Articles

Abstract 3841: A hybrid mapping approach improves genomic and transcriptomic analysis of patient derived orthotropic xenograft (PDOX) models of pediatric CNS tumors

Oliver A. Hampton, Michael C. Gundry, Mari Kogiso, Lin Qi, Yuchen Du, Yulun Huang, Frank K. Braun, Huiyuan Zhang, Sibo Zhao, Holly Lindsay, Sarah G. Injac, David A. Wheeler, Xiao-Nan Li, D. William Parsons
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3841.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3841
Published: 01 July 2017
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Journal Articles

Abstract 3214: Systematic drug repurposing for faster cures of pediatric cancer identifies that Digoxin prolongs survival in a PDOX model of group 4 medulloblastoma

Lei Huang, Sarah G. Injac, Hong Zhao, Qi Lin, Mari Kogiso, Chris T. Man, Xiao-Nan Li, Ching C. Lau, Stephen T. Wong
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3214.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3214
Published: 01 July 2017
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Journal Articles

Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors

Sebastian Brabetz, Susanne N. Gröbner, Huriye Seker-Cin, Florian Selt, Till Milde, David T. Jones, Madison T. Wise, Jessica M. Rusert, Kyle Pedro, Andy Strand, Olaf Witt, Sarah E. Leary, Xiao-Nan Li, Robert J. Wechsler-Reya, James M. Olson, Stefan M. Pfister, Marcel Kool
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1935.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1935
Published: 01 July 2017
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Journal Articles

Abstract 5058: Lysine specific demethylase-1 (LSD-1) Inhibitor SYC-836 in combination with radiation prolongs animal survival in patient-derived posterior fossa ependymoma xenograft mouse models

Sibo Zhao, Huiyuan Zhang, Lin Qi, Holly Lindsay, Yuchen Du, Mari Kogiso, Frank Braun, Sarah Injac, Laszlo Perlaky, Donald W. Parsons, Murali Chintagumpala, Adekunle Adesina, Yongcheng Song, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5058.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5058
Published: 01 July 2017
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Journal Articles

Abstract 2821: Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-responses in patient derived orthotopic xenograft models (PDOX) of malignant brain tumors

Lin Qi, Mari Kogiso, Yuchen Du, Huiyuan Zhang, Frank Braun, Holly Lindsay, Sibo Zhao, Sarah Injac, Patricia Baxter, Zhigang Liu, Yujing Zhang, Jack Su, Adekunle Adesina, Andrew Walter, Jeffery Murray, Javad Nazarian, Will Parsons, Murali Chintagumpala, Xiao-nan Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2821.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2821
Published: 01 July 2017
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Journal Articles

Abstract 4031: Mutant isocitrate dehydrogenase 1 (IDH1) inhibitor synergistically prolongs animal survival with standard therapies in patient-derived IDH1 mutant glioma xenograft mouse models

Mari Kogiso, Lin Qi, Huiyuan Zhang, Frank K. Braun, Yuchen Du, Yulun Huang, Holly Lindsay, Sibo Zhao, Sarah G. G. Injac, Zhen Liu, Patricia A. Baxter, Jack M. Su, Laszlo Perlaky, D. Williams Parsons, Murali Chintagumpala, Adekunle Adesina, Jialiang Wang, Yongcheng Song, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4031.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4031
Published: 01 July 2017
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Journal Articles

Abstract 4214: Identification of personalized active agents in pediatric gliomas through high-throughput drug screening in matching pairs of patient derived orthotopic xenograft (PDOX) neurosphere and monolayer cells

Lin Qi, Yuchen Du, Mari Kogiso, Goeun Bae, Frank Braun, Holly Lindsay, Huiyuan Zhang, Sibo Zhao, Sarah Injac, Patricia Baxter, Jack Su, Michael Mancini, Oliver Hampton, William Parsons, Murali Chintagumpala, Clifford Stephan, Peter Davies, Xiao-Nan Li, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4214.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4214
Published: 01 July 2017
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Journal Articles

Abstract 4812: A novel set of patient-derived orthotopic xenograft (PDOX) models of primary and recurrent intracranial meningioma

Huiyuan Zhang, Lin Qi, Yuchen Du, Frank K. Braun, Mari Kogiso, Sibo Zhao, Holly B. Lindsay, Sarah G. Injac, Patricia A. Baxter, Jack M. Su, Akash J. Patel, Xiao-nan Li, Baylor College of Medicine
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4812.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4812
Published: 01 July 2017
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Journal Articles

Abstract 4874: Application of quantitative analysis of mouse cell contamination and purification of human tumor cells in patient derived orthotopic xenograft mouse models of pediatric brain tumors

Frank K. Braun, Mari Kogiso, Lin Qi, Huiyuan Zhang, Yuchen Du, Holly B. Lindsay, Sibo Zhao, Sarah G. Injac, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4874.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4874
Published: 01 July 2017
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Journal Articles

Abstract 1950: Whole genome microRNA profiling in functionally validated invasive GBM cells identifies a novel set of microRNAs driving GBM invasion

Lin Qi, Yu-lun Huang, Hua Mao, Mari Kogiso, Xiumei Zhao, Yuchen Du, Holly Lindsay, Xiaojun Yuan, Patricia Baxter, Jack Su, Chris Man, Laszlo Perlaky, Zhong Wang, You-Xing Zhou, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1950.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1950
Published: 15 July 2016
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