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Journal Articles

Abstract CT010: Phase I dose-escalation and expansion study of JS107, a claudin 18.2 (CLDN18.2)-targeting antibody-drug conjugate (ADC), as monotherapy or in combination for patients (pts) with advanced solid tumors

Free
Rui-Hua Xu, Dan-Yun Ruan, Rong-Bo Lin, Jian-Zhen Shan, Peng Nie, Ying-Hua Ji, Jing Wang, Yu Cao, Fu-Nan Liu, Jie-Er Ying, Li Liu, Tao Zhang, Hui-Ting Xu, Yan-Qiao Zhang, Wen-Can Song, Jin Xia, Wen-Feng Li, Zhi-Ye Zhang, Jian Shi, Ming-Xia Wang, Long Wu, Yan-Yan Lu, Xiao Zhang, Yan-Yan Hu, Yong-Dong Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT010.
https://doi.org/10.1158/1538-7445.AM2025-CT010
Published: 25 April 2025
View articletitled, Abstract CT010: Phase I dose-escalation and expansion study of JS107, a claudin 18.2 (CLDN18.2)-targeting antibody-drug conjugate (ADC), as monotherapy or in combination for patients (pts) with advanced solid tumors
Journal Articles

Abstract 3064: The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma

Free
Fuhao Wang, Ming Chang, Xiao Zhang, Xiaoyi Li, Zhiying Chen, Wei Zhang, Jian Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3064.
https://doi.org/10.1158/1538-7445.AM2025-3064
Published: 21 April 2025
View articletitled, Abstract 3064: The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma
Journal Articles

Abstract 4384: SYNB021225: a potent oral pan-KRAS peptide inhibitor that can address unmet needs of small molecule inhibitors

Free
Michael Poss, Caihong Zhou, Cheng Lu, Ruochi Zhang, Yu Wang, Yuanpeng Xiong, Xin Gao, Xiao Zhang, Yan Degenhardt
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4384.
https://doi.org/10.1158/1538-7445.AM2025-4384
Published: 21 April 2025
View articletitled, Abstract 4384: SYNB021225: a potent oral pan-KRAS peptide inhibitor that can address unmet needs of small molecule inhibitors
Journal Articles

Abstract 1761: SYNB011128: A novel bispecific peptide-drug-conjugate targeting EGFR and CAIX

Free
Caihong Zhou, Michael Poss, Cheng Lu, Ruochi Zhang, Yu Wang, Yuanpeng Xiong, Xin Gao, Xiao Zhang, Yan Degenhardt
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1761.
https://doi.org/10.1158/1538-7445.AM2025-1761
Published: 21 April 2025
View articletitled, Abstract 1761: SYNB011128: A novel bispecific peptide-drug-conjugate targeting EGFR and CAIX
Journal Articles

Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming That Drives Immune Evasion

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Linlin Yan, Mingming Wu, Tianyu Wang, Hui Yuan, Xiao Zhang, Huafeng Zhang, Tao Li, Vijay Pandey, Xinghua Han, Peter E. Lobie, Tao Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1270–1285.
https://doi.org/10.1158/0008-5472.CAN-23-2390
Published: 15 April 2024
View articletitled, Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming That Drives Immune Evasion
Open the PDF for Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming That Drives Immune Evasion in another window
Includes: Supplementary data
Journal Articles

Abstract LB055: IBI3001: A potentially first-in-class site-specifically conjugated B7-H3/EGFR bispecific ADC for multiple solid tumors

Free
Jian Guan, Xiao Zhang, Weiwei Wu, Lei Cao, Zhengguang Liao, Tianyu Zhu, Chentao Liu, Shuaixiang Zhou, Jia Lu, Ninghuan Li, Nana Luo, Ying Zhang, Kang Dian, Tiong Sun Chia, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB055.
https://doi.org/10.1158/1538-7445.AM2024-LB055
Published: 05 April 2024
View articletitled, Abstract LB055: IBI3001: A potentially first-in-class site-specifically conjugated B7-H3/EGFR bispecific ADC for multiple solid tumors
Journal Articles

Abstract 161: Aged mice decelerate bone metastasis of prostate cancer by decreasing infiltration of M2 macrophages

Free
Xiao Zhang, Wei Yu, Xin Huang, Yi Lu, Jian Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 161.
https://doi.org/10.1158/1538-7445.AM2024-161
Published: 22 March 2024
View articletitled, Abstract 161: Aged mice decelerate bone metastasis of prostate cancer by decreasing infiltration of M2 macrophages
Journal Articles

Abstract 7054: L1-ATP8B1 exacerbates high-level reduction-oxidation homeostasis to promote carcinogenesis via affecting PHB1 sumoylation in LUSC

Free
Rui Zhang, Xiao Zhang, Zeguo Sun, Pengpeng Liu, Guidong Chen, Weijia Zhang, Jinpu Yu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7054.
https://doi.org/10.1158/1538-7445.AM2024-7054
Published: 22 March 2024
View articletitled, Abstract 7054: L1-ATP8B1 exacerbates high-level reduction-oxidation homeostasis to promote carcinogenesis via affecting PHB1 sumoylation in LUSC
Journal Articles

Abstract 2752: ICA1 promotes prostate cancer progression and metastasis via AR down-regulation

Free
Fuhao Wang, Yu He, Xin Huang, Ming Chang, Xiao Zhang, Xiaoyi Li, Xinyu Ye, Yi Lu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2752.
https://doi.org/10.1158/1538-7445.AM2024-2752
Published: 22 March 2024
View articletitled, Abstract 2752: ICA1 promotes prostate cancer progression and metastasis via AR down-regulation
Journal Articles

Abstract LB251: Blocking genomic instability delays acquired resistance to MAPK inhibitor therapy in melanoma

Free
Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, Roger S. Lo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB251.
https://doi.org/10.1158/1538-7445.AM2023-LB251
Published: 14 April 2023
View articletitled, Abstract LB251: Blocking genomic instability delays acquired resistance to MAPK inhibitor therapy in melanoma
Journal Articles

Abstract LB562: L1-ATP8B1 exacerbated pathogenic high-level reduction-oxidation homeostasis to promote carcinogenesis in lung squamous cell carcinoma via affecting mitochondrial prohibitin 1 SUMOylation and increasing SLC1A5 expression

Free
Jinpu Yu, Xiao Zhang, Rui Zhang, Zeguo Sun, Weijia Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB562.
https://doi.org/10.1158/1538-7445.AM2022-LB562
Published: 15 June 2022
View articletitled, Abstract LB562: L1-ATP8B1 exacerbated pathogenic high-level reduction-oxidation homeostasis to promote carcinogenesis in lung squamous cell carcinoma via affecting mitochondrial prohibitin 1 SUMOylation and increasing SLC1A5 expression
Journal Articles

EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation

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Xiaobing Duan, Haiwen Chen, Xiang Zhou, Pingjuan Liu, Xiao Zhang, Qian Zhu, Ling Zhong, Wanlin Zhang, Shanshan Zhang, Xinyu Zhang, Yanhong Chen, Yan Zhou, Chaopin Yang, Qisheng Feng, Yi-Xin Zeng, Miao Xu, Tong Xiang
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1070–1083.
https://doi.org/10.1158/0008-5472.CAN-21-2292
Published: 15 March 2022
View articletitled, EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Open the PDF for EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation in another window
Includes: Supplementary data
Journal Articles

Abstract P4-11-14: Importance of work and work-related needs among survivors living with metastatic breast cancer

Free
Cibele B. Carroll, Mary E. Sesto, Xiao Zhang, Karen B. Chen, Abigail Terhaar, Athena S. Wilson, Amye J. Tevaarwerk
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-11-14.
https://doi.org/10.1158/1538-7445.SABCS21-P4-11-14
Published: 15 February 2022
View articletitled, Abstract P4-11-14: Importance of work and work-related needs among survivors living with metastatic breast cancer
Journal Articles

Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression

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Hui Yuan, Linlin Yan, Mingming Wu, Yinzhong Shang, Qianying Guo, Xin Ma, Xiao Zhang, Yong Zhu, Zhengsheng Wu, Peter E. Lobie, Tao Zhu
Journal: Cancer Research
Cancer Res (2022) 82 (3): 391–405.
https://doi.org/10.1158/0008-5472.CAN-21-1155
Published: 02 February 2022
View articletitled, Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression
Open the PDF for Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY

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Rui Zhang, Fan Zhang, Zeguo Sun, Pengpeng Liu, Xiao Zhang, Yingnan Ye, Beiqi Cai, Martin J. Walsh, Xiubao Ren, Xishan Hao, Weijia Zhang, Jinpu Yu
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4453–4465.
https://doi.org/10.1158/0008-5472.CAN-19-0076
Published: 03 September 2019
View articletitled, LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Open the PDF for LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY in another window
Includes: Supplementary data
Journal Articles

Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

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Luca D'Agostino, Yingchao Nie, Sayantani Goswami, Kevin Tong, Shiyan Yu, Sheila Bandyopadhyay, Juan Flores, Xiao Zhang, Iyshwarya Balasubramanian, Ivor Joseph, Ryotaro Sakamori, Victoria Farrell, Qi Li, Chung S. Yang, Bin Gao, Ronaldo P. Ferraris, Ghassan Yehia, Edward M. Bonder, James R. Goldenring, Michael P. Verzi, Lanjing Zhang, Y. Tony Ip, Nan Gao
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (16): 4099–4112.
https://doi.org/10.1158/0008-5472.CAN-18-4075
Published: 15 August 2019
View articletitled, Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Open the PDF for Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 3908: The combination of NVP-BEZ235 & endostatin exerts synergistic anticancer activity against triple-negative breast cancer in vitro and in vivo

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Xiaoshan Wang, Xiao Zhang, Fanghua Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3908.
https://doi.org/10.1158/1538-7445.AM2019-3908
Published: 01 July 2019
View articletitled, Abstract 3908: The combination of NVP-BEZ235 & endostatin exerts synergistic anticancer activity against triple-negative breast cancer in vitro and in vivo
Journal Articles

A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis

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Guifang Yan, Huakan Zhao, Qi Zhang, Yu Zhou, Lei Wu, Juan Lei, Xiang Wang, Jiangang Zhang, Xiao Zhang, Lu Zheng, Guangsheng Du, Weidong Xiao, Bo Tang, Hongming Miao, Yongsheng Li
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (19): 5586–5599.
https://doi.org/10.1158/0008-5472.CAN-17-3962
Published: 01 October 2018
View articletitled, A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis
Open the PDF for A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis in another window
Includes: Supplementary data
Journal Articles

Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer

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Weijie Zhang, Mingming Wu, Qing-Yun Chong, Min Zhang, Xiao Zhang, Lan Hu, Yanghao Zhong, Pengxu Qian, Xiangjun Kong, Sheng Tan, Gaopeng Li, Keshuo Ding, Peter E. Lobie, Tao Zhu
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4915–4928.
https://doi.org/10.1158/0008-5472.CAN-18-0069
Published: 04 September 2018
View articletitled, Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer
Open the PDF for Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway

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Tao Yu, Yingjun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He, Ming Yao
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5782–5794.
https://doi.org/10.1158/0008-5472.CAN-17-0671
Published: 31 October 2017
View articletitled, MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway
Open the PDF for MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway in another window
Includes: Supplementary data