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Journal Articles

Abstract 2810: Investigating the oncogenic function of the long noncoding RNA KCNQ1OT1 in rhabdomyosarcoma

Ara Jo, Alex Kovach, Christian Stackhouse, Samantha Weitzel, Brian Masters, Justina McEvoy, Wenyue Sun, Frederic G. Barr, Mauro Calabrese, Xiang Chen, Corinne M. Linardic
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2810.
https://doi.org/10.1158/1538-7445.AM2025-2810
Published: 21 April 2025
View articletitled, Abstract 2810: Investigating the oncogenic function of the long noncoding RNA KCNQ1OT1 in rhabdomyosarcoma
Journal Articles

Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma

Tingting Wang, Lingling Liu, Jie Fang, Hongjian Jin, Sivaraman Natarajan, Heather Sheppard, Meifen Lu, Gregory Turner, Thomas Confer, Melissa Johnson, Jeffrey Steinberg, Larry Ha, Nour Yadak, Richa Jain, David J. Picketts, Xiaotu Ma, Andrew Murphy, Andrew M. Davidoff, Evan S. Glazer, John Easton, Xiang Chen, Ruoning Wang, Jun Yang
Journal: Cancer Research
Cancer Res (2025) 85 (3): 424–441.
https://doi.org/10.1158/0008-5472.CAN-24-1142
Published: 01 February 2025
View articletitled, Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Open the PDF for Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma in another window
Includes: Supplementary data
Journal Articles

Neural Circuitries between the Brain and Peripheral Solid Tumors

Xiang Chen, Yuli Geng, Guanxin Wei, Danzeng He, Jialong Lv, Wenhao Wen, Fan Xiang, Kaixiong Tao, Chuanqing Wu
Journal: Cancer Research
Cancer Res (2024) 84 (21): 3509–3521.
https://doi.org/10.1158/0008-5472.CAN-24-1779
Published: 04 November 2024
View articletitled, Neural Circuitries between the Brain and Peripheral Solid Tumors
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Journal Articles

The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression

Dandan Liu, Benliang Wei, Long Liang, Yue Sheng, Shengjie Sun, Xing Sun, Maohua Li, Haobo Li, Chaoying Yang, Yuanliang Peng, Yifang Xie, Chengcai Wen, Lu Chen, Xionghao Liu, Xiang Chen, Hong Liu, Jing Liu
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2265–2281.
https://doi.org/10.1158/0008-5472.CAN-23-3942
Published: 15 July 2024
View articletitled, The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression
Open the PDF for The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression in another window
Includes: Supplementary data
Journal Articles

Abstract 4943: Benchmarking unpaired single-cell RNA and single-cell ATAC integration

Jiani Chen, Wanzi Xiao, Eric Zhang, Xiang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4943.
https://doi.org/10.1158/1538-7445.AM2024-4943
Published: 22 March 2024
View articletitled, Abstract 4943: Benchmarking unpaired single-cell RNA and single-cell ATAC integration
Journal Articles

Abstract 1394: The CXCL10-CXCR3 axis as Jekyll and Hyde: A regulator of metastasis and immune response in osteosarcoma

Benjamin B. Gyau, Xiang Chen, Junyan Wang, Margaret A. Clement, Angela M. Major, Jun Xu, M. John Hicks, Tsz-Kwong Man
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1394.
https://doi.org/10.1158/1538-7445.AM2024-1394
Published: 22 March 2024
View articletitled, Abstract 1394: The CXCL10-CXCR3 axis as Jekyll and Hyde: A regulator of metastasis and immune response in osteosarcoma
Journal Articles

Abstract 4132: Low-dose carbon monoxide therapies suppress cancer metastasis

Tiantian Zhang, Cheryl Zhang, Xiang Chen, Xiaoxiao Yang, Qiyue Mao, George Zhang, Zhengming Chen, Adrian Tan, Jenny Zhaoying Xiang, Erika Hissong, Yao-Tseng Chen, Binghe Wang, Nancy Du
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4132.
https://doi.org/10.1158/1538-7445.AM2024-4132
Published: 22 March 2024
View articletitled, Abstract 4132: Low-dose carbon monoxide therapies suppress cancer metastasis
Journal Articles

Abstract 3954: Increased mosaic chromosomal alterations among survivors of childhood acute myeloid leukemia

Xijun Zhang, Na Qin, Qian Dong, Cheng Chen, John Easton, Heather Mulder, Xiang Chen, Kyla Shelton, Cindy Im, Yutaka Yasui, Greg Armstrong, Kirsten K. Ness, Melissa M. Hudson, Paul Auer, Jinghui Zhang, Zhaoming Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3954.
https://doi.org/10.1158/1538-7445.AM2024-3954
Published: 22 March 2024
View articletitled, Abstract 3954: Increased mosaic chromosomal alterations among survivors of childhood acute myeloid leukemia
Journal Articles

Abstract 7419: Seq2Karyotype (S2K): A method for deconvoluting heterogeneity of copy number alterations using single-sample whole-genome sequencing data

Limeng Pu, Karol Szlachta, Virginia Valentine, Xiaolong Chen, Jian Wang, Dennis Kennetz, Daniel Putnam, Sivaraman Natarajan, Li Dong, Thomas Look, Marcin Wlodarski, Lu Wang, Steven Burden, John Easton, Xiang Chen, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7419.
https://doi.org/10.1158/1538-7445.AM2024-7419
Published: 22 March 2024
View articletitled, Abstract 7419: Seq2Karyotype (S2K): A method for deconvoluting heterogeneity of copy number alterations using single-sample whole-genome sequencing data
Journal Articles

Abstract A114: Low-dose carbon monoxide halts pancreatic cancer metastasis

Tiantian Zhang, George Zhang, Xiang Chen, Zhengming Chen, Adrian Y. Tan, Anthony Lin, Cheryl Zhang, Guoan Zhang, Jenny Xiang, Erika Hissong, Yao-Tseng Chen, Nancy Du
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A114.
https://doi.org/10.1158/1538-7445.PANCA2023-A114
Published: 16 January 2024
View articletitled, Abstract A114: Low-dose carbon monoxide halts pancreatic cancer metastasis
Journal Articles

Abstract 1307: The effect of circulating CXCL10 on osteosarcoma metastasis using orthotopic xenograft mouse models

Xiang Chen, Margaret Clement, John Hicks, Tsz Kwong Man
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1307.
https://doi.org/10.1158/1538-7445.AM2023-1307
Published: 04 April 2023
View articletitled, Abstract 1307: The effect of circulating CXCL10 on osteosarcoma metastasis using orthotopic xenograft mouse models
Journal Articles

Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors

Karissa Dieseldorff Jones, Waise Quarni, Daniel Putnam, Shivendra Singh, Qiong Wu, Jun Yang, Xiang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5363.
https://doi.org/10.1158/1538-7445.AM2023-5363
Published: 04 April 2023
View articletitled, Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors
Journal Articles

Abstract 4363: Monocyte-specific epigenetic age acceleration and cardiomyopathy risk among survivors of childhood cancer

Cheng Chen, Qian Dong, Qin Na, Nan Song, John Easton, Heather L. Mulder, Emily Walker, Geoffrey Neale, Emily R. Finch, Qian Li, Yutaka Yasui, Daniel A. Mulrooney, Melissa M. Hudson, Kirsten K. Ness, Jinghui Zhang, Xiang Chen, Hui Wang, Leslie L. Robison, Zhaoming Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4363.
https://doi.org/10.1158/1538-7445.AM2023-4363
Published: 04 April 2023
View articletitled, Abstract 4363: Monocyte-specific epigenetic age acceleration and cardiomyopathy risk among survivors of childhood cancer
Journal Articles

Abstract B023: RHAMMB promotes pancreatic cancer metastasis

Xiang Chen, Tiantian Zhang, Seung Koo Lee, Dunrui Wang, Zhengming Chen, Ching-Hsuan Tung, Yao-Tseng Chen, Yi-Chieh Nancy Du
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B023.
https://doi.org/10.1158/1538-7445.PANCA22-B023
Published: 15 November 2022
View articletitled, Abstract B023: RHAMMB promotes pancreatic cancer metastasis
Journal Articles

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy

Gaoyang Wang, Zuozhong Xie, Juan Su, Meishan Chen, Yanhua Du, Qian Gao, Guanxiong Zhang, Hailun Zhang, Xiang Chen, Hong Liu, Leng Han, Youqiong Ye
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3474–3485.
https://doi.org/10.1158/0008-5472.CAN-22-1417
Published: 04 October 2022
View articletitled, Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy
Open the PDF for Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells

Li Pan, Xiang Chen, Feyruz V. Rassool, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2678.
https://doi.org/10.1158/1538-7445.AM2022-2678
Published: 15 June 2022
View articletitled, Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells
Journal Articles

Abstract 6092: The dual roles of C-X-C MOTIF chemokine LIGAND 10 in pediatric osteosarcoma

Xiang Chen, Margaret Clement, John Hicks, Tsz Kwong Man
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6092.
https://doi.org/10.1158/1538-7445.AM2022-6092
Published: 15 June 2022
View articletitled, Abstract 6092: The dual roles of C-X-C MOTIF chemokine LIGAND 10 in pediatric osteosarcoma
Journal Articles

Abstract 1936: MethylationToRegulation: A deep-learning approach to infer chromatin properties from DNA methylomes

Daniel K. Putnam, Brian J. Abraham, Xiang Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1936.
https://doi.org/10.1158/1538-7445.AM2022-1936
Published: 15 June 2022
View articletitled, Abstract 1936: MethylationToRegulation: A deep-learning approach to infer chromatin properties from DNA methylomes
Journal Articles

Abstract PO-060: N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer

Anthony Lin, Jennifer Feng, Xiang Chen, Dunrui Wang, Megan Wong, George Zhang, Joseph Na, Tiantian Zhang, Zhengming Chen, Yao-Tseng Chen, Yi-Chieh Nancy Du
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-060.
https://doi.org/10.1158/1538-7445.PANCA21-PO-060
Published: 15 November 2021
View articletitled, Abstract PO-060: N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer
Journal Articles

Abstract 965: The role of LOX-mediated FAK phosphorylation in osteosarcoma metastasis

Xiang Chen, John M. Hicks, Poonam Sarkar, Waleed M. Gaber, Tsz-Kwong MAN
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 965.
https://doi.org/10.1158/1538-7445.AM2021-965
Published: 01 July 2021
View articletitled, Abstract 965: The role of LOX-mediated FAK phosphorylation in osteosarcoma metastasis