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Journal Articles

Abstract 1307: The effect of circulating CXCL10 on osteosarcoma metastasis using orthotopic xenograft mouse models

Xiang Chen, Margaret Clement, John Hicks, Tsz Kwong Man
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1307.
https://doi.org/10.1158/1538-7445.AM2023-1307
Published: 04 April 2023
View article titled, Abstract 1307: The effect of circulating CXCL10 on osteosarcoma metastasis using orthotopic xenograft mouse models
Journal Articles

Abstract 4363: Monocyte-specific epigenetic age acceleration and cardiomyopathy risk among survivors of childhood cancer

Cheng Chen, Qian Dong, Qin Na, Nan Song, John Easton, Heather L. Mulder, Emily Walker, Geoffrey Neale, Emily R. Finch, Qian Li, Yutaka Yasui, Daniel A. Mulrooney, Melissa M. Hudson, Kirsten K. Ness, Jinghui Zhang, Xiang Chen, Hui Wang, Leslie L. Robison, Zhaoming Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4363.
https://doi.org/10.1158/1538-7445.AM2023-4363
Published: 04 April 2023
View article titled, Abstract 4363: Monocyte-specific epigenetic age acceleration and cardiomyopathy risk among survivors of childhood cancer
Journal Articles

Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors

Karissa Dieseldorff Jones, Waise Quarni, Daniel Putnam, Shivendra Singh, Qiong Wu, Jun Yang, Xiang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5363.
https://doi.org/10.1158/1538-7445.AM2023-5363
Published: 04 April 2023
View article titled, Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors
Journal Articles

Abstract B023: RHAMMB promotes pancreatic cancer metastasis

Xiang Chen, Tiantian Zhang, Seung Koo Lee, Dunrui Wang, Zhengming Chen, Ching-Hsuan Tung, Yao-Tseng Chen, Yi-Chieh Nancy Du
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B023.
https://doi.org/10.1158/1538-7445.PANCA22-B023
Published: 15 November 2022
View article titled, Abstract B023: RHAMM<sup>B</sup> promotes pancreatic cancer metastasis
Journal Articles

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy

Gaoyang Wang, Zuozhong Xie, Juan Su, Meishan Chen, Yanhua Du, Qian Gao, Guanxiong Zhang, Hailun Zhang, Xiang Chen, Hong Liu, Leng Han, Youqiong Ye
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3474–3485.
https://doi.org/10.1158/0008-5472.CAN-22-1417
Published: 04 October 2022
View article titled, Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy
Open the PDF for Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 6092: The dual roles of C-X-C MOTIF chemokine LIGAND 10 in pediatric osteosarcoma

Xiang Chen, Margaret Clement, John Hicks, Tsz Kwong Man
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6092.
https://doi.org/10.1158/1538-7445.AM2022-6092
Published: 15 June 2022
View article titled, Abstract 6092: The dual roles of C-X-C MOTIF chemokine LIGAND 10 in pediatric osteosarcoma
Journal Articles

Abstract 1936: MethylationToRegulation: A deep-learning approach to infer chromatin properties from DNA methylomes

Daniel K. Putnam, Brian J. Abraham, Xiang Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1936.
https://doi.org/10.1158/1538-7445.AM2022-1936
Published: 15 June 2022
View article titled, Abstract 1936: MethylationToRegulation: A deep-learning approach to infer chromatin properties from DNA methylomes
Journal Articles

Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells

Li Pan, Xiang Chen, Feyruz V. Rassool, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2678.
https://doi.org/10.1158/1538-7445.AM2022-2678
Published: 15 June 2022
View article titled, Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells
Journal Articles

Abstract PO-060: N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer

Anthony Lin, Jennifer Feng, Xiang Chen, Dunrui Wang, Megan Wong, George Zhang, Joseph Na, Tiantian Zhang, Zhengming Chen, Yao-Tseng Chen, Yi-Chieh Nancy Du
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-060.
https://doi.org/10.1158/1538-7445.PANCA21-PO-060
Published: 15 November 2021
View article titled, Abstract PO-060: N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer
Journal Articles

Abstract 965: The role of LOX-mediated FAK phosphorylation in osteosarcoma metastasis

Xiang Chen, John M. Hicks, Poonam Sarkar, Waleed M. Gaber, Tsz-Kwong MAN
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 965.
https://doi.org/10.1158/1538-7445.AM2021-965
Published: 01 July 2021
View article titled, Abstract 965: The role of LOX-mediated FAK phosphorylation in osteosarcoma metastasis
Journal Articles

Abstract LB-230: Nanotherapy targeting metastatic factor RHAMMB-positive pancreatic neuroendocrine tumors

Seung Koo Lee, Xiang Chen, Yi-Chieh Nancy Du, Ching-Hsuan Tung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-230.
https://doi.org/10.1158/1538-7445.AM2020-LB-230
Published: 15 August 2020
View article titled, Abstract LB-230: Nanotherapy targeting metastatic factor RHAMM<sup>B</sup>-positive pancreatic neuroendocrine tumors
Journal Articles

Abstract 6155: Pediatric rhabdomyosarcomas recapitulate the transcriptomic and epigenomic development of skeletal myogenesis

Anand G. Patel, Xiang Chen, Michael Clay, Brittney Gordon, Jim Houston, Asa Karlstrom, Jackie Norrie, Elizabeth Stewart, Michael Dyer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6155.
https://doi.org/10.1158/1538-7445.AM2020-6155
Published: 15 August 2020
View article titled, Abstract 6155: Pediatric rhabdomyosarcomas recapitulate the transcriptomic and epigenomic development of skeletal myogenesis
Journal Articles

Abstract 6576: DNA methylation reveals alternative promoter usage in genes critical to pediatric tumors

Justin Williams, Beisi Xu, Daniel Putnam, Xiang Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6576.
https://doi.org/10.1158/1538-7445.AM2020-6576
Published: 15 August 2020
View article titled, Abstract 6576: DNA methylation reveals alternative promoter usage in genes critical to pediatric tumors
Journal Articles

Abstract 6149: An innovative integrated cloud-based data portal for orthotopic patient-derived xenografts (O-PDX) available through the Childhood Solid Tumor Network (CSTN)

Asa Karlstrom*, Ti-Cheng Chang*, Darrell Gentry*, Xin Zhou, Elizabeth Stewart, Brittney Gordon, Sara M. Federico, Rachel Brennan, Michael R. Clay, Sharon Frase, Armita Bahrami, Xiang Chen, Anang A. Shelat, Nathaniel R. Twarog, Daniel Alford, Anthony Woodard, Edgar Sioson, Irina McGuire, Cynthia Williams, Nedra Robison, Brandon McMahan, Ashok K. Boddu, Swapnali Mohite, Kirby Birch, Clay McLeod, Michael Rusch, Alberto Pappo, Keith Perry, Gang Wu, Ed Suh#, Michael A. Dyer#
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6149.
https://doi.org/10.1158/1538-7445.AM2020-6149
Published: 15 August 2020
View article titled, Abstract 6149: An innovative integrated cloud-based data portal for orthotopic patient-derived xenografts (O-PDX) available through the Childhood Solid Tumor Network (CSTN)
Journal Articles

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Adam D. Durbin, Guillaume Kugener, Mark W. Zimmerman, Chuan Yan, Neekesh V. Dharia, Elizabeth S. Frank, Xiang Chen, Ken N. Ross, Brenton Paolella, Michael Krill-Burger, David E. Root, Jesse S. Boehm, Francisca Vazquez, Andrew L. Hong, Aviad Tsherniak, David M. Langenau, William C. Hahn, Todd R. Golub, Brian J. Abraham, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B10.
https://doi.org/10.1158/1538-7445.PEDCA19-B10
Published: 15 July 2020
View article titled, Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry
Journal Articles

Abstract P5-05-11: Novel small molecule STAT3 inhibitors induce apoptosis and suppress cell migration and tumor growth in triple-negative breast cancer cells

Li Pan, Xiang Chen, Shengling Fu, Chenglong Li, Hui-Wen Lo, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-05-11.
https://doi.org/10.1158/1538-7445.SABCS19-P5-05-11
Published: 15 February 2020
View article titled, Abstract P5-05-11: Novel small molecule STAT3 inhibitors induce apoptosis and suppress cell migration and tumor growth in triple-negative breast cancer cells
Journal Articles

Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition

Molly Gale, Yao Li, Jian Cao, Zongzhi Z. Liu, Marissa A. Holmbeck, Meiling Zhang, Sabine M. Lang, Lizhen Wu, Mariana Do Carmo, Swati Gupta, Keisuke Aoshima, Michael P. DiGiovanna, David F. Stern, David L. Rimm, Gerald S. Shadel, Xiang Chen, Qin Yan
Journal: Cancer Research
Cancer Res (2020) 80 (3): 524–535.
https://doi.org/10.1158/0008-5472.CAN-18-3985
Published: 03 February 2020
View article titled, Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition
Open the PDF for Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 2876: p21-activated kinase 1 is a novel therapeutic target for metastatic osteosarcoma harboring p27 mislocalization

Xiang Chen, Justin Cates, Yuchen Du, Yun Jung Sung, Xiao-nan Lo, John Hicks, Tsz-Kwong Man
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2876.
https://doi.org/10.1158/1538-7445.AM2019-2876
Published: 01 July 2019
View article titled, Abstract 2876: p21-activated kinase 1 is a novel therapeutic target for metastatic osteosarcoma harboring p27 mislocalization
Journal Articles

Abstract 3768: Single-cell characterization and lineage tracking of recurrent pediatric rhabdomyosarcoma

Anand G. Patel, Elizabeth Stewart, Michael Clay, Xiang Chen, Michael Dyer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3768.
https://doi.org/10.1158/1538-7445.AM2019-3768
Published: 01 July 2019
View article titled, Abstract 3768: Single-cell characterization and lineage tracking of recurrent pediatric rhabdomyosarcoma
Journal Articles

Abstract IA18: MYCN amplification and ATRX mutations are incompatible in neuroblastoma

Maged Zeineldin, Sara Federico, Xiang Chen, Beisi Xu, Elizabeth Stewart, Arlene Naranjo, Michael D. Hogarty, Michael A. Dyer
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA18.
https://doi.org/10.1158/1538-7445.PEDCA17-IA18
Published: 01 October 2018
View article titled, Abstract IA18: <em>MYCN</em> amplification and <em>ATRX</em> mutations are incompatible in neuroblastoma