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Journal Articles

Abstract 1814: Novel ABC transport inhibitor as a treatment for pancreatic and prostate cancers

Marco Falasca, Xi Chen, Gary Piazza
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1814.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1814
Published: 15 June 2022
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Journal Articles

Abstract 3504: QL415, a tumor targeted IL-15 fusion protein stimulating both lymphoid and myeloid immune cells for optimal anti-tumor immune response

Irene Tang, Lauren Schwimmer, Monica Jin, Shenda Gu, Wei Wei Prior, Arianne Capacio, Hieu V. Tran, Allan Chan, Anna McClain, Shihao Chen, Chuanzeng Cao, Xiaoran Wu, Yanling Xu, Dongmei Guan, Xi Chen, Xianli Su
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3504.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3504
Published: 15 June 2022
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Journal Articles

Abstract 5322: The antitumor activity and immumodulatory effect of a novel phosphodiesterase 10 inhibitor

Md Yeashin Gazi, Caitlin Brandle, Ogacheko Okoko, Xi Chen, Adam Keeton, Yulia Maxuitenko, Gary Piazza, Gang Zhou
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5322.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5322
Published: 15 June 2022
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Journal Articles

Abstract 5558: Discovery of a novel Claudin 6 X 4-1BB bispecific antibody with potent anti-tumor activity through conditional 4-1BB activation

Jian Li, Wenqing Jiang, Yan Liu, Zhengyi Wang, Xi Chen, Taylor B. Guo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5558.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5558
Published: 15 June 2022
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Journal Articles

Abstract 3335: ORIC-114, an orally bioavailable, irreversible kinase inhibitor, has superior brain penetration and antitumor activity in subcutaneous and intracranial NSCLC models

Jason E. Long, Soochan Kim, Ha Yeong Kim, Dong Guk Shin, Dong Hyun Park, Robert Warne, Akash Das, Ganapati Hegde, Padmini Narayanan, Lidia Sambucetti, Brenda Chan, Xi Chen, Jae H. Chang, Paul Gibbons, Jessica Sun, Matthew Panuwat, Lori S. Friedman, Melissa R. Junttila
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3335.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3335
Published: 15 June 2022
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Journal Articles

Abstract 1328: Deciphering the role of CREB1 in shaping the tumor immune landscape of pancreatic ductal adenocarcinoma

Siddharth Mehra, Vanessa Garrido, Samara Singh, Iago D Silva, Luis Alberto Nivelo, Anna Bianchi, Shrey Modi, Zhiqun Zhou, Austin Dosch, Nilesh Deshpande, Supriya Srinivasan, Christine Rafie, Ifeanyichukwu Ogobuiro, Xi Chen, Alejandro Villarino, Jashodeep Datta, Nipun Merchant, Nagaraj Nagathihalli
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1328.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1328
Published: 15 June 2022
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Journal Articles

Abstract CT222: Pembrolizumab (pembro) for previously treated advanced hepatocellular carcinoma (aHCC): Meta-analysis of the phase 3 KEYNOTE-240 and KEYNOTE-394 studies

Richard S. Finn, Kangsheng Gu, Xi Chen, Philippe Merle, Kyung-Hun Lee, Mohamed Bouattour, Peiguo Cao, Wei Wang, Ann-Lii Cheng, Liangjun Zhu, Ho Yeong Lim, Masatoshi Kudo, Yueyin Pan, Ting-Tsung Chang, Julien Edeline, Wei Li, Ping Yang, Chen Li, Jianfeng Li, Abby B. Siegel, Shukui Qin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT222.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT222
Published: 15 June 2022
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Journal Articles

Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma

Melissa R. Junttila, Arghya Ray, Robert Warne, Xi Chen, Ting Du, Dena Sutimantanapi, Jae H. Chang, Brian Blank, Jared Moore, Chudi O. Ndubaku, Tatiana Zavorotinskaya, Pratik Multani, Omar Nadeem, Dharminder Chauhan, Kenneth C. Anderson, Lori S. Friedman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2074.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2074
Published: 15 June 2022
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Journal Articles

Abstract 2633: Discovery of novel, highly selective inhibitors of PLK4 that demonstrate in vivo regressions in TRIM37 high xenografts

Kyle A. Edgar, Amy Young, Jared Moore, Xi Chen, Wei Fang, Jae H. Chang, Wayne Kong, Jason E. Long, Aleksandr Pankov, Anneleen Daemen, Daniel G. Shore, Robert Warne, Paul Gibbons, Chudi O. Ndubaku, Melissa R. Junttila, Lori S. Friedman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2633.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2633
Published: 15 June 2022
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Journal Articles

Abstract P5-07-01: Proteogenomic analysis of differential chemotherapy responses in patient-derived xenografts of triple-negative breast cancer

Jonathan T Lei, Chen Huang, Ramakrishnan R Srinivasan, Suhas Vasaikar, Lacey E Dobrolecki, Alaina N Lewis, Christina Sallas, Susan G Hilsenbeck, C. Kent Osborne, Mothaffar F Rimawi, Matthew J Ellis, Varduhi Petrosyan, Alexander B Saltzman, Anna Malovannaya, Gerburg Wulf, Daniel C Kraushaar, Tao Wang, Xi Chen, Gloria V Echeverria, Meenakshi Anurag, Bing Zhang, Michael T Lewis
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-07-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-07-01
Published: 15 February 2022
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Journal Articles

Abstract GS1-06: A randomized control phase III trial of entinostat, a once weekly, class I selective histone deacetylase inhibitor, in combination with exemestane in patients with hormone receptor positive advanced breast cancer

Binghe Xu, Qingyuan Zhang, Xichun Hu, Qing Li, Tao Sun, Wei Li, Quchang Ouyang, Jingfen Wang, Zhongsheng Tong, Min Yan, Huiping Li, Xiaohua Zeng, Changping Shan, Xian Wang, Xi Yan, Jian Zhang, Yue Zhang, Jiani Wang, Liang Zhang, Ying Lin, Jifeng Feng, Qianjun Chen, Jian Huang, Yongkui Lu, Hongsheng Li, Jinsheng Wu, Jing Cheng, Yanrong Hao, Cuizhi Geng, Min Lu, Yanping Li, Xi Chen, Lihua Song, Xueying Wu, Changlu Hu, Xinhong Wu, Xiaojia Wang, Yueyin Pan, Yuehong Cui, Guohua Yu, Sanyuan Sun
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS1-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS1-06
Published: 15 February 2022
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Journal Articles

Abstract LB215: Transglutaminase 2 maintains hepatocyte growth factor signaling to enhance the epidermal cancer stem cell phenotype

Xi Chen, Gautam Adhikary, Suruchi Shrestha, Wen Xu, Richard Eckert
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB215.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB215
Published: 01 July 2021
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Journal Articles

Abstract 93: Single cell transcriptome analysis maps dynamic epithelial mesenchymal transition and immunological remodeling in thyroid cancer progression

Xi Chen, Jennifer Rui Wang, Ying Henderson, Yuanqing Yan, Shanshan Bai, Rachel Kieser, Min Hu, Jiping Wang, Nicholas Navin, Stephen Lai, Ruli Gao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 93.
DOI: https://doi.org/10.1158/1538-7445.AM2021-93
Published: 01 July 2021
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Journal Articles

Abstract 2492: Association of TP53 and LRP1B co-mutation status with response to immunotherapy in lung squamous cell carcinoma

Jiangyong Yu, Zhipeng Zhou, Ping Zhang, Pansong Li, Xu Li, Min Tang, Nannan Fan, Xiaonan Wu, Xin Nie, Xiaoyan Chen, Di Ma, Xi Chen, Yanfang Guan, Xuefeng Xia, Ling Yang, Xin Yi, Lin Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2492.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2492
Published: 01 July 2021
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Journal Articles

Abstract 2490: Optimizing treatment strategy for NF1-depleted estrogen receptor positive breast cancer

Zeyi Zheng, Jonathan T. Lei, Meenakshi Anurag, Long Feng, Purba Singh, Hilda Kennedy, Jin Cao, Xi Chen, Matthew J. Ellis, Eric C. Chang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2490.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2490
Published: 01 July 2021
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Journal Articles

Abstract 1119: Molecular characteristics of repotrectinib that enable potent inhibition of TRK fusion proteins and broad mutant selectivity

Alexander Drilon, Dayong Zhai, Evan Rogers, Wei Deng, Xi Chen, Paul Sprengeler, Siegfried H. Reich, Brion W. Murray
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1119.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1119
Published: 01 July 2021
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Journal Articles

Abstract 1213: PDE10A as a novel target to suppress Wnt/β-catenin signaling and other oncogenic pathways in ovarian cancer

Rebecca M. Barber, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, Annelise Wilhite, Joel F. Andrews, Steve McClellan, Ileana Aragon, Antonio Ward, Xi Chen, Adam Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1213.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1213
Published: 01 July 2021
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Journal Articles

Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non–Small Cell Lung Cancer Growth

Chen Wang, Xiangfeng Meng, Yu Zhou, Jing Yu, Qing Li, Zhicong Liao, Yuanyuan Gu, Jiayi Han, Shuo Linghu, Zichen Jiao, Tao Wang, Chen-Yu Zhang, Xi Chen
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3509–3524.
DOI: https://doi.org/10.1158/0008-5472.CAN-19-3806
Published: 01 July 2021
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Journal Articles

Abstract PS13-25: Management of abemaciclib associated diarrhea in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: Analysis of the MONARCH plus study

Zefei Jiang, Xichun Hu, Qingyuan Zhang, Tao Sun, Yongmei Yin, Huiping Li, Min Yan, Zhongsheng Tong, Christina Pimentel Oppermann, Yunpeng Liu, Romulo Costa, Man Li, Xi Chen, Ying Cheng, Quchang Ouyang, Ning Liao, Xiaojia Wang, Xinhong Wu, Jifeng Feng, Roberto Hegg, Govindbabu Kanaka Setty, Amit Agarwal, Jyoti Bajpai, Jing Cheng, Gustavo Girotto, Chanchal Goswami, Wenjing Hu, Jian Huang, MA Coccia Portugal, Jin Yang, Rongsheng Zheng, Fabio Andre Franke, Qiang Liu, Yunjiang Liu, Yongkui Lu, Cristiano Souza, Shiying Yu, Nalini Kilara, Harsha Panchal, Ashish Singh, Shona Nag, Jian Liu, Bernardo Rapoport, Neonyana Keorapetse Rebecca Tabane, Hongxia Wang, Ning Wang, Rubing Han, Wanli Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS13-25.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS13-25
Published: 15 February 2021
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Journal Articles

Abstract PS16-22: Targeting resistance to current CDK4/6 therapies by RGT-419B, an inhibitor with optimized kinase activity spectrum

Zhi Xie, Jing Han, Zhilong Hu, Hu He, Xianqiang Sun, Fei Zhang, Jing Lin, Lili Yao, Xinjuan Wang, Liufeng Mei, Yangyang Liu, Guoyun Zhu, Xi Chen, Xiaotian Zhu, Wenge Zhong
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS16-22.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS16-22
Published: 15 February 2021
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