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Winfried Edelmann
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Journal Articles

Abstract 7552: Inhibition of histone methyltransferase EZH2 for immune-interception of colorectal cancer in Lynch syndrome

Fahriye Duzagac, Charles M. Bowen, Laura Reyes-Uribe, Mahira Zaheer, Jacklyn Thompson, Nan Deng, Melissa Taggart, Abhinav Jain, Winfried Edelmann, Krishna M. Sinha, Eduardo Vilar
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7552.
https://doi.org/10.1158/1538-7445.AM2024-7552
Published: 22 March 2024
View article titled, Abstract 7552: Inhibition of histone methyltransferase EZH2 for immune-interception of colorectal cancer in Lynch syndrome
Journal Articles

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Prashant V. Bommi, Charles M. Bowen, Laura Reyes-Uribe, Wenhui Wu, Hiroyuki Katayama, Pedro Rocha, Edwin R. Parra, Alejandro Francisco-Cruz, Zuhal Ozcan, Elena Tosti, Jason A. Willis, Hong Wu, Melissa W. Taggart, Jared K. Burks, Patrick M. Lynch, Winfried Edelmann, Paul A. Scheet, Ignacio I. Wistuba, Krishna M. Sinha, Samir M. Hanash, Eduardo Vilar
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2760–2773.
https://doi.org/10.1158/0008-5472.CAN-20-2896
Published: 15 May 2021
View article titled, The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells
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Includes: Supplementary data
Journal Articles

MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development

Yuji Eso, Atsushi Takai, Tomonori Matsumoto, Tadashi Inuzuka, Takahiro Horie, Koh Ono, Shinji Uemoto, Kyeryoung Lee, Winfried Edelmann, Tsutomu Chiba, Hiroyuki Marusawa
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4383–4393.
https://doi.org/10.1158/0008-5472.CAN-15-2926
Published: 31 July 2016
View article titled, <em>MSH2</em> Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Open the PDF for <em>MSH2</em> Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development in another window
Includes: Supplementary data
Journal Articles

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies

Yongliang Zhang, Jennifer T. Fox, Young-Un Park, Gene Elliott, Ganesha Rai, Mengli Cai, Srilatha Sakamuru, Ruili Huang, Menghang Xia, Kyeryoung Lee, Min Ho Jeon, Bijoy P. Mathew, Hee Dong Park, Winfried Edelmann, Chan Young Park, Sung You Hong, David Maloney, Kyungjae Myung
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (14): 4183–4191.
https://doi.org/10.1158/0008-5472.CAN-15-2974
Published: 14 July 2016
View article titled, A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies
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Includes: Supplementary data
Journal Articles

Abstract 2891: Chemokine-targeted models of human orthotopic colorectal cancer in immunocompetant mice

Steven M. Lipkin, Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Kathy Zhou, Robert Edwards, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew Miller, Zeynep Gümüş, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2891.
https://doi.org/10.1158/1538-7445.AM2015-2891
Published: 01 August 2015
View article titled, Abstract 2891: Chemokine-targeted models of human orthotopic colorectal cancer in immunocompetant mice
Journal Articles

Abstract 3118: Chemokine-targeted colorectal cancer: improved models of human primary tumor formation, liver metastasis and chemoresistance

Huanhuan Joyce Chen, Jian Sun, Harry Hou, Winfried Edelmann, Xiling Shen, Steven M. Lipkin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3118.
https://doi.org/10.1158/1538-7445.AM2014-3118
Published: 01 October 2014
View article titled, Abstract 3118: Chemokine-targeted colorectal cancer: improved models of human primary tumor formation, liver metastasis and chemoresistance
Journal Articles

Abstract 176: Thymoquinone attenuates tumor development in a mouse model of Lynch syndrome.

Benedikt Kortüm, Christoph Campregher, Matthias Pinter, Michaela Lang, Rayko Evstatiev, Vineeta Khare, Melanie H. Kucherlapati, Winfried Edelmann, Christoph Gasche
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 176.
https://doi.org/10.1158/1538-7445.AM2013-176
Published: 15 April 2013
View article titled, Abstract 176: Thymoquinone attenuates tumor development in a mouse model of Lynch syndrome.
Journal Articles

Abstract 2219: Identification of oncogenes in mutant Rpa1 associated tumorigenesis

Bin Huang, Weijia Zhang, Winfried Edelmann, Yuxun Wang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2219.
https://doi.org/10.1158/1538-7445.AM10-2219
Published: 15 April 2010
View article titled, Abstract 2219: Identification of oncogenes in mutant Rpa1 associated tumorigenesis
Journal Articles

Abstract #4916: Abrogation of Pms2 endonuclease activity leads to increased genetic instability in mice

Johanna van Oers, Sergio Roa, Uwe Werling, Paul Modrich, Matthew Scharff, Winfried Edelmann
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4916.
Published: 01 May 2009
View article titled, Abstract #4916: Abrogation of Pms2 endonuclease activity leads to increased genetic instability in mice
Journal Articles

Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer

Kan Yang, Naoto Kurihara, Kunhua Fan, Harold Newmark, Basil Rigas, Laura Bancroft, Georgia Corner, Elayne Livote, Martin Lesser, Winfried Edelmann, Anna Velcich, Martin Lipkin, Leonard Augenlicht
Journal: Cancer Research
Cancer Res (2008) 68 (19): 7803–7810.
https://doi.org/10.1158/0008-5472.CAN-08-1209
Published: 30 September 2008
View article titled, Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer
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Includes: Supplementary data
Journal Articles

Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation

Kan Yang, Natalia V. Popova, Wan Cai Yang, Ioanna Lozonschi, Selam Tadesse, Scott Kent, Laura Bancroft, Ilze Matise, Robert T. Cormier, Stefan J. Scherer, Winfried Edelmann, Martin Lipkin, Leonard Augenlicht, Anna Velcich
Journal: Cancer Research
Cancer Res (2008) 68 (18): 7313–7322.
https://doi.org/10.1158/0008-5472.CAN-08-0598
Published: 14 September 2008
View article titled, Interaction of <em>Muc2</em> and <em>Apc</em> on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation
Open the PDF for Interaction of <em>Muc2</em> and <em>Apc</em> on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation in another window
Includes: Supplementary data
Journal Articles

Novel mechanisms of mismatch repair-deficient gastrointestinal tumorigenesis and progression

Peng-Chieh Chen, Mari Kuraguchi, Kan Yang, Robert Edwards, Dan Gillen, Winfried Edelmann, Raju Kucherlapati, Steven Lipkin
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4322.
Published: 01 May 2008
View article titled, Novel mechanisms of mismatch repair-deficient gastrointestinal tumorigenesis and progression
Journal Articles

An Msh2 conditional knockout mouse model for hereditary nonpolyposis colorectal cancer

Melanie Kucherlapati, Kye Ryoung, Anh Nguyen, Alan Clark, Kan Yang, Kunhua Fan, Martin Lipklin, Roderick Bronson, Thomas Kunkel, Raju Kucherlapati, Winfried Edelmann
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2943.
Published: 01 May 2008
View article titled, An <em>Msh2 </em>conditional knockout mouse model for hereditary nonpolyposis colorectal cancer
Journal Articles

Obesity enhances gastrointestinal tumorigenesis in Apc mutant mice

Claudia Gravaghi, Jin Bo, Krista LaPerle, Fred Quimby, Raju Kucherlapati, Martin Lipkin, Winfried Edelmann, Sergio Lamprecht
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-81.
Published: 01 May 2008
View article titled, Obesity enhances gastrointestinal tumorigenesis in <em>Apc </em>mutant mice
Journal Articles

Inhibition of the inflammatory process by n-3 PUFA in colonic cells of transgenic mice

Claudia Gravaghi, Krista La Perle, Jing Kang, Fred Quimby, Winfried Edelmann, Martin Lipkin, Lisa Hudgins, Sergio Lamprecht
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5666.
Published: 01 May 2007
View article titled, Inhibition of the inflammatory process by <em>n</em>-3 PUFA in colonic cells of transgenic mice
Journal Articles

Effect of specific nutrients and caloric intake on intestinal tumors in a Western diet mouse model for hereditary colon cancer

Osamu Itano, Kan Yang, Kunhua Fan, Keiichi Suzuki, Zhiqian Dong, Bo Jin, Fred Quimby, Winfried Edelmann, Raju Kucherlapati, Leonard Augenlicht, Levy Kopelovich, Martin Lipkin
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 915.
Published: 15 April 2006
View article titled, Effect of specific nutrients and caloric intake on intestinal tumors in a Western diet mouse model for hereditary colon cancer
Journal Articles

Msh2-mediated mismatch repair and apoptosis cooperate with DNA polymerase proofreading to suppress spontaneous cancer in mice

Tina M. Albertson, Laura E. Hays, Robert E. Goldsby, Winfried Edelmann, Bradley D. Preston
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1139.
Published: 15 April 2006
View article titled, Msh2-mediated mismatch repair and apoptosis cooperate with DNA polymerase proofreading to suppress spontaneous cancer in mice
Journal Articles

A missense mutation in replication protein A1 acts as a genetic modifier of p53 tumorigenesis

Yuxun Wang, Michael Kane, Steven Brunnert, Raju Kucherlapati, Richard D. Kolodner, Winfried Edelmann
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 382–383.
Published: 01 May 2005
View article titled, A missense mutation in replication protein A1 acts as a genetic modifier of p53 tumorigenesis
Journal Articles

Sulindac increases colonic tumors in mice with Apc, Mlh1 and Apc/Mlh1 mutations.

Osamu Itano, Naoto Kurihara, Kunhua Fan, Sadanori Abe, Levy Kopelovich, Leonard Augenlicht, Winfried Edelmann, Raju Kucherlapati, Kan Yang, Martin Lipkin
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 732.
Published: 01 April 2004
View article titled, Sulindac increases colonic tumors in mice with <em>Apc</em>, <em>Mlh1</em> and <em>Apc/Mlh1</em> mutations.
Journal Articles

Tumors in small intestine and colon of Mlh1/Apc mutant mice after administration of the cyclooxygenase-2 inhibitor nimesulide.

Kan Yang, Osamu Itano, Kunhua Fan, Sadanori Abe, Zhiqian Dong, Ronald Lubet, Levy Kopelovich, Winfried Edelmann, Raju Kucherlapati, Martin Lipkin
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 732.
Published: 01 April 2004
View article titled, Tumors in small intestine and colon of <em>Mlh1/Apc</em> mutant mice after administration of the cyclooxygenase-2 inhibitor nimesulide.