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William W. Lockwood
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Journal Articles

Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification

Arielle Elkrief, Vladimir Markov, Álvaro Quintanal-Villalonga, Rebecca Caeser, Pawel Sobczuk, Emily Cheng, Alexander Drilon, Gregory J. Riely, William W. Lockwood, Elisa de Stanchina, Charles M. Rudin, Igor Odintsov, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6127.
https://doi.org/10.1158/1538-7445.AM2023-6127
Published: 04 April 2023
View article titled, Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with <em>MDM2</em> amplification
Journal Articles

Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Jacqueline H. Starrett, Alexis A. Guernet, Maria Emanuela Cuomo, Kamrine E. Poels, Iris K. van Alderwerelt van Rosenburgh, Amy Nagelberg, Dylan Farnsworth, Kristin S. Price, Hina Khan, Kumar Dilip Ashtekar, Mmaserame Gaefele, Deborah Ayeni, Tyler F. Stewart, Alexandra Kuhlmann, Susan M. Kaech, Arun M. Unni, Robert Homer, William W. Lockwood, Franziska Michor, Sarah B. Goldberg, Mark A. Lemmon, Paul D. Smith, Darren A.E. Cross, Katerina Politi
Journal: Cancer Research
Cancer Res (2020) 80 (10): 2017–2030.
https://doi.org/10.1158/0008-5472.CAN-19-3819
Published: 15 May 2020
View article titled, Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance <em>EGFR</em> Mutations
Open the PDF for Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance <em>EGFR</em> Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract 1826: Oncogenic KRAS mediates resistance to MET targeted therapy in non-small cell lung cancer (NSCLC) with MET mutations that induce exon14 skipping

Ken Suzawa, Michael D. Offin, Christopher Kurzatkowski, Daniel Liu, Morana Vojnic, Roger S. Smith, Marissa Mattar, Inna Khodos, Elisa de Stanchina, Joshua K. Sabari, William W. Lockwood, Alexander E. Drilon, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1826.
https://doi.org/10.1158/1538-7445.AM2018-1826
Published: 01 July 2018
View article titled, Abstract 1826: Oncogenic KRAS mediates resistance to MET targeted therapy in non-small cell lung cancer (NSCLC) with MET mutations that induce exon14 skipping
Journal Articles

YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway

Larissa A. Pikor, William W. Lockwood, Kelsie L. Thu, Emily A. Vucic, Raj Chari, Adi F. Gazdar, Stephen Lam, Wan L. Lam
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (24): 7301–7312.
https://doi.org/10.1158/0008-5472.CAN-13-1897
Published: 16 December 2013
View article titled, YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Open the PDF for YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract 2966: Amplification and activation of GATA6 sustain oncogenic lineage-survival in esophageal adenocarcinoma

Lin Lin, Adam J. Bass, William W. Lockwood, Zhuwen Wang, Amy L. Silvers, Dafydd G. Thomas, Andrew C. Chang, Jules Lin, Mark B. Orringer, Weiquan Li, Thomas W. Glover, Thomas J. Giordano, Wan L. Lam, Matthew L. Meyerson, David G. Beer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2966.
https://doi.org/10.1158/1538-7445.AM2012-2966
Published: 15 April 2012
View article titled, Abstract 2966: Amplification and activation of <em>GATA6</em> sustain oncogenic lineage-survival in esophageal adenocarcinoma
Journal Articles

Abstract 3166: Lung cancer bio-signatures in plasma based on the analysis of mouse models

Ayumu Taguchi, Katerina Politi, Sharon J. Pitteri, William W. Lockwood, Vitor M. Faça, Julien Sage, Christopher J. Kemp, Harold E. Varmus, Samir M. Hanash
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3166.
https://doi.org/10.1158/1538-7445.AM2011-3166
Published: 15 April 2011
View article titled, Abstract 3166: Lung cancer bio-signatures in plasma based on the analysis of mouse models
Journal Articles

Abstract 240: Amplification status of GAS41 and MDM2 in lung adenocarcinomas

Larissa Pikor, William W. Lockwood, Emily A. Vucic, Wan L. Lam
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 240.
https://doi.org/10.1158/1538-7445.AM10-240
Published: 15 April 2010
View article titled, Abstract 240: Amplification status of GAS41 and MDM2 in lung adenocarcinomas
Journal Articles

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

Hiromasa Yamamoto, Hisayuki Shigematsu, Masaharu Nomura, William W. Lockwood, Mitsuo Sato, Naoki Okumura, Junichi Soh, Makoto Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi Toyooka, Hiroshi Date, Wan L. Lam, John D. Minna, Adi F. Gazdar
Journal: Cancer Research
Cancer Res (2008) 68 (17): 6913–6921.
https://doi.org/10.1158/0008-5472.CAN-07-5084
Published: 28 August 2008
View article titled, <em>PIK3CA</em> Mutations and Copy Number Gains in Human Lung Cancers
Open the PDF for <em>PIK3CA</em> Mutations and Copy Number Gains in Human Lung Cancers in another window
Includes: Supplementary data
Journal Articles

Array CGH coupled with expression profiling identifies disruption of different pathways between small and non-small cell lung carcinoma cell lines

Bradley P. Coe, William W. Lockwood, Luc Girard, Raj Chari, Calum Macaulay, Stephen Lam, Adi F. Gazdar, John D. Minna, Wan L. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 38.
Published: 15 April 2006
View article titled, Array CGH coupled with expression profiling identifies disruption of different pathways between small and non-small cell lung carcinoma cell lines
Journal Articles

A comprehensive and interactive array comparative genomic hybridization database for cancer genomes

Raj Chari, William W. Lockwood, Bradley P. Coe, Calum Macaulay, Wan L. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 616.
Published: 15 April 2006
View article titled, A comprehensive and interactive array comparative genomic hybridization database for cancer genomes
Journal Articles

The contribution of gene amplification to the activation of oncogenes in cancer genomes

William W. Lockwood, Bradley P. Coe, Raj Chari, Calum Macaulay, Wan L. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 601.
Published: 15 April 2006
View article titled, The contribution of gene amplification to the activation of oncogenes in cancer genomes
Journal Articles

Whole genome tiling path array CGH analysis localizes breakpoints corresponding to HPV integration sites in cervical carcinoma genomes

William W. Lockwood, Bradley P. Coe, Ariane C. Williams, Stephen Lam, Calum Macaulay, Wan L. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 602.
Published: 15 April 2006
View article titled, Whole genome tiling path array CGH analysis localizes breakpoints corresponding to HPV integration sites in cervical carcinoma genomes
Journal Articles

Comparison of lung adenocarcinoma and squamous cell carcinoma genomes reveals distinct regions of amplification on chromosome 3q

William W. Lockwood, Cathie Garnis, Yong Ge, Adi F. Gazdar, John D. Minna, Stephen Lam, Calum Macaulay, Wan L. Lam
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 206–207.
Published: 01 May 2005
View article titled, Comparison of lung adenocarcinoma and squamous cell carcinoma genomes reveals distinct regions of amplification on chromosome 3q