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William R. Roush
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Journal Articles

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Karen L. Burger, Mario R. Fernandez, Mark B. Meads, Praneeth Sudalagunta, Paula S. Oliveira, Rafael Renatino Canevarolo, Raghunandan Reddy Alugubelli, Alexandre Tungsevik, Gabe De Avila, Maria Silva, Allison I. Graeter, Hongyue A. Dai, Nicole D. Vincelette, Antony Prabhu, Dario Magaletti, Chunying Yang, Weimin Li, Amit Kulkarni, Oliver Hampton, John M. Koomen, William R. Roush, Andrii Monastyrskyi, Anders E. Berglund, Ariosto S. Silva, John L. Cleveland, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3901–3919.
https://doi.org/10.1158/0008-5472.CAN-22-2350
Published: 01 December 2023
View article titled, CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Open the PDF for CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival

Chen Hao Lo, Gemma Shay, Jeremy J. McGuire, Tao Li, Kenneth H. Shain, Jun Yong Choi, Rita Fuerst, William R. Roush, Anna M. Knapinska, Gregg B. Fields, Conor C. Lynch
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2415–2428.
https://doi.org/10.1158/0008-5472.CAN-20-2705
Published: 01 May 2021
View article titled, Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival
Open the PDF for Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival in another window
Includes: Supplementary data
Journal Articles

Abstract 4718: SR-4370, a potent and selective inhibitor of class I HDACs, suppresses AR signaling and in vivo prostate tumor growth

Iqbal Mahmud, Guimei Tian, Jia Wang, Ryan Stowe, Zhiguang Huo, Yushan Zhang, Hamsa Thayek Purayil, Eric Helm, Theodore Drashansky, Dorina Avram, Yehia Daaka, William R. Roush, Daiqing Liao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4718.
https://doi.org/10.1158/1538-7445.AM2019-4718
Published: 01 July 2019
View article titled, Abstract 4718: SR-4370, a potent and selective inhibitor of class I HDACs, suppresses AR signaling and in vivo prostate tumor growth
Journal Articles

Abstract LB-248: Chemically distinct class I HDAC inhibitors synergize to inhibit global lipid metabolism in cancer

Iqbal Mahmud, Timothy J. Garrett, Ryan Stowe, William R. Roush, Daiqing Liao
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-248.
https://doi.org/10.1158/1538-7445.AM2018-LB-248
Published: 01 July 2018
View article titled, Abstract LB-248: Chemically distinct class I HDAC inhibitors synergize to inhibit global lipid metabolism in cancer
Journal Articles

Abstract 2525: Identification and characterization of class I HDAC-specific small-molecule inhibitors with a novel pharmacophore

Yunfei Wang, Ryan Stowe, Christie E. Pinello, Lisa Y. Zhao, Guimei Tian, Peter Hodder, William R. Roush, Daiqing Liao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2525.
https://doi.org/10.1158/1538-7445.AM2014-2525
Published: 01 October 2014
View article titled, Abstract 2525: Identification and characterization of class I HDAC-specific small-molecule inhibitors with a novel pharmacophore
Journal Articles

Abstract PR16: A new class of small molecule acetyltransferase inhibitors discovered through high-throughput screening are potent anticancer agents with cancer-type specific activity

Heng Yang, Christie E. Pinello, Jian Luo, Dawei Li, Yunfei Wang, Zhao Y. Lisa, Stephan C. Jahn, S. Adrian Saldanha, Jamie Planck, Kyla R. Geary, Haiching Ma, Brian K. Law, William R. Roush, Peter Hodder, Daiqing Liao
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): PR16.
https://doi.org/10.1158/1538-7445.CEC13-PR16
Published: 13 May 2014
View article titled, Abstract PR16: A new class of small molecule acetyltransferase inhibitors discovered through high-throughput screening are potent anticancer agents with cancer-type specific activity
Journal Articles

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

Joanne R. Doherty, Chunying Yang, Kristen E.N. Scott, Michael D. Cameron, Mohammad Fallahi, Weimin Li, Mark A. Hall, Antonio L. Amelio, Jitendra K. Mishra, Fangzheng Li, Mariola Tortosa, Heide Marika Genau, Robert J. Rounbehler, Yunqi Lu, Chi V. Dang, K. Ganesh Kumar, Andrew A. Butler, Thomas D. Bannister, Andrea T. Hooper, Keziban Unsal-Kacmaz, William R. Roush, John L. Cleveland
Journal: Cancer Research
Cancer Res (2014) 74 (3): 908–920.
https://doi.org/10.1158/0008-5472.CAN-13-2034
Published: 02 February 2014
View article titled, Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Open the PDF for Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis in another window
Includes: Supplementary data