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William L. Brown
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Journal Articles

An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations

Jesse Boumelha, Sophie de Carné Trécesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel I. Vogel, Alejandro Suárez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3435–3448.
https://doi.org/10.1158/0008-5472.CAN-22-0325
Published: 04 October 2022
View article titled, An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
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Includes: Supplementary data
Journal Articles

Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance

Manasi Mayekar, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, Andrew Rowan, Maise Al Bakir, Clare Weeden, Caroline E. McCoach, Collin M. Blakely, Nuri Alpay Temiz, Ai Nagano, Daniel L. Kerr, Julia K. Rotow, Oriol Pich, Franziska Haderk, Michelle Dietzen, Carlos Martinez Ruiz, Bruna Almeida, Lauren Cech, Beatrice Gini, Joanna Przewrocka, Chris Moore, Miguel Murillo, Bjorn Bakker, Brandon Rule, Cameron Durfee, Shigeki Nanj, Lisa Tan, Lindsay K. Larson, Prokopios P. Argyris, William L. Brown, Johnny Yu, Carlos Gomez, Philippe Gui, Rachel I. Vogel, Elizabeth A. Yu, Nicholas J. Thomas, Subramanian Venkatesan, Sebastijan Hobor, Su Kit Chew, Nicholas McGranahan, Nnennaya Kanu, Eliezer M. Van Allen, Julian Downward, Reuben S. Harris, Trever Bivona, Charles Swanton
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2197.
https://doi.org/10.1158/1538-7445.AM2022-2197
Published: 15 June 2022
View article titled, Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance
Journal Articles

Abstract 286: Regulation of APOBEC3B gene expression through the Rb/E2F pathway

Pieter A. Roelofs, William L. Brown, Paul N. Span, John W. Martens, Chai Y. Goh, Boon H. Chua, Dennis Kappei, Reuben S. Harris
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 286.
https://doi.org/10.1158/1538-7445.AM2020-286
Published: 15 August 2020
View article titled, Abstract 286: Regulation of APOBEC3B gene expression through the Rb/E2F pathway
Journal Articles

The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers

Brandon Leonard, Jennifer L. McCann, Gabriel J. Starrett, Leah Kosyakovsky, Elizabeth M. Luengas, Amy M. Molan, Michael B. Burns, Rebecca M. McDougle, Peter J. Parker, William L. Brown, Reuben S. Harris
Journal: Cancer Research
Cancer Res (2015) 75 (21): 4538–4547.
https://doi.org/10.1158/0008-5472.CAN-15-2171-T
Published: 01 November 2015
View article titled, The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers
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Includes: Supplementary data
Journal Articles

APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma

Brandon Leonard, Steven N. Hart, Michael B. Burns, Michael A. Carpenter, Nuri A. Temiz, Anurag Rathore, Rachel I. Vogel, Jason B. Nikas, Emily K. Law, William L. Brown, Ying Li, Yuji Zhang, Matthew J. Maurer, Ann L. Oberg, Julie M. Cunningham, Viji Shridhar, Debra A. Bell, Craig April, David Bentley, Marina Bibikova, R. Keira Cheetham, Jian-Bing Fan, Russell Grocock, Sean Humphray, Zoya Kingsbury, John Peden, Jeremy Chien, Elizabeth M. Swisher, Lynn C. Hartmann, Kimberly R. Kalli, Ellen L. Goode, Hugues Sicotte, Scott H. Kaufmann, Reuben S. Harris
Journal: Cancer Research
Cancer Res (2013) 73 (24): 7222–7231.
https://doi.org/10.1158/0008-5472.CAN-13-1753
Published: 16 December 2013
View article titled, APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma
Open the PDF for APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma in another window
Includes: Supplementary data