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William J. Muller
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Journal Articles

Abstract 1279: Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis

Emma Ciccolini, Valérie Sabourin, David Patten, Young K. Im, Steven Hébert, William J. Muller, Claudia Kleinman, Julie St-Pierre, Josie Ursini-Siegel
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1279.
https://doi.org/10.1158/1538-7445.AM2023-1279
Published: 04 April 2023
View article titled, Abstract 1279: Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis
Journal Articles

Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases

Matthew Dankner, Sarah M. Maritan, Neibla Priego, Javad Nadaf, Andy Nkili, Rebecca Zhuang, Georgia Kruck, Dongmei Zuo, Alexander Nowakowski, Yanis Inglebert, Paul Savage, Morag Park, Marie-Christine Guiot, Anne McKinney, William J. Muller, Manuel Valiente, Kevin Petrecca, Peter M. Siegel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2022-1569
Published: 15 June 2022
View article titled, Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases
Journal Articles

Abstract PD1-08: Esr1 mutant breast cancers show elevated basal cytokeratins and immune activation

Zheqi Li, Yang Wu, Olivia Mcginn, Amir Bahreini, Nolan M. Priedigkeit, Kai Ding, Sayali Onkar, Carol A. Sartorius, Lori Miller, Margaret Rosenzweig, Nikhil Wagle, Jennifer K. Richer, William J. Muller, Laki Buluwela, Simak Ali, Dario A.A. Vignali, Yusi Fang, Li Zhu, George C. Tseng, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-08.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-08
Published: 15 February 2022
View article titled, Abstract PD1-08: <em>Esr1</em> mutant breast cancers show elevated basal cytokeratins and immune activation
Journal Articles

Abstract 904: Stimulation and expansion of oncogene-reactive tumor infiltrating T cells through combined Ad-HER2Δ16 vaccination and anti-PD1 enable anti-tumor responses against established HER2 BC

Erika J. Crosby, Chaitanya Acharya, Christopher Rabiola, William J. Muller, Lewis A. Chodosh, Gloria Broadwater, Jonathan Shepherd, Daniel Hollern, Xiaping He, Charles M. Perou, Benjamin K. Ashby, Benjamin G. Vincent, Michael A. Morse, Herbert K. Lyerly, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 904.
https://doi.org/10.1158/1538-7445.AM2020-904
Published: 15 August 2020
View article titled, Abstract 904: Stimulation and expansion of oncogene-reactive tumor infiltrating T cells through combined Ad-HER2Δ16 vaccination and anti-PD1 enable anti-tumor responses against established HER2 BC
Journal Articles

Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases

Jianqiang Bao, Alessandra Di Lorenzo, Kevin Lin, Yue Lu, Yi Zhong, Manu M. Sebastian, William J. Muller, Yanzhong Yang, Mark T. Bedford
Journal: Cancer Research
Cancer Res (2019) 79 (1): 21–32.
https://doi.org/10.1158/0008-5472.CAN-18-1995
Published: 02 January 2019
View article titled, Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases
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Includes: Supplementary data
Journal Articles

Abstract 1388: Pharmacologic targeting of DNA methylation blocks breast cancer growth and metastasis

Niaz Mahmood, Ani Arakelian, William J. Muller, Moshe Szyf, Shafaat A. Rabbani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1388.
https://doi.org/10.1158/1538-7445.AM2018-1388
Published: 01 July 2018
View article titled, Abstract 1388: Pharmacologic targeting of DNA methylation blocks breast cancer growth and metastasis
Journal Articles

Abstract 322: Distinct pools of ShcA coupled tyrosine kinase signaling influences breast tumor heterogeneity and therapeutic responsiveness

Jacqueline R. Ha, Ryuhjin Ahn, Young Kyuen Im, Valerie Sabourin, Harvey W. Smith, Ivan Topisirovic, Tony Pawson, Peter Siegel, William J. Muller, Josie Ursini-Siegel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 322.
https://doi.org/10.1158/1538-7445.AM2017-322
Published: 01 July 2017
View article titled, Abstract 322: Distinct pools of ShcA coupled tyrosine kinase signaling influences breast tumor heterogeneity and therapeutic responsiveness
Journal Articles

Abstract 4346: S-Adenosyl methionine (SAM) blocks breast cancer growth, invasion and metastasis in vitro and in vivo

Niaz Mahmood, David Cheishvili, Ani Arakelian, William J. Muller, Moshe Szyf, Shafaat A. Rabbani
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4346.
https://doi.org/10.1158/1538-7445.AM2017-4346
Published: 01 July 2017
View article titled, Abstract 4346: S-Adenosyl methionine (SAM) blocks breast cancer growth, invasion and metastasis <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways

Jongchan Kim, Ashley N. Siverly, Dahu Chen, Min Wang, Yuan Yuan, Yumeng Wang, Hyemin Lee, Jinsong Zhang, William J. Muller, Han Liang, Boyi Gan, Xianbin Yang, Yutong Sun, M. James You, Li Ma
Journal: Cancer Research
Cancer Res (2016) 76 (21): 6424–6435.
https://doi.org/10.1158/0008-5472.CAN-16-1571
Published: 31 October 2016
View article titled, Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways
Open the PDF for Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways in another window
Includes: Supplementary data
Journal Articles

Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers

Meghan Morrison Joly, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Monica Valeria Estrada, Christian Young, Michelle Williams, Brent N. Rexer, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders, Rebecca S. Cook
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4752–4764.
https://doi.org/10.1158/0008-5472.CAN-15-3393
Published: 14 August 2016
View article titled, Rictor/mTORC2 Drives Progression and Therapeutic Resistance of <em>HER2</em>-Amplified Breast Cancers
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Includes: Supplementary data
Journal Articles

Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Pierre-Luc Boulay, Louise Mitchell, Jason Turpin, Julie-Émilie Huot-Marchand, Cynthia Lavoie, Virginie Sanguin-Gendreau, Laura Jones, Shreya Mitra, Julie M. Livingstone, Shirley Campbell, Michael Hallett, Gordon B. Mills, Morag Park, Lewis Chodosh, Douglas Strathdee, Jim C. Norman, William J. Muller
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2662–2674.
https://doi.org/10.1158/0008-5472.CAN-15-2782
Published: 01 May 2016
View article titled, Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
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Includes: Supplementary data
Journal Articles

STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis

Laura M. Jones, Miranda L. Broz, Jill J. Ranger, John Ozcelik, Ryuhjin Ahn, Dongmei Zuo, Josie Ursini-Siegel, Michael T. Hallett, Matthew Krummel, William J. Muller
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1416–1428.
https://doi.org/10.1158/0008-5472.CAN-15-2770
Published: 14 March 2016
View article titled, STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis
Open the PDF for STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis in another window
Includes: Supplementary data
Journal Articles

14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation

Sumaiyah K. Rehman, Shau-Hsuan Li, Shannon L. Wyszomierski, Qingfei Wang, Ping Li, Ozgur Sahin, Yi Xiao, Siyuan Zhang, Yan Xiong, Jun Yang, Hai Wang, Hua Guo, Jitao D. Zhang, Daniel Medina, William J. Muller, Dihua Yu
Journal: Cancer Research
Cancer Res (2014) 74 (1): 363–373.
https://doi.org/10.1158/0008-5472.CAN-13-2016
Published: 05 January 2014
View article titled, 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Open the PDF for 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation in another window
Includes: Supplementary data
Journal Articles

β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression

Babette Schade, Robert Lesurf, Virginie Sanguin-Gendreau, Tung Bui, Geneviève Deblois, Sandra A. O'Toole, Ewan K.A. Millar, Sara J. Zardawi, Elena Lopez-Knowles, Robert L. Sutherland, Vincent Giguère, Michael Kahn, Michael Hallett, William J. Muller
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (14): 4474–4487.
https://doi.org/10.1158/0008-5472.CAN-12-3925
Published: 15 July 2013
View article titled, β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
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Includes: Supplementary data
Journal Articles

Abstract 89: Parathyroid Hormone-related Protein (PTHrP) is critical for breast tumour metastasis and may constitute a novel target for therapeutic intervention.

Jiarong Li, Andrew C. Karaplis, Dao C. Huang, Peter M. Siegel, Anne Camirand, Xian Fang Yang1, William J. Muller, Richard Kremer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 89.
https://doi.org/10.1158/1538-7445.AM2013-89
Published: 15 April 2013
View article titled, Abstract 89: Parathyroid Hormone-related Protein (PTHrP) is critical for breast tumour metastasis and may constitute a novel target for therapeutic intervention.
Journal Articles

Abstract 769: Integrin-Linked Kinase (ILK) breaks Merlin's spell to inhibit the Hippo tumor suppressor pathway and activate the YAP oncogene.

Isabel Serrano, William J. Muller, Shoukat Dedhar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 769.
https://doi.org/10.1158/1538-7445.AM2013-769
Published: 15 April 2013
View article titled, Abstract 769: Integrin-Linked Kinase (ILK) breaks Merlin's spell to inhibit the Hippo tumor suppressor pathway and activate the YAP oncogene.
Journal Articles

Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors

Alison Wakefield, Jitka Soukupova, Amelie Montagne, Jill Ranger, Rhiannon French, William J. Muller, Richard W. E. Clarkson
Journal: Cancer Research
Cancer Res (2013) 73 (2): 745–755.
https://doi.org/10.1158/0008-5472.CAN-12-1321
Published: 16 January 2013
View article titled, Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
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Includes: Supplementary data
Journal Articles

Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer

Qingfei Wang, Shau-Hsuan Li, Hai Wang, Yi Xiao, Ozgur Sahin, Samuel W. Brady, Ping Li, Hailiang Ge, Elizabeth M. Jaffee, William J. Muller, Gabriel N. Hortobagyi, Dihua Yu
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4417–4428.
https://doi.org/10.1158/0008-5472.CAN-12-1339-T
Published: 30 August 2012
View article titled, Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer
Open the PDF for Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Uncoupling of PI3K from ErbB3 Impairs Mammary Gland Development but Does Not Impact on ErbB2-Induced Mammary Tumorigenesis

Hicham Lahlou, Thomas Müller, Virginie Sanguin-Gendreau, Carmen Birchmeier, William J. Muller
Journal: Cancer Research
Cancer Res (2012) 72 (12): 3080–3090.
https://doi.org/10.1158/0008-5472.CAN-11-3513
Published: 14 June 2012
View article titled, Uncoupling of PI3K from ErbB3 Impairs Mammary Gland Development but Does Not Impact on ErbB2-Induced Mammary Tumorigenesis
Open the PDF for Uncoupling of PI3K from ErbB3 Impairs Mammary Gland Development but Does Not Impact on ErbB2-Induced Mammary Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation

David B. Vaught, Jamie C. Stanford, Christian Young, Donna J. Hicks, Frank Wheeler, Cammie Rinehart, Violeta Sánchez, John Koland, William J. Muller, Carlos L. Arteaga, Rebecca S. Cook
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2672–2682.
https://doi.org/10.1158/0008-5472.CAN-11-3594
Published: 14 May 2012
View article titled, HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation
Open the PDF for HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation in another window
Includes: Supplementary data