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William J. LaRochelle
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Journal Articles

CR014-vcMMAE, a potent fully human monoclonal antibody-monomethylauristatin E conjugated drug targeting ovarian and renal cell carcinoma

Kam F. Tse, Vincent A. Pollack, Denise A. McCabe, Melanie Shadish, John R. Macdougall, Nikolai V. Khramtsov, Craig S. Hackett, Suresh G. Shenoy, Michael Gallo, Gadi Gazit-Bornstein, Peter D. Senter, Damon L. Meyer, Traci A. Mansfield, Henri S. Lichenstein, Michael E. Jeffers, William J. Larochelle
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 275.
Published: 15 April 2006
View article titled, CR014-vcMMAE, a potent fully human monoclonal antibody-monomethylauristatin E conjugated drug targeting ovarian and renal cell carcinoma
Journal Articles

CR012, a secretory leukocyte protease inhibitor (SLPI) neutralizing fully human monoclonal antibody inhibits the growth of colon carcinoma in vitro and in vivo

Haihong Zhong, John Macdougall, Danny Chui, Michael Gallo, Gulshan Ara, William J. Larochelle
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1082–1083.
Published: 15 April 2006
View article titled, CR012, a secretory leukocyte protease inhibitor (SLPI) neutralizing fully human monoclonal antibody inhibits the growth of colon carcinoma in vitro and in vivo
Journal Articles

Activity of the HDAC inhibitor, PXD101, used as monotherapy and combination therapy in preclinical NSCLC studies

Xiaozhong Qian, William J. Larochelle, Gulshan Ara, Maxwell Sehested, Henri S. Lichestein, Michael Jeffers
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1114.
Published: 15 April 2006
View article titled, Activity of the HDAC inhibitor, PXD101, used as monotherapy and combination therapy in preclinical NSCLC studies
Journal Articles

CR011, a potent fully human monoclonal antibody-auristatin E conjugate for the treatment of melanoma

Kam Fai Tse, Denise A. McCabe, Vincent A. Pollack, Nikolai V. Khramtsov, Ferenc L. Boldog, John R. Macdougall, Michael Gallo, Gadi Gazit-Bornstein, Peter D. Senter, Damon L. Meyer, Katherine Fries, Enrique Alvarez, Henri S. Lichenstein, Michael E. Jeffers, William J. Larochelle
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 131.
Published: 01 May 2005
View article titled, CR011, a potent fully human monoclonal antibody-auristatin E conjugate for the treatment of melanoma
Journal Articles

CR064, a fully human monoclonal antibody to angiopoietin related protein 4 (ARP4) inhibits ARP4-mediated angiogenesis and renal cell carcinoma survival in vitro

Haihong Zhong, Seth A. Ettenberg, Mohan Dhanabal, Melanie Baron, Nikolai Khramtsov, Ferenc Boldog, Qing Zhou, Henri Lichenstein, Gulshan Ara, William J. Larochelle
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 706.
Published: 01 May 2005
View article titled, CR064, a fully human monoclonal antibody to angiopoietin related protein 4 (ARP4) inhibits ARP4-mediated angiogenesis and renal cell carcinoma survival in vitro
Journal Articles

CG53135 (FGF-20) is a novel efficacious radioprotectant in vivo.

Enrique Alvarez, Bisni Narayanan, Timothy Maclachlan, Edward Fey, Bryn Watkins, Michael S. Braverman, Robert Gerwien, Craig Hyde, Nancy Twomlow, Thomas Seed, William J. Larochelle, Jeffrey D. Peterson
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 723–724.
Published: 01 April 2004
View article titled, CG53135 (FGF-20) is a novel efficacious radioprotectant <em>in vivo</em>.
Journal Articles

An EGF repeat-containing domain of human Ten-m3 inhibits tumor cell migration in vitro and angiogenesis in vivo

Timothy K. Maclachlan, Angela Marino, Seth Ettenberg, Ferenc Boldog, Craig Hackett, Enrique Alvarez, Catherine Burgess, Michael Jeffers, Henri S. Lichenstein, William J. Larochelle
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 692–693.
Published: 01 April 2004
View article titled, An EGF repeat-containing domain of human Ten-m3 inhibits tumor cell migration <em>in vitro</em> and angiogenesis <em>in vivo</em>
Journal Articles

Secretory leukocyte protease inhibitor neutralizing fully human monoclonal antibody CR012 inhibits ovarian carcinoma cell growth in vitro

Zhong Haihong, Gulshan Ara, John Macdougall, Henri H. Lichenstein, Jennifer Macaluso, Danny Chui, Francine Chen, Michael Gallo, William J. Larochelle
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1054–1055.
Published: 01 April 2004
View article titled, Secretory leukocyte protease inhibitor neutralizing fully human monoclonal antibody CR012 inhibits ovarian carcinoma cell growth <em>in vitro</em>
Journal Articles

An angioarrestin-immunoglobulin chimera inhibits endothelial cell migration through integrin-mediated pathways and disrupts in vivo angiogenesis

Frank Wu, Mohanraj Dhanabal, Enrique Alvarez, Kelly D. McQueeney, Michael Jeffers, Uriel Malyankar, Haihong Zhong, Ferenc L. Boldog, Craig Hackett, Nikolai Khramtsov, Muralidhara Padigaru, Suresh Shenoy, Rajeev Chillakuru, Catherine E. Burgess, Henri S. Lichenstein, William J. Larochelle
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 16–17.
Published: 01 April 2004
View article titled, An angioarrestin-immunoglobulin chimera inhibits endothelial cell migration through integrin-mediated pathways and disrupts <em>in vivo</em> angiogenesis
Journal Articles

Angioarrestin: An Antiangiogenic Protein with Tumor-inhibiting Properties

Mohanraj Dhanabal, William J. LaRochelle, Michael Jeffers, John Herrmann, Luca Rastelli, William F. McDonald, Rajeev A. Chillakuru, Meijia Yang, Ferenc L. Boldog, Muralidhara Padigaru, Kelly D. McQueeney, Frank Wu, Stacey A. Minskoff, Richard A. Shimkets, Henri S. Lichenstein
Journal: Cancer Research
Cancer Res (2002) 62 (13): 3834–3841.
Published: 01 July 2002
View article titled, Angioarrestin: <subtitle>An Antiangiogenic Protein with Tumor-inhibiting Properties</subtitle>
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Journal Articles

Platelet-derived Growth Factor D: Tumorigenicity in Mice and Dysregulated Expression in Human Cancer

William J. LaRochelle, Michael Jeffers, Jose R. F. Corvalan, Xiao-Chi Jia, Xiao Feng, Sandra Vanegas, Justin D. Vickroy, Xiao-Dong Yang, Francine Chen, Gadi Gazit, Jane Mayotte, Jennifer Macaluso, Beth Rittman, Frank Wu, Mohan Dhanabal, John Herrmann, Henri S. Lichenstein
Journal: Cancer Research
Cancer Res (2002) 62 (9): 2468–2473.
Published: 01 May 2002
View article titled, Platelet-derived Growth Factor D: <subtitle>Tumorigenicity in Mice and Dysregulated Expression in Human Cancer</subtitle>
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Journal Articles

Identification of a Novel Human Fibroblast Growth Factor and Characterization of Its Role in Oncogenesis

Michael Jeffers, Richard Shimkets, Sudhirdas Prayaga, Ferenc Boldog, Meijia Yang, Catherine Burgess, Elma Fernandes, Beth Rittman, Juliette Shimkets, William J. LaRochelle, Henri S. Lichenstein
Journal: Cancer Research
Cancer Res (2001) 61 (7): 3131–3138.
Published: 01 April 2001
View article titled, Identification of a Novel Human Fibroblast Growth Factor and Characterization of Its Role in Oncogenesis
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Journal Articles

c-Met Autocrine Activation Induces Development of Malignant Melanoma and Acquisition of the Metastatic Phenotype

Toshiyuki Otsuka, Hisashi Takayama, Richard Sharp, Giulia Celli, William J. LaRochelle, Donald P. Bottaro, Nelson Ellmore, Wilfred Vieira, Jennie W. Owens, Miriam Anver, Glenn Merlino
Journal: Cancer Research
Cancer Res (1998) 58 (22): 5157–5167.
Published: 01 November 1998
View article titled, c-Met Autocrine Activation Induces Development of Malignant Melanoma and Acquisition of the Metastatic Phenotype
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