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William G. Nelson
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Journal Articles

Abstract LB324: STING protein expression is increased in intermediate luminal cells in proliferative inflammatory atrophy of the prostate (PIA) and is absent in the majority of primary prostatic adenocarcinomas

Thomas M. Steele, Alan K. Meeker, Mindy K. Graham, Rulin Wang, Carolina Gomes-Alexandre, William G. Nelson, Fernanda Caramella Pereiria, Sushant Kachhap, Srinivasan Yegnasubramanian, Angelo Michael De Marzo
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB324.
https://doi.org/10.1158/1538-7445.AM2024-LB324
Published: 05 April 2024
View articletitled, Abstract LB324: STING protein expression is increased in intermediate luminal cells in proliferative inflammatory atrophy of the prostate (PIA) and is absent in the majority of primary prostatic adenocarcinomas
Journal Articles

Abstract B011: PRAC1 epigenetic silencing in castration resistant prostate cancer and its novel role in androgen receptor biology

Jin-Yih Low, David M. Esopi, Yiting Lim, Ajay M. Vaghasia, Harrison Tsai, Qizhi Zheng, Jessica Hicks, Nicolas Wyhs, Tamara L. Lotan, William B. Isaacs, Angelo M. DeMarzo, William G. Nelson, Andrew C. Hsieh, Srinivasan Yegnasubramanian, Michael C. Haffner
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B011.
https://doi.org/10.1158/1538-7445.PRCA2023-B011
Published: 02 June 2023
View articletitled, Abstract B011: PRAC1 epigenetic silencing in castration resistant prostate cancer and its novel role in androgen receptor biology
Journal Articles

Abstract 680: Topoisomerase 2 beta facilitates chromatin reorganization during Androgen Receptor induced transcription and contributes to chromoplexy in prostate cancer

Minh-Tam N. Pham, Michael C. Haffner, Heather C. Wick, Jonathan B. Coulter, Anuj Gupta, Roshan V. Chikarmane, Harshath Gupta, Sarah Wheelan, William G. Nelson, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 680.
https://doi.org/10.1158/1538-7445.AM2022-680
Published: 15 June 2022
View articletitled, Abstract 680: Topoisomerase 2 beta facilitates chromatin reorganization during Androgen Receptor induced transcription and contributes to chromoplexy in prostate cancer
Journal Articles

Abstract 3734: Progressive spreading of CpG methylation in the CpG island of Glutathione S-Transferase pi 1 (GSTP1) alleles across transitions from precursor to invasive prostate cancer

Harshath Gupta, Hitoshi Inoue, Yasutomo Nakai, Masashi Nakayama, William G. Nelson, Angelo M. De Marzo, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3734.
https://doi.org/10.1158/1538-7445.AM2022-3734
Published: 15 June 2022
View articletitled, Abstract 3734: Progressive spreading of CpG methylation in the CpG island of Glutathione S-Transferase pi 1 (GSTP1) alleles across transitions from precursor to invasive prostate cancer
Journal Articles

Abstract 2198: Allelic phasing of genomic alterations through linked read whole genome sequencing in human prostate cancer cell lines

Minh-Tam Pham, Harshath Gupta, Anuj Gupta, Ajay Vaghasia, Alyza M. Skaist, McKinzie A. Garrison, Roshan Chikamarne, Sarah J. Wheelan, William G. Nelson, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2198.
https://doi.org/10.1158/1538-7445.AM2021-2198
Published: 01 July 2021
View articletitled, Abstract 2198: Allelic phasing of genomic alterations through linked read whole genome sequencing in human prostate cancer cell lines
Journal Articles

Abstract 157: Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

Mindy K. Graham, David Esopi, Jacqueline A. Brosnan-Cashman, Anuj Gupta, Angelo De Marzo, William G. Nelson, Christopher M. Heaphy, Alan K. Meeker, Sarah J. Wheelan, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 157.
https://doi.org/10.1158/1538-7445.AM2020-157
Published: 15 August 2020
View articletitled, Abstract 157: Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
Journal Articles

Abstract 5881: Novel inhibitors of the epigenetic reader protein MBD2

Hugh Giovinazzo, Zachary R. Reichert, Andries Bergman, Xiaohui Lin, Nicolas Wyhs, David Esopi, Ajay Vaghasia, Jianyong Liu, Yash Jain, Akshay Bhamidipati, Ruchama Steinberg, Traci Speed, Matthew Vaughn, Yonggang Zhang, Nate Brennen, Theodore Deweese, Srinivasan Yegnasubramanian, William G. Nelson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5881.
https://doi.org/10.1158/1538-7445.AM2018-5881
Published: 01 July 2018
View articletitled, Abstract 5881: Novel inhibitors of the epigenetic reader protein MBD2
Journal Articles

Commentary on Huggins and Hodges: “Studies on Prostatic Cancer”

William G. Nelson
Journal: Cancer Research
Cancer Res (2016) 76 (2): 186–187.
https://doi.org/10.1158/0008-5472.CAN-15-3172
Published: 14 January 2016
View articletitled, Commentary on Huggins and Hodges: “Studies on Prostatic Cancer”
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Journal Articles

Abstract 5021: Histopathologic and gene expression analysis in mouse models of long-term chronic prostatic inflammation using human prostate cancer-derived bacterial isolates

Gretchen K. Hubbard, Shu-Han Yu, Debika Biswal Shinohara, Ajay Vaghasia, William G. Nelson, Srinivasan Yegnasubramanian, Angelo M. De Marzo, Karen S. Sfanos
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5021.
https://doi.org/10.1158/1538-7445.AM2015-5021
Published: 01 August 2015
View articletitled, Abstract 5021: Histopathologic and gene expression analysis in mouse models of long-term chronic prostatic inflammation using human prostate cancer-derived bacterial isolates
Journal Articles

Abstract LB-129: Small molecular library screening to find methyl binding domain 2 protein inhibitors

Nicolas A. Wyhs, Hugh Giovinazzo, David Walker, Srinivasan Yegnasubramanian, William G. Nelson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-129.
https://doi.org/10.1158/1538-7445.AM2014-LB-129
Published: 01 October 2014
View articletitled, Abstract LB-129: Small molecular library screening to find methyl binding domain 2 protein inhibitors
Journal Articles

Abstract 5390: Development of a high-throughput screening assay to identify UHRF1 inhibitors via time-resolved fluorescence resonance energy transfer (TR-FRET)

David A. Walker, Nicolas Wyhs, Hugh Giovinazzo, Srinivasan Yegnasubramanian, William G. Nelson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5390.
https://doi.org/10.1158/1538-7445.AM2014-5390
Published: 01 October 2014
View articletitled, Abstract 5390: Development of a high-throughput screening assay to identify UHRF1 inhibitors via time-resolved fluorescence resonance energy transfer (TR-FRET)
Journal Articles

Abstract IA25: Inflammation as the trigger of somatic epigenome defects in prostate cancer

William G. Nelson
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): IA25.
https://doi.org/10.1158/1538-7445.PRCA2012-IA25
Published: 09 May 2013
View articletitled, Abstract IA25: Inflammation as the trigger of somatic epigenome defects in prostate cancer
Journal Articles

Abstract 3614: Are circulating testosterone and PSA levels associated in a nationally representative sample of men without a diagnosis of prostate cancer.

Sarah B. Peskoe, William G. Nelson, Corinne E. Joshu, Sabine Rohrmann, Katherine A. McGlynn, Elizabeth A. Platz
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3614.
https://doi.org/10.1158/1538-7445.AM2013-3614
Published: 15 April 2013
View articletitled, Abstract 3614: Are circulating testosterone and PSA levels associated in a nationally representative sample of men without a diagnosis of prostate cancer.
Journal Articles

Abstract 312: A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes.

Debika Biswal Shinohara, Ajay Vaghasia, Shu-Han Yu, William G. Nelson, Angelo M. De Marzo, Srinivasan Yegnasubramanian, Karen S. Sfanos
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 312.
https://doi.org/10.1158/1538-7445.AM2013-312
Published: 15 April 2013
View articletitled, Abstract 312: A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes.
Journal Articles

Abstract 1773: Nucleotide-resolution genomic breakpoint analysis of TMPRSS2-ERG rearrangements in prostate cancer by target-capture next-generation sequencing.

Christopher Weier, Michael Haffner, Timothy Mosbruger, David Esopi, Jessica Hicks, Qizhi Zheng, William B. Isaacs, Angelo M. De Marzo, William G. Nelson, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1773.
https://doi.org/10.1158/1538-7445.AM2013-1773
Published: 15 April 2013
View articletitled, Abstract 1773: Nucleotide-resolution genomic breakpoint analysis of TMPRSS2-ERG rearrangements in prostate cancer by target-capture next-generation sequencing.
Journal Articles

Abstract 262: Complex epigenetic alterations induced by MYC during activation of the rDNA locus

Motohide Uemura, William G. Nelson, Srinivasan Yegnasubramanian, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 262.
https://doi.org/10.1158/1538-7445.AM2011-262
Published: 15 April 2011
View articletitled, Abstract 262: Complex epigenetic alterations induced by MYC during activation of the rDNA locus
Journal Articles

Abstract 1921: Body fatness and sex steroid hormone concentrations in US men – Results from NHANES III

Sabine Rohrmann, Meredith S. Shiels, David S. Lopez, Nader Rifai, William G. Nelson, Norma Kanarek, Eliseo Guallar, Andy Menke, Corinne E. Joshu, Manning Feinlieb, Siobhan Sutcliffe, Elizabeth A. Platz
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1921.
https://doi.org/10.1158/1538-7445.AM2011-1921
Published: 15 April 2011
View articletitled, Abstract 1921: Body fatness and sex steroid hormone concentrations in US men – Results from NHANES III
Journal Articles

Abstract 175: Lack of rDNA promoter hypomethylation in clinical prostate cancer specimens and cell lines

Motohide Uemura, Qizhi Zheng, William G. Nelson, Srinivasan Yegnasubramanian, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 175.
https://doi.org/10.1158/1538-7445.AM10-175
Published: 15 April 2010
View articletitled, Abstract 175: Lack of rDNA promoter hypomethylation in clinical prostate cancer specimens and cell lines
Journal Articles

DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang, Bora Gurel, Toby C. Cornish, Zhijin Wu, Rafael A. Irizarry, James Morgan, Jessica Hicks, Theodore L. DeWeese, William B. Isaacs, G. Steven Bova, Angelo M. De Marzo, William G. Nelson
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8954–8967.
https://doi.org/10.1158/0008-5472.CAN-07-6088
Published: 30 October 2008
View articletitled, DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
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Includes: Supplementary data
Journal Articles

The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Acts as Both a Tumor Initiator and Promoter in the Rat Ventral Prostate

Yasutomo Nakai, William G. Nelson, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2007) 67 (3): 1378–1384.
https://doi.org/10.1158/0008-5472.CAN-06-1336
Published: 05 February 2007
View articletitled, The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Acts as Both a Tumor Initiator and Promoter in the Rat Ventral Prostate
Open the PDF for The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Acts as Both a Tumor Initiator and Promoter in the Rat Ventral Prostate in another window