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Journal Articles

Abstract 7632: Final survival outcomes and post-hoc tumor gene expression pathway analyses of complete responders from a phase Ib clinical trial of HSP90 inhibitor onalespib and paclitaxel in patients with advanced triple-negative breast cancer

Cancer Res (2024) 84 (6_Supplement): 7632.

https://doi.org/10.1158/1538-7445.AM2024-7632

Published: 22 March 2024

View article titled, Abstract 7632: Final survival outcomes and post-hoc tumor gene expression pathway analyses of complete responders from a phase Ib clinical trial of HSP90 inhibitor onalespib and paclitaxel in patients with advanced triple-negative breast cancer

Journal Articles

Abstract 5831: CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor associated macrophages

Cho-Hao Lin, Fatemeh Talebian, Yang Li, Jianmin Zhu, Bolin Zhao, Jin-Qing Liu, Sujit Basu, Xueling Pan, Xi Chen, Pearlly Yan, William E. Carson, Gang Xin, Haitao Wen, Ruoning Wang, Zihai Li, Qin Ma, Xue-Feng Bai

Cancer Res (2023) 83 (7_Supplement): 5831.

https://doi.org/10.1158/1538-7445.AM2023-5831

Published: 04 April 2023

View article titled, Abstract 5831: CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor associated macrophages

Journal Articles

Abstract 3764: Expression patterns of microRNAs and associated target genes in ulcerated primary cutaneous melanoma

Emily Schwarz, Mallory J. DiVincenzo, Casey Ren, Zoe Barricklow, Maribelle Moufawad, Lianbo Yu, Paolo Fadda, Colin Angell, Sara Zelinskas, Steven Sun, John H. Howard, Catherine Chung, Craig Slingluff, Alejandro A. Gru, Kari Kendra, William E. Carson

Cancer Res (2023) 83 (7_Supplement): 3764.

https://doi.org/10.1158/1538-7445.AM2023-3764

Published: 04 April 2023

View article titled, Abstract 3764: Expression patterns of microRNAs and associated target genes in ulcerated primary cutaneous melanoma

Journal Articles

Abstract 3414: Brd4 inhibition enhances checkpoint therapy by inducing MDSC apoptosis

Andrew Stiff, Himanshu Savardekar, Robert Wesolowski, Megan Duggan, Luke Scarberry, Brooke Benner, Darren Wethington, Gabby Lapurga, Steven Sun, Jack Hedberg, Logan Good, William E. Carson

Cancer Res (2020) 80 (16_Supplement): 3414.

https://doi.org/10.1158/1538-7445.AM2020-3414

Published: 15 August 2020

View article titled, Abstract 3414: Brd4 inhibition enhances checkpoint therapy by inducing MDSC apoptosis

Journal Articles

Abstract 5514: Analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients pre- and post-neoadjuvant chemotherapy for operable breast cancer

Cancer Res (2020) 80 (16_Supplement): 5514.

https://doi.org/10.1158/1538-7445.AM2020-5514

Published: 15 August 2020

View article titled, Abstract 5514: Analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients pre- and post-neoadjuvant chemotherapy for operable breast cancer

Journal Articles

Abstract 3696: Determination of the expression patterns and functional implications of microRNAs in ulcerated cutaneous melanoma

Mallory J. DiVincenzo, Casey Ren, Lorena Suarez-Kelly, Maribelle Moufawad, Zoe Barricklow, Paolo Fadda, Lianbo Yu, John H. Howard, Alejandro A. Gru, William E. Carson

Cancer Res (2020) 80 (16_Supplement): 3696.

https://doi.org/10.1158/1538-7445.AM2020-3696

Published: 15 August 2020

View article titled, Abstract 3696: Determination of the expression patterns and functional implications of microRNAs in ulcerated cutaneous melanoma

Journal Articles

Abstract 4481: Effect of immune checkpoint blockade on myeloid derived suppressor cell populations in patients with melanoma

Steven Hao Sun, Brooke Benner, Himanshu Savardekar, Mallory DiVincenzo, David Abood, Andrew Stiff, Megan Duggan, Erin Nagle, John H. Howard, Manisha H. Shah, Kari Kendra, William E. Carson

Cancer Res (2020) 80 (16_Supplement): 4481.

https://doi.org/10.1158/1538-7445.AM2020-4481

Published: 15 August 2020

View article titled, Abstract 4481: Effect of immune checkpoint blockade on myeloid derived suppressor cell populations in patients with melanoma

Journal Articles

Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma

Michael B. Ware, Christopher McQuinn, Thomas A. Mace, Jacob Bowers, Reena Shakya, Brad Farris, Gregory Young, William E. Carson, III, Chrystal M. Paulos, Bassel El-Rayes, Gregory B. Lesinski

Cancer Res (2019) 79 (24_Supplement): B59.

https://doi.org/10.1158/1538-7445.PANCA19-B59

Published: 13 December 2019

View article titled, Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma

Journal Articles

Abstract CT169: Pilot study testing the effects of BTK inhibitor ibrutinib and nivolumab on levels and function of myeloid-derived suppressor cells and other immune subsets in patients with metastatic solid tumors (NCT03525925)

Brooke Benner, Megan Duggan, Andrew Stiff, Bhavana Konda, Robert D. Rupert, Paul Monk, Claire Verschraegen, Hiral Shah, Anne Noonan, William E. Carson, Robert Wesolowski

Cancer Res (2019) 79 (13_Supplement): CT169.

https://doi.org/10.1158/1538-7445.AM2019-CT169

Published: 01 July 2019

View article titled, Abstract CT169: Pilot study testing the effects of BTK inhibitor ibrutinib and nivolumab on levels and function of myeloid-derived suppressor cells and other immune subsets in patients with metastatic solid tumors (NCT03525925)

Journal Articles

Abstract 5607: Tissue factor is a novel oncotarget for immunotherapy of triple-negative breast cancer using a second generation ICON in orthotopic mouse models of human and murine TNBC cell line- and patient-derived xenografts

Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth McMichael, Lianbo Yu, Bhuvaneswari Ramaswamy, Cheryl A. London, Tian Xu, William E. Carson

Cancer Res (2018) 78 (13_Supplement): 5607.

https://doi.org/10.1158/1538-7445.AM2018-5607

Published: 01 July 2018

View article titled, Abstract 5607: Tissue factor is a novel oncotarget for immunotherapy of triple-negative breast cancer using a second generation ICON in orthotopic mouse models of human and murine TNBC cell line- and patient-derived xenografts

Journal Articles

Abstract 3093: 3D structural report of NRAS isoform 5

Joseph Markowitz, Tapas K. Mal, Chunhua Yuan, Nicholas B. Courtney, Mitra Patel, Andrew R. Stiff, James Blachly, Christopher Walker, Ann-Kathrin Eisfeld, Albert de la Chapelle, William E. Carson

Cancer Res (2016) 76 (14_Supplement): 3093.

https://doi.org/10.1158/1538-7445.AM2016-3093

Published: 15 July 2016

View article titled, Abstract 3093: 3D structural report of NRAS isoform 5

Journal Articles

Abstract 195: Defining the role of PAK7 variants in melanoma

Kyle M. LaPak, Michael A. Gross, Denny C. Vroom, Greg B. Lesinski, William E. Carson, Christin E. Burd

Cancer Res (2016) 76 (14_Supplement): 195.

https://doi.org/10.1158/1538-7445.AM2016-195

Published: 15 July 2016

View article titled, Abstract 195: Defining the role of PAK7 variants in melanoma

Journal Articles

Abstract 553: Ibrutinib, a BTK inhibitor, impairs the generation and function of myeloid derived suppressor cells

Andrew R. Stiff, Prashant Trikha, Robert Wesolowski, Kari Kendra, Sarvani Uppati, David Abood, Elizabeth McMichael, Megan Duggan, Amanda Campbell, Natarajan Muthusamy, Susheela Tridandapani, Michael Caliguiri, John C. Byrd, William E. Carson

Cancer Res (2016) 76 (14_Supplement): 553.

https://doi.org/10.1158/1538-7445.AM2016-553

Published: 15 July 2016

View article titled, Abstract 553: Ibrutinib, a BTK inhibitor, impairs the generation and function of myeloid derived suppressor cells

Journal Articles

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

Cancer Res (2016) 76 (8): 2125–2136.

https://doi.org/10.1158/0008-5472.CAN-15-1490

Published: 14 April 2016

View article titled, Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

Journal Articles

Abstract 4278: Soy isoflavones and their metabolites modulate IL-12-induced NK cell IFN-γ production

Thomas A. Mace, Samantha King, Matthew Farren, Elizabeth McMichael, Steven Scoville, William E. Carson, Gregory Young, Jennifer Thomas-Ahner, Kenneth M. Riedl, Steven Schwartz, Steven K. Clinton, Gregory Lesinski

Cancer Res (2015) 75 (15_Supplement): 4278.

https://doi.org/10.1158/1538-7445.AM2015-4278

Published: 01 August 2015

View article titled, Abstract 4278: Soy isoflavones and their metabolites modulate IL-12-induced NK cell IFN-γ production

Journal Articles

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

Mohd W. Nasser, Nissar Ahmad Wani, Dinesh K. Ahirwar, Catherine A. Powell, Janani Ravi, Mohamad Elbaz, Helong Zhao, Laura Padilla, Xiaoli Zhang, Konstantin Shilo, Michael Ostrowski, Charles Shapiro, William E. Carson, III, Ramesh K. Ganju

Cancer Res (2015) 75 (6): 974–985.

https://doi.org/10.1158/0008-5472.CAN-14-2161

Published: 12 March 2015

View article titled, RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

Includes: Supplementary data

Journal Articles

Abstract 3663: Immune suppressive myeloid cells expansion in vitro requires a simulated tumor microenvironment

Joseph Markowitz, Taylor R. Brooks, William E. Carson

Cancer Res (2014) 74 (19_Supplement): 3663.

https://doi.org/10.1158/1538-7445.AM2014-3663

Published: 01 October 2014

View article titled, Abstract 3663: Immune suppressive myeloid cells expansion in vitro requires a simulated tumor microenvironment

Journal Articles

Abstract 4790: Overexpression of miR-3151 leads to direct deregulation of the TP53 pathway and is associated with BRAF mutations in malignant melanoma

Malori Lankenau, Ravi Patel, Joseph Markowitz, William E. Carson, Albert de la Chapelle, Ann-Kathrin Eisfeld

Cancer Res (2014) 74 (19_Supplement): 4790.

https://doi.org/10.1158/1538-7445.AM2014-4790

Published: 01 October 2014

View article titled, Abstract 4790: Overexpression of <em>miR-3151</em> leads to direct deregulation of the TP53 pathway and is associated with <em>BRAF</em> mutations in malignant melanoma

Journal Articles

Abstract 456: Immune-suppressive myeloid cells are induced during disease progression in patients with advanced pancreatic adenocarcinoma.

Joseph Markowitz, Bonnie K. Paul, Taylor R. Brooks, Lai Wei, Jeff Pan, Katherine L. Martin, Eric Luedke, Bethany L. Mundy-Bosse, Gregory B. Lesinski, Tanios Bekaii-Saab, William E. Carson

Cancer Res (2013) 73 (8_Supplement): 456.

https://doi.org/10.1158/1538-7445.AM2013-456

Published: 15 April 2013

View article titled, Abstract 456: Immune-suppressive myeloid cells are induced during disease progression in patients with advanced pancreatic adenocarcinoma.

Journal Articles

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

Bethany L. Mundy-Bosse, Gregory B. Lesinski, Alena C. Jaime-Ramirez, Kristen Benninger, Mahmood Khan, Periannan Kuppusamy, Kristan Guenterberg, Sri Vidya Kondadasula, Abhik Ray Chaudhury, Krista M. La Perle, Melanie Kreiner, Gregory Young, Denis C. Guttridge, William E. Carson, III

Cancer Res (2011) 71 (15): 5101–5110.

https://doi.org/10.1158/0008-5472.CAN-10-2670

Published: 28 July 2011

View article titled, Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

Includes: Supplementary data

NARROW

Abstract 7632: Final survival outcomes and post-hoc tumor gene expression pathway analyses of complete responders from a phase Ib clinical trial of HSP90 inhibitor onalespib and paclitaxel in patients with advanced triple-negative breast cancer

Abstract 5831: CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor associated macrophages

Abstract 3764: Expression patterns of microRNAs and associated target genes in ulcerated primary cutaneous melanoma

Abstract 3414: Brd4 inhibition enhances checkpoint therapy by inducing MDSC apoptosis

Abstract 5514: Analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients pre- and post-neoadjuvant chemotherapy for operable breast cancer

Abstract 3696: Determination of the expression patterns and functional implications of microRNAs in ulcerated cutaneous melanoma

Abstract 4481: Effect of immune checkpoint blockade on myeloid derived suppressor cell populations in patients with melanoma

Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma

Abstract CT169: Pilot study testing the effects of BTK inhibitor ibrutinib and nivolumab on levels and function of myeloid-derived suppressor cells and other immune subsets in patients with metastatic solid tumors (NCT03525925)

Abstract 5607: Tissue factor is a novel oncotarget for immunotherapy of triple-negative breast cancer using a second generation ICON in orthotopic mouse models of human and murine TNBC cell line- and patient-derived xenografts

Abstract 3093: 3D structural report of NRAS isoform 5

Abstract 195: Defining the role of PAK7 variants in melanoma

Abstract 553: Ibrutinib, a BTK inhibitor, impairs the generation and function of myeloid derived suppressor cells

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

Abstract 4278: Soy isoflavones and their metabolites modulate IL-12-induced NK cell IFN-γ production

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

Abstract 3663: Immune suppressive myeloid cells expansion in vitro requires a simulated tumor microenvironment

Abstract 4790: Overexpression of miR-3151 leads to direct deregulation of the TP53 pathway and is associated with BRAF mutations in malignant melanoma

Abstract 456: Immune-suppressive myeloid cells are induced during disease progression in patients with advanced pancreatic adenocarcinoma.

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

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