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William C. Hahn
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Journal Articles

Abstract LB318: MYC primes a paralog synthetic lethality involving the mitochondrial transporters TIMM17A and TIMM17B and N-acetylaspartate

Free
Sydney M. Moyer, Nina Ilic, Sydney Gang, Jasmine Stavridi, Gaia Taig, Joseph D. DeAngelo, Andrea Jiang, Brian H. Shim, Jonathan P. Rennhack, Melis A. Akinci, Jonathan So, Helen Wang, Federica Piccioni, Jessica A. Talamas, David E. Root, William C. Hahn
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB318.
https://doi.org/10.1158/1538-7445.AM2025-LB318
Published: 25 April 2025
View articletitled, Abstract LB318: MYC primes a paralog synthetic lethality involving the mitochondrial transporters TIMM17A and TIMM17B and N-acetylaspartate
Journal Articles

Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells

Free
Raanan Berger, Phillip G. Febbo, Pradip K. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, K. Thirza Campbell, William R. Sellers, Thomas M. Roberts, Massimo Loda, Todd R. Golub, William C. Hahn
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2561.
https://doi.org/10.1158/0008-5472.CAN-24-1910
Published: 01 August 2024
View articletitled, Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
Open the PDF for Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells in another window
Journal Articles

Retraction: Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity

Free
Wen Chen, Jason D. Arroyo, Jamie C. Timmons, Richard Possemato, William C. Hahn
Journal: Cancer Research
Cancer Res (2024) 84 (6): 935.
https://doi.org/10.1158/0008-5472.CAN-24-0434
Published: 15 March 2024
View articletitled, Retraction: Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity
Open the PDF for Retraction: Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity in another window
Journal Articles

Abstract IA11: Using the Cancer Dependency Map

Free
William C Hahn
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): IA11.
https://doi.org/10.1158/1538-7445.ADVBC23-IA11
Published: 01 February 2024
View articletitled, Abstract IA11: Using the Cancer Dependency Map
Journal Articles

Abstract LB074: Towards the next generation cancer dependency map

Free
Kirsty Wienand, Samantha Stokes, Philip G. Montgomery, Kelly Sullivan, Joshua M. Dempster, William C. Hahn, Jennifer A. Roth, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB074.
https://doi.org/10.1158/1538-7445.AM2023-LB074
Published: 14 April 2023
View articletitled, Abstract LB074: Towards the next generation cancer dependency map
Journal Articles

Abstract 5524: Persistent patient barriers to genomic testing in ambulatory oncology

Free
Ellana K. Haakenstad, Jane Roberts, Anna C. Revette, Wendy Loeser, Joseph Grider, Andrea Kruse, Alissa Gentile, Rachel Freedman, Neal I. Lindeman, Olga Kozyreva, Pedro Sanz-Altamira, Christopher S. Lathan, Michael Hassett, Ethan Cerami, Annette S. Kim, Danielle K. Manning, Jonathan Nowak, Marios Giannakis, R Coleman Lindsley, William C. Hahn, Barrett J. Rollins, Levi Garraway, Bruce E. Johnson, Nadine Jackson McCleary
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5524.
https://doi.org/10.1158/1538-7445.AM2023-5524
Published: 04 April 2023
View articletitled, Abstract 5524: Persistent patient barriers to genomic testing in ambulatory oncology
Journal Articles

Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer

Open Access
Kimberly R. Hagel, Rand Arafeh, Sydney Gang, Taylor E. Arnoff, Rebecca C. Larson, John G. Doench, Nathan D. Mathewson, Kai W. Wucherpfennig, Marcela V. Maus, William C. Hahn
Journal: Cancer Research
Cancer Res (2023) 83 (4): 613–625.
https://doi.org/10.1158/0008-5472.CAN-22-2245
Published: 15 February 2023
View articletitled, Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
Open the PDF for Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Available to Purchase
Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 441–455.
https://doi.org/10.1158/0008-5472.CAN-22-3050
Published: 03 February 2023
View articletitled, Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Open the PDF for Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Abstract PR014: Cytokine mediated epigenetic reprogramming of CRC primary tumors drives liver metastasis

Free
Jonathan Rennhack, Arika Dwivedi, Nathan Wu, Brian Shim, Alba Font-Tello, Nikolas Kesten, Andrew Aguirre, Henry Long, Kimmie Ng, William C. Hahn
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): PR014.
https://doi.org/10.1158/1538-7445.METASTASIS22-PR014
Published: 15 January 2023
View articletitled, Abstract PR014: Cytokine mediated epigenetic reprogramming of CRC primary tumors drives liver metastasis
Journal Articles

Abstract B023: Sox9 drives an aberrant transcriptional program impeding intestinal differentiation in colorectal cancer initiation

Free
Pratyusha Bala, Jonathan P. Rennhack, Clare Morris, Daulet Aitymbayev, Sydney M. Moyer, Gina Nicole Duronio, Paul Doan, William C. Hahn, Nilay S. Sethi
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): B023.
https://doi.org/10.1158/1538-7445.CRC22-B023
Published: 01 December 2022
View articletitled, Abstract B023: Sox9 drives an aberrant transcriptional program impeding intestinal differentiation in colorectal cancer initiation
Journal Articles

Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers

Free
Daniel Bondeson, Brenton Paolella, Adhana Asfaw, Michael Rothberg, Thomas Skipper, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allie Warren, Joshua Dempster, J Michael Krill-Burger, Maria Ericsson, Andrew Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John Doench, Federica Piccioni, David Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James McFarland, Francisca Vazquez, Todd Golub
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1028.
https://doi.org/10.1158/1538-7445.AM2022-1028
Published: 15 June 2022
View articletitled, Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers
Journal Articles

Abstract 2361: MYC-driven breast cancer tumorigenesis is dependent on normal mitochondrial function

Free
Sydney M. Moyer, Nina Ilic, Sydney Gang, Taylor E. Arnoff, William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2361.
https://doi.org/10.1158/1538-7445.AM2022-2361
Published: 15 June 2022
View articletitled, Abstract 2361: MYC-driven breast cancer tumorigenesis is dependent on normal mitochondrial function
Journal Articles

Abstract SY27-03: Using the cancer dependency map

Free
William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): SY27-03.
https://doi.org/10.1158/1538-7445.AM2022-SY27-03
Published: 15 June 2022
View articletitled, Abstract SY27-03: Using the cancer dependency map
Journal Articles

Abstract 2402: SMAD4 represses PDAC metastatic colonization through binding FOSL1 enhancer regions

Free
Jonathan P. Rennhack, Chao Dai, Andrew Aguirre, John Doench, David Root, William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2402.
https://doi.org/10.1158/1538-7445.AM2022-2402
Published: 15 June 2022
View articletitled, Abstract 2402: SMAD4 represses PDAC metastatic colonization through binding FOSL1 enhancer regions
Journal Articles

Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Free
Lisa D. Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A. Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M. Dempster, John M. Krill-Burger, Federica Piccioni, Namrata D. Udeshi, Meagan E. Olive, Steven A. Carr, David E. Root, James M. McFarland, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 73.
https://doi.org/10.1158/1538-7445.AM2022-73
Published: 15 June 2022
View articletitled, Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Free
Lisa D Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M Dempster, John M Krill-Burger, Federica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-01.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-01
Published: 15 February 2022
View articletitled, Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Free
Jasper E. Neggers, Brenton Paolella, Adhana Asfaw, Michael V. Rothberg, Tom A. Skipper, Radha Kalekar, Michael Burger, Neekesh Dharia, Guillaume Kugener, Jeremie Kalfon, Nancy Dumont, Yvonne Li, Liam Spurr, Annan Yang, Wenbo Wu, AndrewAdam Durbin, Brian M. Wolpin, David E. Root, Jesse Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2021-NG01
Published: 01 July 2021
View articletitled, Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
Journal Articles

Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival

Free
Lisa D. Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua Dempster, John M. Krill-Burger, Namrata Udeshi, Meagan Olive, Steven A. Carr, David E. Root, Federica Piccioni, James M. McFarland, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1950.
https://doi.org/10.1158/1538-7445.AM2021-1950
Published: 01 July 2021
View articletitled, Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival
Journal Articles

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Free
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, Michael J. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Adam D. Durbin, Annan Yang, Nancy Dumont, Yvonne Y. Li, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-011.
https://doi.org/10.1158/1538-7445.PANCA20-PO-011
Published: 13 November 2020
View articletitled, Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers
Journal Articles

Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer

Free
Srivatsan Raghavan, Peter S. Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Radha L. Kalekar, Jennyfer Galvez-Reyes, Kristen E. Lowder, Nolawit Mulugeta, Manisha S. Raghavan, Ashir A. Borah, Sara A. Vayrynen, Andressa Dias Costa, Junning Wang, Emma Reilly, Dorisanne Y. Ragon, Lauren K. Brais, Alex M. Jaeger, James M. Cleary, Lorin Crawford, Jonathan A. Nowak, Brian M. Wolpin, William C. Hahn, Andrew J. Aguirre, Alex K. Shalek
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-058.
https://doi.org/10.1158/1538-7445.PANCA20-PO-058
Published: 13 November 2020
View articletitled, Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer