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William Bornmann
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Journal Articles

Abstract 5361: Development of targeted inhibitors against RecQ1 helicase

Mingxin Zuo, David Maxwell, Basvoju A. Bhanu Prasad, Zhenghong Peng, William Bornmann, Milind M. Javle
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5361.
https://doi.org/10.1158/1538-7445.AM2014-5361
Published: 01 October 2014
View article titled, Abstract 5361: Development of targeted inhibitors against RecQ1 helicase
Journal Articles

Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers

Xiumei Huang, Zachary Moore, Xiuquan Luo, Gaurab Chakrabarti, Mariya Ilcheva, Rolf Brekken, Sandeep Burma, Jinming Gao, Ralph Deberardinis, William Bornmann, Paul Hergenrother, David A. Boothman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 787.
https://doi.org/10.1158/1538-7445.AM2014-787
Published: 01 October 2014
View article titled, Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers
Journal Articles

Abstract #4773: Activation of a novel Jak-Stat inhibitory pathway by a small molecule

Vaibhav Kapuria, Luke Peterson, Hanshi Sun, Geoffrey Bartholomeusz, William Bornmann, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4773.
Published: 01 May 2009
View article titled, Abstract #4773: Activation of a novel Jak-Stat inhibitory pathway by a small molecule
Journal Articles

Abstract #3720: Inhibition of BCR-ABL signaling in imatinib sensitive and resistant chronic myelogenous leukemia and progenitor cells through small molecule-mediated BCR-ABL ubiquitination and aggresomal deposition

Nicholas Donato, Hanshi Sun, Vaibhav Kapuria, Luke Peterson, Zhenghong Peng, David Maxwell, William Bornmann, Moshe Talpaz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3720.
Published: 01 May 2009
View article titled, Abstract #3720: Inhibition of BCR-ABL signaling in imatinib sensitive and resistant chronic myelogenous leukemia and progenitor cells through small molecule-mediated BCR-ABL ubiquitination and aggresomal deposition
Journal Articles

Abstract #2047: Non-genotoxic p53 activation and blockade of Bcl-2 signaling synergistically induce apoptosis in AML through induction of Noxa and Bak/Bax heterodimerization

Twee Tsao, Marina Konopleva, Xiaoyang Ling, Kensuke Kojima, Julie Watt, Duncan Mak, Monique Verhaegen, William Bornmann, Maria Soengas, Michael Andreeff
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2047.
Published: 01 May 2009
View article titled, Abstract #2047: Non-genotoxic p53 activation and blockade of Bcl-2 signaling synergistically induce apoptosis in AML through induction of Noxa and Bak/Bax heterodimerization
Journal Articles

Abstract #2841: Targeting histone deacetylase to inhibit the stem cell phenotype of inflammatory breast cancer cells

Fredika Robertson, Carolyn Hall, William Bornmann, Ashatosh Pal, Zhenhong Peng, Wendy Woodward, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2841.
Published: 01 May 2009
View article titled, Abstract #2841: Targeting histone deacetylase to inhibit the stem cell phenotype of inflammatory breast cancer cells
Journal Articles

Kit Inhibitor APcK110 Induces Apoptosis and Inhibits Proliferation of Acute Myeloid Leukemia Cells

Stefan Faderl, Ashutosh Pal, William Bornmann, Maher Albitar, David Maxwell, Quin Van, Zhenghong Peng, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Hagop M. Kantarjian, Zeev Estrov
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3910–3917.
https://doi.org/10.1158/0008-5472.CAN-08-0034
Published: 30 April 2009
View article titled, Kit Inhibitor APcK110 Induces Apoptosis and Inhibits Proliferation of Acute Myeloid Leukemia Cells
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Journal Articles

Simultaneous blockade of the Bcl-2 and mTOR/Akt pathways induces apoptosis in AML cells under bone marrow microenvironment simulating conditions

Marina Konopleva, Zhihong Zeng, Ismael Samudio, William Bornmann, Michael Andreeff
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3719.
Published: 01 May 2008
View article titled, Simultaneous blockade of the Bcl-2 and mTOR/Akt pathways induces apoptosis in AML cells under bone marrow microenvironment simulating conditions
Journal Articles

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

Marina Konopleva, Julie Watt, Rooha Contractor, Twee Tsao, David Harris, Zeev Estrov, William Bornmann, Hagop Kantarjian, Jean Viallet, Ismael Samudio, Michael Andreeff
Journal: Cancer Research
Cancer Res (2008) 68 (9): 3413–3420.
https://doi.org/10.1158/0008-5472.CAN-07-1919
Published: 01 May 2008
View article titled, Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)
Open the PDF for Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax) in another window
Includes: Supplementary data
Journal Articles

Mutations in the EGFR kinase domain mediate Stat3 activation via IL-6 production in human lung adenocarcinomas

Sizhi Gao, Kevin Mark, Kenneth Leslie, William Pao, Noriko Motoi, William Gerald, William Travis, William Bornmann, Darren Veach, Bayard Clarkson, Jacqueline Bromberg
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3544.
Published: 01 May 2008
View article titled, Mutations in the EGFR kinase domain mediate Stat3 activation via IL-6 production in human lung adenocarcinomas
Journal Articles

Molecular-genetic image guided studies of the antitumor HIF-1α inhibitor PX-478 in combination with radiation

David Schwartz, Oh J, Ryan Williams, Robert Lemos, Andrei Volgin, Norihito Kuno, Suren Soghomonyan, Ryuichi Nishii, Mian Aluaddin, Uday Mukhopadhay, William Bornmann, Zheng-Hong Peng, Juri Gelovani, Garth Powis
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2566.
Published: 01 May 2008
View article titled, Molecular-genetic image guided studies of the antitumor HIF-1α inhibitor PX-478 in combination with radiation
Journal Articles

Lapatinib activity is independent of EGFR expression levels in HER2-overexpressing breast cancer cells

Dongwei Zhang, Ashutosh Pal, William Bornmann, Francisco Esteva, Gabriel Hortobagyi, Naoto Ueno
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4855.
Published: 01 May 2008
View article titled, Lapatinib activity is independent of EGFR expression levels in HER2-overexpressing breast cancer cells
Journal Articles

Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

Jyotsnabaran Halder, Yvonne G. Lin, William M. Merritt, Whitney A. Spannuth, Alpa M. Nick, Toshiyuki Honda, Aparna A. Kamat, Liz Y. Han, Tae Jin Kim, Chunhua Lu, Ana M. Tari, William Bornmann, Ariel Fernandez, Gabriel Lopez-Berestein, Anil K. Sood
Journal: Cancer Research
Cancer Res (2007) 67 (22): 10976–10983.
https://doi.org/10.1158/0008-5472.CAN-07-2667
Published: 15 November 2007
View article titled, Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma
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Journal Articles

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target

Ariel Fernández, Angela Sanguino, Zhenghong Peng, Alejandro Crespo, Eylem Ozturk, Xi Zhang, Shimei Wang, William Bornmann, Gabriel Lopez-Berestein
Journal: Cancer Research
Cancer Res (2007) 67 (9): 4028–4033.
https://doi.org/10.1158/0008-5472.CAN-07-0345
Published: 04 May 2007
View article titled, Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target
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Includes: Supplementary data
Journal Articles

PSMA activation of antifolate prodrugs for treatment of prostate cancer

Tatiana Litvin-Vechnyak, Natalia Lavnikova, Emine Abali, Zhenghong Peng, William Bornmann, Joseph Bertino
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5732.
Published: 01 May 2007
View article titled, PSMA activation of antifolate prodrugs for treatment of prostate cancer
Journal Articles

Downregulation of p21 induces cisplatin resistance in tumor cells harboring wild-type p53

Bahareh Tavana, Zai-Feng Huang, Abdul Khokhar, William Bornmann, Zahid Siddik
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3194.
Published: 01 May 2007
View article titled, Downregulation of p21 induces cisplatin resistance in tumor cells harboring wild-type p53
Journal Articles

Structure-based drug design of c-kit inhibitors for use in the treatment of several types of cancer

David Maxwell, Ashutosh Pal, Zhenghong Peng, Alexandr Shavrin, Stefan Faderl, Davis Harris, Quin Van, Liu Zhiming, Srdan Verstovsek, Taghi Manshouri, Alessandra Ferrajoli, Hagop Kantarjian, Zeev Estrov, Eylem Ozturk, Angelo Sanguino, Gabriel Lopez-Berestein, William Bornmann
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3959.
Published: 01 May 2007
View article titled, Structure-based drug design of c-kit inhibitors for use in the treatment of several types of cancer
Journal Articles

Molecularly engineered specificity in anti-cancer activity

Ariel Fernandez, Zhenghong Peng, William Bornmann, David Maxwell, Gariel Lopez-Berestein, Juri Gelovani, Anil Sood, Angela Sanguino
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3962.
Published: 01 May 2007
View article titled, Molecularly engineered specificity in anti-cancer activity
Journal Articles

Degrasyn Activates Proteasomal-Dependent Degradation of c-Myc

Geoffrey Bartholomeusz, Moshe Talpaz, William Bornmann, Ling-Yuan Kong, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3912–3918.
https://doi.org/10.1158/0008-5472.CAN-06-4464
Published: 17 April 2007
View article titled, Degrasyn Activates Proteasomal-Dependent Degradation of c-Myc
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Journal Articles

Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells

Laura Pedranzini, Tobias Dechow, Marjan Berishaj, Raymond Comenzo, Ping Zhou, Janeen Azare, William Bornmann, Jacqueline Bromberg
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9714–9721.
https://doi.org/10.1158/0008-5472.CAN-05-4280
Published: 03 October 2006
View article titled, Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells
Open the PDF for Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells in another window
Includes: Supplementary data