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William B. Isaacs
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Journal Articles

Abstract B011: PRAC1 epigenetic silencing in castration resistant prostate cancer and its novel role in androgen receptor biology

Jin-Yih Low, David M. Esopi, Yiting Lim, Ajay M. Vaghasia, Harrison Tsai, Qizhi Zheng, Jessica Hicks, Nicolas Wyhs, Tamara L. Lotan, William B. Isaacs, Angelo M. DeMarzo, William G. Nelson, Andrew C. Hsieh, Srinivasan Yegnasubramanian, Michael C. Haffner
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B011.
https://doi.org/10.1158/1538-7445.PRCA2023-B011
Published: 02 June 2023
View article titled, Abstract B011: <em>PRAC1</em> epigenetic silencing in castration resistant prostate cancer and its novel role in androgen receptor biology
Journal Articles

Abstract 3517: A germline variant at 8q24 contributes to familial clustering of prostate cancer in men of African ancestry

Burcu F. Darst, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Victoria L. Stevens, Sonja I. Berndt, Chad D. Huff, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Shiv Srivastava, John Carpten, Thomas A. Sellers, Maureen Sanderson, Dana C. Crawford, Olivier Cussenot, Jennifer Cullen, Rick A. Kittles, Jianfeng Xu, Zsofia Kote-Jarai, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Jennifer J. Hu, Graham Casey, Anselm J. Hennis, Ian M. Thompson, Robin Leach, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Rosalind A. Eeles, Laurent Brureau, Stephen J. Chanock, Stephen Watya, Janet L. Stanford, Diptasri Mandal, William B. Isaacs, Kathleen A. Cooney, William J. Blot, David V. Conti, Christopher A. Haiman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3517.
https://doi.org/10.1158/1538-7445.AM2020-3517
Published: 15 August 2020
View article titled, Abstract 3517: A germline variant at 8q24 contributes to familial clustering of prostate cancer in men of African ancestry
Journal Articles

Abstract 2595: HMGA1 induces the HOXB13 developmental gene to drive tumor progression in androgen receptor negative, castrate-resistant prostate cancer

Lionel Chia, Guangjing Zhu, Mikhail Gorbounov, Lingling Xian, Briyana Chisholm, Mohammad Heydarian, Dorhyun Johng, William B. Isaacs, Karen Reddy, Linda S. Resar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2595.
https://doi.org/10.1158/1538-7445.AM2019-2595
Published: 01 July 2019
View article titled, Abstract 2595: HMGA1 induces the <em>HOXB13</em> developmental gene to drive tumor progression in androgen receptor negative, castrate-resistant prostate cancer
Journal Articles

Abstract 4582: Mannose receptor positive macrophage infiltrate correlates with prostate cancer onset and metastatic castration-resistant disease

Jelani C. Zarif, Javier A. Baena-Del Valle, Jessica L. Hicks, Christopher M. Heaphy, Igor Vidal, Jacob Luo, Tamara L. Lotan, Jody E. Hooper, William B. Isaacs, Kenneth J. Pienta, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4582.
https://doi.org/10.1158/1538-7445.AM2019-4582
Published: 01 July 2019
View article titled, Abstract 4582: Mannose receptor positive macrophage infiltrate correlates with prostate cancer onset and metastatic castration-resistant disease
Journal Articles

Abstract 1094: A role for olfactory-like chemosensory signaling in prostate cancer metastasis

Hong Lam, Wanqu Zhu, Hailun Wang, Jun Luo, Qizhi Zheng, Ken Valkenburg, Paula Hurley, Jennifer L. Pluznick, Phuoc T. Tran, Angelo M. De Marzo, William B. Isaacs, Kenneth J. Pienta, Steven S. An
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1094.
https://doi.org/10.1158/1538-7445.AM2018-1094
Published: 01 July 2018
View article titled, Abstract 1094: A role for olfactory-like chemosensory signaling in prostate cancer metastasis
Journal Articles

Abstract 1802: Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases

Heini M. Kallio, Reija Hieta, Anniina Brofeldt, Matti Annala, Kati Kivinummi, Teuvo L. Tammela, Matti Nykter, William B. Isaacs, Hans G. Lilja, G Steven Bova, Tapio Visakorpi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1802.
https://doi.org/10.1158/1538-7445.AM2018-1802
Published: 01 July 2018
View article titled, Abstract 1802: Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases
Journal Articles

Abstract 651: Development of an RNA in situ hybridization assay for the detection of prostate cancer cells in urine

Jillian N. Eskra, Daniel Rabizadeh, Christian P. Pavlovich, Leslie Mangold, Elizabeth Fabian, William B. Isaacs, Jun Luo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 651.
https://doi.org/10.1158/1538-7445.AM2018-651
Published: 01 July 2018
View article titled, Abstract 651: Development of an RNA <em>in situ</em> hybridization assay for the detection of prostate cancer cells in urine
Journal Articles

Abstract 3524: HOXB13 collaborates with AR to alter the cellular phenotype of prostate epithelial cells through cytokeratin 14 upregulation

Dorhyun Johng, Charles M. Ewing, William B. Isaacs
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3524.
https://doi.org/10.1158/1538-7445.AM2017-3524
Published: 01 July 2017
View article titled, Abstract 3524: HOXB13 collaborates with AR to alter the cellular phenotype of prostate epithelial cells through cytokeratin 14 upregulation
Journal Articles

Abstract 2027: Global analyses of HOXB13-regulated transcription reveal a potential link between HOXB13 G84E and prostate cancer risk

Dorhyun Johng, Michael C. Haffner, Steven M. Mooney, David M. Esopi, Charles M. Ewing, Shuangling Chen, William B. Isaacs
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2027.
https://doi.org/10.1158/1538-7445.AM2016-2027
Published: 15 July 2016
View article titled, Abstract 2027: Global analyses of HOXB13-regulated transcription reveal a potential link between HOXB13 G84E and prostate cancer risk
Journal Articles

Abstract A1-04: The role of chromatin remodeler CHD1 in genomic alterations and prostate cancer progression

Wennuan Liu, Lindsey Ulkus Rodrigues, Tao Li, Zheng Zhang, Leah Rider, Lina Romero, Lilly S. Zheng, William B. Isaacs, Scott Cramer, Jianfeng Xu
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A1-04.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A1-04
Published: 15 November 2015
View article titled, Abstract A1-04: The role of chromatin remodeler CHD1 in genomic alterations and prostate cancer progression
Journal Articles

Abstract 961: Genome– and proteome–wide analyses of HOXB13 and the G84E variant associated with prostate cancer

Dorhyun Johng, Michael C. Haffner, David M. Esopi, William B. Isaacs
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 961.
https://doi.org/10.1158/1538-7445.AM2015-961
Published: 01 August 2015
View article titled, Abstract 961: Genome– and proteome–wide analyses of HOXB13 and the G84E variant associated with prostate cancer
Journal Articles

Abstract 4605: Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

Danyelle A. Winchester, Cathee Till, Phyllis J. Goodman, Catherine M. Tangen, Regina M. Santella, Teresa L. Johnson-Pais, Robin J. Leach, Jianfeng Xu, S. Lilly Zheng, Ian M. Thompson, M. Scott Lucia, Scott M. Lippmann, Howard L. Parnes, Paul J. Dluzniewski, William B. Isaacs, Angelo M. De Marzo, Charles G. Drake, Elizabeth A. Platz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4605.
https://doi.org/10.1158/1538-7445.AM2015-4605
Published: 01 August 2015
View article titled, Abstract 4605: Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial
Journal Articles

Abstract 3883: Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study

Heini M.L. Kallio, Matti Annala, Kati Kivinummi, Gunilla Högnäs, Gunes Gundem, David C. Wedge, Peter Van Loo, Holger Heyn, Michael R. Emmert-Buck, William B. Isaacs, Manel Esteller, Ultan McDermott, Matti Nykter, Tapio Visakorpi, G. Steven Bova
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3883.
https://doi.org/10.1158/1538-7445.AM2015-3883
Published: 01 August 2015
View article titled, Abstract 3883: Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study
Journal Articles

Abstract 2948: HOXB13: Investigating mechanisms of G84E mutation associated with prostate carcinogenesis

Dorhyun Johng, Charles M. Ewing, Steven M. Mooney, Shuangling Chen, William B. Isaacs
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2948.
https://doi.org/10.1158/1538-7445.AM2014-2948
Published: 01 October 2014
View article titled, Abstract 2948: HOXB13: Investigating mechanisms of G84E mutation associated with prostate carcinogenesis
Journal Articles

Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer

Emmanuel S. Antonarakis, Changxue Lu, Hao Wang, Brandon Luber, Mary Nakazawa, Jeffrey C. Roeser, Yan Chen, Helen L. Fedor, Tamara L. Lotan, Angelo M. De Marzo, John T. Isaacs, William B. Isaacs, Rosa Nadal, Channing J. Paller, Samuel R. Denmeade, Michael A. Carducci, Mario A. Eisenberger, Jun Luo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2910.
https://doi.org/10.1158/1538-7445.AM2014-2910
Published: 01 October 2014
View article titled, Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer
Journal Articles

Abstract 5066: Generalizability of established prostate cancer risk variants in men of African ancestry

Ying Han, Lisa B. Signorello, Sara S. Strom, Rick A. Kittles, Benjamin A. Rybicki, Janet L. Stanford, Phyllis J. Goodman, Sonja I. Berndt, John Carpten, Graham Casey, Lisa Chu, David V. Conti, Kristin A. Rand, Ryan Diver, Anselm J. Hennis, Esther M. John, Adam S. Kibel, Eric A. Klein, Suzanne Kolb, Loic L. Marchand, M Cristina Leske, Adam B. Murphy, Christine Neslund-Dudas, Jong Y. Park, Curtis A. Pettaway, Timothy R. Rebbeck, Susan M. Gapstur, Siqun Lilly Zheng, Suh-Yuh Wu, John S. Witte, Jianfeng Xu, William B. Isaacs, Sue A. Ingles, Ann W. Hsing, The PRACTICAL Consortium, The ELLIPSE GAME-ON Consortium, Douglas F. Easton, Rosalind A. Eeles, Fredrick R. Schumacher, Stephen J. Chanock, Barbara Nemesure, William J. Blot, Daniel O. Stram, Brian E. Henderson, Christopher A. Haiman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5066.
https://doi.org/10.1158/1538-7445.AM2014-5066
Published: 01 October 2014
View article titled, Abstract 5066: Generalizability of established prostate cancer risk variants in men of African ancestry
Journal Articles

Abstract A04: HOXB13 regulates androgen receptor expression in prostate cancer

Shuangling Chen, William B. Isaacs
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): A04.
https://doi.org/10.1158/1538-7445.FBCR13-A04
Published: 15 May 2014
View article titled, Abstract A04: HOXB13 regulates androgen receptor expression in prostate cancer
Journal Articles

Abstract 753: Reciprocal regulation of HOXB13 and androgen receptor in prostate cancer.

Shuangling Chen, Dorhyun Johng, William B. Isaacs
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 753.
https://doi.org/10.1158/1538-7445.AM2013-753
Published: 15 April 2013
View article titled, Abstract 753: Reciprocal regulation of HOXB13 and androgen receptor in prostate cancer.
Journal Articles

Abstract 3618: Peripheral cytokine profiles and prostate cancer risk in CLUE II.

Nrupen A. Bhavsar, Jay J. Bream, Alan K. Meeker, Charles G. Drake, Sarah B. Peskoe, Angelo M. De Marzo, William B. Isaacs, Elizabeth A. Platz
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3618.
https://doi.org/10.1158/1538-7445.AM2013-3618
Published: 15 April 2013
View article titled, Abstract 3618: Peripheral cytokine profiles and prostate cancer risk in CLUE II.
Journal Articles

Abstract 1773: Nucleotide-resolution genomic breakpoint analysis of TMPRSS2-ERG rearrangements in prostate cancer by target-capture next-generation sequencing.

Christopher Weier, Michael Haffner, Timothy Mosbruger, David Esopi, Jessica Hicks, Qizhi Zheng, William B. Isaacs, Angelo M. De Marzo, William G. Nelson, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1773.
https://doi.org/10.1158/1538-7445.AM2013-1773
Published: 15 April 2013
View article titled, Abstract 1773: Nucleotide-resolution genomic breakpoint analysis of TMPRSS2-ERG rearrangements in prostate cancer by target-capture next-generation sequencing.