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Journal Articles

Editor’s Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma

Louis Chesler, Chris Schlieve, David D. Goldenberg, Anna Kenney, Grace Kim, Alex McMillan, Katherine K. Matthay, David Rowitch, William A. Weiss
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3311.
https://doi.org/10.1158/0008-5472.CAN-24-2888
Published: 01 October 2024
View articletitled, Editor’s Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma
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Journal Articles

Abstract 2848: MYC and TGFβ promote group 3 medulloblastoma tumor resistance through deregulation of Polycomb targets

Zulekha A. Qadeer, Samanta Westelman, Mackenzie O. Johnson, Elise Hou, Shane Grele, Kyle Smith, Liam Hendrikse, Linyu Wang, Sarah Husain, Mary Clare Beytagh, Christin Schmidt, Miller Huang, Michael D. Taylor, Paul Northcott, William A. Weiss
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2848.
https://doi.org/10.1158/1538-7445.AM2024-2848
Published: 22 March 2024
View articletitled, Abstract 2848: MYC and TGFβ promote group 3 medulloblastoma tumor resistance through deregulation of Polycomb targets
Journal Articles

N-myc–Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma

Duygu Kuzuoglu-Ozturk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D. Larson, Ryan R.L. Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert Wechsler-Reya, Joanna J. Phillips, Jason E. Gestwicki, Davide Ruggero, William A. Weiss
Journal: Cancer Research
Cancer Res (2023) 83 (1): 130–140.
https://doi.org/10.1158/0008-5472.CAN-22-0945
Published: 04 January 2023
View articletitled, N-myc–Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma
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Includes: Supplementary data
Journal Articles

Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages

Megan L. Tigue, Matthew A. Loberg, Jeremy A. Goettel, William A. Weiss, Ethan Lee, Vivian L. Weiss
Journal: Cancer Research
Cancer Res (2023) 83 (1): 3–11.
https://doi.org/10.1158/0008-5472.CAN-22-1403
Published: 04 January 2023
View articletitled, Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages
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Journal Articles

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Aria Vaishnavi, Joseph Juan, Maebh Jacob, Christopher Stehn, Eric E. Gardner, Michael T. Scherzer, Sophia Schuman, J. Edward Van Veen, Brandon Murphy, Christopher S. Hackett, Adam J. Dupuy, Steven A. Chmura, Louise van der Weyden, Justin Y. Newberg, Annie Liu, Karen Mann, Alistair G. Rust, William A. Weiss, Conan G. Kinsey, David J. Adams, Allie Grossmann, Michael B. Mann, Martin McMahon
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4261–4273.
https://doi.org/10.1158/0008-5472.CAN-21-3214
Published: 15 November 2022
View articletitled, Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis
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Includes: Supplementary data
Journal Articles

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Levens, John M. Maris, Ronen Marmorstein, Steven J. Metallo, Julie R. Park, Linda Z. Penn, Michael Rape, Martine F. Roussel, Kevan M. Shokat, William P. Tansey, Kliment A. Verba, Seychelle M. Vos, William A. Weiss, Elmar Wolf, Yaël P. Mossé
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1627–1632.
https://doi.org/10.1158/0008-5472.CAN-20-3108
Published: 01 April 2021
View articletitled, Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
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Journal Articles

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma

Robyn A. Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A. Haas-Kogan, Joanna J. Phillips, Kevan M. Shokat, William A. Weiss, Qi Wen Fan
Journal: Cancer Research
Cancer Res (2020) 80 (4): 709–718.
https://doi.org/10.1158/0008-5472.CAN-18-2808
Published: 14 February 2020
View articletitled, Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma
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Includes: Supplementary data
Journal Articles

Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

Zhenyi An, Christiane B. Knobbe-Thomsen, Xiaohua Wan, Qi Wen Fan, Guido Reifenberger, William A. Weiss
Journal: Cancer Research
Cancer Res (2019) 79 (21): 5681.
https://doi.org/10.1158/0008-5472.CAN-19-2800
Published: 01 November 2019
View articletitled, Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma
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Journal Articles

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

Zhenyi An, Christiane B. Knobbe-Thomsen, Xiaohua Wan, Qi Wen Fan, Guido Reifenberger, William A. Weiss
Journal: Cancer Research
Cancer Res (2018) 78 (24): 6785–6794.
https://doi.org/10.1158/0008-5472.CAN-17-3551
Published: 13 December 2018
View articletitled, EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma
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Includes: Supplementary data
Journal Articles

Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

Sharmistha Pal, David Kozono, Xiaodong Yang, Wojciech Fendler, Whitney Fitts, Jing Ni, John A. Alberta, Jean Zhao, Kevin X. Liu, Jie Bian, Nathalene Truffaux, William A. Weiss, Adam C. Resnick, Pratiti Bandopadhayay, Keith L. Ligon, Steven G. DuBois, Sabine Mueller, Dipanjan Chowdhury, Daphne A. Haas-Kogan
Journal: Cancer Research
Cancer Res (2018) 78 (14): 4007–4021.
https://doi.org/10.1158/0008-5472.CAN-17-3691
Published: 15 July 2018
View articletitled, Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas
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Includes: Supplementary data
Journal Articles

Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma

QiWen Fan, Ozlem Aksoy, Robyn Wong, Shirin Ilkhanizadeh, Chris Novotny, William Gustafson, Albert Tuong, Geraldine Cayanan, Erin Simonds, Daphne Haas-Kogan, Joanna Phillips, Theo Nicolaides, Theo Nicolaides, Masanori Okaniwa, Kevan Shokat, William A. Weiss
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): IA27.
https://doi.org/10.1158/1538-7445.Transcontrol16-IA27
Published: 14 March 2017
View articletitled, Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma
Journal Articles

Abstract 2473: Combined BET-bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Sara Bolin, Anna Borgenvik, Camilla Persson, Gabriela Rosén, Anders Sundström, Jun Qi, James E. Bradner, William A. Weiss, Yoon-Jae Cho, Holger Weishaupt, Fredrik J. Swartling
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2473.
https://doi.org/10.1158/1538-7445.AM2016-2473
Published: 15 July 2016
View articletitled, Abstract 2473: Combined BET-bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
Journal Articles

Abstract 1916: Targeting a MAPK-miR-124-Sox9 axis radiosensitizes human glioblastoma cells

Hanna Sabelstrom, Rahul Jandial, Ksenya Shchors, Selma Masic, Edith Yuan, Trenten Fenster, Supna Saxena, Allen Ho, Theodore P. Nicolaides, Robyn Wong, Stanislava Yakovenko, Mitchel H. Berger, Evan Y. Snyder, Johan Jakobsson, William A. Weiss, Anders I. Persson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1916.
https://doi.org/10.1158/1538-7445.AM2016-1916
Published: 15 July 2016
View articletitled, Abstract 1916: Targeting a MAPK-miR-124-Sox9 axis radiosensitizes human glioblastoma cells
Journal Articles

Abstract A46: Transcriptome analysis on tumor and its normal cerebellar counterpart from mouse models reveals molecular mechanisms underlying evolution of SHH and Group3 medulloblastoma

Xiaochong Wu, Adrian Dubuc, William A. Weiss, Robert J. Wechsler-Reya, Michael D. Taylor
Journal: Cancer Research
Cancer Res (2015) 75 (23_Supplement): A46.
https://doi.org/10.1158/1538-7445.BRAIN15-A46
Published: 09 December 2015
View articletitled, Abstract A46: Transcriptome analysis on tumor and its normal cerebellar counterpart from mouse models reveals molecular mechanisms underlying evolution of SHH and Group3 medulloblastoma
Journal Articles

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma

Jasmine Lau, Shirin Ilkhanizadeh, Susan Wang, Yekaterina A. Miroshnikova, Nicolas A. Salvatierra, Robyn A. Wong, Christin Schmidt, Valerie M. Weaver, William A. Weiss, Anders I. Persson
Journal: Cancer Research
Cancer Res (2015) 75 (20): 4302–4311.
https://doi.org/10.1158/0008-5472.CAN-14-3331
Published: 14 October 2015
View articletitled, STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
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Includes: Supplementary data
Journal Articles

Abstract 2313: Characterizing intratumoral cellular heterogeneity in human glioblastoma xenografts by 30+ parameter single-cell mass cytometry

Erin F. Simonds, Garry P. Nolan, William A. Weiss
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2313.
https://doi.org/10.1158/1538-7445.AM2015-2313
Published: 01 August 2015
View articletitled, Abstract 2313: Characterizing intratumoral cellular heterogeneity in human glioblastoma xenografts by 30+ parameter single-cell mass cytometry
Journal Articles

Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma

Miller Huang, Lauren K. McHenry, Matthew L. Miller, Grace E. Kim, Branden S. Moriarity, Yuichiro Miyaoka, Marianne E. Bronner, David A. Largaespada, Bruce R. Conklin, Hanlee P. Ji, John M. Maris, Katherine K. Matthay, William A. Weiss
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3230.
https://doi.org/10.1158/1538-7445.AM2015-3230
Published: 01 August 2015
View articletitled, Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma
Journal Articles

Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A

W. Clay Gustafson, Justin G. Meyerowitz, Erin A. Nekritz, Elise Charron, Katherine K. Matthay, Nicholas T. Hertz, Martin Eilers, Kevan M. Shokat, William A. Weiss
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): PR08.
https://doi.org/10.1158/1538-7445.PEDCAN-PR08
Published: 09 October 2014
View articletitled, Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A
Journal Articles

Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma

Justin G. Meyerowitz, W. Clay Gustafson, Erin Nekritz, Fredrik Swartling, Kevan M. Shokat, Davide Ruggero, William A. Weiss
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B78.
https://doi.org/10.1158/1538-7445.PEDCAN-B78
Published: 09 October 2014
View articletitled, Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma
Journal Articles

Abstract 3413: A genetic analysis of splicing in neuroblastoma identifies opposing functions for FUBP1 splice variants in MYC regulation

Justin Chen, Christopher S. Hackett, Shile Zhang, Young K. Song, Annette Molinaro, David A. Quigley, Allan Balmain, William C. Gustafson, Terry A. Van Dyke, Pui-Yan Kwok, Javed Khan, William A. Weiss
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3413.
https://doi.org/10.1158/1538-7445.AM2014-3413
Published: 01 October 2014
View articletitled, Abstract 3413: A genetic analysis of splicing in neuroblastoma identifies opposing functions for FUBP1 splice variants in MYC regulation