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Wilko Weichert
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Journal Articles

Abstract 4539: Tumor evolution and immune microenvironment dynamics define response to neoadjuvant treatment of esophageal adenocarcinoma

Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland M. Schmid, Jens T. Siveke, Michael Quante, Trevor A. Graham
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4539.
https://doi.org/10.1158/1538-7445.AM2023-4539
Published: 04 April 2023
View article titled, Abstract 4539: Tumor evolution and immune microenvironment dynamics define response to neoadjuvant treatment of esophageal adenocarcinoma
Journal Articles

Abstract P6-01-24: Long-term outcome data using Endopredict® as risk stratification and chemotherapy decision biomarker in hormone receptor positive, HER2-negative early breast cancer

Evelyn Klein, Adriana Josipovic, Aurelia Noske, Sophie Anders, Carolin Mogler, Wilko Weichert, Alexander Hapfelmeier, Marion Kiechle, Johannes Ettl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-01-24.
https://doi.org/10.1158/1538-7445.SABCS22-P6-01-24
Published: 01 March 2023
View article titled, Abstract P6-01-24: Long-term outcome data using Endopredict® as risk stratification and chemotherapy decision biomarker in hormone receptor positive, HER2-negative early breast cancer
Journal Articles

Abstract 4018: Long-term response to Trastuzumab in patients with advanced gastric or gastroesophageal adenocarcinoma - A retrospective study

Isabel Porth, Philip Weidner, Sylvie Lorenzen, Wilko Weichert, Thorsten Oliver Götze, Sven Perner, Kim Luley, Daniela Hirsch, Ralf-Dieter Hofheinz, Diana B. Peckys, Zahra Mostajeran, Niels de Jonge, Timo Gaiser
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4018.
https://doi.org/10.1158/1538-7445.AM2022-4018
Published: 15 June 2022
View article titled, Abstract 4018: Long-term response to Trastuzumab in patients with advanced gastric or gastroesophageal adenocarcinoma - A retrospective study
Journal Articles

Abstract PD9-07: Mdm2 gene amplification in estrogen receptor-positive breast cancer cells is associated with enhanced solid tumor growth and pronounced metastatic potential in humanized tumor mice (HTM) and a poor outcome of patients with luminal breast cancer

Anja Kathrin Wege, Valentina Vladimirova, Christine Solbach, Eva-Maria Rom-Jurek, Jens-Uwe Blohmer, Paul Jank, Bruno Sinn, Andreas Trumpp, Elisabetta Marangoni, Knut Engels, Wilko Weichert, Nicole Pfarr, Christoph Irlbeck, Bernhard Polzer, Olaf Ortmann, Marion van Mackelenbergh, Carsten Denkert, Sibylle Loibl, Gero Brockhoff
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-07.
https://doi.org/10.1158/1538-7445.SABCS21-PD9-07
Published: 15 February 2022
View article titled, Abstract PD9-07: Mdm2 gene amplification in estrogen receptor-positive breast cancer cells is associated with enhanced solid tumor growth and pronounced metastatic potential in humanized tumor mice (HTM) and a poor outcome of patients with luminal breast cancer
Journal Articles

Abstract PO-070: Longitudinal precision oncology platform to identify chemotherapy-induced vulnerabilities in pancreatic cancer

Katja Peschke, Hannah Jakubowski, Arlett Schäfer, Carlo Maurer, Sebastian Lange, Felix Orben, Raquel Bernad, Felix Harder, Matthias Eiber, Rupert Öllinger, Melissa Schlitter, Wilko Weichert, Veit Phillip, Christoph Schlag, Roland Schmid, Rickmer Braren, Bo Kong, Ekin Demir, Helmut Friess, Roland Rad, Dieter Saur, Günter Schneider, Maximilian Reichert
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-070.
https://doi.org/10.1158/1538-7445.PANCA21-PO-070
Published: 15 November 2021
View article titled, Abstract PO-070: Longitudinal precision oncology platform to identify chemotherapy-induced vulnerabilities in pancreatic cancer
Journal Articles

Abstract PR003: Fibroblast plasticity driven by Prrx1 interferes the tumor cells - tumor microenvironment crosstalk towards a more aggressive pancreatic ductal adenocarcinoma

Karin Feldmann, Carlo Maurer, Katja Peschke, Steffen Teller, Kathleen Schuck, Katja Steiger, Thomas Engleitner, Rupert Öllinger, Aristeidis Papargyriou, Rim Sabrina Jahan Sarker, Wilko Weichert, Anil K. Rustgi, Roland M. Schmid, Roland Rad, Günter Schneider, Dieter Saur, Maximilian Reichert
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PR003.
https://doi.org/10.1158/1538-7445.TME21-PR003
Published: 01 March 2021
View article titled, Abstract PR003: Fibroblast plasticity driven by Prrx1 interferes the tumor cells - tumor microenvironment crosstalk towards a more aggressive pancreatic ductal adenocarcinoma
Journal Articles

Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement

Jan Budczies, Daniel Kazdal, Michael Allgäuer, Petros Christopoulos, Eugen Rempel, Nicole Pfarr, Wilko Weichert, Stefan Fröhling, Michael Thomas, Solange Peters, Volker Endris, Peter Schirmacher, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3093.
https://doi.org/10.1158/1538-7445.AM2020-3093
Published: 15 August 2020
View article titled, Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement
Journal Articles

Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium

Peter Horak, Christoph Heining, Andreas Mock, Simon Kreutzfeldt, Andreas Lassmann, Lino Möhrmann, Jennifer Hüllein, Dorothea Hanf, Arne Jahn, Leo Ruhnke, Laura Gieldon, Christoph E. Heilig, Veronica Teleanu, Martina Fröhlich, Sebastian Uhrig, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meissburger, Frederick Klauschen, Ulrich Keilholz, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard F. Schlenk, Barbara Klink, Barbara Hutter, Daniel Hübschmann, Albrecht Stenzinger, Wilko Weichert, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling, German Cancer Consortium (DKTK)
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 821.
https://doi.org/10.1158/1538-7445.AM2020-821
Published: 15 August 2020
View article titled, Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium
Journal Articles

Abstract 4037: Analytical and inter-observer comparability of 4 clinically developed programmed death-ligand 1 (PD-L1) immunohistochemistry assays in advanced clear cell renal cell carcinoma (CCRCC)

Ulrich Sommer, Markus Eckstein, Johannes Ammann, Till Braunschweig, Stephan Macher-Goeppinger, Kristina Schwamborn, Stefanie Hieke-Schulz, Bernd Wullich, Manfred Wirth, Wilfried Roth, Ruth Knüchel, Wilko Weichert, Gustavo Baretton, Arndt Hartmann
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4037.
https://doi.org/10.1158/1538-7445.AM2019-4037
Published: 01 July 2019
View article titled, Abstract 4037: Analytical and inter-observer comparability of 4 clinically developed programmed death-ligand 1 (PD-L1) immunohistochemistry assays in advanced clear cell renal cell carcinoma (CCRCC)
Journal Articles

Abstract 1686: Comprehensive genomic and transcriptomic profiling of gastrointestinal stromal tumors

Peter Horak, Matea Hajnic, Laura Gieldon, Mario Hlevnjak, Susan Richter, Barbara Hutter, Johanna Falkenhorst, Sebastian Uhrig, Gregor Warsow, Nagarajan Paramasivam, Stefan Gröschel, Barbara Klink, Simon Kreutzfeldt, Christoph Heining, Christoph E. Heilig, Martina Fröhlich, Stephan Richter, Christian Brandts, Wilko Weichert, Philipp Jost, Olaf Neumann, Marc Zapatka, Albrecht Stenzinger, Alexander Marx, Benedikt Brors, Evelin Schröck, Sebastian Bauer, Peter Hohenberger, Hanno Glimm, Claudia Scholl, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1686.
https://doi.org/10.1158/1538-7445.AM2019-1686
Published: 01 July 2019
View article titled, Abstract 1686: Comprehensive genomic and transcriptomic profiling of gastrointestinal stromal tumors
Journal Articles

Abstract 2723: Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Stefan Gröschel, Daniel Hübschmann, Francesco Raimondi, Peter Horak, Gregor Warsow, Martina Fröhlich, Barbara Klink, Laura Gieldon, Barbara Hutter, Kortine Kleinhenz, David Bonekamp, Oliver Marschal, Priya Chudasama, Jagoda Mika, Marie Groth, Sebastian Uhrig, Stephen Krämer, Christoph Heining, Christoph Heilig, Daniela Richter, Eva Reisinger, Katrin Pfütze, Roland Eils, Stephan Wolf, Christof von Kalle, Christian Brandts, Claudia Scholl, Wilko Weichert, Stephan Richter, Sebastian Bauer, Roland Penzel, Evelin Schröck, Albrecht Stenzinger, Richard Schlenk, Benedikt Brors, Robert Russell, Hanno Glimm, Matthias Schlesner, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2723.
https://doi.org/10.1158/1538-7445.AM2019-2723
Published: 01 July 2019
View article titled, Abstract 2723: Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Journal Articles

Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium

Peter Horak, Christoph Heining, Simon Kreutzfeldt, Christoph E. Heilig, Lino Möhrmann, Laura Gieldon, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meißburger, Frederick Klauschen, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Börries, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard Schlenk, Barbara Klink, Barbara Hutter, Wilko Weichert, Albrecht Stenzinger, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 468.
https://doi.org/10.1158/1538-7445.AM2019-468
Published: 01 July 2019
View article titled, Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium
Journal Articles

Abstract LB-027: Mutational diversity and therapy response in breast cancer-a sequencing analysis in the neoadjuvant GeparSepto trial

Sibylle Loibl, Denise Treue, Jan Budczies, Karsten Weber, Albrecht Stenzinger, Wolfgang D. Schmitt, Wilko Weichert, Paul Jank, Jenny Furlanetto, Frederick Klauschen, Thomas Karn, Nicole Pfarr, Gunter von Minckwitz, Annika Lehmann, Christian Jackisch, Christine Sers, Andreas Schneeweiss, Peter A. Fasching, Christian Schem, Michael Hummel, Marion van Mackelenbergh, Valentina Nekljudova, Michael Untch, Carsten Denkert
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-027.
https://doi.org/10.1158/1538-7445.AM2018-LB-027
Published: 01 July 2018
View article titled, Abstract LB-027: Mutational diversity and therapy response in breast cancer-a sequencing analysis in the neoadjuvant GeparSepto trial
Journal Articles

Abstract 391: Evolutionary trajectories and KRAS gene dosage define pancreatic cancer phenotypes

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M. Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I. Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Roland M. Schmid, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 391.
https://doi.org/10.1158/1538-7445.AM2018-391
Published: 01 July 2018
View article titled, Abstract 391: Evolutionary trajectories and <em>KRAS</em> gene dosage define pancreatic cancer phenotypes
Journal Articles

Abstract 1063: A clear cell renal cancer metastasis model identifies novel mediators of tumor aggressiveness and predictors of patient survival

Felix Geist, Teresa Dolt, Thomas Höfner, Corinna Klein, Vanessa Vogel, Albrecht Stenzinger, Tim Holland-Letz, Ornella Kossi, Wilko Weichert, Peter Schirmacher, Sascha Pahernik, Markus Hohenfellner, Andreas Trumpp, Martin Sprick
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1063.
https://doi.org/10.1158/1538-7445.AM2018-1063
Published: 01 July 2018
View article titled, Abstract 1063: A clear cell renal cancer metastasis model identifies novel mediators of tumor aggressiveness and predictors of patient survival
Journal Articles

Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program

Evelin Schrock, Barbara Hutter, Martina Fröhlich, Falk Zakrzewski, Sebastian Uhrig, Andreas Rump, Karl Hackmann, Joseph Porrmann, Laura Gieldon, Daniela Richter, Albrecht Stenzinger, Thomas Kindler, Wilko Weichert, Philipp J. Jost, Christian Brandts, Klaus Schulze-Osthoff, Johanna Falkenhorst, Sebastian Bauer, Frederick Klauschen, Konrad Klinghammer, Gunnar Folprecht, Martin Wermke, Karsten Spiekermann, Benedikt Brors, Stefan Gröschel, Christoph Heining, Peter Horak, Hanno Glimm, Stefan Fröhling, Barbara Klink
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-287.
https://doi.org/10.1158/1538-7445.AM2017-LB-287
Published: 01 July 2017
View article titled, Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program
Journal Articles

Abstract B77: CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Elisa M. Noll, Christian Eisen, Albrecht Stenzinger, Elisa Espinet, Alexander Muckenhuber, Corinna Klein, Vanessa Vogel, Bernd Klaus, Wiebke Nadler, Christoph Rösli, Christian Lutz, Michael Kulke, Jan Engelhardt, Franziska Zickgraf, Octavio Espinosa, Matthias Schlesner, Xiaoqi Jiang, Annette Kopp-Schneider, Peter Neuhaus, Marcus Bahra, Bruno V. Sinn, Roland Eils, Nathalia A. Giese, Thilo Hackert, Oliver Strobel, Jens Werner, Markus W. Büchler, Wilko Weichert, Andreas Trumpp, Martin R. Sprick
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B77.
https://doi.org/10.1158/1538-7445.PANCA16-B77
Published: 14 December 2016
View article titled, Abstract B77: CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 3167: CNV patterns in 822 routine diagnostic cases of NSCLC, melanoma, and colorectal cancer

Albrecht Stenzinger, Roland Penzel, Frederick Klauschen, Arne Warth, Regine Brandt, Daniel Heim, Peter Schirmacher, Wilko Weichert, Volker Endris, Nicole Pfarr
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3167.
https://doi.org/10.1158/1538-7445.AM2016-3167
Published: 15 July 2016
View article titled, Abstract 3167: CNV patterns in 822 routine diagnostic cases of NSCLC, melanoma, and colorectal cancer
Journal Articles

Abstract 3254: Discovery of histone demethylase KDM5C inactivation as a novel mechanism for tumors resistant to VEGF RTKi via genome-wide in-vivo RNAi

Azadeh Fahim Golestaneh, Maoyun Sun, Christian Schwager, Zili Tang, Stephan Macher-Goeppinger, Lila Ma, Philip Hahnfeldt, Mahmoud Moustafa, Wilko Weichert, Sascha Pahernik, Carsten Grüllich, Wilfried Roth, Jürgen Debus, Lynn Hlatky, Amir Abdollahi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3254.
https://doi.org/10.1158/1538-7445.AM2016-3254
Published: 15 July 2016
View article titled, Abstract 3254: Discovery of histone demethylase KDM5C inactivation as a novel mechanism for tumors resistant to VEGF RTKi via genome-wide in-vivo RNAi
Journal Articles

Abstract 2283: Molecular signaling in multiple myeloma: association of RAS/RAF mutation status and MAPK pathway activation in primary myeloma patient biopsies

Jing Xu, Nicole Pfarr, Volker Endris, Elias K. Mai, Nur Hafzan Md Hanafiah, Nicola Lehners, Roland Penzel, Wilko Weichert, Anthony D. Ho, Peter Schirmacher, Hartmut Goldschmidt, Mindaugas Andrulis, Marc S. Raab
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2283.
https://doi.org/10.1158/1538-7445.AM2016-2283
Published: 15 July 2016
View article titled, Abstract 2283: Molecular signaling in multiple myeloma: association of RAS/RAF mutation status and MAPK pathway activation in primary myeloma patient biopsies