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Journal Articles

Abstract 432: The noncanonical mechanism of metabolic enzyme LDHA in cancer progression

Juan Liu, Wenwei Hu, Zhaohui Feng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 432.
https://doi.org/10.1158/1538-7445.AM2024-432
Published: 22 March 2024
View article titled, Abstract 432: The noncanonical mechanism of metabolic enzyme LDHA in cancer progression
Journal Articles

Abstract 272: Autophagy and MEK inhibition promotes ferroptosis in liver kinase B1 (Lkb1)-deficient Kras-driven lung tumors

Vrushank Bhatt, Taijin Lan, Wenping Wang, Jerry Kong, Eduardo Cararo Lopes, Khoosheh Khayati, Jianming Wang, Akash Raju, Michael Rangel, Enrique Lopez, Zhixian Sherrie Hu, Xuefei Luo, Xiaoyang Su, Jyoti Malhotra, Wenwei Hu, Sharon R. Pine, Eileen White, Jessie Yanxiang Guo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 272.
https://doi.org/10.1158/1538-7445.AM2023-272
Published: 04 April 2023
View article titled, Abstract 272: Autophagy and MEK inhibition promotes ferroptosis in liver kinase B1 (Lkb1)-deficient Kras-driven lung tumors
Journal Articles

Hypothermia Is a Potential New Therapy for a Subset of Tumors with Mutant p53

Wenwei Hu, Zhaohui Feng
Journal: Cancer Research
Cancer Res (2021) 81 (14): 3762–3763.
https://doi.org/10.1158/0008-5472.CAN-21-1025
Published: 15 July 2021
View article titled, Hypothermia Is a Potential New Therapy for a Subset of Tumors with Mutant p53
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Journal Articles

Abstract CT184: First-Line (1L) nivolumab (NIVO) plus chemotherapy (chemo) versus chemo in patients (pts) with advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Chinese subgroup analysis

Lin Shen, Yuxian Bai, Xiaoyan Lin, Wei Li, Jufeng Wang, Xiaochun Zhang, Hongming Pan, Chunmei Bai, Li Bai, Ying Cheng, Jingdong Zhang, Haijun Zhong, Yi Ba, Wenwei Hu, Ruihua Xu, Weijian Guo, Shukui Qin, Nong Yang, Jianwei Lu, Kohei Shitara, Ming Lei, Mingshun Li, Nicole Bao, Tian Chen, Tianshu Liu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT184.
https://doi.org/10.1158/1538-7445.AM2021-CT184
Published: 01 July 2021
View article titled, Abstract CT184: First-Line (1L) nivolumab (NIVO) plus chemotherapy (chemo) versus chemo in patients (pts) with advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Chinese subgroup analysis
Journal Articles

Abstract 762: Clinical characteristics and prognostic value of the KRASmutation in Chinese colorectal cancer patients

Ye Yuan, Wei Wang, Jiemin Zhao, Junling Zhang, Shiqing Chen, Chunti Shen, Changping Wu, Wenwei Hu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 762.
https://doi.org/10.1158/1538-7445.AM2021-762
Published: 01 July 2021
View article titled, Abstract 762: Clinical characteristics and prognostic value of the <em>KRAS</em>mutation in Chinese colorectal cancer patients
Journal Articles

Abstract 88: Autophagy inhibition sensitizes liver kinase b1 (LKB1)-deficient kras-driven lung tumors to MEK inhibitor trametinib

Vrushank Dharmesh Bhatt, Taijin Lan, Wenping Wang, Khoosheh Khayati, Eduardo Cararo-Lopes, Jianming Wang, Jerry Kong, Akash Raju, Xuefei Luo, Wenwei Hu, Xiaoyang Su, Eileen White, Jessie Yanxiang Guo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 88.
https://doi.org/10.1158/1538-7445.AM2021-88
Published: 01 July 2021
View article titled, Abstract 88: Autophagy inhibition sensitizes liver kinase b1 (LKB1)-deficient kras-driven lung tumors to MEK inhibitor trametinib
Journal Articles

Abstract 4406: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression

Cen Zhang, Juan Liu, Yuhan Zhao, Xuetian Yue, Hao Wu, Jun Li, Zhiyuan Shen, Bruce Haffty, Wenwei Hu, Zhaohui Feng
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4406.
https://doi.org/10.1158/1538-7445.AM2017-4406
Published: 01 July 2017
View article titled, Abstract 4406: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression
Journal Articles

Abstract 2493: Identification of the mutant p53-PARP-MCM chromatin axis as a triple negative breast cancer replication stress target

Wei-Gang Qiu, Alla Polotskaia, Gu Xiao, Lia Di, Yuhan Zhao, Wenwei Hu, John Philip, Ronald Hendrickson, Jill Bargonetti
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2493.
https://doi.org/10.1158/1538-7445.AM2017-2493
Published: 01 July 2017
View article titled, Abstract 2493: Identification of the mutant p53-PARP-MCM chromatin axis as a triple negative breast cancer replication stress target
Journal Articles

Abstract 3417: The impact of p53 codon 72 SNP upon aging and longevity in mouse models

Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jun Li, Jianming Wang, Zhaohui Feng, Wenwei Hu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3417.
https://doi.org/10.1158/1538-7445.AM2017-3417
Published: 01 July 2017
View article titled, Abstract 3417: The impact of p53 codon 72 SNP upon aging and longevity in mouse models
Journal Articles

Abstract 1229: E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Cen Zhang, Juan Liu, Xiaolong Wang, Ken H. Young, Wenwei Hu, Zhaohui Feng
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1229.
https://doi.org/10.1158/1538-7445.AM2015-1229
Published: 01 August 2015
View article titled, Abstract 1229: E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis
Journal Articles

Abstract 1221: Pontin, a new mutant p53 binding protein, promotes gain-of-function of mutant p53

Yuhan Zhao, Cen Zhang, Xuetian Yue, Xiaoyan Li, Juan Liu, Haiyang Yu, Qifeng Yang, Zhaohui Feng, Wenwei Hu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1221.
https://doi.org/10.1158/1538-7445.AM2015-1221
Published: 01 August 2015
View article titled, Abstract 1221: Pontin, a new mutant p53 binding protein, promotes gain-of-function of mutant p53
Journal Articles

Abstract 1223: LIF is a novel negative regulator of p53 in colorectal cancers

Wenwei Hu, Haiyang Yu, Xuetian Yue, Yuhan Zhao, Cen Zhang, Ken Young, Juan Liu, Zhaohui Feng
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1223.
https://doi.org/10.1158/1538-7445.AM2015-1223
Published: 01 August 2015
View article titled, Abstract 1223: LIF is a novel negative regulator of p53 in colorectal cancers
Journal Articles

Abstract 784: Chronic stress promotes tumorigenesis through attenuation of p53 function .

Cen Zhang, Meihua Lin, Yuhan Zhao, Tongsen Zheng, Jiabei Wang, Arnold Levine, Zhaohui Feng, Wenwei Hu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 784.
https://doi.org/10.1158/1538-7445.AM2013-784
Published: 15 April 2013
View article titled, Abstract 784: Chronic stress promotes tumorigenesis through attenuation of p53 function .
Journal Articles

Abstract 2642: Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

Lan Yi, Chiwei Lu, Wenwei Hu, Arnold J. Levine
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2642.
https://doi.org/10.1158/1538-7445.AM2013-2642
Published: 15 April 2013
View article titled, Abstract 2642: Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.
Journal Articles

Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation

Lan Yi, Chiwei Lu, Wenwei Hu, Yvonne Sun, Arnold J. Levine
Journal: Cancer Research
Cancer Res (2012) 72 (21): 5635–5645.
https://doi.org/10.1158/0008-5472.CAN-12-1451
Published: 31 October 2012
View article titled, Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation
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Includes: Supplementary data
Journal Articles

Single Nucleotide Polymorphisms in the p53 Pathway

Alexei Vazquez, Wenwei Hu, Zhaohui Feng, Gareth Bond, Gurinder Atwal, Arnold Levine
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LE09.
Published: 01 May 2008
View article titled, Single Nucleotide Polymorphisms in the p53 Pathway
Journal Articles

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Zhaohui Feng, Wenwei Hu, Elisa de Stanchina, Angelika K. Teresky, Shengkan Jin, Scott Lowe, Arnold J. Levine
Journal: Cancer Research
Cancer Res (2007) 67 (7): 3043–3053.
https://doi.org/10.1158/0008-5472.CAN-06-4149
Published: 04 April 2007
View article titled, The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
Open the PDF for The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways in another window
Includes: Supplementary data
Journal Articles

A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells

Wenwei Hu, Zhaohui Feng, Lan Ma, John Wagner, J. Jeremy Rice, Gustavo Stolovitzky, Arnold J. Levine
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2757–2765.
https://doi.org/10.1158/0008-5472.CAN-06-2656
Published: 15 March 2007
View article titled, A Single Nucleotide Polymorphism in the <em>MDM2</em> Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells
Open the PDF for A Single Nucleotide Polymorphism in the <em>MDM2</em> Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells in another window
Journal Articles

A Single Nucleotide Polymorphism in the MDM2 Gene: From a Molecular and Cellular Explanation to Clinical Effect

Gareth L. Bond, Wenwei Hu, Arnold Levine
Journal: Cancer Research
Cancer Res (2005) 65 (13): 5481–5484.
https://doi.org/10.1158/0008-5472.CAN-05-0825
Published: 01 July 2005
View article titled, A Single Nucleotide Polymorphism in the <em>MDM2</em> Gene: From a Molecular and Cellular Explanation to Clinical Effect
Open the PDF for A Single Nucleotide Polymorphism in the <em>MDM2</em> Gene: From a Molecular and Cellular Explanation to Clinical Effect in another window
Journal Articles

Inhibition of Benzo(a)pyrene Diol-Epoxide-induced Transactivation of Activated Protein 1 and Nuclear Factor κB by Black Raspberry Extracts

Chuanshu Huang, Yi Huang, Jingxia Li, Wenwei Hu, Robeena Aziz, Moon-shong Tang, Nanjun Sun, John Cassady, Gary D. Stoner
Journal: Cancer Research
Cancer Res (2002) 62 (23): 6857–6863.
Published: 01 December 2002
View article titled, Inhibition of Benzo(a)pyrene Diol-Epoxide-induced Transactivation of Activated Protein 1 and Nuclear Factor κB by Black Raspberry Extracts
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