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Wendy B. London
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Journal Articles

Abstract CT195: A phase 2 clinical trial of palbociclib and ganitumab for relapsed/refractory Ewing sarcoma

David S. Shulman, Katherine Thornton, Edwin Choy, Lillian M. Guenther, Kerri Cavanaugh, Megan Forsyth, Kylene DeSmith, Catherine Clinton, Kimberly Stegmaier, Brian Crompton, Wendy B. London, Steven G. DuBois
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT195.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT195
Published: 15 August 2020
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Journal Articles

Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Ting Tao, Hui Shi, Adam D. Durbin, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3450.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3450
Published: 15 August 2020
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Abstract A28: Targeted sequencing in 388 patients with high-risk or recurrent/refractory pediatric extracranial solid malignancies: An interim report from the GAIN Consortium/iCat2 Study

Laura B. Corson, Alanna J. Church, Deirdre Reidy, Pei-Chi Kao, Wenjun Kang, Navin Pinto, Luke Maese, Theodore W. Laetsch, AeRang Kim, Susan I. Vear, Margaret E. Macy, Mark A. Applebaum, Lobin A. Lee, Duong Doan, R. Seth Pinches, Seong Choi, Suzanne J. Forrest, Catherine M. Clinton, Brian D. Crompton, Laura E. MacConaill, Samuel L. Volchenboum, Neal I. Lindeman, Steven G. DuBois, Wendy B. London, Katherine A. Janeway
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A28.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A28
Published: 15 July 2020
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Journal Articles

Abstract CT112: A Phase I multicenter trial of the dual MDM2/MDMX inhibitor ALRN-6924 in children and young adults with relapsed/refractory pediatric cancers

David S. Shulman, Kieuhoa T. Vo, Elizabeth Fox, Jodi A. Muscal, Loren D. Walensky, Yana Pikman, Kimberly Stegmaier, Alanna Church, Brian D. Crompton, Andrew E. Place, Susan N. Chi, Allison F. O'Neill, Junne Kamihara, Suzanne Ezrre, Cecilia Carlowicz, Dawn Pinchasik, Hasan Al-Sayegh, Clement Ma, Wendy B. London, Steven G. DuBois
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT112.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT112
Published: 01 July 2019
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Journal Articles

Abstract LB-048: Impact of KIR/KIR ligand genotype for neuroblastoma patients in a Phase 3 COG immunotherapy trial

Amy K. Erbe, Wei Wang, Lakeesha Carmichael, KyungMann Kim, Patrick K. Reville, Wendy B. London, Jacquelyn A. Hank, Mitchell B. Diccianni, Arlene Naranjo, Michael Hogarty, Julie R. Park, Alice L. Yu, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-048.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-048
Published: 01 July 2017
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Journal Articles

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

MoonSun Jung, Amanda J. Russell, Bing Liu, Joshy George, Pei Yan Liu, Tao Liu, Anna DeFazio, David D.L. Bowtell, André Oberthuer, Wendy B. London, Jamie I. Fletcher, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (4): 971–981.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2906
Published: 14 February 2017
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Includes: Supplementary data
Journal Articles

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Rosemary O'Brien, Sieu L. Tran, Michelle F. Maritz, Bing Liu, Cheng Fei Kong, Stefania Purgato, Chen Yang, Jayne Murray, Amanda J. Russell, Claudia L. Flemming, Georg von Jonquieres, Hilda A. Pickett, Wendy B. London, Michelle Haber, Preethi H. Gunaratne, Murray D. Norris, Giovanni Perini, Jamie I. Fletcher, Karen L. MacKenzie
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3604–3617.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-0879
Published: 14 June 2016
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Includes: Supplementary data
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Abstract 475: Identification of SHANK2 as a tumor suppressor disrupted by recurrent somatic structural variation (SV) in neuroblastoma

Karina Conkrite, Nicole Ferraro, Lee McDaniel, Derek A. Oldridge, Edward Attiyeh, Shahab Asgharzadeh, Maura Diamond, Jaime Guidry Auvil, Tanja Davidsen, Malcom Smith, Wendy B. London, Robert Seeger, Javed Khan, Daniela S. Gerhard, John M. Maris, Sharon J. Diskin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 475.
DOI: https://doi.org/10.1158/1538-7445.AM2015-475
Published: 01 August 2015
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Journal Articles

Abstract B40: MYCN/MYC protein expression in high-MKI (Mitosis-Karyorrhexis Index) neuroblastomas: A report from the Children's Oncology Group

Larry L. Wang, Risa Teshiba, Lejian He, Arlene Naranjo, Wendy B. London, Julie M. Gastier-Foster, Robert C. Seeger, Susan L. Cohn, John M. Maris, Julie R. Park, Michael D. Hogarty, Hiroyuki Shimada
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B40.
DOI: https://doi.org/10.1158/1538-7445.PEDCAN-B40
Published: 09 October 2014
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Journal Articles

Abstract 5138: Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

Jeyran Shahbazi, Christopher J. Scarlett, Murray Norris, Bing Liu, Michelle Haber, Andrew E. Tee, Alice Carrier, Andrew V. Biankin, Wendy B. London, Glenn M. Marshall, Richard Lock, Tao Liu
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5138.
DOI: https://doi.org/10.1158/1538-7445.AM2014-5138
Published: 01 October 2014
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Journal Articles

Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Murray D. Norris, Laura D. Gamble, Jayne Murray, Stefania Purgato, Giorgio Milazzo, Lesley J. Ashton, Andrei Oberthuer, Wendy B. London, Mike D. Hogarty, Mattias Fischer, David Ziegler, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3808.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3808
Published: 15 April 2013
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Journal Articles

Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma

Murray D. Norris, Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine Burkhart, Amanda Russell, Emanuele Valli, Andre Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 789.
DOI: https://doi.org/10.1158/1538-7445.AM2012-789
Published: 15 April 2012
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Journal Articles

Abstract 2486: African ancestry is associated with high-risk disease and event-free survival in children with neuroblastoma

Navin Pinto, Eric R. Gamazon, Hae Kyung Im, Anuar Konkashbaev, Nancy J. Cox, Mary Eileen Dolan, Sharon J. Diskin, Wendy B. London, John M. Maris, Susan L. Cohn
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2486.
DOI: https://doi.org/10.1158/1538-7445.AM2012-2486
Published: 15 April 2012
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Journal Articles

N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine A. Burkhart, Amanda Russell, Emanuele Valli, Janice Smith, André Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Murray D. Norris, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2012) 72 (4): 845–853.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-1885
Published: 14 February 2012
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Includes: Supplementary data
Journal Articles

Abstract 4756: Exome sequencing of 81 neuroblastomas identifies a wide diversity of somatic mutation

Trevor J. Pugh, Michael Lawrence, Carrie Sougnez, Gad Getz, Edward Attiyeh, Michael Hogarty, Sharon Diskin, Mosse Yael, Maura Diamond, Shahab Asgharzadeh, Richard Sposto, Jun S. Wei, Thomas Badgett, Wendy B. London, Julie Gastier-Foster, Malcolm A. Smith, Daniela S. Gerhard, Robert Seeger, Javed Khan, Matthew L. Meyerson, John M. Maris, NCI Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4756.
DOI: https://doi.org/10.1158/1538-7445.AM2011-4756
Published: 15 April 2011
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Journal Articles

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Murray D. Norris, Michelle J. Henderson, Antonio Porro, Marcia Munoz, Nunzio Iraci, Chengyuan Xue, Jayne Murray, Claudia Flemming, Jamie Fletcher, Samuele Gherardi, Alan Kwek, Amanda Russell, Wendy B. London, Allen B. Buxton, Lesley Ashton, Alan C. Sartorelli, Susan L. Cohn, Manfred Schwab, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 954.
DOI: https://doi.org/10.1158/1538-7445.AM2011-954
Published: 15 April 2011
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Journal Articles

Genotypes of NK Cell KIR Receptors, Their Ligands, and Fcγ Receptors in the Response of Neuroblastoma Patients to Hu14.18-IL2 Immunotherapy

David C. Delgado, Jacquelyn A. Hank, Jill Kolesar, David Lorentzen, Jacek Gan, Songwon Seo, KyungMann Kim, Suzanne Shusterman, Stephen D. Gillies, Ralph A. Reisfeld, Richard Yang, Brian Gadbaw, Kenneth B. DeSantes, Wendy B. London, Robert C. Seeger, John M. Maris, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9554–9561.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-2211
Published: 06 December 2010
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microRNA Signature and Expression of Dicer and Drosha Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma

Ruey-Jen Lin, You-Chin Lin, Jeremy Chen, Huan-Hsien Kuo, Yuan-Yan Chen, Mitchell B. Diccianni, Wendy B. London, Chih-Hao Chang, Alice L. Yu
Journal: Cancer Research
Cancer Res (2010) 70 (20): 7841–7850.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-0970
Published: 13 October 2010
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Includes: Supplementary data
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Abstract 5249: Identification of genome-wide alternative splicing events in high-risk MYCN amplified neuroblastomas

Shahab Asgharzadeh, Lingyun Ji, Richard Sposto, Edward Attiyeh, Yue-Xian Tu, Michael Hadjidaniel, Michael D. Hogarty, Wendy B. London, Julie Gastier-Foster, Jun Wei, Xiang Guo, Daniela S. Gerhard, Malcolm A. Smith, Javed Khan, John M. Maris, Robert C. Seeger
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5249.
DOI: https://doi.org/10.1158/1538-7445.AM10-5249
Published: 15 April 2010
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Journal Articles

Abstract 5015: Hcasz5, CASZ1 gene transcript variant 2 with 5 zinc fingers functions as a tumor suppressor in Neuroblastoma

Zhihui Liu, Wendy B. London, John Maris, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5015.
DOI: https://doi.org/10.1158/1538-7445.AM10-5015
Published: 15 April 2010
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