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Journal Articles

Abstract B008: Machine-learning modelling of lung cancer metastasis to the brain using alterations in DNA methylation

Jeffrey A Zuccato, Yasin Mamatjan, Farshad Nassiri, Andrew Ajisebutu, Jeffrey Liu, Ammara Muazzam, Olivia Singh, Wen Zhang, Mathew Voisin, Suganth Suppiah, Olli Saarela, Ming Tsao, Thomas Kislinger, Kenneth Aldape, Michael Moran, Vikas Patil, Gelareh Zadeh
Journal: Cancer Research
Cancer Res (2025) 85 (3_Supplement): B008.
https://doi.org/10.1158/1538-7445.DNAMETHYLATION-B008
Published: 01 February 2025
View article titled, Abstract B008: <em>Machine-learning modelling of lung cancer metastasis to the brain using alterations in DNA methylation</em>
Journal Articles

Abstract 2152: Targetable oncogenic fusions and other alterations in bone and soft-tissue tumors assessed by RNA and DNA-based next-generation sequencing in real-world experience

Rongfang Dong, Lan Li, Lihua Gong, Mengmeng Tian, Tingting Zhang, Wen Zhang, Yi Ding
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2152.
https://doi.org/10.1158/1538-7445.AM2023-2152
Published: 04 April 2023
View article titled, Abstract 2152: Targetable oncogenic fusions and other alterations in bone and soft-tissue tumors assessed by RNA and DNA-based next-generation sequencing in real-world experience
Journal Articles

Abstract 3755: Comprehensive antitumor immune activation by a novel TLR7/8 targeting agent NKTR-262 combined with CD122-biased immunostimulatory cytokine NKTR-214

Saul Kivimae, Marlene Hennessy, Rhoneil Pena, Yolanda Kirksey, Wildaliz Nieves, Phi Quatch, Janet Cetz, Zhongxu Ren, Haiying Cai, BoLiang Deng, Wen Zhang, John L. Langowski, Christie Fanton, Neel K. Anand, Werner Rubas, Steve Doberstein, Jonathan Zalevsky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3755.
https://doi.org/10.1158/1538-7445.AM2018-3755
Published: 01 July 2018
View article titled, Abstract 3755: Comprehensive antitumor immune activation by a novel TLR7/8 targeting agent NKTR-262 combined with CD122-biased immunostimulatory cytokine NKTR-214
Journal Articles

Abstract 2674: Novel tubulin polymerization inhibitors repress tumor xenografts in nude mice and leukemia in zebrafish

Yanqi Xie, Liliia Kril, Wen Zhang, Mykhaylo Frasinyuk, Svitlana Bondarenko, Elizabeth Hausman, Zachary Martin, Przemyslaw Wyrebek, Tianxin Yu, Changguo Zhan, Vitaliy Sviripa, Jessica Blackburn, David Watt, Chunming Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2674.
https://doi.org/10.1158/1538-7445.AM2018-2674
Published: 01 July 2018
View article titled, Abstract 2674: Novel tubulin polymerization inhibitors repress tumor xenografts in nude mice and leukemia in zebrafish
Journal Articles

Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors

Fabio Conforti, Xu Zhang, Guanhua Rao, Tommaso De Pas, Yoko Yonemori, Jose Antonio Rodriguez, Justine N. McCutcheon, Raneen Rahhal, Anna T. Alberobello, Yisong Wang, Yu-Wen Zhang, Udayan Guha, Giuseppe Giaccone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (20): 5614–5627.
https://doi.org/10.1158/0008-5472.CAN-17-1323
Published: 15 October 2017
View article titled, Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors
Open the PDF for Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2148: Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effects

Wen Zhang, Kin Yip Tam
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2148.
https://doi.org/10.1158/1538-7445.AM2017-2148
Published: 01 July 2017
View article titled, Abstract 2148: Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effects
Journal Articles

Abstract 4893: AKT1 signaling negatively regulates invasion and metastasis of non-small cell lung cancer cells carrying mutations in KRAS or EGFR

Guanhua Rao, Mariaelena Pierobon, In-Kyu Kim, Wei-Hsun Hsu, Jianghong Deng, Yong-Wha Moon, Emanuel F. Petricoin, Yu-Wen Zhang, Yisong Wang, Giuseppe Giaccone
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4893.
https://doi.org/10.1158/1538-7445.AM2017-4893
Published: 01 July 2017
View article titled, Abstract 4893: AKT1 signaling negatively regulates invasion and metastasis of non-small cell lung cancer cells carrying mutations in KRAS or EGFR
Journal Articles

Abstract 764: Survival analysis for the elderly esophageal cancer patients (≥80 years) with surgery and non-surgery treatments

Dan Feng Du, Dan Feng Du, Fu You Zhou, Lian Qun Zhang, Xue Na Han, Yuan Yuan, Zong Min Fan, Jian Po Wang, Yao Wen Zhang, Tai Jiang Liu, Guo Hua Liu, Yi Jun Qi, Yan Rui Zhang, Li Dong Wang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 764.
https://doi.org/10.1158/1538-7445.AM2017-764
Published: 01 July 2017
View article titled, Abstract 764: Survival analysis for the elderly esophageal cancer patients (≥80 years) with surgery and non-surgery treatments
Journal Articles

Abstract 2026: CHK1 inhibition synergizes with cisplatin to promote mitotic cell death via activation of caspase 2 and downregulation of E2F1 in small cell lung cancer

Wei-Hsun Hsu, Xiaoliang Zhao, In-Gyu Kim, Guanhua Rao, Justine McCutcheon, Shuo-Tse Hsu, Afshin Dowlati, Yu-Wen Zhang, Giuseppe Giaccone
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2026.
https://doi.org/10.1158/1538-7445.AM2017-2026
Published: 01 July 2017
View article titled, Abstract 2026: CHK1 inhibition synergizes with cisplatin to promote mitotic cell death via activation of caspase 2 and downregulation of E2F1 in small cell lung cancer
Journal Articles

Abstract 175: Transcriptomic and epigenetic dynamics of breast cancer progression in the MMTV-PyMT mouse model

Ying Cai, Ruben Nogales-Cadenas, Quanwei Zhang, Jhih-rong Lin, Wen Zhang, Zhengdong Zhang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 175.
https://doi.org/10.1158/1538-7445.AM2016-175
Published: 15 July 2016
View article titled, Abstract 175: Transcriptomic and epigenetic dynamics of breast cancer progression in the MMTV-PyMT mouse model
Journal Articles

Abstract 2724: Collaborative regulation of cell cycle progression by Chk1 and E2F1 in small cell lung cancer cells

Wei-Hsun Hsu, In-Gyu Kim, Guanhua Rao, Justine McCutcheon, Shuo-Tse Hsu, Yu-Wen Zhang, Giuseppe Giaccone
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2724.
https://doi.org/10.1158/1538-7445.AM2016-2724
Published: 15 July 2016
View article titled, Abstract 2724: Collaborative regulation of cell cycle progression by Chk1 and E2F1 in small cell lung cancer cells
Journal Articles

Abstract 1822: Proteome signatures distinguish lung cancer subtypes, define metabolism states, and have prognostic impact

Wen Zhang, Paul Taylor, Lei Li, Yuhong Wei, Jiefei Tong, Vladimir Ignatchenko, Nhu-An Pham, Thomas Kislinger, Ming-sound Tsao, Michael Moran
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1822.
https://doi.org/10.1158/1538-7445.AM2015-1822
Published: 01 August 2015
View article titled, Abstract 1822: Proteome signatures distinguish lung cancer subtypes, define metabolism states, and have prognostic impact
Journal Articles

Abstract SY33-04: Integrated omic analysis of lung cancer reveals metabolism-proteome signatures with prognostic impact

Michael F. Moran, Lei Li, Yuhong Wei, Paul Taylor, Christine To, Jiefei Tong, Vladimir Ignatchenko, Melania Pintilie, Nhu-An Pham, Wen Zhang, Lakshmi Muthuswamy, Frances A. Shepherd, Thomas Kislinger, Ming S. Tsao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY33-04.
https://doi.org/10.1158/1538-7445.AM2015-SY33-04
Published: 01 August 2015
View article titled, Abstract SY33-04: Integrated omic analysis of lung cancer reveals metabolism-proteome signatures with prognostic impact
Journal Articles

Abstract 1088: Exploration of the human peptidome for cancer-specific peptide-MHC targets

Ankur Dhanik, Wen Zhang, Jessica Kirshner, Douglas MacDonald, Susan Croll, Calvin Lin, Gavin Thurston, Andrew Murphy
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1088.
https://doi.org/10.1158/1538-7445.AM2015-1088
Published: 01 August 2015
View article titled, Abstract 1088: Exploration of the human peptidome for cancer-specific peptide-MHC targets
Journal Articles

Abstract 5388: Methionine S-adenosyltransferase 2A (MAT2A) inhibitors for cancer treatment

Wen Zhang, Vitaliy Sviripa, David Watt, Chunming Liu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5388.
https://doi.org/10.1158/1538-7445.AM2015-5388
Published: 01 August 2015
View article titled, Abstract 5388: Methionine S-adenosyltransferase 2A (MAT2A) inhibitors for cancer treatment
Journal Articles

Abstract 2167: Strengthening anti-cancer effects on non-small cell lung carcinoma by dual blockage of MET and EGFR in a context-dependent manner.

Yu-Wen Zhang, Ben Staal, Curt Essenburg, Steven Lewis, Dafna Kaufman, George F. Vande Woude
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2167.
https://doi.org/10.1158/1538-7445.AM2013-2167
Published: 15 April 2013
View article titled, Abstract 2167: Strengthening anti-cancer effects on non-small cell lung carcinoma by dual blockage of MET and EGFR in a context-dependent manner.
Journal Articles

Abstract 2465: A new polymer conjugated taxane shows improved efficacy in tumor xenograft models.

Dennis G. Fry, Christine Brew, Steve Lee, Ute Hoch, Wen Zhang, Antoni Kozlowski, Fadil Dahhani, Nagabhusan Tangudu, Stephen D. Harrison, Jennifer Riggs-Sauthier
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2465.
https://doi.org/10.1158/1538-7445.AM2013-2465
Published: 15 April 2013
View article titled, Abstract 2465: A new polymer conjugated taxane shows improved efficacy in tumor xenograft models.
Journal Articles

Abstract 4092: Cancer-type regulation of MIG-6 expression by 5-Aza-2′-deoxycytidine and Trichostatin A

Yu-Wen Zhang, Ben Staal, George F. Vande Woude
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4092.
https://doi.org/10.1158/1538-7445.AM2012-4092
Published: 15 April 2012
View article titled, Abstract 4092: Cancer-type regulation of MIG-6 expression by 5-Aza-2′-deoxycytidine and Trichostatin A
Journal Articles

Abstract LB-21: Regulation of Bmi1 by β-catenin and KLF4 and its implication in colon cancer

Tianxin Yu, Xi Chen, Wen Zhang, Deannon Colon, Jiandang Shi, Dana Napier, Piotr Rychahou, Wang Lu, Eun Y. Lee, Heidi Weiss, B. Mark Evers, Chunming Liu
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-21.
https://doi.org/10.1158/1538-7445.AM2012-LB-21
Published: 15 April 2012
View article titled, Abstract LB-21: Regulation of Bmi1 by β-catenin and KLF4 and its implication in colon cancer
Journal Articles

MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor–Dependent Fashion to Suppress Carcinoma Growth

Yu-Wen Zhang, Ben Staal, Curt Essenburg, Yanli Su, Liang Kang, Rich West, Dafna Kaufman, Tom DeKoning, Bryn Eagleson, Sean G. Buchanan, George F. Vande Woude
Journal: Cancer Research
Cancer Res (2010) 70 (17): 6880–6890.
https://doi.org/10.1158/0008-5472.CAN-10-0898
Published: 31 August 2010
View article titled, MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor–Dependent Fashion to Suppress Carcinoma Growth
Open the PDF for MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor–Dependent Fashion to Suppress Carcinoma Growth in another window
Includes: Supplementary data