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Weiguang Wang
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Journal Articles

Abstract 5877: Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells

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Benjamin J. Small, Ogechi Nkeonye, Vinodh Kannappan, Shalini Kumarasamy, Kate Butcher, Karim Azar, Gowtham Rajendran, Yoshitha Lakshmanan Lakshmanan, Mark Morris, Christopher Heeschen, Yaohe Wang, Weiguang Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5877.
https://doi.org/10.1158/1538-7445.AM2024-5877
Published: 22 March 2024
View article titled, Abstract 5877: Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells
Journal Articles

Abstract 5053: A critical role for copper in enhanced radioirdide uptake in thyroid cancer cells

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Katie Brookes, Ling Zha, Jana Kim, Vinodh Kannappans, Weiguang Wang, Kavitha Sunassee, Philip J. Blower, Vicki E. Smith, Martin L. Read, Christopher J. McCabe
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5053.
https://doi.org/10.1158/1538-7445.AM2023-5053
Published: 04 April 2023
View article titled, Abstract 5053: A critical role for copper in enhanced radioirdide uptake in thyroid cancer cells
Journal Articles

Abstract 1975: Disulfiram targets hypoxia-induced cancer stem cells and reverses chemoresistance in non-small cell lung cancer

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Kate Butcher, Vinodh Kannappan, Karim Azar, Rajagopal Kilari, Ogechi Nkeonye, Mark R. Morris, Christopher McConville, Yaohe Wang, Weiguang Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1975.
https://doi.org/10.1158/1538-7445.AM2018-1975
Published: 01 July 2018
View article titled, Abstract 1975: Disulfiram targets hypoxia-induced cancer stem cells and reverses chemoresistance in non-small cell lung cancer
Journal Articles

The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects

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Xiaoyan Sun, Weiguang Wang, Jiao Chen, Xueting Cai, Jie Yang, Yang Yang, Huaijiang Yan, Xiaolan Cheng, Juan Ye, Wuguang Lu, Chunping Hu, Handong Sun, Jianxin Pu, Peng Cao
Journal: Cancer Research
Cancer Res (2017) 77 (4): 926–936.
https://doi.org/10.1158/0008-5472.CAN-16-0987
Published: 14 February 2017
View article titled, The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
Open the PDF for The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects in another window
Includes: Supplementary data
Journal Articles

Abstract 4067: Pluronic micelle-encapsulated Disulfiram targets cancer stem-like cells and reverses pan-resistance in acquired resistant breast cancer cell lines

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EREBI P. TAWARI, Peng Liu, Zhipeng Wang, Vinodh Kannappan, Christopher Mcconville, Angel Armesilla, John Darling, Juan Irache, Krassimira Yoncheva, Weiguang Wang, Petar Petrov
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4067.
https://doi.org/10.1158/1538-7445.AM2015-4067
Published: 01 August 2015
View article titled, Abstract 4067: Pluronic micelle-encapsulated Disulfiram targets cancer stem-like cells and reverses pan-resistance in acquired resistant breast cancer cell lines
Journal Articles

Abstract 222: Disulfiram targets glioblsatoma stem like cells by modulating aldehyde dehydrogenase and hypoxia-NF-κB pathway

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Vinodh Kannappan, Peng Liu, Sarah Brown, Xiuwu Bian, Tawari Patricia Erebi, Angel L. Armesilla, John L. Darling, Weiguang Wang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 222.
https://doi.org/10.1158/1538-7445.AM2014-222
Published: 01 October 2014
View article titled, Abstract 222: Disulfiram targets glioblsatoma stem like cells by modulating aldehyde dehydrogenase and hypoxia-NF-κB pathway
Journal Articles

Abstract 227: Manipulation of hypoxia-NFκB pathway to target breast cancer stem cells.

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Peng Liu, Sarah Brown, Vinodh Kannappan, Angel L. Armesilla, John L. Darling, Weiguang Wang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 227.
https://doi.org/10.1158/1538-7445.AM2013-227
Published: 15 April 2013
View article titled, Abstract 227: Manipulation of hypoxia-NFκB pathway to target breast cancer stem cells.
Journal Articles

Abstract 5410: Simultaneously tackling NFκB and JNK pathways to sensitise breast cancer cell lines to conventional anticancer drugs

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Nga C. Yip*, Ivo S. Fombon*, Peng Liu, Sarah Brown, Angel L. Armesilla, James Cassidy, John L. Darling, Weiguang Wang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5410.
https://doi.org/10.1158/1538-7445.AM10-5410
Published: 15 April 2010
View article titled, Abstract 5410: Simultaneously tackling NFκB and JNK pathways to sensitise breast cancer cell lines to conventional anticancer drugs
Journal Articles

Abstract 5380: Disulfiram sensitised cytotoxicity of gemcitabine in human glioblastoma cell lines

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Sarah Brown, Peng Liu, Tuge Goktug, John Darling, Weiguang Wang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5380.
https://doi.org/10.1158/1538-7445.AM10-5380
Published: 15 April 2010
View article titled, Abstract 5380: Disulfiram sensitised cytotoxicity of gemcitabine in human glioblastoma cell lines
Journal Articles

Abstract #4586: Disulfiram inhibits NF-\#954;B activity and reverses gemcitabine resistance in breast and colon cancer cell lines

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Xiaoxia Guo, Shuchita Pandey, Angel Armessilla, John Darling, James Cassidy, Weiguang Wang
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4586.
Published: 01 May 2009
View article titled, Abstract #4586: Disulfiram inhibits NF-\#954;B activity and reverses gemcitabine resistance in breast and colon cancer cell lines
Journal Articles

In vitro     evaluation of cancer specific a novel     CEA     enhancer-promoter system for gene-directed enzyme prodrug therapy in colon cancer cell lines

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Xiaoxia Guo, Jeffry Evans, Sangeeta Somanath, Andreas Schatzlein, James Cassidy, Weiguang Wang
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3290.
Published: 01 May 2007
View article titled, In vitro     evaluation of cancer specific a novel     CEA     enhancer-promoter system for gene-directed enzyme prodrug therapy in colon cancer cell lines
Journal Articles

Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells

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Weiguang Wang, James Cassidy, Vincent O’Brien, Kevin M. Ryan, Elaina Collie-Duguid
Journal: Cancer Research
Cancer Res (2004) 64 (22): 8167–8176.
https://doi.org/10.1158/0008-5472.CAN-04-0970
Published: 17 November 2004
View article titled, Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells
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Includes: Supplementary data
Journal Articles

Global analysis of molecular genetic mechanisms in anticancer drug chemoresistance.

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Weiguang Wang, Elaina Collie-Duguid, James Cassidy
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 517–518.
Published: 01 April 2004
View article titled, Global analysis of molecular genetic mechanisms in anticancer drug chemoresistance.
Journal Articles

Pharmacogenomic Dissection of Resistance to Thymidylate Synthase Inhibitors

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Weiguang Wang, Sharon Marsh, James Cassidy, Howard L. McLeod
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5505–5510.
Published: 01 July 2001
View article titled, Pharmacogenomic Dissection of Resistance to Thymidylate Synthase Inhibitors
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Journal Articles

Insulin-like Growth Factor II and PAX3-FKHR Cooperate in the Oncogenesis of Rhabdomyosarcoma

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Weiguang Wang, Pat Kumar, Weizhi Wang, John Epstein, Lee Helman, Jim V. Moore, Shant Kumar
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4426–4433.
Published: 01 October 1998
View article titled, Insulin-like Growth Factor II and PAX3-FKHR Cooperate in the Oncogenesis of Rhabdomyosarcoma
Open the PDF for Insulin-like Growth Factor II and PAX3-FKHR Cooperate in the Oncogenesis of Rhabdomyosarcoma in another window